UniProtKB - P51826 (AFF3_HUMAN)

BLAST

>sp|P51826|AFF3_HUMAN AF4/FMR2 family member 3 OS=Homo sapiens OX=9606 GN=AFF3 PE=1 SV=3
MDSFDLALLQEWDLESLCVYEPDRNALRRKERERRNQETQQDDGTFNSSYSLFSEPYKTN
KGDELSNRIQNTLGNYDEMKDFLTDRSNQSHLVGVPKPGVPQTPVNKIDEHFVADSRAQN
QPSSICSTTTSTPAAVPVQQSKRGTMGWQKAGHPPSDGQQRATQQGSLRTLLGDGVGRQQ
PRAKQVCNVEVGLQTQERPPAMAAKHSSSGHCVQNFPPSLASKPSLVQQKPTAYVRPMDG
QDQAPDESPKLKSSSETSVHCTSYRGVPASKPEPARAKAKLSKFSIPKQGEESRSGETNS
CVEEIIREMTWLPPLSAIQAPGKVEPTKFPFPNKDSQLVSSGHNNPKKGDAEPESPDNGT
SNTSMLEDDLKLSSDEEENEQQAAQRTALRALSDSAVVQQPNCRTSVPSSKGSSSSSSSG
SSSSSSDSESSSGSDSETESSSSESEGSKPPHFSSPEAEPASSNKWQLDKWLNKVNPHKP
PILIQNESHGSESNQYYNPVKEDVQDCGKVPDVCQPSLREKEIKSTCKEEQRPRTANKAP
GSKGVKQKSPPAAVAVAVSAAAPPPAVPCAPAENAPAPARRSAGKKPTRRTERTSAGDGA
NCHRPEEPAAADALGTSVVVPPEPTKTRPCGNNRASHRKELRSSVTCEKRRTRGLSRIVP
KSKEFIETESSSSSSSSDSDLESEQEEYPLSKAQTVAASASSGNDQRLKEAAANGGSGPR
APVGSINARTTSDIAKELEEQFYTLVPFGRNELLSPLKDSDEIRSLWVKIDLTLLSRIPE
HLPQEPGVLSAPATKDSESAPPSHTSDTPAEKALPKSKRKRKCDNEDDYREIKKSQGEKD
SSSRLATSTSNTLSANHCNMNINSVAIPINKNEKMLRSPISPLSDASKHKYTSEDLTSSS
RPNGNSLFTSASSSKKPKADSQLQPHGGDLTKAAHNNSENIPLHKSRPQTKPWSPGSNGH
RDCKRQKLVFDDMPRSADYFMQEAKRMKHKADAMVEKFGKALNYAEAALSFIECGNAMEQ
GPMESKSPYTMYSETVELIRYAMRLKTHSGPNATPEDKQLAALCYRCLALLYWRMFRLKR
DHAVKYSKALIDYFKNSSKAAQAPSPWGASGKSTGTPSPMSPNPSPASSVGSQGSLSNAS
ALSPSTIVSIPQRIHQMAANHVSITNSILHSYDYWEMADNLAKENREFFNDLDLLMGPVT
LHSSMEHLVQYSQQGLHWLRNSAHLS

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History
Entry version 138 (07 Nov 2018)
Sequence version 3 (12 Sep 2018)
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Protein

AF4/FMR2 family member 3

Gene

AFF3

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Putative transcription activator that may function in lymphoid development and oncogenesis. Binds, in vitro, to double-stranded DNA.

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
double-stranded DNA binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 8555498

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

embryonic hindlimb morphogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18616733
response to tumor necrosis factor
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 20444755

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: AF4/FMR2 family member 3 Alternative name(s): Lymphoid nuclear protein related to AF4 Short name: Protein LAF-4
Gene namesⁱ	Name:AFF31 PublicationImported Synonyms:LAF4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000144218.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6473 AFF3
MIMⁱ	601464 gene
neXtProtⁱ	NX_P51826

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3899
Open Targets More...OpenTargetsⁱ	ENSG00000144218
PharmGKBⁱ	PA30264

