UniProtKB - P51812 (KS6A3_HUMAN)
Ribosomal protein S6 kinase alpha-3
RPS6KA3
Functioni
Serine/threonine-protein kinase that acts downstream of ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic and stress-induced activation of the transcription factors CREB1, ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and EIF4B phosphorylation, and mediates cellular proliferation, survival, and differentiation by modulating mTOR signaling and repressing pro-apoptotic function of BAD and DAPK1 (PubMed:9770464, PubMed:16223362, PubMed:17360704, PubMed:16213824).
In fibroblast, is required for EGF-stimulated phosphorylation of CREB1 and histone H3 at 'Ser-10', which results in the subsequent transcriptional activation of several immediate-early genes (PubMed:9770464, PubMed:10436156).
In response to mitogenic stimulation (EGF and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81 transcription factors and the cofactor CREBBP (PubMed:16223362).
Upon insulin-derived signal, acts indirectly on the transcription regulation of several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting its activity (PubMed:8250835).
Phosphorylates RPS6 in response to serum or EGF via an mTOR-independent mechanism and promotes translation initiation by facilitating assembly of the preinitiation complex (PubMed:17360704).
In response to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the EIF3 complex and stimulating cap-dependent translation (PubMed:18508509, PubMed:18813292).
Is involved in the mTOR nutrient-sensing pathway by directly phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2 ability to suppress mTOR signaling, and mediates phosphorylation of RPTOR, which regulates mTORC1 activity and may promote rapamycin-sensitive signaling independently of the PI3K/AKT pathway (PubMed:18722121).
Mediates cell survival by phosphorylating the pro-apoptotic proteins BAD and DAPK1 and suppressing their pro-apoptotic function (PubMed:16213824).
Promotes the survival of hepatic stellate cells by phosphorylating CEBPB in response to the hepatotoxin carbon tetrachloride (CCl4) (PubMed:18508509, PubMed:18813292).
Is involved in cell cycle regulation by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B association with 14-3-3 proteins and prevents its translocation to the nucleus and inhibition of G1 progression (By similarity).
In LPS-stimulated dendritic cells, is involved in TLR4-induced macropinocytosis, and in myeloma cells, acts as effector of FGFR3-mediated transformation signaling, after direct phosphorylation at Tyr-529 by FGFR3 (By similarity).
Negatively regulates EGF-induced MAPK1/3 phosphorylation via phosphorylation of SOS1 (By similarity).
Phosphorylates SOS1 at 'Ser-1134' and 'Ser-1161' that create YWHAB and YWHAE binding sites and which contribute to the negative regulation of MAPK1/3 phosphorylation (By similarity).
Phosphorylates EPHA2 at 'Ser-897', the RPS6KA-EPHA2 signaling pathway controls cell migration (PubMed:26158630).
Acts as a regulator of osteoblast differentiation by mediating phosphorylation of ATF4, thereby promoting ATF4 transactivation activity (By similarity).
