UniProtKB - P51784 (UBP11_HUMAN)
Ubiquitin carboxyl-terminal hydrolase 11
USP11
Functioni
Caution
Catalytic activityi
- Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).2 Publications EC:3.4.19.12
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 318 | Nucleophile | 1 | |
Active sitei | 888 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- cysteine-type endopeptidase activity Source: ProtInc
- RNA polymerase II transcription corepressor binding Source: ARUK-UCL
- thiol-dependent ubiquitin-specific protease activity Source: UniProtKB
GO - Biological processi
- protein deubiquitination Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: InterPro
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Hydrolase, Protease, Thiol protease |
Biological process | Host-virus interaction, Ubl conjugation pathway |
Enzyme and pathway databases
PathwayCommonsi | P51784 |
Reactomei | R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis R-HSA-5689880, Ub-specific processing proteases |
Protein family/group databases
MEROPSi | C19.014 |
Names & Taxonomyi
Protein namesi | Recommended name: Ubiquitin carboxyl-terminal hydrolase 11 (EC:3.4.19.122 Publications)Alternative name(s): Deubiquitinating enzyme 11 Ubiquitin thioesterase 11 Ubiquitin-specific-processing protease 11 |
Gene namesi | Name:USP11 Synonyms:UHX1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:12609, USP11 |
MIMi | 300050, gene |
neXtProti | NX_P51784 |
VEuPathDBi | HostDB:ENSG00000102226.9 |
Subcellular locationi
Cytosol
- cytosol Source: HPA
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- chromosome Source: UniProtKB-SubCell
Keywords - Cellular componenti
Chromosome, Cytoplasm, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 318 | C → S: Loss of deubiquitinase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 8237 |
OpenTargetsi | ENSG00000102226 |
PharmGKBi | PA37235 |
Miscellaneous databases
Pharosi | P51784, Tbio |
Genetic variation databases
BioMutai | USP11 |
DMDMi | 251757432 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080632 | 1 – 963 | Ubiquitin carboxyl-terminal hydrolase 11Add BLAST | 963 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 245 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 648 | PhosphoserineCombined sources | 1 | |
Modified residuei | 733 | PhosphoserineBy similarity | 1 | |
Modified residuei | 948 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | P51784 |
jPOSTi | P51784 |
MassIVEi | P51784 |
MaxQBi | P51784 |
PaxDbi | P51784 |
PeptideAtlasi | P51784 |
PRIDEi | P51784 |
ProteomicsDBi | 56381 |
PTM databases
iPTMneti | P51784 |
MetOSitei | P51784 |
PhosphoSitePlusi | P51784 |
Expressioni
Gene expression databases
Bgeei | ENSG00000102226, Expressed in frontal cortex and 239 other tissues |
ExpressionAtlasi | P51784, baseline and differential |
Genevisiblei | P51784, HS |
Organism-specific databases
HPAi | ENSG00000102226, Tissue enhanced (brain) |
Interactioni
Subunit structurei
Monomer (PubMed:24724799). Associated component of the Polycomb group (PcG) multiprotein PRC1-like complex (PubMed:20601937).
Interacts with RANBP9/RANBPM (PubMed:12084015).
Interacts with BRCA2 (PubMed:15314155).
Interacts with CHUK/IKKA (PubMed:17897950).
Interacts with NFKBIA (PubMed:19874889).
Interacts with SPRY3, RAE1, MYCBP2/PAM, and KCTD6 (PubMed:29293652).
