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UniProtKB - P51784 (UBP11_HUMAN)

Protein

Ubiquitin carboxyl-terminal hydrolase 11

Gene

USP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937).6 Publications

Caution

It is uncertain whether Met-1 or Met-44 is the initiator.Curated

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei318Nucleophile1
Active sitei888Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: ProtInc
  • thiol-dependent ubiquitin-specific protease activity Source: UniProtKB
  • thiol-dependent ubiquitinyl hydrolase activity Source: Reactome
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPSiC19.014

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 11 (EC:3.4.19.122 Publications)
Alternative name(s):
Deubiquitinating enzyme 11
Ubiquitin thioesterase 11
Ubiquitin-specific-processing protease 11
Gene namesi
Name:USP11
Synonyms:UHX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102226.9
HGNCiHGNC:12609 USP11
MIMi300050 gene
neXtProtiNX_P51784

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi318C → S: Loss of deubiquitinase activity. 1 Publication1

Organism-specific databases

DisGeNETi8237
OpenTargetsiENSG00000102226
PharmGKBiPA37235

Polymorphism and mutation databases

BioMutaiUSP11
DMDMi251757432

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806321 – 963Ubiquitin carboxyl-terminal hydrolase 11Add BLAST963

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei245N6-acetyllysineCombined sources1
Modified residuei648PhosphoserineCombined sources1
Modified residuei733PhosphoserineBy similarity1
Modified residuei948PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP51784
MaxQBiP51784
PaxDbiP51784
PeptideAtlasiP51784
PRIDEiP51784
ProteomicsDBi56381

PTM databases

iPTMnetiP51784
PhosphoSitePlusiP51784

Expressioni

Gene expression databases

BgeeiENSG00000102226 Expressed in 229 organ(s), highest expression level in frontal cortex
CleanExiHS_USP11
ExpressionAtlasiP51784 baseline and differential
GenevisibleiP51784 HS

Organism-specific databases

HPAiHPA003103
HPA037536

Interactioni

Subunit structurei

Monomer (PubMed:24724799). Interacts with RANBP9/RANBPM (PubMed:12084015). Interacts with BRCA2 (PubMed:15314155). Interacts with CHUK/IKKA (PubMed:17897950). Interacts with NFKBIA (PubMed:19874889). Associated component of the Polycomb group (PcG) multiprotein PRC1-like complex (PubMed:20601937).5 Publications
(Microbial infection) Interacts with papilloma virus protein 16E7 (PubMed:18408009).1 Publication

Binary interactionsi

Protein-protein interaction databases

BioGridi113866, 147 interactors
DIPiDIP-27567N
IntActiP51784, 110 interactors
MINTiP51784
STRINGi9606.ENSP00000218348

Structurei

Secondary structure

1963
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP51784
SMRiP51784
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 184DUSPPROSITE-ProRule annotationAdd BLAST109
Domaini309 – 930USPAdd BLAST622

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiKOG1870 Eukaryota
COG5560 LUCA
GeneTreeiENSGT00670000097750
HOGENOMiHOG000264375
HOVERGENiHBG000864
InParanoidiP51784
KOiK11835
OMAiQGQPGIC
OrthoDBiEOG091G0157
PhylomeDBiP51784
TreeFamiTF106276

