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Protein

Signal transducer and activator of transcription 5B

Gene

STAT5B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.2 Publications

Caution

It was reported that dephosphorylation on tyrosine residues by PTPN2 would negatively regulate prolactin signaling pathway (PubMed:11773439). However, the corresponding article has been retracted (PubMed:24319783).1 Publication1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-1170546 Prolactin receptor signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-186763 Downstream signal transduction
R-HSA-2586552 Signaling by Leptin
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-8983432 Interleukin-15 signaling
R-HSA-8985947 Interleukin-9 signaling
R-HSA-9020558 Interleukin-2 signaling
R-HSA-9020958 Interleukin-21 signaling
R-HSA-982772 Growth hormone receptor signaling
SignaLinkiP51692
SIGNORiP51692

Names & Taxonomyi

Protein namesi
Recommended name:
Signal transducer and activator of transcription 5B
Gene namesi
Name:STAT5B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000173757.9
HGNCiHGNC:11367 STAT5B
MIMi604260 gene
neXtProtiNX_P51692

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Growth hormone insensitivity with immunodeficiency (GHII)3 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to hexogeneous growth hormone therapy, and recurrent infections.
See also OMIM:245590
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_018728630A → P in GHII; affects activation by growth hormone or interferon-gamma. 1 PublicationCorresponds to variant dbSNP:rs121908501EnsemblClinVar.1
Natural variantiVAR_067368646F → S in GHII; transcriptionally inactive. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi684T → A: Abolishes interaction with INSR. 1 Publication1
Mutagenesisi699Y → F: Abolishes phosphorylation by HCK. 1 Publication1

Keywords - Diseasei

Disease mutation, Dwarfism

Organism-specific databases

DisGeNETi6777
MalaCardsiSTAT5B
MIMi245590 phenotype
OpenTargetsiENSG00000173757
Orphaneti520 Acute promyelocytic leukemia
220465 Laron syndrome with immunodeficiency
PharmGKBiPA36186

Chemistry databases

ChEMBLiCHEMBL5817
DrugBankiDB01254 Dasatinib

Polymorphism and mutation databases

BioMutaiSTAT5B
DMDMi41019536

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001824291 – 787Signal transducer and activator of transcription 5BAdd BLAST787

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei90PhosphotyrosineCombined sources1
Modified residuei128PhosphoserineCombined sources1
Modified residuei193PhosphoserineCombined sources1
Modified residuei682PhosphotyrosineBy similarity1
Modified residuei699Phosphotyrosine; by HCK, JAK and PTK62 Publications1

Post-translational modificationi

Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity.6 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP51692
MaxQBiP51692
PaxDbiP51692
PeptideAtlasiP51692
PRIDEiP51692
ProteomicsDBi56378

PTM databases

iPTMnetiP51692
PhosphoSitePlusiP51692

Miscellaneous databases

PMAP-CutDBiP51692

Expressioni

Gene expression databases

BgeeiENSG00000173757 Expressed in 234 organ(s), highest expression level in blood
CleanExiHS_STAT5B
ExpressionAtlasiP51692 baseline and differential
GenevisibleiP51692 HS

Organism-specific databases

HPAiCAB004298
HPA042128
HPA049883
HPA051156

Interactioni

Subunit structurei

Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 (PubMed:12954634). Interacts with NMI (PubMed:9989503). Interacts with SOCS7 (PubMed:15677474). Interacts (via SH2 domain) with INSR (PubMed:9428692). Interacts with CPEB3; this inhibits STAT5B-mediated transcriptional activation (PubMed:20639532).By similarity5 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112654, 59 interactors
CORUMiP51692
IntActiP51692, 39 interactors
MINTiP51692
STRINGi9606.ENSP00000293328

Chemistry databases

BindingDBiP51692

Structurei

3D structure databases

ProteinModelPortaliP51692
SMRiP51692
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini589 – 686SH2PROSITE-ProRule annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni232 – 321Required for interaction with NMI1 PublicationAdd BLAST90

Sequence similaritiesi

Belongs to the transcription factor STAT family.Curated

Keywords - Domaini

SH2 domain

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236
HOVERGENiHBG107486
InParanoidiP51692
KOiK11224
OMAiTIWQNRQ
OrthoDBiEOG091G03O3
PhylomeDBiP51692
TreeFamiTF318648

