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Protein

Membrane transport protein XK

Gene

XK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in sodium-dependent transport of neutral amino acids or oligopeptides.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • transporter activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionBlood group antigen
Biological processAmino-acid transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-375276 Peptide ligand-binding receptors

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.112.1.1 the kx blood-group antigen (kxa) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membrane transport protein XK
Alternative name(s):
Kell complex 37 kDa component
Kx antigen
XK-related protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:XK
Synonyms:XKR1, XRG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000047597.5

Human Gene Nomenclature Database

More...
HGNCi
HGNC:12811 XK

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
314850 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P51811

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 2CytoplasmicSequence analysis2
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei3 – 23HelicalSequence analysisAdd BLAST21
Topological domaini24 – 37ExtracellularSequence analysisAdd BLAST14
Transmembranei38 – 58HelicalSequence analysisAdd BLAST21
Topological domaini59 – 68CytoplasmicSequence analysis10
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 140ExtracellularSequence analysisAdd BLAST51
Transmembranei141 – 161HelicalSequence analysisAdd BLAST21
Topological domaini162 – 171CytoplasmicSequence analysis10
Transmembranei172 – 192HelicalSequence analysisAdd BLAST21
Topological domaini193 – 208ExtracellularSequence analysisAdd BLAST16
Transmembranei209 – 229HelicalSequence analysisAdd BLAST21
Topological domaini230 – 235CytoplasmicSequence analysis6
Transmembranei236 – 256HelicalSequence analysisAdd BLAST21
Topological domaini257 – 277ExtracellularSequence analysisAdd BLAST21
Transmembranei278 – 298HelicalSequence analysisAdd BLAST21
Topological domaini299 – 317CytoplasmicSequence analysisAdd BLAST19
Transmembranei318 – 338HelicalSequence analysisAdd BLAST21
Topological domaini339 – 349ExtracellularSequence analysisAdd BLAST11
Transmembranei350 – 370HelicalSequence analysisAdd BLAST21
Topological domaini371 – 444CytoplasmicSequence analysisAdd BLAST74

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

McLeod syndrome (MLS)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA multisystem disorder characterized by the absence of red blood cell Kx antigen, weak expression of Kell red blood cell antigens, acanthocytosis, and compensated hemolysis. Most carriers of this McLeod blood group phenotype have acanthocytosis and elevated serum creatine kinase levels and are prone to develop a severe neurologic disorder resembling Huntington disease. Additional symptoms include generalized seizures, neuromuscular symptoms leading to weakness and atrophy, and cardiomyopathy mainly manifesting with atrial fibrillation, malignant arrhythmias, and dilated cardiomyopathy.
See also OMIM:300842
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_013817222R → G in MLS. 1 Publication1
Natural variantiVAR_013818294C → R in MLS. 1 PublicationCorresponds to variant dbSNP:rs28933690EnsemblClinVar.1
Natural variantiVAR_023581327E → K in MLS; atypical without hematologic, neuromuscular, or cerebral involvement. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi347C → S: Loss of Kell-XK complex. 1 Publication1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
7504

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

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GeneReviewsi
XK

MalaCards human disease database

More...
MalaCardsi
XK
MIMi300842 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000047597

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
59306 McLeod neuroacanthocytosis syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA37410

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
XK

Domain mapping of disease mutations (DMDM)

More...
DMDMi
85700269

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001907671 – 444Membrane transport protein XKAdd BLAST444

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei115PhosphoserineBy similarity1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi347Interchain (with C-72 in Kell)1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Not glycosylated.

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P51811

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P51811

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P51811

PeptideAtlas

More...
PeptideAtlasi
P51811

PRoteomics IDEntifications database

More...
PRIDEi
P51811

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56407

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P51811

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P51811

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P51811

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

High levels in skeletal muscle, heart, brain, and pancreas; low levels in placenta, lung, liver, and kidney.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000047597 Expressed in 170 organ(s), highest expression level in liver

CleanEx database of gene expression profiles

More...
CleanExi
HS_XK

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P51811 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA019036

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterodimer with Kell; disulfide-linked.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
113341, 7 interactors

Protein interaction database and analysis system

More...
IntActi
P51811, 1 interactor

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000367879

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P51811

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the XK family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IE7C Eukaryota
ENOG410XP4P LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003231

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000118070

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG055838

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P51811

KEGG Orthology (KO)

