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Protein

GTPase Era

Gene

era

Organism
Coxiella burnetii (strain RSA 493 / Nine Mile phase I)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi13 – 20GTPUniRule annotation8
Nucleotide bindingi60 – 64GTPUniRule annotation5
Nucleotide bindingi121 – 124GTPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding, rRNA-binding
Biological processRibosome biogenesis
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciCBUR227377:G1G0B-1485-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
GTPase EraUniRule annotation
Gene namesi
Name:eraUniRule annotation
Ordered Locus Names:CBU_1502
OrganismiCoxiella burnetii (strain RSA 493 / Nine Mile phase I)
Taxonomic identifieri227377 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaLegionellalesCoxiellaceaeCoxiella
Proteomesi
  • UP000002671 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm
  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001800101 – 295GTPase EraAdd BLAST295

Proteomic databases

PRIDEiP51836

Expressioni

Developmental stagei

More than twofold more abundant in the small cell variant (SCV) stage than in the large cell variant (LCV) stage (at protein level). LCVs are more metabolically active than SCVs.1 Publication

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi227377.CBU_1502

Structurei

3D structure databases

ProteinModelPortaliP51836
SMRiP51836
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 172Era-type GAdd BLAST168
Domaini203 – 279KH type-2UniRule annotationAdd BLAST77

Sequence similaritiesi

Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CWT Bacteria
COG1159 LUCA
HOGENOMiHOG000245596
KOiK03595
OMAiKVAKDWQ

Family and domain databases

CDDicd04163 Era, 1 hit
Gene3Di3.30.300.20, 1 hit
HAMAPiMF_00367 GTPase_Era, 1 hit
InterProiView protein in InterPro
IPR030388 G_ERA_dom
IPR005662 GTP-bd_Era
IPR006073 GTP_binding_domain
IPR015946 KH_dom-like_a/b
IPR004044 KH_dom_type_2
IPR009019 KH_sf_prok-type
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
PfamiView protein in Pfam
PF07650 KH_2, 1 hit
PF01926 MMR_HSR1, 1 hit
PRINTSiPR00326 GTP1OBG
SUPFAMiSSF52540 SSF52540, 1 hit
SSF54814 SSF54814, 1 hit
TIGRFAMsiTIGR00436 era, 1 hit
TIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51713 G_ERA, 1 hit
PS50823 KH_TYPE_2, 1 hit

Sequencei

Sequence statusi: Complete.

P51836-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKPTYCGYAA IIGRPNVGKS TLLNQLLEQK ISITSRKPQT TRYQILGVKT
60 70 80 90 100
FKDIQVIYVD TPGLHAGTER TINRYMNRTA RGALRDVDAI VFVIEPHWES
110 120 130 140 150
QDAWVLDNLK EIETPVFLVI NKVDKIKNRA ELLPLIEKVS SLYAFQKITP
160 170 180 190 200
LSAKTGDQVG TLEQAVHQLM PESPFYFPPE QVTDRSDQFM ASEIIREKLM
210 220 230 240 250
RLLGQEIPYS LAVTLIEFRK EEKIIRISAV IWVEKKSQKG IVIGKGGERL
260 270 280 290
KRVGTNARLD MEKWFGKRVF LQLWVKVKSG WADNERLLRE LGFEE
Length:295
Mass (Da):33,873
Last modified:October 1, 1996 - v1
Checksum:i559AB52D2922119E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L27436 Genomic DNA Translation: AAA69691.1
AE016828 Genomic DNA Translation: AAO90999.1
PIRiS60768
RefSeqiNP_820485.1, NC_002971.3
WP_010958267.1, NC_002971.4

Genome annotation databases

EnsemblBacteriaiAAO90999; AAO90999; CBU_1502
GeneIDi1209412
KEGGicbu:CBU_1502
PATRICifig|227377.7.peg.1504

Similar proteinsi

Entry informationi

Entry nameiERA_COXBU
AccessioniPrimary (citable) accession number: P51836
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 28, 2018
This is version 115 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Coxiella burnetii
    Coxiella burnetii (strain RSA 493): entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families

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