UniProtKB - P51809 (VAMP7_HUMAN)
Vesicle-associated membrane protein 7
VAMP7
Functioni
Miscellaneous
GO - Molecular functioni
- SNAP receptor activity Source: GO_Central
- SNARE binding Source: GO_Central
- syntaxin binding Source: Ensembl
GO - Biological processi
- calcium-ion regulated exocytosis Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: UniProtKB
- endosome to lysosome transport Source: UniProtKB
- eosinophil degranulation Source: UniProtKB
- exocytosis Source: GO_Central
- Golgi to plasma membrane protein transport Source: Ensembl
- membrane organization Source: Reactome
- natural killer cell degranulation Source: UniProtKB
- neutrophil degranulation Source: UniProtKB
- phagocytosis, engulfment Source: UniProtKB
- positive regulation of dendrite morphogenesis Source: Ensembl
- positive regulation of histamine secretion by mast cell Source: UniProtKB
- post-Golgi vesicle-mediated transport Source: Reactome
- regulation of protein targeting to vacuolar membrane Source: Ensembl
- SNARE complex assembly Source: Ensembl
- triglyceride transport Source: Ensembl
- vesicle fusion Source: UniProtKB
- vesicle fusion with Golgi apparatus Source: Ensembl
- vesicle-mediated transport Source: UniProtKB
- vesicle transport along microtubule Source: Ensembl
Keywordsi
Biological process | Exocytosis, Protein transport, Transport |
Enzyme and pathway databases
PathwayCommonsi | P51809 |
Reactomei | R-HSA-199992, trans-Golgi Network Vesicle Budding R-HSA-432720, Lysosome Vesicle Biogenesis R-HSA-432722, Golgi Associated Vesicle Biogenesis R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-9020591, Interleukin-12 signaling |
Names & Taxonomyi
Protein namesi | Recommended name: Vesicle-associated membrane protein 7Short name: VAMP-7 Alternative name(s): Synaptobrevin-like protein 1 Tetanus-insensitive VAMP Short name: Ti-VAMP |
Gene namesi | Name:VAMP7 Synonyms:SYBL1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000124333.15 |
HGNCi | HGNC:11486, VAMP7 |
MIMi | 300053, gene |
neXtProti | NX_P51809 |
Subcellular locationi
Golgi apparatus
- trans-Golgi network membrane By similarity; Single-pass type IV membrane protein By similarity
Endosome
- Late endosome membrane By similarity; Single-pass type IV membrane protein By similarity
Endoplasmic reticulum
- Endoplasmic reticulum membrane By similarity; Single-pass type IV membrane protein By similarity
Lysosome
- Lysosome membrane 1 Publication; Single-pass type IV membrane protein 1 Publication
Other locations
- secretory vesicle membrane By similarity; Single-pass type IV membrane protein By similarity
- phagosome membrane By similarity; Single-pass type IV membrane protein By similarity
- synaptosome By similarity
Note: In immature neurons expression is localized in vesicular structures in axons and dendrites while in mature neurons it is localized to the somatodendritic region. Colocalizes with LAMP1 in kidney cells. Localization to the endoplasmic reticulum membrane was observed in the intestine but not in liver or kidney (By similarity).By similarity
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: UniProtKB
Endosome
- late endosome membrane Source: UniProtKB