Polymorphism and mutation databases

BioMutaⁱ	AFF3
DMDMⁱ	126302515

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000215916	1 – 1226	AF4/FMR2 family member 3Add BLAST		1226

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	755	PhosphoserineCombined sources		1
Modified residueⁱ	881	PhosphoserineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51826
PaxDbⁱ	P51826
PeptideAtlas More...PeptideAtlasⁱ	P51826
PRIDEⁱ	P51826
ProteomicsDBⁱ	56428 56429 [P51826-2]

PTM databases

iPTMnetⁱ	P51826
PhosphoSitePlusⁱ	P51826

Expressionⁱ

Tissue specificityⁱ

Preferentially expressed in lymphoid tissues, highest levels being found in the thymus.

Gene expression databases

Bgeeⁱ	ENSG00000144218 Expressed in 192 organ(s), highest expression level in neocortex
CleanExⁱ	HS_AFF3
ExpressionAtlasⁱ	P51826 baseline and differential
Genevisibleⁱ	P51826 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044512 HPA053379

HPAⁱ

HPA044512
HPA053379

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	110096, 4 interactors
IntActⁱ	P51826, 1 interactor
STRINGⁱ	9606.ENSP00000348793

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51826
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	413 – 419	Poly-Ser	7
Compositional biasⁱ	422 – 432	Poly-SerAdd BLAST	11
Compositional biasⁱ	440 – 445	Poly-Ser	6
Compositional biasⁱ	670 – 679	Poly-Ser	10

Sequence similaritiesⁱ

Belongs to the AF4 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IGJB Eukaryota ENOG410XRXU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000063217
HOVERGENⁱ	HBG004189
InParanoidⁱ	P51826
KEGG Orthology (KO) More...KOⁱ	K15195
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0KKW
PhylomeDBⁱ	P51826
TreeFamⁱ	TF326216

Family and domain databases

InterProⁱ	View protein in InterPro IPR007797 TF_AF4/FMR2
PANTHERⁱ	PTHR10528 PTHR10528, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05110 AF-4, 2 hits

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 10 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P51826-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDSFDLALLQ EWDLESLCVY EPDRNALRRK ERERRNQETQ QDDGTFNSSY 
        60         70         80         90        100
SLFSEPYKTN KGDELSNRIQ NTLGNYDEMK DFLTDRSNQS HLVGVPKPGV 
       110        120        130        140        150
PQTPVNKIDE HFVADSRAQN QPSSICSTTT STPAAVPVQQ SKRGTMGWQK 
       160        170        180        190        200
AGHPPSDGQQ RATQQGSLRT LLGDGVGRQQ PRAKQVCNVE VGLQTQERPP 
       210        220        230        240        250
AMAAKHSSSG HCVQNFPPSL ASKPSLVQQK PTAYVRPMDG QDQAPDESPK 
       260        270        280        290        300
LKSSSETSVH CTSYRGVPAS KPEPARAKAK LSKFSIPKQG EESRSGETNS 
       310        320        330        340        350
CVEEIIREMT WLPPLSAIQA PGKVEPTKFP FPNKDSQLVS SGHNNPKKGD 
       360        370        380        390        400
AEPESPDNGT SNTSMLEDDL KLSSDEEENE QQAAQRTALR ALSDSAVVQQ 
       410        420        430        440        450
PNCRTSVPSS KGSSSSSSSG SSSSSSDSES SSGSDSETES SSSESEGSKP 
       460        470        480        490        500
PHFSSPEAEP ASSNKWQLDK WLNKVNPHKP PILIQNESHG SESNQYYNPV 
       510        520        530        540        550
KEDVQDCGKV PDVCQPSLRE KEIKSTCKEE QRPRTANKAP GSKGVKQKSP 
       560        570        580        590        600
PAAVAVAVSA AAPPPAVPCA PAENAPAPAR RSAGKKPTRR TERTSAGDGA 
       610        620        630        640        650
NCHRPEEPAA ADALGTSVVV PPEPTKTRPC GNNRASHRKE LRSSVTCEKR 
       660        670        680        690        700
RTRGLSRIVP KSKEFIETES SSSSSSSDSD LESEQEEYPL SKAQTVAASA 
       710        720        730        740        750
SSGNDQRLKE AAANGGSGPR APVGSINART TSDIAKELEE QFYTLVPFGR 
       760        770        780        790        800
NELLSPLKDS DEIRSLWVKI DLTLLSRIPE HLPQEPGVLS APATKDSESA 
       810        820        830        840        850
PPSHTSDTPA EKALPKSKRK RKCDNEDDYR EIKKSQGEKD SSSRLATSTS 
       860        870        880        890        900
NTLSANHCNM NINSVAIPIN KNEKMLRSPI SPLSDASKHK YTSEDLTSSS 
       910        920        930        940        950
RPNGNSLFTS ASSSKKPKAD SQLQPHGGDL TKAAHNNSEN IPLHKSRPQT 
       960        970        980        990       1000
KPWSPGSNGH RDCKRQKLVF DDMPRSADYF MQEAKRMKHK ADAMVEKFGK 
      1010       1020       1030       1040       1050
ALNYAEAALS FIECGNAMEQ GPMESKSPYT MYSETVELIR YAMRLKTHSG 
      1060       1070       1080       1090       1100
PNATPEDKQL AALCYRCLAL LYWRMFRLKR DHAVKYSKAL IDYFKNSSKA 
      1110       1120       1130       1140       1150
AQAPSPWGAS GKSTGTPSPM SPNPSPASSV GSQGSLSNAS ALSPSTIVSI 
      1160       1170       1180       1190       1200
PQRIHQMAAN HVSITNSILH SYDYWEMADN LAKENREFFN DLDLLMGPVT 
      1210       1220 
LHSSMEHLVQ YSQQGLHWLR NSAHLS