Family and domain databases

CDDicd10420 SH2_STAT5b, 1 hit
Gene3Di1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR035858 STAT5a/5b
IPR035886 STAT5b_SH2
IPR036535 STAT_N_sf
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
IPR013799 STAT_TF_prot_interaction
PANTHERiPTHR11801 PTHR11801, 1 hit
PTHR11801:SF39 PTHR11801:SF39, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
PF02865 STAT_int, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00964 STAT_int, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF48092 SSF48092, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P51692-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSVDLDN
60 70 80 90 100
PQENIKATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR
110 120 130 140 150
CPMELVRCIR HILYNEQRLV REANNGSSPA GSLADAMSQK HLQINQTFEE
160 170 180 190 200
LRLVTQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFGPLA QLSPQERLSR
210 220 230 240 250
ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD
260 270 280 290 300
ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC
310 320 330 340 350
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA
360 370 380 390 400
TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC
410 420 430 440 450
CVMEYHQATG TLSAHFRNMS LKRIKRSDRR GAESVTEEKF TILFESQFSV
460 470 480 490 500
GGNELVFQVK TLSLPVVVIV HGSQDNNATA TVLWDNAFAE PGRVPFAVPD
510 520 530 540 550
KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN SSSHLEDYSG
560 570 580 590 600
LSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK
610 620 630 640 650
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD
660 670 680 690 700
FSIRSLADRL GDLNYLIYVF PDRPKDEVYS KYYTPVPCES ATAKAVDGYV
710 720 730 740 750
KPQIKQVVPE FVNASADAGG GSATYMDQAP SPAVCPQAHY NMYPQNPDSV
760 770 780
LDTDGDFDLE DTMDVARRVE ELLGRPMDSQ WIPHAQS
Length:787
Mass (Da):89,866
Last modified:January 16, 2004 - v2
Checksum:iAA2F1CAB20955ACA
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9J4I3C9J4I3_HUMAN
Signal transducer and activator of ...
STAT5B
156Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti230A → P in AAC50491 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052074130A → V. Corresponds to variant dbSNP:rs2277619Ensembl.1
Natural variantiVAR_018728630A → P in GHII; affects activation by growth hormone or interferon-gamma. 1 PublicationCorresponds to variant dbSNP:rs121908501EnsemblClinVar.1
Natural variantiVAR_067368646F → S in GHII; transcriptionally inactive. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48730 mRNA Translation: AAC50485.2
U47686 mRNA Translation: AAC50491.1
AJ412888
, AJ412889, AJ412890, AJ412891, AJ412892, AJ412893, AJ412894, AJ412895, AJ412896, AJ412897, AJ412898, AJ412899 Genomic DNA Translation: CAD19638.1
BC065227 mRNA Translation: AAH65227.1
CCDSiCCDS11423.1
RefSeqiNP_036580.2, NM_012448.3
UniGeneiHs.595276

Genome annotation databases

EnsembliENST00000293328; ENSP00000293328; ENSG00000173757
GeneIDi6777
KEGGihsa:6777
UCSCiuc002hzh.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

STAT5Bbase

STAT5B mutation db

Wikipedia

STAT5 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48730 mRNA Translation: AAC50485.2
U47686 mRNA Translation: AAC50491.1
AJ412888
, AJ412889, AJ412890, AJ412891, AJ412892, AJ412893, AJ412894, AJ412895, AJ412896, AJ412897, AJ412898, AJ412899 Genomic DNA Translation: CAD19638.1
BC065227 mRNA Translation: AAH65227.1
CCDSiCCDS11423.1
RefSeqiNP_036580.2, NM_012448.3
UniGeneiHs.595276

3D structure databases

ProteinModelPortaliP51692
SMRiP51692
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112654, 59 interactors
CORUMiP51692
IntActiP51692, 39 interactors
MINTiP51692
STRINGi9606.ENSP00000293328

Chemistry databases

BindingDBiP51692
ChEMBLiCHEMBL5817
DrugBankiDB01254 Dasatinib

PTM databases

iPTMnetiP51692
PhosphoSitePlusiP51692

Polymorphism and mutation databases

BioMutaiSTAT5B
DMDMi41019536

Proteomic databases

EPDiP51692
MaxQBiP51692
PaxDbiP51692
PeptideAtlasiP51692
PRIDEiP51692
ProteomicsDBi56378

Protocols and materials databases

DNASUi6777
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000293328; ENSP00000293328; ENSG00000173757
GeneIDi6777
KEGGihsa:6777
UCSCiuc002hzh.4 human

Organism-specific databases

CTDi6777
DisGeNETi6777
EuPathDBiHostDB:ENSG00000173757.9
GeneCardsiSTAT5B
HGNCiHGNC:11367 STAT5B
HPAiCAB004298
HPA042128
HPA049883
HPA051156
MalaCardsiSTAT5B
MIMi245590 phenotype
604260 gene
neXtProtiNX_P51692
OpenTargetsiENSG00000173757
Orphaneti520 Acute promyelocytic leukemia
220465 Laron syndrome with immunodeficiency
PharmGKBiPA36186
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3667 Eukaryota
ENOG410XPN8 LUCA
GeneTreeiENSGT00760000119236
HOVERGENiHBG107486
InParanoidiP51692
KOiK11224
OMAiTIWQNRQ
OrthoDBiEOG091G03O3
PhylomeDBiP51692
TreeFamiTF318648

Enzyme and pathway databases

ReactomeiR-HSA-1170546 Prolactin receptor signaling
R-HSA-1266695 Interleukin-7 signaling
R-HSA-1433557 Signaling by SCF-KIT
R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants
R-HSA-186763 Downstream signal transduction
R-HSA-2586552 Signaling by Leptin
R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling
R-HSA-8854691 Interleukin-20 family signaling
R-HSA-8983432 Interleukin-15 signaling
R-HSA-8985947 Interleukin-9 signaling
R-HSA-9020558 Interleukin-2 signaling
R-HSA-9020958 Interleukin-21 signaling
R-HSA-982772 Growth hormone receptor signaling
SignaLinkiP51692
SIGNORiP51692

Miscellaneous databases

ChiTaRSiSTAT5B human
GeneWikiiSTAT5B
GenomeRNAii6777
PMAP-CutDBiP51692
PROiPR:P51692
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173757 Expressed in 234 organ(s), highest expression level in blood
CleanExiHS_STAT5B
ExpressionAtlasiP51692 baseline and differential
GenevisibleiP51692 HS

Family and domain databases

CDDicd10420 SH2_STAT5b, 1 hit
Gene3Di1.10.532.10, 1 hit
2.60.40.630, 1 hit
3.30.505.10, 1 hit
InterProiView protein in InterPro
IPR008967 p53-like_TF_DNA-bd
IPR000980 SH2
IPR036860 SH2_dom_sf
IPR001217 STAT
IPR035858 STAT5a/5b
IPR035886 STAT5b_SH2
IPR036535 STAT_N_sf
IPR013800 STAT_TF_alpha
IPR015988 STAT_TF_coiled-coil
IPR013801 STAT_TF_DNA-bd
IPR012345 STAT_TF_DNA-bd_N
IPR013799 STAT_TF_prot_interaction
PANTHERiPTHR11801 PTHR11801, 1 hit
PTHR11801:SF39 PTHR11801:SF39, 1 hit
PfamiView protein in Pfam
PF00017 SH2, 1 hit
PF01017 STAT_alpha, 1 hit
PF02864 STAT_bind, 1 hit
PF02865 STAT_int, 1 hit
SMARTiView protein in SMART
SM00252 SH2, 1 hit
SM00964 STAT_int, 1 hit
SUPFAMiSSF47655 SSF47655, 1 hit
SSF48092 SSF48092, 1 hit
SSF49417 SSF49417, 1 hit
SSF55550 SSF55550, 1 hit
PROSITEiView protein in PROSITE
PS50001 SH2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTA5B_HUMAN
AccessioniPrimary (citable) accession number: P51692
Secondary accession number(s): Q8WWS8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 16, 2004
Last modified: November 7, 2018
This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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