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Protein

Plexin-A3

Gene

PLXNA3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Coreceptor for SEMA3A and SEMA3F. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance in the developing nervous system. Regulates the migration of sympathetic neurons, but not of neural crest precursors. Required for normal dendrite spine morphology in pyramidal neurons. May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system. Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin. The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm.

GO - Molecular functioni

  • semaphorin receptor activity Source: Ensembl
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionReceptor

Enzyme and pathway databases

ReactomeiR-HSA-399954 Sema3A PAK dependent Axon repulsion
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399956 CRMPs in Sema3A signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Plexin-A3
Alternative name(s):
Plexin-4
Semaphorin receptor SEX
Gene namesi
Name:PLXNA3
Synonyms:PLXN4, SEX
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000130827.6
HGNCiHGNC:9101 PLXNA3
MIMi300022 gene
neXtProtiNX_P51805

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini20 – 1220ExtracellularSequence analysisAdd BLAST1201
Transmembranei1221 – 1241HelicalSequence analysisAdd BLAST21
Topological domaini1242 – 1871CytoplasmicSequence analysisAdd BLAST630

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi55558
PharmGKBiPA33427

Polymorphism and mutation databases

DMDMi118572690

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Sequence analysisAdd BLAST19
ChainiPRO_000002467020 – 1871Plexin-A3Add BLAST1852

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi59N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
Disulfide bondi112 ↔ 120PROSITE-ProRule annotation
Disulfide bondi266 ↔ 387PROSITE-ProRule annotation
Disulfide bondi282 ↔ 338PROSITE-ProRule annotation
Disulfide bondi356 ↔ 375PROSITE-ProRule annotation
Disulfide bondi491 ↔ 508PROSITE-ProRule annotation
Disulfide bondi497 ↔ 539PROSITE-ProRule annotation
Disulfide bondi500 ↔ 517PROSITE-ProRule annotation
Disulfide bondi511 ↔ 523PROSITE-ProRule annotation
Glycosylationi548N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi574 ↔ 594PROSITE-ProRule annotation
Glycosylationi637N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi738N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi746N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1009N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1036N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1073N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1115N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1162N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1596PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP51805
MaxQBiP51805
PaxDbiP51805
PeptideAtlasiP51805
PRIDEiP51805
ProteomicsDBi56401

PTM databases

iPTMnetiP51805
PhosphoSitePlusiP51805

Expressioni

Gene expression databases

BgeeiENSG00000130827 Expressed in 163 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_PLXNA3
GenevisibleiP51805 HS

Organism-specific databases

HPAiHPA058989

Interactioni

Subunit structurei

Interacts with CBFA2T3/MTG16.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CBFA2T3O750812EBI-7135904,EBI-1190217

Protein-protein interaction databases

BioGridi120717, 53 interactors
CORUMiP51805
DIPiDIP-57386N
IntActiP51805, 43 interactors
MINTiP51805
STRINGi9606.ENSP00000358696

Structurei

3D structure databases

ProteinModelPortaliP51805
SMRiP51805
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 488SemaPROSITE-ProRule annotationAdd BLAST469
Domaini840 – 933IPT/TIG 1Add BLAST94
Domaini935 – 1020IPT/TIG 2Add BLAST86
Domaini1023 – 1122IPT/TIG 3Add BLAST100
Domaini1125 – 1211IPT/TIG 4Add BLAST87

Sequence similaritiesi

Belongs to the plexin family.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
HOGENOMiHOG000231377
HOVERGENiHBG105711
InParanoidiP51805
KOiK06820
OrthoDBiEOG091G00EK
PhylomeDBiP51805
TreeFamiTF312962