2 PublicationsBy similarity8 PublicationsCatalytic activityi
Cofactori
Activity regulationi
Kineticsi
- KM=3.56 µM for NFATC41 Publication
- Vmax=11.5 µmol/min/µg enzyme toward ATP1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 100 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 193 | Proton acceptorBy similarity | 1 | |
Binding sitei | 451 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 539 | Proton acceptorBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 74 – 82 | ATPPROSITE-ProRule annotation | 9 | |
Nucleotide bindingi | 428 – 436 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- cysteine-type endopeptidase inhibitor activity involved in apoptotic process Source: UniProtKB
- magnesium ion binding Source: InterPro
- protein kinase activity Source: ProtInc
- protein kinase binding Source: Ensembl
- protein serine/threonine/tyrosine kinase activity Source: RHEA
- protein serine/threonine kinase activity Source: GO_Central
- protein serine kinase activity Source: RHEA
- ribosomal protein S6 kinase activity Source: GO_Central
GO - Biological processi
- cell cycle Source: UniProtKB-KW
- central nervous system development Source: ProtInc
- chemical synaptic transmission Source: Reactome
- intracellular signal transduction Source: InterPro
- negative regulation of apoptotic process Source: UniProtKB
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- peptidyl-serine phosphorylation Source: GO_Central
- positive regulation of cell differentiation Source: UniProtKB
- positive regulation of cell growth Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: BHF-UCL
- regulation of DNA-templated transcription in response to stress Source: UniProtKB
- regulation of translation in response to stress Source: UniProtKB
- response to lipopolysaccharide Source: UniProtKB
- signal transduction Source: ProtInc
- skeletal system development Source: ProtInc
- toll-like receptor signaling pathway Source: UniProtKB
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Cell cycle, Stress response |
Ligand | ATP-binding, Magnesium, Metal-binding, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | P51812 |
Reactomei | R-HSA-198753, ERK/MAPK targets R-HSA-199920, CREB phosphorylation R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-437239, Recycling pathway of L1 R-HSA-442742, CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-444257, RSK activation R-HSA-881907, Gastrin-CREB signalling pathway via PKC and MAPK |
SignaLinki | P51812 |
SIGNORi | P51812 |
Names & Taxonomyi
Protein namesi | Recommended name: Ribosomal protein S6 kinase alpha-3 (EC:2.7.11.11 Publication)Short name: S6K-alpha-3 Alternative name(s): 90 kDa ribosomal protein S6 kinase 3 Short name: p90-RSK 3 Short name: p90RSK3 Insulin-stimulated protein kinase 1 Short name: ISPK-1 MAP kinase-activated protein kinase 1b Short name: MAPK-activated protein kinase 1b Short name: MAPKAP kinase 1b Short name: MAPKAPK-1b Ribosomal S6 kinase 2 Short name: RSK-2 pp90RSK2 |
Gene namesi | Name:RPS6KA3 Synonyms:ISPK1, MAPKAPK1B, RSK2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:10432, RPS6KA3 |
MIMi | 300075, gene |
neXtProti | NX_P51812 |
VEuPathDBi | HostDB:ENSG00000177189 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleolus Source: HPA
- nucleoplasm Source: HPA
Other locations
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Involvement in diseasei
Coffin-Lowry syndrome (CLS)6 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_006189 | 75 | G → V in CLS. 1 PublicationCorresponds to variant dbSNP:rs122454124EnsemblClinVar. | 1 | |
Natural variantiVAR_006190 | 82 | V → F in CLS. 1 PublicationCorresponds to variant dbSNP:rs122454126EnsemblClinVar. | 1 | |
Natural variantiVAR_006191 | 114 | R → W in CLS. 1 PublicationCorresponds to variant dbSNP:rs122454127EnsemblClinVar. | 1 | |
