UniProtKB - P51790 (CLCN3_HUMAN)
Protein
H(+)/Cl(-) exchange transporter 3
Gene
CLCN3
Organism
Homo sapiens (Human)
Status
Functioni
Strongly outwardly rectifying, electrogenic H+/Cl-exchanger which mediates the exchange of chloride ions against protons (By similarity). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874).1 PublicationBy similarity
Strongly outwardly rectifying, electrogenic H+/Cl-exchanger which mediates the exchange of chloride ions against protons.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 239 | ChlorideBy similarity | 1 | |
Sitei | 282 | Mediates proton transfer from the outer aqueous phase to the interior of the protein; involved in linking H(+) and Cl(-) transportBy similarity | 1 | |
Sitei | 339 | Mediates proton transfer from the protein to the inner aqueous phaseBy similarity | 1 | |
Binding sitei | 527 | Chloride; via amide nitrogenBy similarity | 1 | |
Binding sitei | 630 | ChlorideBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 689 – 691 | ATPBy similarity | 3 | |
Nucleotide bindingi | 796 – 799 | ATPBy similarity | 4 |
GO - Molecular functioni
- antiporter activity Source: UniProtKB
- ATP binding Source: UniProtKB-KW
- chloride channel activity Source: GO_Central
- PDZ domain binding Source: UniProtKB
- solute:proton antiporter activity Source: GO_Central
- voltage-gated chloride channel activity Source: GO_Central
- volume-sensitive chloride channel activity Source: GO_Central
GO - Biological processi
- adult locomotory behavior Source: Ensembl
- chloride transmembrane transport Source: GO_Central
- endosomal lumen acidification Source: UniProtKB
- negative regulation of cell volume Source: GO_Central
- phagocytosis, engulfment Source: Ensembl
- photoreceptor cell maintenance Source: Ensembl
- positive regulation of reactive oxygen species biosynthetic process Source: Ensembl
- regulation of pH Source: UniProtKB
- synaptic transmission, GABAergic Source: Ensembl
- synaptic transmission, glutamatergic Source: Ensembl
- synaptic vesicle lumen acidification Source: Ensembl
Keywordsi
Biological process | Antiport, Ion transport, Transport |
Ligand | ATP-binding, Chloride, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P51790 |
Reactomei | R-HSA-2672351, Stimuli-sensing channels |
Names & Taxonomyi
Protein namesi | Recommended name: H(+)/Cl(-) exchange transporter 3Alternative name(s): Chloride channel protein 3 Short name: ClC-3 Chloride transporter ClC-3 |
Gene namesi | Name:CLCN3 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:2021, CLCN3 |
MIMi | 600580, gene |
neXtProti | NX_P51790 |
VEuPathDBi | HostDB:ENSG00000109572.13 |
Subcellular locationi
Lysosome
- Lysosome membrane By similarity; Multi-pass membrane protein Sequence analysis
Endosome
- Early endosome membrane 1 Publication; Multi-pass membrane protein Sequence analysis
- Late endosome membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein Sequence analysis
Note: Isoform 1 is localized mainly in late endosomes.1 Publication
Golgi apparatus
- Golgi apparatus membrane 1 Publication; Multi-pass membrane protein Sequence analysis
Plasma membrane
- ruffle membrane 1 Publication; Multi-pass membrane protein 1 Publication
Note: Isoform 2 is mainly enriched in the Golgi (PubMed:12471024). Colocalizes with SLC9A3R1/EBP50 in membrane ruffles (PubMed:11967229).2 Publications
Endosome
- early endosome Source: UniProtKB
- early endosome membrane Source: UniProtKB-SubCell
- endosome membrane Source: UniProtKB
- late endosome Source: UniProtKB
- late endosome membrane Source: UniProtKB-SubCell
- recycling endosome Source: UniProtKB
Golgi apparatus
- Golgi apparatus Source: UniProtKB
- Golgi membrane Source: UniProtKB-SubCell
Lysosome
- lysosomal membrane Source: UniProtKB
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: GO_Central
- ruffle membrane Source: UniProtKB-SubCell
Other locations