7 Publications(Microbial infection) Interacts with papilloma virus protein 16E7 (PubMed:18408009).
1 PublicationBinary interactionsi
Hide detailsP51784
GO - Molecular functioni
- RNA polymerase II transcription corepressor binding Source: ARUK-UCL
Protein-protein interaction databases
BioGRIDi | 113866, 207 interactors |
DIPi | DIP-27567N |
IntActi | P51784, 127 interactors |
MINTi | P51784 |
STRINGi | 9606.ENSP00000218348 |
Miscellaneous databases
RNActi | P51784, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P51784 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 76 – 184 | DUSPPROSITE-ProRule annotationAdd BLAST | 109 | |
Domaini | 309 – 930 | USPAdd BLAST | 622 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1870, Eukaryota |
GeneTreei | ENSGT00940000160485 |
InParanoidi | P51784 |
OMAi | TGQLVIM |
OrthoDBi | 1283205at2759 |
PhylomeDBi | P51784 |
TreeFami | TF106276 |
Family and domain databases
InterProi | View protein in InterPro IPR035927, DUSP-like_sf IPR038765, Papain-like_cys_pep_sf IPR006615, Pept_C19_DUSP IPR001394, Peptidase_C19_UCH IPR028135, Ub_USP-typ IPR029346, USP_C IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF06337, DUSP, 1 hit PF14836, Ubiquitin_3, 1 hit PF00443, UCH, 1 hit PF14533, USP7_C2, 1 hit |
SMARTi | View protein in SMART SM00695, DUSP, 1 hit |
SUPFAMi | SSF143791, SSF143791, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS51283, DUSP, 1 hit PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MAVAPRLFGG LCFRFRDQNP EVAVEGRLPI SHSCVGCRRE RTAMATVAAN
60 70 80 90 100
PAAAAAAVAA AAAVTEDREP QHEELPGLDS QWRQIENGES GRERPLRAGE
110 120 130 140 150
SWFLVEKHWY KQWEAYVQGG DQDSSTFPGC INNATLFQDE INWRLKEGLV
160 170 180 190 200
EGEDYVLLPA AAWHYLVSWY GLEHGQPPIE RKVIELPNIQ KVEVYPVELL
210 220 230 240 250
LVRHNDLGKS HTVQFSHTDS IGLVLRTARE RFLVEPQEDT RLWAKNSEGS
260 270 280 290 300
LDRLYDTHIT VLDAALETGQ LIIMETRKKD GTWPSAQLHV MNNNMSEEDE
310 320 330 340 350
DFKGQPGICG LTNLGNTCFM NSALQCLSNV PQLTEYFLNN CYLEELNFRN
360 370 380 390 400
PLGMKGEIAE AYADLVKQAW SGHHRSIVPH VFKNKVGHFA SQFLGYQQHD
410 420 430 440 450
SQELLSFLLD GLHEDLNRVK KKEYVELCDA AGRPDQEVAQ EAWQNHKRRN
460 470 480 490 500
DSVIVDTFHG LFKSTLVCPD CGNVSVTFDP FCYLSVPLPI SHKRVLEVFF
510 520 530 540 550
IPMDPRRKPE QHRLVVPKKG KISDLCVALS KHTGISPERM MVADVFSHRF
560 570 580 590 600
YKLYQLEEPL SSILDRDDIF VYEVSGRIEA IEGSREDIVV PVYLRERTPA
610 620 630 640 650
RDYNNSYYGL MLFGHPLLVS VPRDRFTWEG LYNVLMYRLS RYVTKPNSDD
660 670 680 690 700
EDDGDEKEDD EEDKDDVPGP STGGSLRDPE PEQAGPSSGV TNRCPFLLDN
710 720 730 740 750
CLGTSQWPPR RRRKQLFTLQ TVNSNGTSDR TTSPEEVHAQ PYIAIDWEPE
760 770 780 790 800
MKKRYYDEVE AEGYVKHDCV GYVMKKAPVR LQECIELFTT VETLEKENPW
810 820 830 840 850
YCPSCKQHQL ATKKLDLWML PEILIIHLKR FSYTKFSREK LDTLVEFPIR
860 870 880 890 900
DLDFSEFVIQ PQNESNPELY KYDLIAVSNH YGGMRDGHYT TFACNKDSGQ
910 920 930 940 950
WHYFDDNSVS PVNENQIESK AAYVLFYQRQ DVARRLLSPA GSSGAPASPA
960
CSSPPSSEFM DVN
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketG5E9A6 | G5E9A6_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP11 hCG_17279 | 920 | Annotation score: | ||
Q5JXD3 | Q5JXD3_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP11 | 140 | Annotation score: | ||
C9JBP8 | C9JBP8_HUMAN | Ubiquitin carboxyl-terminal hydrola... | USP11 | 49 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 52 | A → AT in BAC20463 (PubMed:12084015).Curated | 1 | |
Sequence conflicti | 58 | V → M in AAC50450 (PubMed:8845848).Curated | 1 | |
Sequence conflicti | 62 | A → R in AAC50450 (PubMed:8845848).Curated | 1 | |
Sequence conflicti | 82 – 83 | WR → CG in AAC50450 (PubMed:8845848).Curated | 2 | |
Sequence conflicti | 160 | A → R in BAC20463 (PubMed:12084015).Curated | 1 | |
Sequence conflicti | 161 | A → R in BAC20463 (PubMed:12084015).Curated | 1 | |
Sequence conflicti | 161 | A → R in AAC50450 (PubMed:8845848).Curated | 1 | |