Length:1,226

Mass (Da):133,503

Last modified:September 12, 2018 - v3

Checksum:ⁱBD2D90358609E156

Isoform 2 (identifier: P51826-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
18-18: C → WGEDILNQRNDSLVVEFQSSASRCRS

« Hide

        10         20         30         40         50
MDSFDLALLQ EWDLESLWGE DILNQRNDSL VVEFQSSASR CRSVYEPDRN 
        60         70         80         90        100
ALRRKERERR NQETQQDDGT FNSSYSLFSE PYKTNKGDEL SNRIQNTLGN 
       110        120        130        140        150
YDEMKDFLTD RSNQSHLVGV PKPGVPQTPV NKIDEHFVAD SRAQNQPSSI 
       160        170        180        190        200
CSTTTSTPAA VPVQQSKRGT MGWQKAGHPP SDGQQRATQQ GSLRTLLGDG 
       210        220        230        240        250
VGRQQPRAKQ VCNVEVGLQT QERPPAMAAK HSSSGHCVQN FPPSLASKPS 
       260        270        280        290        300
LVQQKPTAYV RPMDGQDQAP DESPKLKSSS ETSVHCTSYR GVPASKPEPA 
       310        320        330        340        350
RAKAKLSKFS IPKQGEESRS GETNSCVEEI IREMTWLPPL SAIQAPGKVE 
       360        370        380        390        400
PTKFPFPNKD SQLVSSGHNN PKKGDAEPES PDNGTSNTSM LEDDLKLSSD 
       410        420        430        440        450
EEENEQQAAQ RTALRALSDS AVVQQPNCRT SVPSSKGSSS SSSSGSSSSS 
       460        470        480        490        500
SDSESSSGSD SETESSSSES EGSKPPHFSS PEAEPASSNK WQLDKWLNKV 
       510        520        530        540        550
NPHKPPILIQ NESHGSESNQ YYNPVKEDVQ DCGKVPDVCQ PSLREKEIKS 
       560        570        580        590        600
TCKEEQRPRT ANKAPGSKGV KQKSPPAAVA VAVSAAAPPP AVPCAPAENA 
       610        620        630        640        650
PAPARRSAGK KPTRRTERTS AGDGANCHRP EEPAAADALG TSVVVPPEPT 
       660        670        680        690        700
KTRPCGNNRA SHRKELRSSV TCEKRRTRGL SRIVPKSKEF IETESSSSSS 
       710        720        730        740        750
SSDSDLESEQ EEYPLSKAQT VAASASSGND QRLKEAAANG GSGPRAPVGS 
       760        770        780        790        800
INARTTSDIA KELEEQFYTL VPFGRNELLS PLKDSDEIRS LWVKIDLTLL 
       810        820        830        840        850
SRIPEHLPQE PGVLSAPATK DSESAPPSHT SDTPAEKALP KSKRKRKCDN 
       860        870        880        890        900
EDDYREIKKS QGEKDSSSRL ATSTSNTLSA NHCNMNINSV AIPINKNEKM 
       910        920        930        940        950
LRSPISPLSD ASKHKYTSED LTSSSRPNGN SLFTSASSSK KPKADSQLQP 
       960        970        980        990       1000
HGGDLTKAAH NNSENIPLHK SRPQTKPWSP GSNGHRDCKR QKLVFDDMPR 
      1010       1020       1030       1040       1050
SADYFMQEAK RMKHKADAMV EKFGKALNYA EAALSFIECG NAMEQGPMES 
      1060       1070       1080       1090       1100
KSPYTMYSET VELIRYAMRL KTHSGPNATP EDKQLAALCY RCLALLYWRM 
      1110       1120       1130       1140       1150
FRLKRDHAVK YSKALIDYFK NSSKAAQAPS PWGASGKSTG TPSPMSPNPS 
      1160       1170       1180       1190       1200
PASSVGSQGS LSNASALSPS TIVSIPQRIH QMAANHVSIT NSILHSYDYW 
      1210       1220       1230       1240       1250
EMADNLAKEN REFFNDLDLL MGPVTLHSSM EHLVQYSQQG LHWLRNSAHL 