Natural variantiVAR_006192 | 127 | H → Q in CLS. 1 Publication | 1 | |
Natural variantiVAR_006193 | 154 | D → Y in CLS. 1 Publication | 1 | |
Natural variantiVAR_065894 | 189 | I → K in CLS. 1 PublicationCorresponds to variant dbSNP:rs122454130EnsemblClinVar. | 1 | |
Natural variantiVAR_006194 | 225 | A → V in CLS. 1 PublicationCorresponds to variant dbSNP:rs879027948Ensembl. | 1 | |
Natural variantiVAR_006195 | 227 | S → A in CLS. 1 PublicationCorresponds to variant dbSNP:rs122454125EnsemblClinVar. | 1 | |
Natural variantiVAR_065896 | 268 | F → S in CLS. 1 PublicationCorresponds to variant dbSNP:rs122454131EnsemblClinVar. | 1 | |
Natural variantiVAR_006196 | 431 | G → D in CLS. 1 Publication | 1 | |
Natural variantiVAR_065898 | 477 | Missing in CLS. 1 Publication | 1 | |
Natural variantiVAR_006197 | 729 | R → Q in CLS. 1 PublicationCorresponds to variant dbSNP:rs28935171EnsemblClinVar. | 1 |
Intellectual developmental disorder, X-linked 19 (XLID19)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_065892 | 115 | T → S in XLID19. 1 PublicationCorresponds to variant dbSNP:rs387906703EnsemblClinVar. | 1 | |
Natural variantiVAR_065893 | 152 | Missing in XLID19. 1 PublicationCorresponds to variant dbSNP:rs398122813Ensembl. | 1 | |
Natural variantiVAR_065895 | 202 | Missing in XLID19. 1 Publication | 1 | |
Natural variantiVAR_065897 | 383 | R → W in XLID19; kinase activity is decreased but not abolished. 1 PublicationCorresponds to variant dbSNP:rs122454129EnsemblClinVar. | 1 |
Keywords - Diseasei
Disease variant, Mental retardationOrganism-specific databases
DisGeNETi | 6197 |
GeneReviewsi | RPS6KA3 |
MalaCardsi | RPS6KA3 |
MIMi | 300844, phenotype 303600, phenotype |
OpenTargetsi | ENSG00000177189 |
Orphaneti | 192, Coffin-Lowry syndrome 276630, Symptomatic form of Coffin-Lowry syndrome in female carriers 777, X-linked non-syndromic intellectual disability |
PharmGKBi | PA34847 |
Miscellaneous databases
Pharosi | P51812, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2345 |
DrugBanki | DB00945, Acetylsalicylic acid DB12010, Fostamatinib |
DrugCentrali | P51812 |
GuidetoPHARMACOLOGYi | 1528 |
Genetic variation databases
BioMutai | RPS6KA3 |
DMDMi | 1730070 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086203 | 1 – 740 | Ribosomal protein S6 kinase alpha-3Add BLAST | 740 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 227 | Phosphoserine; by PDPK1By similarityCurated | 1 | |
Modified residuei | 365 | PhosphothreonineCombined sources | 1 | |
Modified residuei | 369 | PhosphoserineCombined sources | 1 | |
Modified residuei | 375 | PhosphoserineCombined sources | 1 | |
Modified residuei | 386 | Phosphoserine; by autocatalysis and MAPKAPK2Combined sources | 1 | |
Modified residuei | 415 | PhosphoserineCombined sources | 1 | |
Modified residuei | 529 | Phosphotyrosine; by FGFR3By similarity | 1 | |
Modified residuei | 556 | PhosphoserineCombined sources | 1 | |
Modified residuei | 715 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P51812 |
jPOSTi | P51812 |
MassIVEi | P51812 |
MaxQBi | P51812 |
PaxDbi | P51812 |
PeptideAtlasi | P51812 |
PRIDEi | P51812 |
ProteomicsDBi | 56408 |
PTM databases
GlyGeni | P51812, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P51812 |
MetOSitei | P51812 |
PhosphoSitePlusi | P51812 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000177189, Expressed in biceps brachii and 238 other tissues |
ExpressionAtlasi | P51812, baseline and differential |
Genevisiblei | P51812, HS |
Organism-specific databases
HPAi | ENSG00000177189, Low tissue specificity |
Interactioni
Subunit structurei
Forms a complex with either MAPK1/ERK2 or MAPK3/ERK1 in quiescent cells. Transiently dissociates following mitogenic stimulation (By similarity).
Interacts with NFATC4, ETV1/ER81 and FGFR1.