- axon terminus Source: Ensembl
- cell surface Source: UniProtKB
- cytoplasmic vesicle Source: GO_Central
- GABA-ergic synapse Source: SynGO
- glutamatergic synapse Source: SynGO
- integral component of membrane Source: UniProtKB
- integral component of synaptic vesicle membrane Source: SynGO
- intracellular membrane-bounded organelle Source: HPA
- membrane Source: UniProtKB
- phagocytic vesicle Source: GO_Central
- secretory granule Source: GO_Central
- specific granule Source: GO_Central
- synaptic vesicle Source: GO_Central
- vesicle membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 125 | CytoplasmicBy similarityAdd BLAST | 125 | |
Transmembranei | 126 – 163 | HelicalBy similarityAdd BLAST | 38 | |
Transmembranei | 209 – 232 | HelicalBy similarityAdd BLAST | 24 | |
Intramembranei | 241 – 248 | HelicalBy similarity | 8 | |
Transmembranei | 258 – 276 | HelicalBy similarityAdd BLAST | 19 | |
Transmembranei | 282 – 301 | HelicalBy similarityAdd BLAST | 20 | |
Intramembranei | 313 – 325 | HelicalBy similarityAdd BLAST | 13 | |
Intramembranei | 329 – 337 | HelicalBy similarity | 9 | |
Transmembranei | 349 – 367 | HelicalBy similarityAdd BLAST | 19 | |
Transmembranei | 391 – 416 | HelicalBy similarityAdd BLAST | 26 | |
Transmembranei | 423 – 443 | HelicalBy similarityAdd BLAST | 21 | |
Transmembranei | 500 – 520 | HelicalBy similarityAdd BLAST | 21 | |
Transmembranei | 525 – 544 | HelicalBy similarityAdd BLAST | 20 | |
Intramembranei | 572 – 586 | HelicalBy similarityAdd BLAST | 15 | |
Intramembranei | 590 – 601 | HelicalBy similarityAdd BLAST | 12 | |
Intramembranei | 602 – 605 | Note=Loop between two helicesBy similarity | 4 | |
Transmembranei | 606 – 624 | HelicalBy similarityAdd BLAST | 19 | |
Topological domaini | 625 – 818 | CytoplasmicBy similarityAdd BLAST | 194 |
Keywords - Cellular componenti
Cell membrane, Cell projection, Endosome, Golgi apparatus, Lysosome, MembranePathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 280 | G → E: Changes channel selectivity from I(-)>Cl(-) to Cl(-)>I(-). 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 1182 |
OpenTargetsi | ENSG00000109572 |
PharmGKBi | PA26548 |
Miscellaneous databases
Pharosi | P51790, Tchem |
Chemistry databases
ChEMBLi | CHEMBL2401603 |
GuidetoPHARMACOLOGYi | 702 |
Genetic variation databases
BioMutai | CLCN3 |
DMDMi | 226693513 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000094438 | 1 – 818 | H(+)/Cl(-) exchange transporter 3Add BLAST | 818 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 177 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 451 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 479 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated.2 Publications
Keywords - PTMi
GlycoproteinProteomic databases
jPOSTi | P51790 |
MassIVEi | P51790 |
MaxQBi | P51790 |
PaxDbi | P51790 |
PeptideAtlasi | P51790 |
PRIDEi | P51790 |
ProteomicsDBi | 56388 [P51790-1] 56389 [P51790-2] 7526 |
PTM databases
GlyGeni | P51790, 4 sites |
iPTMneti | P51790 |
PhosphoSitePlusi | P51790 |
SwissPalmi | P51790 |
Expressioni
Tissue specificityi
Expressed primarily in tissues derived from neuroectoderm. Within the brain, its expression is particularly evident in the hippocampus, olfactory cortex, and olfactory bulb. Highly expressed in aortic and coronary vascular smooth muscle cells, and aortic endothelial cells. Also expressed in tracheal and alveolar epithelial cells, and intima and media of the pulmonary vessels. Expressed in bronchus and colon (at protein level).3 Publications
Gene expression databases
Bgeei | ENSG00000109572, Expressed in brain and 248 other tissues |
ExpressionAtlasi | P51790, baseline and differential |
Genevisiblei | P51790, HS |
Organism-specific databases
HPAi | ENSG00000109572, Low tissue specificity |
Interactioni
Subunit structurei
Monomer and homodimer (By similarity). Forms heterodimers with CLCN4 (By similarity).