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 4 hits
SMARTiView protein in SMART
SM00429 IPT, 4 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 2 hits
SSF81296 SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51805-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPSVCLLLLL FLAVGGALGN RPFRAFVVTD TTLTHLAVHR VTGEVFVGAV
60 70 80 90 100
NRVFKLAPNL TELRAHVTGP VEDNARCYPP PSMRVCAHRL APVDNINKLL
110 120 130 140 150
LIDYAARRLV ACGSIWQGIC QFLRLDDLFK LGEPHHRKEH YLSGAQEPDS
160 170 180 190 200
MAGVIVEQGQ GPSKLFVGTA VDGKSEYFPT LSSRKLISDE DSADMFSLVY
210 220 230 240 250
QDEFVSSQIK IPSDTLSLYP AFDIYYIYGF VSASFVYFLT LQLDTQQTLL
260 270 280 290 300
DTAGEKFFTS KIVRMCAGDS EFYSYVEFPI GCSWRGVEYR LVQSAHLAKP
310 320 330 340 350
GLLLAQALGV PADEDVLFTI FSQGQKNRAS PPRQTILCLF TLSNINAHIR
360 370 380 390 400
RRIQSCYRGE GTLALPWLLN KELPCINTPM QINGNFCGLV LNQPLGGLHV
410 420 430 440 450
IEGLPLLADS TDGMASVAAY TYRQHSVVFI GTRSGSLKKV RVDGFQDAHL
460 470 480 490 500
YETVPVVDGS PILRDLLFSP DHRHIYLLSE KQVSQLPVET CEQYQSCAAC
510 520 530 540 550
LGSGDPHCGW CVLRHRCCRE GACLGASAPH GFAEELSKCV QVRVRPNNVS
560 570 580 590 600
VTSPGVQLTV TLHNVPDLSA GVSCAFEAAA ENEAVLLPSG ELLCPSPSLQ
610 620 630 640 650
ELRALTRGHG ATRTVRLQLL SKETGVRFAG ADFVFYNCSV LQSCMSCVGS
660 670 680 690 700
PYPCHWCKYR HTCTSRPHEC SFQEGRVHSP EGCPEILPSG DLLIPVGVMQ
710 720 730 740 750
PLTLRAKNLP QPQSGQKNYE CVVRVQGRQQ RVPAVRFNSS SVQCQNASYS
760 770 780 790 800
YEGDEHGDTE LDFSVVWDGD FPIDKPPSFR ALLYKCWAQR PSCGLCLKAD
810 820 830 840 850
PRFNCGWCIS EHRCQLRTHC PAPKTNWMHL SQKGTRCSHP RITQIHPLVG
860 870 880 890 900
PKEGGTRVTI VGDNLGLLSR EVGLRVAGVR CNSIPAEYIS AERIVCEMEE
910 920 930 940 950
SLVPSPPPGP VELCVGDCSA DFRTQSEQVY SFVTPTFDQV SPSRGPASGG
960 970 980 990 1000
TRLTISGSSL DAGSRVTVTV RDSECQFVRR DAKAIVCISP LSTLGPSQAP
1010 1020 1030 1040 1050
ITLAIDRANI SSPGLIYTYT QDPTVTRLEP TWSIINGSTA ITVSGTHLLT
1060 1070 1080 1090 1100
VQEPRVRAKY RGIETTNTCQ VINDTAMLCK APGIFLGRPQ PRAQGEHPDE
1110 1120 1130 1140 1150
FGFLLDHVQT ARSLNRSSFT YYPDPSFEPL GPSGVLDVKP GSHVVLKGKN
1160 1170 1180 1190 1200
LIPAAAGSSR LNYTVLIGGQ PCSLTVSDTQ LLCDSPSQTG RQPVMVLVGG
1210 1220 1230 1240 1250
LEFWLGTLHI SAERALTLPA MMGLAAGGGL LLLAITAVLV AYKRKTQDAD
1260 1270 1280 1290 1300
RTLKRLQLQM DNLESRVALE CKEAFAELQT DINELTNHMD EVQIPFLDYR
1310 1320 1330 1340 1350
TYAVRVLFPG IEAHPVLKEL DTPPNVEKAL RLFGQLLHSR AFVLTFIHTL
1360 1370 1380 1390 1400
EAQSSFSMRD RGTVASLTMV ALQSRLDYAT GLLKQLLADL IEKNLESKNH
1410 1420 1430 1440 1450
PKLLLRRTES VAEKMLTNWF TFLLHKFLKE CAGEPLFLLY CAIKQQMEKG
1460 1470 1480 1490 1500
PIDAITGEAR YSLSEDKLIR QQIDYKTLTL HCVCPENEGS AQVPVKVLNC
1510 1520 1530 1540 1550
DSITQAKDKL LDTVYKGIPY SQRPKAEDMD LEWRQGRMTR IILQDEDVTT
1560 1570 1580 1590 1600
KIECDWKRLN SLAHYQVTDG SLVALVPKQV SAYNMANSFT FTRSLSRYES
1610 1620 1630 1640 1650
LLRTASSPDS LRSRAPMITP DQETGTKLWH LVKNHDHADH REGDRGSKMV
1660 1670 1680 1690 1700
SEIYLTRLLA TKGTLQKFVD DLFETVFSTA HRGSALPLAI KYMFDFLDEQ
1710 1720 1730 1740 1750
ADQRQISDPD VRHTWKSNCL PLRFWVNVIK NPQFVFDIHK NSITDACLSV
1760 1770 1780 1790 1800
VAQTFMDSCS TSEHRLGKDS PSNKLLYAKD IPNYKSWVER YYRDIAKMAS
1810 1820 1830 1840 1850
ISDQDMDAYL VEQSRLHASD FSVLSALNEL YFYVTKYRQE ILTALDRDAS
1860 1870
CRKHKLRQKL EQIISLVSSD S
Length:1,871
Mass (Da):207,703
Last modified:November 28, 2006 - v2
Checksum:iF0D21C3FD4CE9FBA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti222F → L in CAA61132 (PubMed:8570614).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050595384G → S. Corresponds to variant dbSNP:rs34585333Ensembl.1
Natural variantiVAR_050596413G → S. Corresponds to variant dbSNP:rs36115591Ensembl.1
Natural variantiVAR_050597863D → E1 PublicationCorresponds to variant dbSNP:rs5945430Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87852 mRNA Translation: CAA61132.1
BX936365 Genomic DNA No translation available.
CCDSiCCDS14752.1
RefSeqiNP_059984.3, NM_017514.4
UniGeneiHs.632839