By similarity1 PublicationBinary interactionsi
P51812
GO - Molecular functioni
- protein kinase binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 112111, 149 interactors |
DIPi | DIP-38247N |
IntActi | P51812, 90 interactors |
MINTi | P51812 |
STRINGi | 9606.ENSP00000368884 |
Chemistry databases
BindingDBi | P51812 |
Miscellaneous databases
RNActi | P51812, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P51812 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 68 – 327 | Protein kinase 1PROSITE-ProRule annotationAdd BLAST | 260 | |
Domaini | 328 – 397 | AGC-kinase C-terminalPROSITE-ProRule annotationAdd BLAST | 70 | |
Domaini | 422 – 679 | Protein kinase 2PROSITE-ProRule annotationAdd BLAST | 258 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 38 | DisorderedSequence analysisAdd BLAST | 38 |
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0603, Eukaryota |
GeneTreei | ENSGT00940000159370 |
HOGENOMi | CLU_000288_58_3_1 |
InParanoidi | P51812 |
OMAi | ITHHEYQ |
OrthoDBi | 1132245at2759 |
PhylomeDBi | P51812 |
TreeFami | TF313438 |
Family and domain databases
CDDi | cd14176, STKc_RSK2_C, 1 hit cd05582, STKc_RSK_N, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR016239, Ribosomal_S6_kinase_II IPR041905, RPS6KA3_C IPR041906, RSK_N IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 2 hits PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000606, Ribsml_S6_kin_2, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 2 hits |
SUPFAMi | SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 2 hits PS50011, PROTEIN_KINASE_DOM, 2 hits PS00108, PROTEIN_KINASE_ST, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MPLAQLADPW QKMAVESPSD SAENGQQIMD EPMGEEEINP QTEEVSIKEI
60 70 80 90 100
AITHHVKEGH EKADPSQFEL LKVLGQGSFG KVFLVKKISG SDARQLYAMK
110 120 130 140 150
VLKKATLKVR DRVRTKMERD ILVEVNHPFI VKLHYAFQTE GKLYLILDFL
160 170 180 190 200
RGGDLFTRLS KEVMFTEEDV KFYLAELALA LDHLHSLGII YRDLKPENIL
210 220 230 240 250
LDEEGHIKLT DFGLSKESID HEKKAYSFCG TVEYMAPEVV NRRGHTQSAD
260 270 280 290 300
WWSFGVLMFE MLTGTLPFQG KDRKETMTMI LKAKLGMPQF LSPEAQSLLR
310 320 330 340 350
MLFKRNPANR LGAGPDGVEE IKRHSFFSTI DWNKLYRREI HPPFKPATGR
360 370 380 390 400
PEDTFYFDPE FTAKTPKDSP GIPPSANAHQ LFRGFSFVAI TSDDESQAMQ
410 420 430 440 450
TVGVHSIVQQ LHRNSIQFTD GYEVKEDIGV GSYSVCKRCI HKATNMEFAV
460 470 480 490 500
KIIDKSKRDP TEEIEILLRY GQHPNIITLK DVYDDGKYVY VVTELMKGGE
510 520 530 540 550
LLDKILRQKF FSEREASAVL FTITKTVEYL HAQGVVHRDL KPSNILYVDE
560 570 580 590 600
SGNPESIRIC DFGFAKQLRA ENGLLMTPCY TANFVAPEVL KRQGYDAACD
610 620 630 640 650
IWSLGVLLYT MLTGYTPFAN GPDDTPEEIL ARIGSGKFSL SGGYWNSVSD
660 670 680 690 700
TAKDLVSKML HVDPHQRLTA ALVLRHPWIV HWDQLPQYQL NRQDAPHLVK
710 720 730 740
GAMAATYSAL NRNQSPVLEP VGRSTLAQRR GIKKITSTAL
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB7ZB17 | B7ZB17_HUMAN | Non-specific serine/threonine prote... | RPS6KA3 | 712 | Annotation score: | ||
B4DG22 | B4DG22_HUMAN | Non-specific serine/threonine prote... | RPS6KA3 | 711 | Annotation score: | ||