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Golgi apparatus
- trans-Golgi network Source: UniProtKB
Lysosome
- azurophil granule membrane Source: UniProtKB
- lysosomal membrane Source: UniProtKB
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- apical part of cell Source: Ensembl
- cell surface Source: Ensembl
- clathrin-coated vesicle membrane Source: Reactome
- cytoplasm Source: UniProtKB
- filopodium Source: Ensembl
- hippocampal mossy fiber to CA3 synapse Source: Ensembl
- integral component of synaptic vesicle membrane Source: Ensembl
- intracellular membrane-bounded organelle Source: HPA
- lamellipodium Source: UniProtKB
- membrane Source: UniProtKB
- neuron projection Source: UniProtKB
- perinuclear region of cytoplasm Source: Ensembl
- phagocytic vesicle Source: UniProtKB
- phagocytic vesicle membrane Source: UniProtKB-SubCell
- platelet alpha granule Source: UniProtKB
- pseudopodium Source: UniProtKB
- secretory granule Source: UniProtKB
- secretory granule membrane Source: UniProtKB
- SNARE complex Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 188 | CytoplasmicSequence analysisAdd BLAST | 187 | |
Transmembranei | 189 – 209 | Helical; Anchor for type IV membrane proteinSequence analysisAdd BLAST | 21 | |
Topological domaini | 210 – 220 | VesicularSequence analysisAdd BLAST | 11 |
Keywords - Cellular componenti
Cell junction, Cytoplasmic vesicle, Endoplasmic reticulum, Endosome, Golgi apparatus, Lysosome, Membrane, Synapse, SynaptosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 6845 |
MalaCardsi | VAMP7 |
OpenTargetsi | ENSG00000124333 |
Orphaneti | 251510, 46,XY partial gonadal dysgenesis |
PharmGKBi | PA162408786 |
Miscellaneous databases
Pharosi | P51809, Tbio |
Polymorphism and mutation databases
BioMutai | VAMP7 |
DMDMi | 1723133 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000206761 | 2 – 220 | Vesicle-associated membrane protein 7Add BLAST | 219 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanine; partial1 Publication | 1 | |
Modified residuei | 167 | PhosphoserineCombined sources | 1 | |
Modified residuei | 168 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P51809 |
jPOSTi | P51809 |
MassIVEi | P51809 |
MaxQBi | P51809 |
PaxDbi | P51809 |
PeptideAtlasi | P51809 |
PRIDEi | P51809 |
ProteomicsDBi | 56403 [P51809-1] 56404 [P51809-2] 56405 [P51809-3] |
PTM databases
iPTMneti | P51809 |
MetOSitei | P51809 |
PhosphoSitePlusi | P51809 |
SwissPalmi | P51809 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000124333, Expressed in secondary oocyte and 245 other tissues |
ExpressionAtlasi | P51809, baseline and differential |
Genevisiblei | P51809, HS |
Organism-specific databases
HPAi | ENSG00000124333, Low tissue specificity |
Interactioni
Subunit structurei
Component of the SNARE complex composed of STX4, SNAP23 and VAMP7 that binds SYT7 during lysosomal exocytosis.
Component of the SNARE complex composed of STX7, STX8, VAMP7 and VTI1B that is required for heterotypic fusion of late endosomes with lysosomes. May interact with STX17 (By similarity).
Interacts with PICALM (PubMed:23741335).
Interacts with RAB21 (PubMed:25648148).