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KOi
K19522

Identification of Orthologs from Complete Genome Data

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OMAi
YAGINMF

Database of Orthologous Groups

More...
OrthoDBi
EOG091G07Y7

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P51811

TreeFam database of animal gene trees

More...
TreeFami
TF331465

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR018629 XK-rel

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF09815 XK-related, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P51811-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKFPASVLAS VFLFVAETTA ALSLSSTYRS GGDRMWQALT LLFSLLPCAL
60 70 80 90 100
VQLTLLFVHR DLSRDRPLVL LLHLLQLGPL FRCFEVFCIY FQSGNNEEPY
110 120 130 140 150
VSITKKRQMP KNGLSEEIEK EVGQAEGKLI THRSAFSRAS VIQAFLGSAP
160 170 180 190 200
QLTLQLYISV MQQDVTVGRS LLMTISLLSI VYGALRCNIL AIKIKYDEYE
210 220 230 240 250
VKVKPLAYVC IFLWRSFEIA TRVVVLVLFT SVLKTWVVVI ILINFFSFFL
260 270 280 290 300
YPWILFWCSG SPFPENIEKA LSRVGTTIVL CFLTLLYTGI NMFCWSAVQL
310 320 330 340 350
KIDSPDLISK SHNWYQLLVY YMIRFIENAI LLLLWYLFKT DIYMYVCAPL
360 370 380 390 400
LVLQLLIGYC TAILFMLVFY QFFHPCKKLF SSSVSEGFQR WLRCFCWACR
410 420 430 440
QQKPCEPIGK EDLQSSRDRD ETPSSSKTSP EPGQFLNAED LCSA
Length:444
Mass (Da):50,902
Last modified:January 24, 2006 - v5
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6F90B0B45659A1DA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti248F → L (Ref. 3) Curated1
Sequence conflicti248F → L (PubMed:15489334).Curated1

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

XK is responsible for the Kx blood group system.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013817222R → G in MLS. 1 Publication1
Natural variantiVAR_013818294C → R in MLS. 1 PublicationCorresponds to variant dbSNP:rs28933690EnsemblClinVar.1
Natural variantiVAR_023581327E → K in MLS; atypical without hematologic, neuromuscular, or cerebral involvement. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z32684 mRNA Translation: CAA83632.2
AY534238 mRNA Translation: AAT07087.1
DQ062746 Genomic DNA Translation: AAY43132.1
BC036019 mRNA Translation: AAH36019.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS14241.1

Protein sequence database of the Protein Information Resource

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PIRi
I39294

NCBI Reference Sequences

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RefSeqi
NP_066569.1, NM_021083.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.78919

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000378616; ENSP00000367879; ENSG00000047597

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
7504

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7504

UCSC genome browser

More...
UCSCi
uc004ddq.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z32684 mRNA Translation: CAA83632.2
AY534238 mRNA Translation: AAT07087.1
DQ062746 Genomic DNA Translation: AAY43132.1
BC036019 mRNA Translation: AAH36019.1
CCDSiCCDS14241.1
PIRiI39294
RefSeqiNP_066569.1, NM_021083.3
UniGeneiHs.78919

3D structure databases

ProteinModelPortaliP51811
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113341, 7 interactors
IntActiP51811, 1 interactor
STRINGi9606.ENSP00000367879

Protein family/group databases

TCDBi2.A.112.1.1 the kx blood-group antigen (kxa) family

PTM databases

iPTMnetiP51811
PhosphoSitePlusiP51811
SwissPalmiP51811

Polymorphism and mutation databases

BioMutaiXK
DMDMi85700269

Proteomic databases

EPDiP51811
MaxQBiP51811
PaxDbiP51811
PeptideAtlasiP51811
PRIDEiP51811
ProteomicsDBi56407

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000378616; ENSP00000367879; ENSG00000047597
GeneIDi7504
KEGGihsa:7504
UCSCiuc004ddq.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
7504
DisGeNETi7504
EuPathDBiHostDB:ENSG00000047597.5

GeneCards: human genes, protein and diseases

More...
GeneCardsi
XK
GeneReviewsiXK
HGNCiHGNC:12811 XK
HPAiHPA019036
MalaCardsiXK
MIMi300842 phenotype
314850 gene
neXtProtiNX_P51811
OpenTargetsiENSG00000047597
Orphaneti59306 McLeod neuroacanthocytosis syndrome
PharmGKBiPA37410

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IE7C Eukaryota
ENOG410XP4P LUCA
GeneTreeiENSGT00390000003231
HOGENOMiHOG000118070
HOVERGENiHBG055838
InParanoidiP51811
KOiK19522
OMAiYAGINMF
OrthoDBiEOG091G07Y7
PhylomeDBiP51811
TreeFamiTF331465

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
7504

Protein Ontology

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PROi
PR:P51811

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000047597 Expressed in 170 organ(s), highest expression level in liver
CleanExiHS_XK
GenevisibleiP51811 HS

Family and domain databases

InterProiView protein in InterPro
IPR018629 XK-rel
PfamiView protein in Pfam
PF09815 XK-related, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiXK_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51811
Secondary accession number(s): Q4TTN6, Q8IUK6, Q9UC77
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 24, 2006
Last modified: September 12, 2018
This is version 148 of the entry and version 5 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families
  3. Blood group antigen proteins
    Nomenclature of blood group antigens and list of entries
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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