By similarityBinary interactionsi
Hide detailsIsoform 2 [P51790-2]
With | #Exp. | IntAct |
---|---|---|
CFTR [P13569] | 2 | EBI-25495635,EBI-349854 |
CLCN3 - isoform 1 [P51790-1] | 2 | EBI-25495635,EBI-25495642 |
PDZK1 [Q5T2W1] | 2 | EBI-25495635,EBI-349819 |
GO - Molecular functioni
- PDZ domain binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 107596, 21 interactors |
IntActi | P51790, 15 interactors |
STRINGi | 9606.ENSP00000261514 |
Miscellaneous databases
RNActi | P51790, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 658 – 722 | CBS 1PROSITE-ProRule annotationAdd BLAST | 65 | |
Domaini | 755 – 812 | CBS 2PROSITE-ProRule annotationAdd BLAST | 58 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 28 – 29 | Di-leucine internalization motif; mediates targeting to late endosome and lysosome membranesBy similarity | 2 | |
Motifi | 46 – 47 | Di-leucine internalization motif; mediates targeting to late endosome and lysosome membranesBy similarity | 2 | |
Motifi | 71 – 75 | Di-leucine internalization motif; mediates targeting to late endosome and lysosome membranesBy similarity | 5 | |
Motifi | 238 – 242 | Selectivity filter part_1By similarity | 5 | |
Motifi | 280 – 284 | Selectivity filter part_2By similarity | 5 | |
Motifi | 525 – 529 | Selectivity filter part_3By similarity | 5 |
Domaini
Isoform 2 contains a C-terminal PDZ-binding motif mediating the interaction with GOPC.1 Publication
Sequence similaritiesi
Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily. [View classification]Curated
Keywords - Domaini
CBS domain, Repeat, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0475, Eukaryota |
GeneTreei | ENSGT00940000153763 |
HOGENOMi | CLU_003181_2_1_1 |
InParanoidi | P51790 |
OMAi | FCCWGAE |
OrthoDBi | 271925at2759 |
PhylomeDBi | P51790 |
TreeFami | TF313867 |
Family and domain databases
Gene3Di | 1.10.3080.10, 1 hit |
InterProi | View protein in InterPro IPR000644, CBS_dom IPR014743, Cl-channel_core IPR001807, Cl-channel_volt-gated IPR002245, Cl_channel-3 |
Pfami | View protein in Pfam PF00571, CBS, 2 hits PF00654, Voltage_CLC, 1 hit |
PRINTSi | PR00762, CLCHANNEL PR01114, CLCHANNEL3 |
SMARTi | View protein in SMART SM00116, CBS, 2 hits |
SUPFAMi | SSF81340, SSF81340, 1 hit |
PROSITEi | View protein in PROSITE PS51371, CBS, 2 hits |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P51790-1) [UniParc]FASTAAdd to basket
Also known as: ClC-3A
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MESEQLFHRG YYRNSYNSIT SASSDEELLD GAGVIMDFQT SEDDNLLDGD
60 70 80 90 100
TAVGTHYTMT NGGSINSSTH LLDLLDEPIP GVGTYDDFHT IDWVREKCKD
110 120 130 140 150
RERHRRINSK KKESAWEMTK SLYDAWSGWL VVTLTGLASG ALAGLIDIAA
160 170 180 190 200
DWMTDLKEGI CLSALWYNHE QCCWGSNETT FEERDKCPQW KTWAELIIGQ
210 220 230 240 250
AEGPGSYIMN YIMYIFWALS FAFLAVSLVK VFAPYACGSG IPEIKTILSG
260 270 280 290 300
FIIRGYLGKW TLMIKTITLV LAVASGLSLG KEGPLVHVAC CCGNIFSYLF
310 320 330 340 350
PKYSTNEAKK REVLSAASAA GVSVAFGAPI GGVLFSLEEV SYYFPLKTLW
360 370 380 390 400
RSFFAALVAA FVLRSINPFG NSRLVLFYVE YHTPWYLFEL FPFILLGVFG
410 420 430 440 450
GLWGAFFIRA NIAWCRRRKS TKFGKYPVLE VIIVAAITAV IAFPNPYTRL
460 470 480 490 500
NTSELIKELF TDCGPLESSS LCDYRNDMNA SKIVDDIPDR PAGIGVYSAI
510 520 530 540 550
WQLCLALIFK IIMTVFTFGI KVPSGLFIPS MAIGAIAGRI VGIAVEQLAY
560 570 580 590 600
YHHDWFIFKE WCEVGADCIT PGLYAMVGAA ACLGGVTRMT VSLVVIVFEL
610 620 630 640 650
TGGLEYIVPL MAAVMTSKWV GDAFGREGIY EAHIRLNGYP FLDAKEEFTH
660 670 680 690 700