S

Show »

Length:1,251

Mass (Da):136,379

Checksum:ⁱF514E60D22409B45

Computationally mapped potential isoform sequencesⁱ

There are 10 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

H7C3W3	H7C3W3_HUMAN	AF4/FMR2 family member 3 AF4/FMR2 family member 3	AFF3	179	Annotation score:
C9JUC4	C9JUC4_HUMAN	AF4/FMR2 family member 3 AF4/FMR2 family member 3	AFF3	155	Annotation score:
H7C4C2	H7C4C2_HUMAN	AF4/FMR2 family member 3 AF4/FMR2 family member 3	AFF3	185	Annotation score:
C9J847	C9J847_HUMAN	AF4/FMR2 family member 3 AF4/FMR2 family member 3	AFF3	114	Annotation score:
C9JMS1	C9JMS1_HUMAN	AF4/FMR2 family member 3 AF4/FMR2 family member 3	AFF3	99	Annotation score:
C9JZ66	C9JZ66_HUMAN	AF4/FMR2 family member 3 AF4/FMR2 family member 3	AFF3	128	Annotation score:
C9JC67	C9JC67_HUMAN	AF4/FMR2 family member 3 AF4/FMR2 family member 3	AFF3	155	Annotation score:
C9J622	C9J622_HUMAN	AF4/FMR2 family member 3 AF4/FMR2 family member 3	AFF3	161	Annotation score:
C9JUY1	C9JUY1_HUMAN	AF4/FMR2 family member 3 AF4/FMR2 family member 3	AFF3	183	Annotation score:
C9JIB1	C9JIB1_HUMAN	AF4/FMR2 family member 3 AF4/FMR2 family member 3	AFF3	17	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	87	S → T in AAA98763 (PubMed:8555498).Curated	1
Sequence conflictⁱ	421	S → T in AAA98763 (PubMed:8555498).Curated	1
Sequence conflictⁱ	1030	T → YL in AAA98763 (PubMed:8555498).Curated	1
Sequence conflictⁱ	1120	M → I in AAA98763 (PubMed:8555498).Curated	1
Sequence conflictⁱ	1125 – 1127	SPA → FPG in AAA98763 (PubMed:8555498).Curated	3