Family and domain databases

InterProiView protein in InterPro
IPR035927 DUSP-like_sf
IPR038765 Papain_like_cys_pep_sf
IPR006615 Pept_C19_DUSP
IPR001394 Peptidase_C19_UCH
IPR028135 Ub_USP-typ
IPR028134 USP4
IPR029346 USP_C
IPR018200 USP_CS
IPR028889 USP_dom
PANTHERiPTHR43913 PTHR43913, 1 hit
PfamiView protein in Pfam
PF06337 DUSP, 1 hit
PF14836 Ubiquitin_3, 1 hit
PF00443 UCH, 1 hit
PF14533 USP7_C2, 1 hit
SMARTiView protein in SMART
SM00695 DUSP, 1 hit
SUPFAMiSSF143791 SSF143791, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS51283 DUSP, 1 hit
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P51784-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVAPRLFGG LCFRFRDQNP EVAVEGRLPI SHSCVGCRRE RTAMATVAAN 
        60         70         80         90        100
PAAAAAAVAA AAAVTEDREP QHEELPGLDS QWRQIENGES GRERPLRAGE 
       110        120        130        140        150
SWFLVEKHWY KQWEAYVQGG DQDSSTFPGC INNATLFQDE INWRLKEGLV 
       160        170        180        190        200
EGEDYVLLPA AAWHYLVSWY GLEHGQPPIE RKVIELPNIQ KVEVYPVELL 
       210        220        230        240        250
LVRHNDLGKS HTVQFSHTDS IGLVLRTARE RFLVEPQEDT RLWAKNSEGS 
       260        270        280        290        300
LDRLYDTHIT VLDAALETGQ LIIMETRKKD GTWPSAQLHV MNNNMSEEDE 
       310        320        330        340        350
DFKGQPGICG LTNLGNTCFM NSALQCLSNV PQLTEYFLNN CYLEELNFRN 
       360        370        380        390        400
PLGMKGEIAE AYADLVKQAW SGHHRSIVPH VFKNKVGHFA SQFLGYQQHD 
       410        420        430        440        450
SQELLSFLLD GLHEDLNRVK KKEYVELCDA AGRPDQEVAQ EAWQNHKRRN 
       460        470        480        490        500
DSVIVDTFHG LFKSTLVCPD CGNVSVTFDP FCYLSVPLPI SHKRVLEVFF 
       510        520        530        540        550
IPMDPRRKPE QHRLVVPKKG KISDLCVALS KHTGISPERM MVADVFSHRF 
       560        570        580        590        600
YKLYQLEEPL SSILDRDDIF VYEVSGRIEA IEGSREDIVV PVYLRERTPA 
       610        620        630        640        650
RDYNNSYYGL MLFGHPLLVS VPRDRFTWEG LYNVLMYRLS RYVTKPNSDD 
       660        670        680        690        700
EDDGDEKEDD EEDKDDVPGP STGGSLRDPE PEQAGPSSGV TNRCPFLLDN 
       710        720        730        740        750
CLGTSQWPPR RRRKQLFTLQ TVNSNGTSDR TTSPEEVHAQ PYIAIDWEPE 
       760        770        780        790        800
MKKRYYDEVE AEGYVKHDCV GYVMKKAPVR LQECIELFTT VETLEKENPW 
       810        820        830        840        850
YCPSCKQHQL ATKKLDLWML PEILIIHLKR FSYTKFSREK LDTLVEFPIR 
       860        870        880        890        900
DLDFSEFVIQ PQNESNPELY KYDLIAVSNH YGGMRDGHYT TFACNKDSGQ 
       910        920        930        940        950
WHYFDDNSVS PVNENQIESK AAYVLFYQRQ DVARRLLSPA GSSGAPASPA 
       960 
CSSPPSSEFM DVN
Length:963
Mass (Da):109,817
Last modified:July 7, 2009 - v3
Checksum:i876FDC41945AFD9B
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9A6G5E9A6_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP11 hCG_17279
920Annotation score:
Q5JXD3Q5JXD3_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP11
140Annotation score:
C9JBP8C9JBP8_HUMAN
Ubiquitin carboxyl-terminal hydrola...
USP11
49Annotation score:

Sequence cautioni

The sequence AAC50450 differs from that shown. Reason: Frameshift at positions 65, 117, 134 and 146.Curated
The sequence AAC50450 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC20463 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52A → AT in BAC20463 (PubMed:12084015).Curated1
Sequence conflicti58V → M in AAC50450 (PubMed:8845848).Curated1
Sequence conflicti62A → R in AAC50450 (PubMed:8845848).Curated1
Sequence conflicti82 – 83WR → CG in AAC50450 (PubMed:8845848).Curated2
Sequence conflicti160A → R in BAC20463 (PubMed:12084015).Curated1
Sequence conflicti161A → R in BAC20463 (PubMed:12084015).Curated1
Sequence conflicti161A → R in AAC50450 (PubMed:8845848).Curated1
Sequence conflicti489P → L in AAH00350 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096791 Genomic DNA No translation available.
BC140849 mRNA Translation: AAI40850.1
BC000350 mRNA Translation: AAH00350.4
AB073597 mRNA Translation: BAC20463.1 Different initiation.
U44839 mRNA Translation: AAC50450.1 Sequence problems.
CCDSiCCDS14277.1
RefSeqiNP_004642.2, NM_004651.3
XP_005272731.1, XM_005272674.3
XP_011542290.1, XM_011543988.1
UniGeneiHs.171501

