UniProtKB - P51828 (ADCY7_HUMAN)
Protein
Adenylate cyclase type 7
Gene
ADCY7
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:23229509, PubMed:18541530). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23842570, PubMed:23229509). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity).By similarity2 Publications3 Publications
Catalytic activityi
- EC:4.6.1.12 Publications
Cofactori
Mg2+By similarity, Mn2+By similarityNote: Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).By similarity
Activity regulationi
Activated by the G protein alpha subunit (PubMed:18541530). Activated by the G protein beta and gamma subunit complex (PubMed:23229509). Activated by GNA13 and GNA12 (PubMed:18541530). Ethanol and phorbol 12,13-dibutanoate significantly potentiate adenylate cyclase activity generated in response to the activation of the prostanoid receptor by the agonist prostaglandin E11- in a PKC-dependent manner (PubMed:12454008). Inhibited by lithium (By similarity).By similarity3 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 284 | Magnesium 1; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 284 | Magnesium 2; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 285 | Magnesium 2; via carbonyl oxygen; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 328 | Magnesium 1; catalyticPROSITE-ProRule annotation | 1 | |
Metal bindingi | 328 | Magnesium 2; catalyticPROSITE-ProRule annotation | 1 | |
Binding sitei | 372 | ATPBy similarity | 1 | |
Binding sitei | 931 | ATPBy similarity | 1 | |
Binding sitei | 1057 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 284 – 289 | ATPBy similarity | 6 | |
Nucleotide bindingi | 326 – 328 | ATPBy similarity | 3 | |
Nucleotide bindingi | 1010 – 1012 | ATPBy similarity | 3 | |
Nucleotide bindingi | 1017 – 1021 | ATPBy similarity | 5 |
GO - Molecular functioni
- adenylate cyclase activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
GO - Biological processi
- activation of adenylate cyclase activity Source: Reactome
- activation of protein kinase A activity Source: Reactome
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: Reactome
- cAMP biosynthetic process Source: UniProtKB
- cellular response to ethanol Source: UniProtKB
- cellular response to glucagon stimulus Source: Reactome
- cellular response to lithium ion Source: UniProtKB
- G protein-coupled receptor signaling pathway Source: Reactome
- negative regulation of cytokine production involved in inflammatory response Source: UniProtKB
- regulation of adaptive immune response Source: UniProtKB
- renal water homeostasis Source: Reactome
Keywordsi
Molecular function | Lyase |
Biological process | cAMP biosynthesis |
Ligand | ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P51828 |
Reactomei | R-HSA-163359, Glucagon signaling in metabolic regulation R-HSA-163615, PKA activation R-HSA-164378, PKA activation in glucagon signalling R-HSA-170660, Adenylate cyclase activating pathway R-HSA-170670, Adenylate cyclase inhibitory pathway R-HSA-418555, G alpha (s) signalling events R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-5610787, Hedgehog 'off' state R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9664323, FCGR3A-mediated IL10 synthesis |
SIGNORi | P51828 |
Names & Taxonomyi
Protein namesi | Recommended name: Adenylate cyclase type 7Curated (EC:4.6.1.12 Publications)Alternative name(s): ATP pyrophosphate-lyase 7 Adenylate cyclase type VII Adenylyl cyclase 7 |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:238, ADCY7 |
MIMi | 600385, gene |
neXtProti | NX_P51828 |
VEuPathDBi | HostDB:ENSG00000121281.12 |
Subcellular locationi
Other locations
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 33 | CytoplasmicSequence analysisAdd BLAST | 33 | |
Transmembranei | 34 – 54 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 63 – 83 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 95 – 117 | HelicalSequence analysisAdd BLAST | 23 | |