TTLAADVMRP RRNDPPLAVL TQDNMTVDDI ENMINETSYN GFPVIMSKES
710 720 730 740 750
QRLVGFALRR DLTIAIESAR KKQEGIVGSS RVCFAQHTPS LPAESPRPLK
760 770 780 790 800
LRSILDMSPF TVTDHTPMEI VVDIFRKLGL RQCLVTHNGR LLGIITKKDI
810
LRHMAQTANQ DPASIMFN
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketE9PE15 | E9PE15_HUMAN | Chloride channel protein | CLCN3 | 725 | Annotation score: | ||
A0A087WU31 | A0A087WU31_HUMAN | Chloride channel protein | CLCN3 | 791 | Annotation score: | ||
A0A0A0MTB7 | A0A0A0MTB7_HUMAN | Chloride channel protein | CLCN3 | 801 | Annotation score: | ||
D6RDZ6 | D6RDZ6_HUMAN | H(+)/Cl(-) exchange transporter 3 | CLCN3 | 173 | Annotation score: | ||
D6RIX3 | D6RIX3_HUMAN | H(+)/Cl(-) exchange transporter 3 | CLCN3 | 138 | Annotation score: | ||
H0Y8Z8 | H0Y8Z8_HUMAN | H(+)/Cl(-) exchange transporter 3 | CLCN3 | 245 | Annotation score: |
Sequence cautioni
The sequence BAC54560 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA55281 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 209 | M → T in BX647119 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 551 | Y → C in BX647119 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 570 | T → A in BX647119 (PubMed:17974005).Curated | 1 | |
Sequence conflicti | 646 | E → EEF in CAA55280 (PubMed:7665160).Curated | 1 | |
Sequence conflicti | 646 | E → EEF in CAA55281 (PubMed:7665160).Curated | 1 | |
Sequence conflicti | 646 | E → EEF in BAC54560 (PubMed:11967229).Curated | 1 | |
Sequence conflicti | 723 | Q → R in BX647119 (PubMed:17974005).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_054415 | 1 – 53 | MESEQ…GDTAV → MVTLQLGESHYVVQAGLQLL GSSNPPALASQVAEIT in isoform 4. 1 PublicationAdd BLAST | 53 | |
Alternative sequenceiVSP_045105 | 312 – 338 | Missing in isoform 3. 1 PublicationAdd BLAST | 27 | |
Alternative sequenceiVSP_016073 | 790 – 818 | RLLGI…SIMFN → IVLGIITKKNILEHLEQLKQ HVEPLAPPWHYNKKRYPPAY GPDGKPRPRFNNVQLNLTDE EREETEEEVYLLNSTTL in isoform 2. 1 PublicationAdd BLAST | 29 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78520 mRNA Translation: CAA55280.1 X78520 mRNA Translation: CAA55281.1 Different initiation. AF029346 mRNA Translation: AAB95161.1 AF172729 mRNA Translation: AAD51034.1 AB019542 mRNA Translation: BAC54560.1 Different initiation. AK304362 mRNA Translation: BAH14168.1 BX647119 mRNA No translation available. AC084724 Genomic DNA No translation available. AC106878 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04782.1 CH471056 Genomic DNA Translation: EAX04786.1 BC136510 mRNA Translation: AAI36511.1 |
CCDSi | CCDS34100.1 [P51790-2] CCDS34101.1 [P51790-1] CCDS58932.1 [P51790-4] |
PIRi | I37240 |
RefSeqi | NP_001230301.1, NM_001243372.1 [P51790-4] NP_001230303.1, NM_001243374.1 NP_001820.2, NM_001829.3 [P51790-1] NP_776297.2, NM_173872.3 [P51790-2] |
Genome annotation databases
Ensembli | ENST00000347613; ENSP00000261514; ENSG00000109572 [P51790-2] ENST00000360642; ENSP00000353857; ENSG00000109572 [P51790-4] ENST00000513761; ENSP00000424603; ENSG00000109572 [P51790-1] |
GeneIDi | 1182 |
KEGGi | hsa:1182 |
UCSCi | uc003ish.4, human [P51790-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X78520 mRNA Translation: CAA55280.1 X78520 mRNA Translation: CAA55281.1 Different initiation. AF029346 mRNA Translation: AAB95161.1 AF172729 mRNA Translation: AAD51034.1 AB019542 mRNA Translation: BAC54560.1 Different initiation. AK304362 mRNA Translation: BAH14168.1 BX647119 mRNA No translation available. AC084724 Genomic DNA No translation available. AC106878 Genomic DNA No translation available. CH471056 Genomic DNA Translation: EAX04782.1 CH471056 Genomic DNA Translation: EAX04786.1 BC136510 mRNA Translation: AAI36511.1 |