Genome annotation databases

EnsembliENST00000369682; ENSP00000358696; ENSG00000130827
GeneIDi55558
KEGGihsa:55558
UCSCiuc004flm.5 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87852 mRNA Translation: CAA61132.1
BX936365 Genomic DNA No translation available.
CCDSiCCDS14752.1
RefSeqiNP_059984.3, NM_017514.4
UniGeneiHs.632839

3D structure databases

ProteinModelPortaliP51805
SMRiP51805
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi120717, 53 interactors
CORUMiP51805
DIPiDIP-57386N
IntActiP51805, 43 interactors
MINTiP51805
STRINGi9606.ENSP00000358696

PTM databases

iPTMnetiP51805
PhosphoSitePlusiP51805

Polymorphism and mutation databases

DMDMi118572690

Proteomic databases

EPDiP51805
MaxQBiP51805
PaxDbiP51805
PeptideAtlasiP51805
PRIDEiP51805
ProteomicsDBi56401

Protocols and materials databases

DNASUi55558
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369682; ENSP00000358696; ENSG00000130827
GeneIDi55558
KEGGihsa:55558
UCSCiuc004flm.5 human

Organism-specific databases

CTDi55558
DisGeNETi55558
EuPathDBiHostDB:ENSG00000130827.6
GeneCardsiPLXNA3
H-InvDBiHIX0203329
HGNCiHGNC:9101 PLXNA3
HPAiHPA058989
MIMi300022 gene
neXtProtiNX_P51805
PharmGKBiPA33427
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3610 Eukaryota
ENOG410XR88 LUCA
HOGENOMiHOG000231377
HOVERGENiHBG105711
InParanoidiP51805
KOiK06820
OrthoDBiEOG091G00EK
PhylomeDBiP51805
TreeFamiTF312962

Enzyme and pathway databases

ReactomeiR-HSA-399954 Sema3A PAK dependent Axon repulsion
R-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-399956 CRMPs in Sema3A signaling

Miscellaneous databases

ChiTaRSiPLXNA3 human
GeneWikiiPLXNA3
GenomeRNAii55558
PROiPR:P51805
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000130827 Expressed in 163 organ(s), highest expression level in right hemisphere of cerebellum
CleanExiHS_PLXNA3
GenevisibleiP51805 HS

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.60.40.10, 5 hits
InterProiView protein in InterPro
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR031148 Plexin
IPR013548 Plexin_cytoplasmic_RasGAP_dom
IPR002165 Plexin_repeat
IPR016201 PSI
IPR008936 Rho_GTPase_activation_prot
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR22625 PTHR22625, 1 hit
PfamiView protein in Pfam
PF08337 Plexin_cytopl, 1 hit
PF01437 PSI, 2 hits
PF01403 Sema, 1 hit
PF01833 TIG, 4 hits
SMARTiView protein in SMART
SM00429 IPT, 4 hits
SM00423 PSI, 3 hits
SM00630 Sema, 1 hit
SUPFAMiSSF101912 SSF101912, 1 hit
SSF48350 SSF48350, 2 hits
SSF81296 SSF81296, 4 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLXA3_HUMAN
AccessioniPrimary (citable) accession number: P51805
Secondary accession number(s): Q5HY36
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 28, 2006
Last modified: September 12, 2018
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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