Transmembranei | 122 – 142 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 147 – 167 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 197 – 594 | CytoplasmicSequence analysisAdd BLAST | 398 | |
Transmembranei | 595 – 615 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 620 – 640 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 669 – 688 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 718 – 737 | HelicalSequence analysisAdd BLAST | 20 | |
Transmembranei | 746 – 773 | HelicalSequence analysisAdd BLAST | 28 | |
Transmembranei | 794 – 814 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 815 – 1080 | CytoplasmicSequence analysisAdd BLAST | 266 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 477 – 482 | KMRASV → NAAIRS: Does not affect cAMP biosynthetic process in response to sphingosine 1-phosphate stimulation. Reduces by 40% cAMP biosynthetic process in response to C5 alpha chain stimulation. 1 Publication | 6 | |
Mutagenesisi | 485 – 489 | TRYLE → NAAIR: Reduces cAMP biosynthetic process in response to C5 alpha chain stimulation and more severely in response to sphingosine 1-phosphate stimulation. 1 Publication | 5 | |
Mutagenesisi | 491 – 496 | WGAARP → NAAIRS: Does not affect cAMP biosynthetic process in response to C5 alpha chain stimulation. Reduces by 40?60% cAMP biosynthetic process in response to sphingosine 1-phosphate stimulation. 1 Publication | 6 | |
Mutagenesisi | 494 – 499 | ARPFAH → NAAIRS: Does not affect cAMP biosynthetic process in response to C5 alpha chain stimulation. Reduces by 40?60% cAMP biosynthetic process in response to sphingosine 1-phosphate stimulation. 1 Publication | 6 | |
Mutagenesisi | 564 – 569 | SKSDDF → NAAIRS: Reduces cAMP biosynthetic process in response to C5 alpha chain stimulation and more severely in response to sphingosine 1-phosphate stimulation. 1 Publication | 6 |
Organism-specific databases
DisGeNETi | 113 |
OpenTargetsi | ENSG00000121281 |
PharmGKBi | PA28 |
Miscellaneous databases
Pharosi | P51828, Tbio |
Chemistry databases
ChEMBLi | CHEMBL2097167 |
Genetic variation databases
BioMutai | ADCY7 |
DMDMi | 1706218 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000195703 | 1 – 1080 | Adenylate cyclase type 7Add BLAST | 1080 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 701 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 776 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 781 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Phosphorylated by PRKCD.1 Publication
Keywords - PTMi
GlycoproteinProteomic databases
EPDi | P51828 |
jPOSTi | P51828 |
MassIVEi | P51828 |
MaxQBi | P51828 |
PaxDbi | P51828 |
PeptideAtlasi | P51828 |
PRIDEi | P51828 |
ProteomicsDBi | 56430 |
PTM databases
GlyGeni | P51828, 3 sites |
iPTMneti | P51828 |
PhosphoSitePlusi | P51828 |
SwissPalmi | P51828 |
Expressioni
Gene expression databases
Bgeei | ENSG00000121281, Expressed in granulocyte and 230 other tissues |
ExpressionAtlasi | P51828, baseline and differential |
Genevisiblei | P51828, HS |
Organism-specific databases
HPAi | ENSG00000121281, Low tissue specificity |
Interactioni
Protein-protein interaction databases
BioGRIDi | 106626, 4 interactors |
IntActi | P51828, 4 interactors |
STRINGi | 9606.ENSP00000378187 |
Chemistry databases
BindingDBi | P51828 |
Miscellaneous databases
RNActi | P51828, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 279 – 406 | Guanylate cyclase 1PROSITE-ProRule annotationAdd BLAST | 128 | |
Domaini | 879 – 1023 | Guanylate cyclase 2PROSITE-ProRule annotationAdd BLAST | 145 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 477 – 482 | Mediates regulation of adenylate cyclase activity by C5 alpha-induced G- beta and gamma pathway1 Publication | 6 | |
Regioni | 491 – 499 | Mediates regulation of adenylate cyclase activity by sphingosine 1-phosphate-induced G alpha 13 pathway1 Publication | 9 | |
Regioni | 506 – 584 | Modulates adenylate cyclase activity by modulating the binding of G(s)alpha to the high-affinity G(s)alpha binding site in 7C1a/7C21 PublicationAdd BLAST | 79 |
Domaini