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_030805	358	N → S. Corresponds to variant dbSNP:rs4851223Ensembl.	1
Natural variantⁱVAR_030806	494	N → S. Corresponds to variant dbSNP:rs1047265Ensembl.	1
Natural variantⁱVAR_080758	1215	G → V Found in a consanguineous family with intellectual disability; unknown pathological significance. 1 Publication	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_041120	18	C → WGEDILNQRNDSLVVEFQSS ASRCRS in isoform 2. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U34360 mRNA Translation: AAA98763.1 AC092667 Genomic DNA Translation: AAY24278.1 AC010736 Genomic DNA Translation: AAY14792.1 AC073118 Genomic DNA Translation: AAY24187.1 AC018690 Genomic DNA Translation: AAY24315.1 CH471127 Genomic DNA Translation: EAX01854.1 CH471127 Genomic DNA Translation: EAX01855.1 CH471127 Genomic DNA Translation: EAX01856.1 CH471127 Genomic DNA Translation: EAX01857.1 CH471127 Genomic DNA Translation: EAX01858.1 CH471127 Genomic DNA Translation: EAX01859.1 BC036895 mRNA Translation: AAH36895.1 BC136579 mRNA Translation: AAI36580.1 BC144266 mRNA Translation: AAI44267.1 AB209634 mRNA Translation: BAD92871.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS33258.1 [P51826-2] CCDS42723.1 [P51826-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001020279.1, NM_001025108.1 [P51826-2] NP_002276.2, NM_002285.2 [P51826-1] XP_005264000.2, XM_005263943.3 [P51826-1] XP_011509475.1, XM_011511173.2 [P51826-2] XP_011509476.1, XM_011511174.2 [P51826-2] XP_011509477.1, XM_011511175.2 [P51826-1] XP_011509478.1, XM_011511176.2 [P51826-1] XP_011509479.1, XM_011511177.2 [P51826-1]
UniGeneⁱ	Hs.444414

Genome annotation databases

Ensemblⁱ	ENST00000317233; ENSP00000317421; ENSG00000144218 [P51826-1] ENST00000409236; ENSP00000387207; ENSG00000144218 [P51826-1] ENST00000409579; ENSP00000386834; ENSG00000144218 [P51826-2]
GeneIDⁱ	3899
KEGGⁱ	hsa:3899
UCSC genome browser More...UCSCⁱ	uc002tag.4 human [P51826-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P51826	AF4/FMR2 family member 3 (Fragment)		HUMAN		155	UniRef100_P51826
AF4/FMR2 family member 3 (Fragment)		HUMAN		128
AF4/FMR2 family member 3 (Fragment)		HUMAN		161
P51826-2	AF4/FMR2 family member 3 (Fragment)		HUMAN		183	UniRef100_P51826-2
UPI000D0C8C64		HUMAN		1380
UPI0007DC648B		HUMAN		862

Protein	Similar proteins		Species	Score	Length	Source
P51826	AF4/FMR2 family member 3 (Fragment)		HUMAN		155	UniRef90_P51826
AFF3 isoform 5		PANTR		1251
Uncharacterized protein		RHIRO		1251
Uncharacterized protein		PAPAN		1251
Uncharacterized protein		CERAT		1251
+26
P51826-2	AF4/FMR2 family member 3 (Fragment)		HUMAN		183	UniRef90_P51826-2
AF4/FMR2 family member 3		TARSY		1268
AFF3 isoform 15 (Fragment)		PANTR		185
AFF3 isoform 7 (Fragment)		PONAB		184
UPI000D2F7BF1		MACNE		168
+13

Protein	Similar proteins		Species	Score	Length	Source
P51826	AF4/FMR2 family member 3 (Fragment)		HUMAN		155	UniRef50_P51826
Uncharacterized protein		CERAT		1251
AF4/FMR2 family member 3		GORGO		1251
Uncharacterized protein		RHIRO		1251
AFF3 isoform 5		PONAB		1251
+74