Sequence conflicti | 489 | P → L in AAH00350 (PubMed:15489334).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL096791 Genomic DNA No translation available. BC140849 mRNA Translation: AAI40850.1 BC000350 mRNA Translation: AAH00350.4 AB073597 mRNA Translation: BAC20463.1 Different initiation. U44839 mRNA Translation: AAC50450.1 Sequence problems. |
RefSeqi | NP_004642.2, NM_004651.3 XP_005272731.1, XM_005272674.3 XP_011542290.1, XM_011543988.1 |
Genome annotation databases
Ensembli | ENST00000218348; ENSP00000218348; ENSG00000102226 |
GeneIDi | 8237 |
UCSCi | uc064yux.1, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL096791 Genomic DNA No translation available. BC140849 mRNA Translation: AAI40850.1 BC000350 mRNA Translation: AAH00350.4 AB073597 mRNA Translation: BAC20463.1 Different initiation. U44839 mRNA Translation: AAC50450.1 Sequence problems. |
RefSeqi | NP_004642.2, NM_004651.3 XP_005272731.1, XM_005272674.3 XP_011542290.1, XM_011543988.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4MEL | X-ray | 2.90 | A/B | 67-288 | [»] | |
5OK6 | X-ray | 1.30 | A/B | 67-288 | [»] | |
SMRi | P51784 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113866, 207 interactors |
DIPi | DIP-27567N |
IntActi | P51784, 127 interactors |
MINTi | P51784 |
STRINGi | 9606.ENSP00000218348 |
Protein family/group databases
MEROPSi | C19.014 |
PTM databases
iPTMneti | P51784 |
MetOSitei | P51784 |
PhosphoSitePlusi | P51784 |
Genetic variation databases
BioMutai | USP11 |
DMDMi | 251757432 |
Proteomic databases
EPDi | P51784 |
jPOSTi | P51784 |
MassIVEi | P51784 |
MaxQBi | P51784 |
PaxDbi | P51784 |
PeptideAtlasi | P51784 |
PRIDEi | P51784 |
ProteomicsDBi | 56381 |
Protocols and materials databases
Antibodypediai | 25411, 285 antibodies |
Genome annotation databases
Ensembli | ENST00000218348; ENSP00000218348; ENSG00000102226 |
GeneIDi | 8237 |
UCSCi | uc064yux.1, human |
Organism-specific databases
CTDi | 8237 |
DisGeNETi | 8237 |
GeneCardsi | USP11 |
HGNCi | HGNC:12609, USP11 |
HPAi | ENSG00000102226, Tissue enhanced (brain) |
MIMi | 300050, gene |
neXtProti | NX_P51784 |
OpenTargetsi | ENSG00000102226 |
PharmGKBi | PA37235 |
VEuPathDBi | HostDB:ENSG00000102226.9 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1870, Eukaryota |
GeneTreei | ENSGT00940000160485 |
InParanoidi | P51784 |
OMAi | TGQLVIM |
OrthoDBi | 1283205at2759 |
PhylomeDBi | P51784 |
TreeFami | TF106276 |
Enzyme and pathway databases
PathwayCommonsi | P51784 |
Reactomei | R-HSA-390471, Association of TriC/CCT with target proteins during biosynthesis R-HSA-5689880, Ub-specific processing proteases |
Miscellaneous databases
BioGRID-ORCSi | 8237, 2 hits in 507 CRISPR screens |
ChiTaRSi | USP11, human |
GeneWikii | USP11 |
GenomeRNAii | 8237 |
Pharosi | P51784, Tbio |
PROi | PR:P51784 |
RNActi | P51784, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000102226, Expressed in frontal cortex and 239 other tissues |
ExpressionAtlasi | P51784, baseline and differential |
Genevisiblei | P51784, HS |
Family and domain databases
InterProi | View protein in InterPro IPR035927, DUSP-like_sf IPR038765, Papain-like_cys_pep_sf IPR006615, Pept_C19_DUSP IPR001394, Peptidase_C19_UCH IPR028135, Ub_USP-typ IPR029346, USP_C IPR018200, USP_CS IPR028889, USP_dom |
Pfami | View protein in Pfam PF06337, DUSP, 1 hit PF14836, Ubiquitin_3, 1 hit PF00443, UCH, 1 hit PF14533, USP7_C2, 1 hit |
SMARTi | View protein in SMART SM00695, DUSP, 1 hit |
SUPFAMi | SSF143791, SSF143791, 1 hit SSF54001, SSF54001, 1 hit |
PROSITEi | View protein in PROSITE PS51283, DUSP, 1 hit PS00972, USP_1, 1 hit PS00973, USP_2, 1 hit PS50235, USP_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBP11_HUMAN | |
Accessioni | P51784Primary (citable) accession number: P51784 Secondary accession number(s): B2RTX1, Q8IUG6, Q9BWE1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | July 7, 2009 | |
Last modified: | February 10, 2021 | |
This is version 200 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Peptidase families
Classification of peptidase families and list of entries - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families