The protein contains two modules with six transmembrane helices each; both are required for catalytic activity. Isolated N-terminal or C-terminal guanylate cyclase domains have no catalytic activity, but when they are brought together, enzyme activity is restored. The active site is at the interface of the two domains. Both contribute substrate-binding residues, but the catalytic metal ions are bound exclusively via the N-terminal guanylate cyclase domain.By similarity
Sequence similaritiesi
Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.PROSITE-ProRule annotation
Keywords - Domaini
Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3619, Eukaryota |
GeneTreei | ENSGT00940000159096 |
HOGENOMi | CLU_001072_2_5_1 |
InParanoidi | P51828 |
OMAi | LTWACLM |
OrthoDBi | 363718at2759 |
PhylomeDBi | P51828 |
TreeFami | TF313845 |
Family and domain databases
Gene3Di | 3.30.70.1230, 2 hits |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR032628, AC_N IPR030672, Adcy IPR009398, Adcy_conserved_dom IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF16214, AC_N, 1 hit PF06327, DUF1053, 1 hit PF00211, Guanylate_cyc, 2 hits |
PIRSFi | PIRSF039050, Ade_cyc, 1 hit |
SMARTi | View protein in SMART SM00044, CYCc, 2 hits |
SUPFAMi | SSF55073, SSF55073, 2 hits |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 1 hit PS50125, GUANYLATE_CYCLASE_2, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
P51828-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPAKGRYFLN EGEEGPDQDA LYEKYQLTSQ HGPLLLTLLL VAATACVALI
60 70 80 90 100
IIAFSQGDPS RHQAILGMAF LVLAVFAALS VLMYVECLLR RWLRALALLT
110 120 130 140 150
WACLVALGYV LVFDAWTKAA CAWEQVPFFL FIVFVVYTLL PFSMRGAVAV
160 170 180 190 200
GAVSTASHLL VLGSLMGGFT TPSVRVGLQL LANAVIFLCG NLTGAFHKHQ
210 220 230 240 250
MQDASRDLFT YTVKCIQIRR KLRIEKRQQE NLLLSVLPAH ISMGMKLAII
260 270 280 290 300
ERLKEHGDRR CMPDNNFHSL YVKRHQNVSI LYADIVGFTQ LASDCSPKEL
310 320 330 340 350
VVVLNELFGK FDQIAKANEC MRIKILGDCY YCVSGLPVSL PTHARNCVKM
360 370 380 390 400
GLDMCQAIKQ VREATGVDIN MRVGIHSGNV LCGVIGLRKW QYDVWSHDVS
410 420 430 440 450
LANRMEAAGV PGRVHITEAT LKHLDKAYEV EDGHGQQRDP YLKEMNIRTY
460 470 480 490 500
LVIDPRSQQP PPPSQHLPRP KGDAALKMRA SVRMTRYLES WGAARPFAHL
510 520 530 540 550
NHRESVSSGE THVPNGRRPK SVPQRHRRTP DRSMSPKGRS EDDSYDDEML
560 570 580 590 600
SAIEGLSSTR PCCSKSDDFY TFGSIFLEKG FEREYRLAPI PRARHDFACA
610 620 630 640 650
SLIFVCILLV HVLLMPRTAA LGVSFGLVAC VLGLVLGLCF ATKFSRCCPA
660 670 680 690 700
RGTLCTISER VETQPLLRLT LAVLTIGSLL TVAIINLPLM PFQVPELPVG
710 720 730 740 750
NETGLLAASS KTRALCEPLP YYTCSCVLGF IACSVFLRMS LEPKVVLLTV
760 770 780 790 800
ALVAYLVLFN LSPCWQWDCC GQGLGNLTKP NGTTSGTPSC SWKDLKTMTN
810 820 830 840 850
FYLVLFYITL LTLSRQIDYY CRLDCLWKKK FKKEHEEFET MENVNRLLLE
860 870 880 890 900
NVLPAHVAAH FIGDKLNEDW YHQSYDCVCV MFASVPDFKV FYTECDVNKE
910 920 930 940 950
GLECLRLLNE IIADFDELLL KPKFSGVEKI KTIGSTYMAA AGLSVASGHE
960 970 980 990 1000
NQELERQHAH IGVMVEFSIA LMSKLDGINR HSFNSFRLRV GINHGPVIAG
1010 1020 1030 1040 1050
VIGARKPQYD IWGNTVNVAS RMESTGELGK IQVTEETCTI LQGLGYSCEC
1060 1070 1080
RGLINVKGKG ELRTYFVCTD TAKFQGLGLN
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF5H4D1 | F5H4D1_HUMAN | Adenylate cyclase | ADCY7 | 734 | Annotation score: | ||
H3BQ93 | H3BQ93_HUMAN | Adenylate cyclase | ADCY7 | 530 | Annotation score: | ||
F5H699 | F5H699_HUMAN | Adenylate cyclase | ADCY7 | 433 | Annotation score: | ||
A0A669KBF7 | A0A669KBF7_HUMAN | Adenylate cyclase | ADCY7 | 152 | Annotation score: | ||
H3BMA5 | H3BMA5_HUMAN | Adenylate cyclase type 7 | ADCY7 | 108 | Annotation score: | ||
I3L3Q5 | I3L3Q5_HUMAN | Adenylate cyclase type 7 | ADCY7 | 81 | Annotation score: | ||
I3L2Y1 | I3L2Y1_HUMAN | Adenylate cyclase type 7 | ADCY7 | 17 | Annotation score: |
Sequence cautioni
The sequence BAA05021 differs from that shown. Reason: Erroneous initiation.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D25538 mRNA Translation: BAA05021.2 Different initiation. AC007597 Genomic DNA No translation available. BC126271 mRNA Translation: AAI26272.1 |
CCDSi | CCDS10741.1 |
PIRi | PN0453 |