B1AXG1 | B1AXG1_HUMAN | Non-specific serine/threonine prote... | RPS6KA3 | 711 | Annotation score: | ||
A0A2R8Y603 | A0A2R8Y603_HUMAN | Ribosomal protein S6 kinase alpha-3 | RPS6KA3 | 282 | Annotation score: | ||
A0A2R8YGB7 | A0A2R8YGB7_HUMAN | Ribosomal protein S6 kinase alpha-3 | RPS6KA3 | 81 | Annotation score: | ||
B1AXG2 | B1AXG2_HUMAN | Ribosomal protein S6 kinase alpha-3 | RPS6KA3 | 65 | Annotation score: | ||
A0A2R8Y7S9 | A0A2R8Y7S9_HUMAN | Ribosomal protein S6 kinase alpha-3 | RPS6KA3 | 144 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 89 | S → L in AAH96303 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 410 | Missing in BAD92170 (Ref. 3) Curated | 1 | |
Sequence conflicti | 424 | V → L in AAC82495 (PubMed:8141249).Curated | 1 | |
Sequence conflicti | 480 | K → N in AAC82495 (PubMed:8141249).Curated | 1 | |
Sequence conflicti | 494 | Missing in AAC82495 (PubMed:8141249).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_006188 | 38 | I → S2 PublicationsCorresponds to variant dbSNP:rs56218010EnsemblClinVar. | 1 | |
Natural variantiVAR_006189 | 75 | G → V in CLS. 1 PublicationCorresponds to variant dbSNP:rs122454124EnsemblClinVar. | 1 | |
Natural variantiVAR_006190 | 82 | V → F in CLS. 1 PublicationCorresponds to variant dbSNP:rs122454126EnsemblClinVar. | 1 | |
Natural variantiVAR_006191 | 114 | R → W in CLS. 1 PublicationCorresponds to variant dbSNP:rs122454127EnsemblClinVar. | 1 | |
Natural variantiVAR_065892 | 115 | T → S in XLID19. 1 PublicationCorresponds to variant dbSNP:rs387906703EnsemblClinVar. | 1 | |
Natural variantiVAR_006192 | 127 | H → Q in CLS. 1 Publication | 1 | |
Natural variantiVAR_065893 | 152 | Missing in XLID19. 1 PublicationCorresponds to variant dbSNP:rs398122813Ensembl. | 1 | |
Natural variantiVAR_006193 | 154 | D → Y in CLS. 1 Publication | 1 | |
Natural variantiVAR_065894 | 189 | I → K in CLS. 1 PublicationCorresponds to variant dbSNP:rs122454130EnsemblClinVar. | 1 | |
Natural variantiVAR_065895 | 202 | Missing in XLID19. 1 Publication | 1 | |
Natural variantiVAR_006194 | 225 | A → V in CLS. 1 PublicationCorresponds to variant dbSNP:rs879027948Ensembl. | 1 | |
Natural variantiVAR_006195 | 227 | S → A in CLS. 1 PublicationCorresponds to variant dbSNP:rs122454125EnsemblClinVar. | 1 | |
Natural variantiVAR_065896 | 268 | F → S in CLS. 1 PublicationCorresponds to variant dbSNP:rs122454131EnsemblClinVar. | 1 | |
Natural variantiVAR_065897 | 383 | R → W in XLID19; kinase activity is decreased but not abolished. 1 PublicationCorresponds to variant dbSNP:rs122454129EnsemblClinVar. | 1 | |
Natural variantiVAR_035627 | 416 | I → V in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs148050184Ensembl. | 1 | |
Natural variantiVAR_006196 | 431 | G → D in CLS. 1 Publication | 1 | |
Natural variantiVAR_065898 | 477 | Missing in CLS. 1 Publication | 1 | |
Natural variantiVAR_040629 | 483 | Y → C in a gastric adenocarcinoma sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs1271090915Ensembl. | 1 | |