Genome annotation databases

EnsembliENST00000218348; ENSP00000218348; ENSG00000102226
GeneIDi8237
KEGGihsa:8237
UCSCiuc064yux.1 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096791 Genomic DNA No translation available.
BC140849 mRNA Translation: AAI40850.1
BC000350 mRNA Translation: AAH00350.4
AB073597 mRNA Translation: BAC20463.1 Different initiation.
U44839 mRNA Translation: AAC50450.1 Sequence problems.
CCDSiCCDS14277.1
RefSeqiNP_004642.2, NM_004651.3
XP_005272731.1, XM_005272674.3
XP_011542290.1, XM_011543988.1
UniGeneiHs.171501

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4MELX-ray2.90A/B67-288[»]
ProteinModelPortaliP51784
SMRiP51784
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113866, 147 interactors
DIPiDIP-27567N
IntActiP51784, 110 interactors
MINTiP51784
STRINGi9606.ENSP00000218348

Protein family/group databases

MEROPSiC19.014

PTM databases

iPTMnetiP51784
PhosphoSitePlusiP51784

Polymorphism and mutation databases

BioMutaiUSP11
DMDMi251757432

Proteomic databases

EPDiP51784
MaxQBiP51784
PaxDbiP51784
PeptideAtlasiP51784
PRIDEiP51784
ProteomicsDBi56381

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000218348; ENSP00000218348; ENSG00000102226
GeneIDi8237
KEGGihsa:8237
UCSCiuc064yux.1 human

Organism-specific databases

CTDi8237
DisGeNETi8237
EuPathDBiHostDB:ENSG00000102226.9
GeneCardsiUSP11
HGNCiHGNC:12609 USP11
HPAiHPA003103
HPA037536
MIMi300050 gene
neXtProtiNX_P51784
OpenTargetsiENSG00000102226
PharmGKBiPA37235
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1870 Eukaryota
COG5560 LUCA
GeneTreeiENSGT00670000097750
HOGENOMiHOG000264375
HOVERGENiHBG000864
InParanoidiP51784
KOiK11835
OMAiQGQPGIC
OrthoDBiEOG091G0157
PhylomeDBiP51784
TreeFamiTF106276

Enzyme and pathway databases

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5689880 Ub-specific processing proteases

Miscellaneous databases

ChiTaRSiUSP11 human
GeneWikiiUSP11
GenomeRNAii8237
PROiPR:P51784
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102226 Expressed in 229 organ(s), highest expression level in frontal cortex
CleanExiHS_USP11
ExpressionAtlasiP51784 baseline and differential
GenevisibleiP51784 HS

Family and domain databases

InterProiView protein in InterPro
IPR035927 DUSP-like_sf
IPR038765 Papain_like_cys_pep_sf
IPR006615 Pept_C19_DUSP
IPR001394 Peptidase_C19_UCH
IPR028135 Ub_USP-typ
IPR028134 USP4
IPR029346 USP_C
IPR018200 USP_CS
IPR028889 USP_dom
PANTHERiPTHR43913 PTHR43913, 1 hit
PfamiView protein in Pfam
PF06337 DUSP, 1 hit
PF14836 Ubiquitin_3, 1 hit
PF00443 UCH, 1 hit
PF14533 USP7_C2, 1 hit
SMARTiView protein in SMART
SM00695 DUSP, 1 hit
SUPFAMiSSF143791 SSF143791, 1 hit
SSF54001 SSF54001, 1 hit
PROSITEiView protein in PROSITE
PS51283 DUSP, 1 hit
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiUBP11_HUMAN
AccessioniPrimary (citable) accession number: P51784
Secondary accession number(s): B2RTX1, Q8IUG6, Q9BWE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: November 7, 2018
This is version 181 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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