By similarity2 PublicationsBinary interactionsi
Hide detailsGO - Molecular functioni
- SNARE binding Source: GO_Central
- syntaxin binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 112712, 34 interactors |
CORUMi | P51809 |
IntActi | P51809, 46 interactors |
MINTi | P51809 |
STRINGi | 9606.ENSP00000262640 |
Miscellaneous databases
RNActi | P51809, protein |
Structurei
Secondary structure
3D structure databases
BMRBi | P51809 |
SMRi | P51809 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P51809 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 7 – 110 | LonginPROSITE-ProRule annotationAdd BLAST | 104 | |
Domaini | 125 – 185 | v-SNARE coiled-coil homologyPROSITE-ProRule annotationAdd BLAST | 61 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0859, Eukaryota |
GeneTreei | ENSGT00510000047733 |
HOGENOMi | CLU_064620_1_1_1 |
InParanoidi | P51809 |
OMAi | DMPNYGA |
PhylomeDBi | P51809 |
TreeFami | TF323448 |
Family and domain databases
InterProi | View protein in InterPro IPR011012, Longin-like_dom_sf IPR010908, Longin_dom IPR001388, Synaptobrevin IPR042855, V_SNARE_CC |
Pfami | View protein in Pfam PF13774, Longin, 1 hit PF00957, Synaptobrevin, 1 hit |
PRINTSi | PR00219, SYNAPTOBREVN |
SMARTi | View protein in SMART SM01270, Longin, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS50859, LONGIN, 1 hit PS00417, SYNAPTOBREVIN, 1 hit PS50892, V_SNARE, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAILFAVVAR GTTILAKHAW CGGNFLEVTE QILAKIPSEN NKLTYSHGNY
60 70 80 90 100
LFHYICQDRI VYLCITDDDF ERSRAFNFLN EIKKRFQTTY GSRAQTALPY
110 120 130 140 150
AMNSEFSSVL AAQLKHHSEN KGLDKVMETQ AQVDELKGIM VRNIDLVAQR
160 170 180 190 200
GERLELLIDK TENLVDSSVT FKTTSRNLAR AMCMKNLKLT IIIIIVSIVF
210 220
IYIIVSPLCG GFTWPSCVKK
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE5RH06 | E5RH06_HUMAN | Vesicle-associated membrane protein... | VAMP7 | 59 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 98 | L → P in BAD96514 (Ref. 5) Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_017508 | 28 – 68 | Missing in isoform 3. 1 PublicationAdd BLAST | 41 | |
Alternative sequenceiVSP_017509 | 145 – 220 | DLVAQ…SCVKK → VCHLQNYQQKSCSSHVYEEP QAHYYHHHRINCVHLYHCFT SLWWIYMAKLCEEIGKKKLP LTKDMREQGVKSNPCDSSLS HTDRWYLPVSSTLFSLFKIL FHASRFIFVLSTSLFL in isoform 2. 1 PublicationAdd BLAST | 76 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X92396 mRNA Translation: CAA63133.1 AJ271736 Genomic DNA Translation: CAB96816.1 AJ549301 mRNA Translation: CAD70593.2 AJ295938 mRNA Translation: CAC16891.1 AK222794 mRNA Translation: BAD96514.1 BC056141 mRNA Translation: AAH56141.1 BI547528 mRNA No translation available. |
CCDSi | CCDS14770.4 [P51809-1] CCDS48199.1 [P51809-3] CCDS55548.1 [P51809-2] |
RefSeqi | NP_001138621.1, NM_001145149.2 [P51809-3] NP_001172112.1, NM_001185183.1 [P51809-2] NP_005629.1, NM_005638.5 [P51809-1] |
Genome annotation databases
Ensembli | ENST00000262640; ENSP00000262640; ENSG00000124333 [P51809-2] ENST00000286448; ENSP00000286448; ENSG00000124333 [P51809-1] ENST00000460621; ENSP00000427822; ENSG00000124333 [P51809-3] |
GeneIDi | 6845 |
KEGGi | hsa:6845 |
UCSCi | uc004fnr.4, human [P51809-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X92396 mRNA Translation: CAA63133.1 AJ271736 Genomic DNA Translation: CAB96816.1 AJ549301 mRNA Translation: CAD70593.2 AJ295938 mRNA Translation: CAC16891.1 AK222794 mRNA Translation: BAD96514.1 BC056141 mRNA Translation: AAH56141.1 BI547528 mRNA No translation available. |