RefSeqi | NP_001105.1, NM_001114.4 XP_016878384.1, XM_017022895.1 |
Genome annotation databases
Ensembli | ENST00000254235; ENSP00000254235; ENSG00000121281 ENST00000394697; ENSP00000378187; ENSG00000121281 ENST00000673801; ENSP00000501053; ENSG00000121281 |
GeneIDi | 113 |
KEGGi | hsa:113 |
UCSCi | uc002egd.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D25538 mRNA Translation: BAA05021.2 Different initiation. AC007597 Genomic DNA No translation available. BC126271 mRNA Translation: AAI26272.1 |
CCDSi | CCDS10741.1 |
PIRi | PN0453 |
RefSeqi | NP_001105.1, NM_001114.4 XP_016878384.1, XM_017022895.1 |
3D structure databases
SMRi | P51828 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 106626, 4 interactors |
IntActi | P51828, 4 interactors |
STRINGi | 9606.ENSP00000378187 |
Chemistry databases
BindingDBi | P51828 |
ChEMBLi | CHEMBL2097167 |
PTM databases
GlyGeni | P51828, 3 sites |
iPTMneti | P51828 |
PhosphoSitePlusi | P51828 |
SwissPalmi | P51828 |
Genetic variation databases
BioMutai | ADCY7 |
DMDMi | 1706218 |
Proteomic databases
EPDi | P51828 |
jPOSTi | P51828 |
MassIVEi | P51828 |
MaxQBi | P51828 |
PaxDbi | P51828 |
PeptideAtlasi | P51828 |
PRIDEi | P51828 |
ProteomicsDBi | 56430 |
Protocols and materials databases
Antibodypediai | 28237, 153 antibodies |
Genome annotation databases
Ensembli | ENST00000254235; ENSP00000254235; ENSG00000121281 ENST00000394697; ENSP00000378187; ENSG00000121281 ENST00000673801; ENSP00000501053; ENSG00000121281 |
GeneIDi | 113 |
KEGGi | hsa:113 |
UCSCi | uc002egd.3, human |
Organism-specific databases
CTDi | 113 |
DisGeNETi | 113 |
GeneCardsi | ADCY7 |
HGNCi | HGNC:238, ADCY7 |
HPAi | ENSG00000121281, Low tissue specificity |
MIMi | 600385, gene |
neXtProti | NX_P51828 |
OpenTargetsi | ENSG00000121281 |
PharmGKBi | PA28 |
VEuPathDBi | HostDB:ENSG00000121281.12 |
HUGEi | Search... |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3619, Eukaryota |
GeneTreei | ENSGT00940000159096 |
HOGENOMi | CLU_001072_2_5_1 |
InParanoidi | P51828 |
OMAi | LTWACLM |
OrthoDBi | 363718at2759 |
PhylomeDBi | P51828 |
TreeFami | TF313845 |
Enzyme and pathway databases
PathwayCommonsi | P51828 |
Reactomei | R-HSA-163359, Glucagon signaling in metabolic regulation R-HSA-163615, PKA activation R-HSA-164378, PKA activation in glucagon signalling R-HSA-170660, Adenylate cyclase activating pathway R-HSA-170670, Adenylate cyclase inhibitory pathway R-HSA-418555, G alpha (s) signalling events R-HSA-418594, G alpha (i) signalling events R-HSA-418597, G alpha (z) signalling events R-HSA-432040, Vasopressin regulates renal water homeostasis via Aquaporins R-HSA-5610787, Hedgehog 'off' state R-HSA-9660821, ADORA2B mediated anti-inflammatory cytokines production R-HSA-9664323, FCGR3A-mediated IL10 synthesis |
SIGNORi | P51828 |
Miscellaneous databases
BioGRID-ORCSi | 113, 10 hits in 873 CRISPR screens |
ChiTaRSi | ADCY7, human |
GeneWikii | ADCY7 |
GenomeRNAii | 113 |
Pharosi | P51828, Tbio |
PROi | PR:P51828 |
RNActi | P51828, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000121281, Expressed in granulocyte and 230 other tissues |
ExpressionAtlasi | P51828, baseline and differential |
Genevisiblei | P51828, HS |
Family and domain databases
Gene3Di | 3.30.70.1230, 2 hits |
InterProi | View protein in InterPro IPR001054, A/G_cyclase IPR018297, A/G_cyclase_CS IPR032628, AC_N IPR030672, Adcy IPR009398, Adcy_conserved_dom IPR029787, Nucleotide_cyclase |
Pfami | View protein in Pfam PF16214, AC_N, 1 hit PF06327, DUF1053, 1 hit PF00211, Guanylate_cyc, 2 hits |
PIRSFi | PIRSF039050, Ade_cyc, 1 hit |
SMARTi | View protein in SMART SM00044, CYCc, 2 hits |
SUPFAMi | SSF55073, SSF55073, 2 hits |
PROSITEi | View protein in PROSITE PS00452, GUANYLATE_CYCLASE_1, 1 hit PS50125, GUANYLATE_CYCLASE_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADCY7_HUMAN | |
Accessioni | P51828Primary (citable) accession number: P51828 Secondary accession number(s): A0AVA6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 16
Human chromosome 16: entries, gene names and cross-references to MIM