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U34360 mRNA Translation: AAA98763.1 AC092667 Genomic DNA Translation: AAY24278.1 AC010736 Genomic DNA Translation: AAY14792.1 AC073118 Genomic DNA Translation: AAY24187.1 AC018690 Genomic DNA Translation: AAY24315.1 CH471127 Genomic DNA Translation: EAX01854.1 CH471127 Genomic DNA Translation: EAX01855.1 CH471127 Genomic DNA Translation: EAX01856.1 CH471127 Genomic DNA Translation: EAX01857.1 CH471127 Genomic DNA Translation: EAX01858.1 CH471127 Genomic DNA Translation: EAX01859.1 BC036895 mRNA Translation: AAH36895.1 BC136579 mRNA Translation: AAI36580.1 BC144266 mRNA Translation: AAI44267.1 AB209634 mRNA Translation: BAD92871.1
CCDSⁱ	CCDS33258.1 [P51826-2] CCDS42723.1 [P51826-1]
RefSeqⁱ	NP_001020279.1, NM_001025108.1 [P51826-2] NP_002276.2, NM_002285.2 [P51826-1] XP_005264000.2, XM_005263943.3 [P51826-1] XP_011509475.1, XM_011511173.2 [P51826-2] XP_011509476.1, XM_011511174.2 [P51826-2] XP_011509477.1, XM_011511175.2 [P51826-1] XP_011509478.1, XM_011511176.2 [P51826-1] XP_011509479.1, XM_011511177.2 [P51826-1]
UniGeneⁱ	Hs.444414

3D structure databases

ProteinModelPortalⁱ	P51826
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110096, 4 interactors
IntActⁱ	P51826, 1 interactor
STRINGⁱ	9606.ENSP00000348793

PTM databases

iPTMnetⁱ	P51826
PhosphoSitePlusⁱ	P51826

Polymorphism and mutation databases

BioMutaⁱ	AFF3
DMDMⁱ	126302515

Proteomic databases

MaxQBⁱ	P51826
PaxDbⁱ	P51826
PeptideAtlasⁱ	P51826
PRIDEⁱ	P51826
ProteomicsDBⁱ	56428 56429 [P51826-2]

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000317233; ENSP00000317421; ENSG00000144218 [P51826-1] ENST00000409236; ENSP00000387207; ENSG00000144218 [P51826-1] ENST00000409579; ENSP00000386834; ENSG00000144218 [P51826-2]
GeneIDⁱ	3899
KEGGⁱ	hsa:3899
UCSCⁱ	uc002tag.4 human [P51826-1]

Organism-specific databases

CTDⁱ	3899
DisGeNETⁱ	3899
EuPathDBⁱ	HostDB:ENSG00000144218.18
GeneCardsⁱ	AFF3
HGNCⁱ	HGNC:6473 AFF3
HPAⁱ	HPA044512 HPA053379
MIMⁱ	601464 gene
neXtProtⁱ	NX_P51826
OpenTargetsⁱ	ENSG00000144218
PharmGKBⁱ	PA30264
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IGJB Eukaryota ENOG410XRXU LUCA
GeneTreeⁱ	ENSGT00530000063217
HOVERGENⁱ	HBG004189
InParanoidⁱ	P51826
KOⁱ	K15195
OrthoDBⁱ	EOG091G0KKW
PhylomeDBⁱ	P51826
TreeFamⁱ	TF326216

Miscellaneous databases

ChiTaRSⁱ	AFF3 human
GeneWikiⁱ	AFF3
GenomeRNAiⁱ	3899
Protein Ontology More...PROⁱ	PR:P51826
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000144218 Expressed in 192 organ(s), highest expression level in neocortex
CleanExⁱ	HS_AFF3
ExpressionAtlasⁱ	P51826 baseline and differential
Genevisibleⁱ	P51826 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR007797 TF_AF4/FMR2
PANTHERⁱ	PTHR10528 PTHR10528, 1 hit
Pfamⁱ	View protein in Pfam PF05110 AF-4, 2 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	AFF3_HUMAN
Accessionⁱ	P51826Primary (citable) accession number: P51826 Secondary accession number(s): B7ZM46 Q8IWJ5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	September 12, 2018
	Last modified:	November 7, 2018
	This is version 138 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P51826 (AFF3_HUMAN)

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AF4/FMR2 family member 3

AFF3

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