Natural variantiVAR_040630 | 608 | L → F in a glioblastoma multiforme sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_040631 | 723 | R → C1 PublicationCorresponds to variant dbSNP:rs35026425Ensembl. | 1 | |
Natural variantiVAR_006197 | 729 | R → Q in CLS. 1 PublicationCorresponds to variant dbSNP:rs28935171EnsemblClinVar. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U08316 mRNA Translation: AAA81952.1 AK313932 mRNA Translation: BAG36651.1 AB208933 mRNA Translation: BAD92170.1 Different initiation. AL732366 Genomic DNA No translation available. AL807772 Genomic DNA No translation available. BC096301 mRNA Translation: AAH96301.1 BC096302 mRNA Translation: AAH96302.1 BC096303 mRNA Translation: AAH96303.1 L07599 mRNA Translation: AAC82495.1 AB102662 mRNA Translation: BAC81131.1 |
CCDSi | CCDS14197.1 |
PIRi | I38556 |
RefSeqi | NP_004577.1, NM_004586.2 |
Genome annotation databases
Ensembli | ENST00000379565; ENSP00000368884; ENSG00000177189 |
GeneIDi | 6197 |
KEGGi | hsa:6197 |
MANE-Selecti | ENST00000379565.9; ENSP00000368884.3; NM_004586.3; NP_004577.1 |
UCSCi | uc004czu.4, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U08316 mRNA Translation: AAA81952.1 AK313932 mRNA Translation: BAG36651.1 AB208933 mRNA Translation: BAD92170.1 Different initiation. AL732366 Genomic DNA No translation available. AL807772 Genomic DNA No translation available. BC096301 mRNA Translation: AAH96301.1 BC096302 mRNA Translation: AAH96302.1 BC096303 mRNA Translation: AAH96303.1 L07599 mRNA Translation: AAC82495.1 AB102662 mRNA Translation: BAC81131.1 |
CCDSi | CCDS14197.1 |
PIRi | I38556 |
RefSeqi | NP_004577.1, NM_004586.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4D9T | X-ray | 2.40 | A | 399-740 | [»] | |
4D9U | X-ray | 2.40 | A | 399-740 | [»] | |
4JG6 | X-ray | 2.60 | A | 399-740 | [»] | |
4JG7 | X-ray | 3.00 | A | 399-740 | [»] | |
4JG8 | X-ray | 3.10 | A | 399-740 | [»] | |
4NUS | X-ray | 2.39 | A | 39-359 | [»] | |
4NW5 | X-ray | 1.94 | A | 39-359 | [»] | |
4NW6 | X-ray | 1.74 | A | 39-359 | [»] | |
5D9K | X-ray | 2.55 | A/B | 39-366 | [»] | |
5D9L | X-ray | 2.15 | A | 39-359 | [»] | |
SMRi | P51812 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112111, 149 interactors |
DIPi | DIP-38247N |
IntActi | P51812, 90 interactors |
MINTi | P51812 |
STRINGi | 9606.ENSP00000368884 |
Chemistry databases
BindingDBi | P51812 |
ChEMBLi | CHEMBL2345 |
DrugBanki | DB00945, Acetylsalicylic acid DB12010, Fostamatinib |
DrugCentrali | P51812 |
GuidetoPHARMACOLOGYi | 1528 |
PTM databases
GlyGeni | P51812, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P51812 |
MetOSitei | P51812 |
PhosphoSitePlusi | P51812 |
Genetic variation databases
BioMutai | RPS6KA3 |
DMDMi | 1730070 |
Proteomic databases
EPDi | P51812 |
jPOSTi | P51812 |
MassIVEi | P51812 |
MaxQBi | P51812 |
PaxDbi | P51812 |
PeptideAtlasi | P51812 |
PRIDEi | P51812 |
ProteomicsDBi | 56408 |
Protocols and materials databases
Antibodypediai | 1004, 600 antibodies from 36 providers |
DNASUi | 6197 |
Genome annotation databases
Ensembli | ENST00000379565; ENSP00000368884; ENSG00000177189 |
