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Protein

Ubiquitin carboxyl-terminal hydrolase 11

Gene

USP11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Protease that can remove conjugated ubiquitin from target proteins and polyubiquitin chains (PubMed:12084015, PubMed:15314155, PubMed:17897950, PubMed:19874889, PubMed:20233726, PubMed:24724799). Inhibits the degradation of target proteins by the proteasome (PubMed:12084015). Cleaves preferentially 'Lys-6' and 'Lys-63'-linked ubiquitin chains. Has lower activity with 'Lys-11' and 'Lys-33'-linked ubiquitin chains, and extremely low activity with 'Lys-27', 'Lys-29' and 'Lys-48'-linked ubiquitin chains (in vitro) (PubMed:24724799). Plays a role in the regulation of pathways leading to NF-kappa-B activation (PubMed:17897950, PubMed:19874889). Plays a role in the regulation of DNA repair after double-stranded DNA breaks (PubMed:15314155, PubMed:20233726). Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex (PubMed:20601937).6 Publications

Caution

It is uncertain whether Met-1 or Met-44 is the initiator.Curated

Catalytic activityi

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei318Nucleophile1
Active sitei888Proton acceptorPROSITE-ProRule annotation1

GO - Molecular functioni

  • cysteine-type endopeptidase activity Source: ProtInc
  • thiol-dependent ubiquitin-specific protease activity Source: UniProtKB
  • thiol-dependent ubiquitinyl hydrolase activity Source: Reactome

GO - Biological processi

  • protein deubiquitination Source: UniProtKB
  • ubiquitin-dependent protein catabolic process Source: InterPro

Keywordsi

Molecular functionHydrolase, Protease, Thiol protease
Biological processUbl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis
R-HSA-5689880 Ub-specific processing proteases

Protein family/group databases

MEROPSiC19.014

Names & Taxonomyi

Protein namesi
Recommended name:
Ubiquitin carboxyl-terminal hydrolase 11 (EC:3.4.19.122 Publications)
Alternative name(s):
Deubiquitinating enzyme 11
Ubiquitin thioesterase 11
Ubiquitin-specific-processing protease 11
Gene namesi
Name:USP11
Synonyms:UHX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102226.9
HGNCiHGNC:12609 USP11
MIMi300050 gene
neXtProtiNX_P51784

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Chromosome, Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi318C → S: Loss of deubiquitinase activity. 1 Publication1

Organism-specific databases

DisGeNETi8237
OpenTargetsiENSG00000102226
PharmGKBiPA37235

Polymorphism and mutation databases

BioMutaiUSP11
DMDMi251757432

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000806321 – 963Ubiquitin carboxyl-terminal hydrolase 11Add BLAST963

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei245N6-acetyllysineCombined sources1
Modified residuei648PhosphoserineCombined sources1
Modified residuei733PhosphoserineBy similarity1
Modified residuei948PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP51784
MaxQBiP51784
PaxDbiP51784
PeptideAtlasiP51784
PRIDEiP51784
ProteomicsDBi56381

PTM databases

iPTMnetiP51784
PhosphoSitePlusiP51784

Expressioni

Gene expression databases

BgeeiENSG00000102226
CleanExiHS_USP11
ExpressionAtlasiP51784 baseline and differential
GenevisibleiP51784 HS

Organism-specific databases

HPAiHPA003103
HPA037536

Interactioni

Subunit structurei

Monomer (PubMed:24724799). Interacts with RANBP9/RANBPM (PubMed:12084015). Interacts with BRCA2 (PubMed:15314155). Interacts with CHUK/IKKA (PubMed:17897950). Interacts with NFKBIA (PubMed:19874889). Associated component of the Polycomb group (PcG) multiprotein PRC1-like complex (PubMed:20601937).5 Publications
(Microbial infection) Interacts with papilloma virus protein 16E7 (PubMed:18408009).1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113866, 146 interactors
DIPiDIP-27567N
IntActiP51784, 112 interactors
MINTiP51784
STRINGi9606.ENSP00000218348