CCDSi | CCDS14770.4 [P51809-1] CCDS48199.1 [P51809-3] CCDS55548.1 [P51809-2] |
RefSeqi | NP_001138621.1, NM_001145149.2 [P51809-3] NP_001172112.1, NM_001185183.1 [P51809-2] NP_005629.1, NM_005638.5 [P51809-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2DMW | NMR | - | A | 1-118 | [»] | |
BMRBi | P51809 | |||||
SMRi | P51809 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112712, 34 interactors |
CORUMi | P51809 |
IntActi | P51809, 46 interactors |
MINTi | P51809 |
STRINGi | 9606.ENSP00000262640 |
PTM databases
iPTMneti | P51809 |
MetOSitei | P51809 |
PhosphoSitePlusi | P51809 |
SwissPalmi | P51809 |
Polymorphism and mutation databases
BioMutai | VAMP7 |
DMDMi | 1723133 |
Proteomic databases
EPDi | P51809 |
jPOSTi | P51809 |
MassIVEi | P51809 |
MaxQBi | P51809 |
PaxDbi | P51809 |
PeptideAtlasi | P51809 |
PRIDEi | P51809 |
ProteomicsDBi | 56403 [P51809-1] 56404 [P51809-2] 56405 [P51809-3] |
Protocols and materials databases
Antibodypediai | 31441, 216 antibodies |
DNASUi | 6845 |
Genome annotation databases
Ensembli | ENST00000262640; ENSP00000262640; ENSG00000124333 [P51809-2] ENST00000286448; ENSP00000286448; ENSG00000124333 [P51809-1] ENST00000460621; ENSP00000427822; ENSG00000124333 [P51809-3] |
GeneIDi | 6845 |
KEGGi | hsa:6845 |
UCSCi | uc004fnr.4, human [P51809-1] |
Organism-specific databases
CTDi | 6845 |
DisGeNETi | 6845 |
EuPathDBi | HostDB:ENSG00000124333.15 |
GeneCardsi | VAMP7 |
HGNCi | HGNC:11486, VAMP7 |
HPAi | ENSG00000124333, Low tissue specificity |
MalaCardsi | VAMP7 |
MIMi | 300053, gene |
neXtProti | NX_P51809 |
OpenTargetsi | ENSG00000124333 |
Orphaneti | 251510, 46,XY partial gonadal dysgenesis |
PharmGKBi | PA162408786 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0859, Eukaryota |
GeneTreei | ENSGT00510000047733 |
HOGENOMi | CLU_064620_1_1_1 |
InParanoidi | P51809 |
OMAi | DMPNYGA |
PhylomeDBi | P51809 |
TreeFami | TF323448 |
Enzyme and pathway databases
PathwayCommonsi | P51809 |
Reactomei | R-HSA-199992, trans-Golgi Network Vesicle Budding R-HSA-432720, Lysosome Vesicle Biogenesis R-HSA-432722, Golgi Associated Vesicle Biogenesis R-HSA-8856825, Cargo recognition for clathrin-mediated endocytosis R-HSA-8856828, Clathrin-mediated endocytosis R-HSA-9020591, Interleukin-12 signaling |
Miscellaneous databases
BioGRID-ORCSi | 6845, 5 hits in 431 CRISPR screens |
ChiTaRSi | VAMP7, human |
EvolutionaryTracei | P51809 |
GeneWikii | SYBL1 |
GenomeRNAii | 6845 |
Pharosi | P51809, Tbio |
PROi | PR:P51809 |
RNActi | P51809, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000124333, Expressed in secondary oocyte and 245 other tissues |
ExpressionAtlasi | P51809, baseline and differential |
Genevisiblei | P51809, HS |
Family and domain databases
InterProi | View protein in InterPro IPR011012, Longin-like_dom_sf IPR010908, Longin_dom IPR001388, Synaptobrevin IPR042855, V_SNARE_CC |
Pfami | View protein in Pfam PF13774, Longin, 1 hit PF00957, Synaptobrevin, 1 hit |
PRINTSi | PR00219, SYNAPTOBREVN |
SMARTi | View protein in SMART SM01270, Longin, 1 hit |
SUPFAMi | SSF64356, SSF64356, 1 hit |
PROSITEi | View protein in PROSITE PS50859, LONGIN, 1 hit PS00417, SYNAPTOBREVIN, 1 hit PS50892, V_SNARE, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VAMP7_HUMAN | |
Accessioni | P51809Primary (citable) accession number: P51809 Secondary accession number(s): Q53GY7, Q7Z409, Q9H4A7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 201 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM