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Protein

Dynein light chain Tctex-type 1

Gene

Dynlt1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia (By similarity). May also be a accessory component of axonemal dynein. Plays an important role in male germ cell development and function. Candidate for involvement in male sterility.By similarity1 Publication
Plays a role in neuronal morphogenesis; the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling; the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis; inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling. Involved in the regulation of mitotic spindle orientation.2 Publications

GO - Molecular functioni

  • G-protein beta-subunit binding Source: MGI
  • GTP-dependent protein binding Source: MGI
  • identical protein binding Source: MGI
  • motor activity Source: UniProtKB-KW
  • protein C-terminus binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionMotor protein
Biological processCell cycle, Cell division, Mitosis, Neurogenesis, Transport

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Dynein light chain Tctex-type 1
Alternative name(s):
Activator of G-protein signaling 2
Short name:
AGS2
T-complex testis-specific protein 1
TCTEX-1
Gene namesi
Name:Dynlt1
Synonyms:Tctel1, Tctex-1, Tctex1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:98643 Dynlt1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Dynein, Golgi apparatus, Microtubule

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001951531 – 113Dynein light chain Tctex-type 1Add BLAST113

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Post-translational modificationi

Phosphorylated by BMPR2. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release (By similarity).By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP51807
MaxQBiP51807
PaxDbiP51807
PRIDEiP51807

PTM databases

iPTMnetiP51807
PhosphoSitePlusiP51807

Expressioni

Tissue specificityi

High level in testis (germ cell-specific). Expressed in sperm (at protein level). 200-fold lower in liver, brain, heart, spleen, and kidney. Levels in thymus and two embryonal carcinoma cell lines were several-fold higher than this low constitutive level.1 Publication

Developmental stagei

First abundantly expressed at the pachytene stage of meiosis and persists throughout spermatogenesis.

Gene expression databases

BgeeiENSMUSG00000000579 Expressed in 80 organ(s), highest expression level in cerebellum
CleanExiMM_DYNLT1
GenevisibleiP51807 MM

Interactioni

Subunit structurei

Homodimer (Probable). The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer. DYNLT1 and DYNLT3 compete for association with dynein IC (DYNC1I1 or DYNC1I2). Self-associates. Interacts with RHO (By similarity). Interacts with DYNC1I1 and DYNC1I2. Interacts with DOC2A, DOC2B and SCN10A. Interacts with PVR. Interacts with SVIL isoform 2. Interacts with GNB1; the interaction occurs in presence of guanine nucleotide-binding protein G(T) subunit gamma; the interaction diminishes the association of DYNLT1 with dynein IC (DYNC1I1 or DYNC1I2). Interacts with GNB2, GNB3 and GNB5; the interactions occur in presence of guanine nucleotide-binding protein G(T) subunit gamma. Interacts with ACVR2B and ARHGEF2 (By similarity).By similarityCurated1 Publication

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204082, 2 interactors
IntActiP51807, 9 interactors
MINTiP51807
STRINGi10090.ENSMUSP00000137171

Structurei

Secondary structure

1113
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP51807
SMRiP51807
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni41 – 113Interaction with GNB1By similarityAdd BLAST73

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4081 Eukaryota
ENOG4111NHR LUCA
GeneTreeiENSGT00390000013998
HOGENOMiHOG000255148
HOVERGENiHBG001217
InParanoidiP51807
KOiK10420
OMAiCYWDNAT
OrthoDBiEOG091G0Y5N
PhylomeDBiP51807
TreeFamiTF313904

Family and domain databases

Gene3Di3.30.1140.40, 1 hit
InterProiView protein in InterPro
IPR005334 Tctex
IPR038586 Tctex-1-like_sf
PANTHERiPTHR21255 PTHR21255, 1 hit
PfamiView protein in Pfam
PF03645 Tctex-1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P51807-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDFQASEET AFVVDEVSSI VKEAIESAIG GNAYQHSKVN QWTTNVLEQT
60 70 80 90 100
LSQLTKLGRP FKYIVTCVIM QKNGAGLHSA SSCFWDSSTD GSCTVRWENK
110
TMYCIVSTFG LSI
Length:113
Mass (Da):12,483
Last modified:October 1, 1996 - v1
Checksum:i92DF96F933DB7AF1
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A338P7B7A0A338P7B7_MOUSE
Dynein light chain Tctex-type 1A
Dynlt1a
112Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti21V → A. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25825 mRNA Translation: AAA40408.1
AK133788 mRNA Translation: BAE21842.1
AK153971 mRNA Translation: BAE32288.1
AK168478 mRNA Translation: BAE40367.1
BC043018 mRNA Translation: AAH43018.1
BC087868 mRNA Translation: AAH87868.1
CCDSiCCDS49936.1
PIRiA32995
RefSeqiNP_001160099.1, NM_001166627.1
NP_001160101.1, NM_001166629.2
NP_001160102.1, NM_001166630.1
NP_033368.1, NM_009342.2
XP_017172676.1, XM_017317187.1
UniGeneiMm.1948
Mm.381893
Mm.428775
Mm.457381
Mm.457987
Mm.458102
Mm.458208
Mm.463722

Genome annotation databases

EnsembliENSMUST00000092966; ENSMUSP00000090644; ENSMUSG00000000579
ENSMUST00000169415; ENSMUSP00000127990; ENSMUSG00000092074
ENSMUST00000179554; ENSMUSP00000135978; ENSMUSG00000095677
ENSMUST00000179569; ENSMUSP00000137171; ENSMUSG00000096255
GeneIDi100040531
100040563
100310872
21648
KEGGimmu:100040531
mmu:100040563
mmu:100310872
mmu:21648
UCSCiuc008agl.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M25825 mRNA Translation: AAA40408.1
AK133788 mRNA Translation: BAE21842.1
AK153971 mRNA Translation: BAE32288.1
AK168478 mRNA Translation: BAE40367.1
BC043018 mRNA Translation: AAH43018.1
BC087868 mRNA Translation: AAH87868.1
CCDSiCCDS49936.1
PIRiA32995
RefSeqiNP_001160099.1, NM_001166627.1
NP_001160101.1, NM_001166629.2
NP_001160102.1, NM_001166630.1
NP_033368.1, NM_009342.2
XP_017172676.1, XM_017317187.1
UniGeneiMm.1948
Mm.381893
Mm.428775
Mm.457381
Mm.457987
Mm.458102
Mm.458208
Mm.463722

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5WI4X-ray2.00A/B/C1-113[»]
ProteinModelPortaliP51807
SMRiP51807
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204082, 2 interactors
IntActiP51807, 9 interactors
MINTiP51807
STRINGi10090.ENSMUSP00000137171

PTM databases

iPTMnetiP51807
PhosphoSitePlusiP51807

Proteomic databases

EPDiP51807
MaxQBiP51807
PaxDbiP51807
PRIDEiP51807

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000092966; ENSMUSP00000090644; ENSMUSG00000000579
ENSMUST00000169415; ENSMUSP00000127990; ENSMUSG00000092074
ENSMUST00000179554; ENSMUSP00000135978; ENSMUSG00000095677
ENSMUST00000179569; ENSMUSP00000137171; ENSMUSG00000096255
GeneIDi100040531
100040563
100310872
21648
KEGGimmu:100040531
mmu:100040563
mmu:100310872
mmu:21648
UCSCiuc008agl.3 mouse

Organism-specific databases

CTDi100040531
100040563
100310872
21648
MGIiMGI:98643 Dynlt1

Phylogenomic databases

eggNOGiKOG4081 Eukaryota
ENOG4111NHR LUCA
GeneTreeiENSGT00390000013998
HOGENOMiHOG000255148
HOVERGENiHBG001217
InParanoidiP51807
KOiK10420
OMAiCYWDNAT
OrthoDBiEOG091G0Y5N
PhylomeDBiP51807
TreeFamiTF313904

Enzyme and pathway databases

ReactomeiR-MMU-6798695 Neutrophil degranulation

Miscellaneous databases

PROiPR:P51807
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000000579 Expressed in 80 organ(s), highest expression level in cerebellum
CleanExiMM_DYNLT1
GenevisibleiP51807 MM

Family and domain databases

Gene3Di3.30.1140.40, 1 hit
InterProiView protein in InterPro
IPR005334 Tctex
IPR038586 Tctex-1-like_sf
PANTHERiPTHR21255 PTHR21255, 1 hit
PfamiView protein in Pfam
PF03645 Tctex-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDYLT1_MOUSE
AccessioniPrimary (citable) accession number: P51807
Secondary accession number(s): Q5M8S6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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