Structurei

Secondary structure

1963
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi78 – 86Combined sources9
Beta strandi87 – 91Combined sources5
Beta strandi101 – 106Combined sources6
Helixi107 – 117Combined sources11
Turni118 – 120Combined sources3
Helixi134 – 136Combined sources3
Beta strandi140 – 142Combined sources3
Turni152 – 154Combined sources3
Beta strandi155 – 159Combined sources5
Helixi160 – 169Combined sources10
Beta strandi180 – 185Combined sources6
Beta strandi190 – 195Combined sources6
Beta strandi197 – 205Combined sources9
Beta strandi207 – 215Combined sources9
Helixi221 – 231Combined sources11
Beta strandi240 – 245Combined sources6
Turni247 – 249Combined sources3
Beta strandi252 – 254Combined sources3
Beta strandi257 – 261Combined sources5
Helixi262 – 264Combined sources3
Beta strandi271 – 276Combined sources6

3D structure databases

ProteinModelPortaliP51784
SMRiP51784
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini76 – 184DUSPPROSITE-ProRule annotationAdd BLAST109
Domaini309 – 930USPAdd BLAST622

Sequence similaritiesi

Belongs to the peptidase C19 family.Curated

Phylogenomic databases

eggNOGiKOG1870 Eukaryota
COG5560 LUCA
GeneTreeiENSGT00670000097750
HOGENOMiHOG000264375
HOVERGENiHBG000864
InParanoidiP51784
KOiK11835
OMAiQNHKRRN
OrthoDBiEOG091G0157
PhylomeDBiP51784
TreeFamiTF106276

Family and domain databases

InterProiView protein in InterPro
IPR035927 DUSP-like_sf
IPR038765 Papain_like_cys_pep_sf
IPR006615 Pept_C19_DUSP
IPR001394 Peptidase_C19_UCH
IPR028135 Ub_USP-typ
IPR028134 USP4
IPR029346 USP_C
IPR018200 USP_CS
IPR028889 USP_dom
PANTHERiPTHR43913 PTHR43913, 1 hit
PfamiView protein in Pfam
PF06337 DUSP, 1 hit
PF14836 Ubiquitin_3, 1 hit
PF00443 UCH, 1 hit
PF14533 USP7_C2, 1 hit
SMARTiView protein in SMART
SM00695 DUSP, 1 hit
SUPFAMiSSF143791 SSF143791, 1 hit
SSF54001 SSF54001, 2 hits
PROSITEiView protein in PROSITE
PS51283 DUSP, 1 hit
PS00972 USP_1, 1 hit
PS00973 USP_2, 1 hit
PS50235 USP_3, 1 hit

Sequencei

Sequence statusi: Complete.