GeneIDi | 6197 |
KEGGi | hsa:6197 |
MANE-Selecti | ENST00000379565.9; ENSP00000368884.3; NM_004586.3; NP_004577.1 |
UCSCi | uc004czu.4, human |
Organism-specific databases
CTDi | 6197 |
DisGeNETi | 6197 |
GeneCardsi | RPS6KA3 |
GeneReviewsi | RPS6KA3 |
HGNCi | HGNC:10432, RPS6KA3 |
HPAi | ENSG00000177189, Low tissue specificity |
MalaCardsi | RPS6KA3 |
MIMi | 300075, gene 300844, phenotype 303600, phenotype |
neXtProti | NX_P51812 |
OpenTargetsi | ENSG00000177189 |
Orphaneti | 192, Coffin-Lowry syndrome 276630, Symptomatic form of Coffin-Lowry syndrome in female carriers 777, X-linked non-syndromic intellectual disability |
PharmGKBi | PA34847 |
VEuPathDBi | HostDB:ENSG00000177189 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0603, Eukaryota |
GeneTreei | ENSGT00940000159370 |
HOGENOMi | CLU_000288_58_3_1 |
InParanoidi | P51812 |
OMAi | ITHHEYQ |
OrthoDBi | 1132245at2759 |
PhylomeDBi | P51812 |
TreeFami | TF313438 |
Enzyme and pathway databases
BRENDAi | 2.7.11.1, 2681 |
PathwayCommonsi | P51812 |
Reactomei | R-HSA-198753, ERK/MAPK targets R-HSA-199920, CREB phosphorylation R-HSA-2559582, Senescence-Associated Secretory Phenotype (SASP) R-HSA-437239, Recycling pathway of L1 R-HSA-442742, CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling R-HSA-444257, RSK activation R-HSA-881907, Gastrin-CREB signalling pathway via PKC and MAPK |
SignaLinki | P51812 |
SIGNORi | P51812 |
Miscellaneous databases
BioGRID-ORCSi | 6197, 16 hits in 702 CRISPR screens |
ChiTaRSi | RPS6KA3, human |
GeneWikii | RPS6KA3 |
GenomeRNAii | 6197 |
Pharosi | P51812, Tchem |
PROi | PR:P51812 |
RNActi | P51812, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000177189, Expressed in biceps brachii and 238 other tissues |
ExpressionAtlasi | P51812, baseline and differential |
Genevisiblei | P51812, HS |
Family and domain databases
CDDi | cd14176, STKc_RSK2_C, 1 hit cd05582, STKc_RSK_N, 1 hit |
InterProi | View protein in InterPro IPR000961, AGC-kinase_C IPR011009, Kinase-like_dom_sf IPR017892, Pkinase_C IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR016239, Ribosomal_S6_kinase_II IPR041905, RPS6KA3_C IPR041906, RSK_N IPR008271, Ser/Thr_kinase_AS |
Pfami | View protein in Pfam PF00069, Pkinase, 2 hits PF00433, Pkinase_C, 1 hit |
PIRSFi | PIRSF000606, Ribsml_S6_kin_2, 1 hit |
SMARTi | View protein in SMART SM00133, S_TK_X, 1 hit SM00220, S_TKc, 2 hits |
SUPFAMi | SSF56112, SSF56112, 2 hits |
PROSITEi | View protein in PROSITE PS51285, AGC_KINASE_CTER, 1 hit PS00107, PROTEIN_KINASE_ATP, 2 hits PS50011, PROTEIN_KINASE_DOM, 2 hits PS00108, PROTEIN_KINASE_ST, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | KS6A3_HUMAN | |
Accessioni | P51812Primary (citable) accession number: P51812 Secondary accession number(s): B2R9V4 Q7Z3Z7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 216 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human and mouse protein kinases
Human and mouse protein kinases: classification and index - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families