CCDSi | CCDS34100.1 [P51790-2] CCDS34101.1 [P51790-1] CCDS58932.1 [P51790-4] |
PIRi | I37240 |
RefSeqi | NP_001230301.1, NM_001243372.1 [P51790-4] NP_001230303.1, NM_001243374.1 NP_001820.2, NM_001829.3 [P51790-1] NP_776297.2, NM_173872.3 [P51790-2] |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 107596, 21 interactors |
IntActi | P51790, 15 interactors |
STRINGi | 9606.ENSP00000261514 |
Chemistry databases
ChEMBLi | CHEMBL2401603 |
GuidetoPHARMACOLOGYi | 702 |
PTM databases
GlyGeni | P51790, 4 sites |
iPTMneti | P51790 |
PhosphoSitePlusi | P51790 |
SwissPalmi | P51790 |
Genetic variation databases
BioMutai | CLCN3 |
DMDMi | 226693513 |
Proteomic databases
jPOSTi | P51790 |
MassIVEi | P51790 |
MaxQBi | P51790 |
PaxDbi | P51790 |
PeptideAtlasi | P51790 |
PRIDEi | P51790 |
ProteomicsDBi | 56388 [P51790-1] 56389 [P51790-2] 7526 |
Protocols and materials databases
ABCDi | P51790, 1 sequenced antibody |
Antibodypediai | 28481, 256 antibodies |
DNASUi | 1182 |
Genome annotation databases
Ensembli | ENST00000347613; ENSP00000261514; ENSG00000109572 [P51790-2] ENST00000360642; ENSP00000353857; ENSG00000109572 [P51790-4] ENST00000513761; ENSP00000424603; ENSG00000109572 [P51790-1] |
GeneIDi | 1182 |
KEGGi | hsa:1182 |
UCSCi | uc003ish.4, human [P51790-1] |
Organism-specific databases
CTDi | 1182 |
DisGeNETi | 1182 |
GeneCardsi | CLCN3 |
HGNCi | HGNC:2021, CLCN3 |
HPAi | ENSG00000109572, Low tissue specificity |
MIMi | 600580, gene |
neXtProti | NX_P51790 |
OpenTargetsi | ENSG00000109572 |
PharmGKBi | PA26548 |
VEuPathDBi | HostDB:ENSG00000109572.13 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0475, Eukaryota |
GeneTreei | ENSGT00940000153763 |
HOGENOMi | CLU_003181_2_1_1 |
InParanoidi | P51790 |
OMAi | FCCWGAE |
OrthoDBi | 271925at2759 |
PhylomeDBi | P51790 |
TreeFami | TF313867 |
Enzyme and pathway databases
PathwayCommonsi | P51790 |
Reactomei | R-HSA-2672351, Stimuli-sensing channels |
Miscellaneous databases
BioGRID-ORCSi | 1182, 8 hits in 995 CRISPR screens |
ChiTaRSi | CLCN3, human |
GeneWikii | CLCN3 |
GenomeRNAii | 1182 |
Pharosi | P51790, Tchem |
PROi | PR:P51790 |
RNActi | P51790, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000109572, Expressed in brain and 248 other tissues |
ExpressionAtlasi | P51790, baseline and differential |
Genevisiblei | P51790, HS |
Family and domain databases
Gene3Di | 1.10.3080.10, 1 hit |
InterProi | View protein in InterPro IPR000644, CBS_dom IPR014743, Cl-channel_core IPR001807, Cl-channel_volt-gated IPR002245, Cl_channel-3 |
Pfami | View protein in Pfam PF00571, CBS, 2 hits PF00654, Voltage_CLC, 1 hit |
PRINTSi | PR00762, CLCHANNEL PR01114, CLCHANNEL3 |
SMARTi | View protein in SMART SM00116, CBS, 2 hits |
SUPFAMi | SSF81340, SSF81340, 1 hit |
PROSITEi | View protein in PROSITE PS51371, CBS, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CLCN3_HUMAN | |
Accessioni | P51790Primary (citable) accession number: P51790 Secondary accession number(s): B7Z932 Q86Z21 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | April 14, 2009 | |
Last modified: | April 7, 2021 | |
This is version 191 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 4
Human chromosome 4: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families