P51784-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAVAPRLFGG LCFRFRDQNP EVAVEGRLPI SHSCVGCRRE RTAMATVAAN
60 70 80 90 100
PAAAAAAVAA AAAVTEDREP QHEELPGLDS QWRQIENGES GRERPLRAGE
110 120 130 140 150
SWFLVEKHWY KQWEAYVQGG DQDSSTFPGC INNATLFQDE INWRLKEGLV
160 170 180 190 200
EGEDYVLLPA AAWHYLVSWY GLEHGQPPIE RKVIELPNIQ KVEVYPVELL
210 220 230 240 250
LVRHNDLGKS HTVQFSHTDS IGLVLRTARE RFLVEPQEDT RLWAKNSEGS
260 270 280 290 300
LDRLYDTHIT VLDAALETGQ LIIMETRKKD GTWPSAQLHV MNNNMSEEDE
310 320 330 340 350
DFKGQPGICG LTNLGNTCFM NSALQCLSNV PQLTEYFLNN CYLEELNFRN
360 370 380 390 400
PLGMKGEIAE AYADLVKQAW SGHHRSIVPH VFKNKVGHFA SQFLGYQQHD
410 420 430 440 450
SQELLSFLLD GLHEDLNRVK KKEYVELCDA AGRPDQEVAQ EAWQNHKRRN
460 470 480 490 500
DSVIVDTFHG LFKSTLVCPD CGNVSVTFDP FCYLSVPLPI SHKRVLEVFF
510 520 530 540 550
IPMDPRRKPE QHRLVVPKKG KISDLCVALS KHTGISPERM MVADVFSHRF
560 570 580 590 600
YKLYQLEEPL SSILDRDDIF VYEVSGRIEA IEGSREDIVV PVYLRERTPA
610 620 630 640 650
RDYNNSYYGL MLFGHPLLVS VPRDRFTWEG LYNVLMYRLS RYVTKPNSDD
660 670 680 690 700
EDDGDEKEDD EEDKDDVPGP STGGSLRDPE PEQAGPSSGV TNRCPFLLDN
710 720 730 740 750
CLGTSQWPPR RRRKQLFTLQ TVNSNGTSDR TTSPEEVHAQ PYIAIDWEPE
760 770 780 790 800
MKKRYYDEVE AEGYVKHDCV GYVMKKAPVR LQECIELFTT VETLEKENPW
810 820 830 840 850
YCPSCKQHQL ATKKLDLWML PEILIIHLKR FSYTKFSREK LDTLVEFPIR
860 870 880 890 900
DLDFSEFVIQ PQNESNPELY KYDLIAVSNH YGGMRDGHYT TFACNKDSGQ
910 920 930 940 950
WHYFDDNSVS PVNENQIESK AAYVLFYQRQ DVARRLLSPA GSSGAPASPA
960
CSSPPSSEFM DVN
Length:963
Mass (Da):109,817
Last modified:July 7, 2009 - v3
Checksum:i876FDC41945AFD9B
GO

Sequence cautioni

The sequence AAC50450 differs from that shown. Reason: Frameshift at positions 65, 117, 134 and 146.Curated
The sequence AAC50450 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC20463 differs from that shown. Reason: Erroneous initiation.Curated
The sequence CAD20056 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti52A → AT in BAC20463 (PubMed:12084015).Curated1
Sequence conflicti58V → M in AAC50450 (PubMed:8845848).Curated1
Sequence conflicti62A → R in AAC50450 (PubMed:8845848).Curated1
Sequence conflicti82 – 83WR → CG in AAC50450 (PubMed:8845848).Curated2
Sequence conflicti160A → R in BAC20463 (PubMed:12084015).Curated1
Sequence conflicti161A → R in BAC20463 (PubMed:12084015).Curated1
Sequence conflicti161A → R in AAC50450 (PubMed:8845848).Curated1
Sequence conflicti489P → L in AAH00350 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL096791 Genomic DNA Translation: CAD20056.1 Sequence problems.
BC140849 mRNA Translation: AAI40850.1
BC000350 mRNA Translation: AAH00350.4
AB073597 mRNA Translation: BAC20463.1 Different initiation.
U44839 mRNA Translation: AAC50450.1 Sequence problems.
CCDSiCCDS14277.1
RefSeqiNP_004642.2, NM_004651.3
XP_005272731.1, XM_005272674.3
XP_011542290.1, XM_011543988.1
UniGeneiHs.171501

Genome annotation databases

EnsembliENST00000218348; ENSP00000218348; ENSG00000102226
GeneIDi8237
KEGGihsa:8237
UCSCiuc064yux.1 human

Similar proteinsi

Entry informationi

Entry nameiUBP11_HUMAN
AccessioniPrimary (citable) accession number: P51784
Secondary accession number(s): B2RTX1, Q8IUG6, Q9BWE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 7, 2009
Last modified: July 18, 2018
This is version 178 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Peptidase families
    Classification of peptidase families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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