Signal transducer and activator of transcription 5B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• chromatin binding Source: UniProtKB
• DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
• DNA-binding transcription factor activity Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.3

    "Cloning of human Stat5B. Reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells."
    Lin J.-X., Mietz J., Modi W.S., John S., Leonard W.J.
    J. Biol. Chem. 271:10738-10744(1996) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
• glucocorticoid receptor binding Source: BHF-UCL <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2."
    Leung K.C., Doyle N., Ballesteros M., Sjogren K., Watts C.K., Low T.H., Leong G.M., Ross R.J., Ho K.K.
    Proc Natl Acad Sci U S A 100:1016-1021(2003) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Structural and functional consequences of the STAT5B^N642H driver mutation."
    de Araujo E.D., Erdogan F., Neubauer H.A., Meneksedag-Erol D., Manaswiyoungkul P., Eram M.S., Seo H.S., Qadree A.K., Israelian J., Orlova A., Suske T., Pham H.T.T., Boersma A., Tangermann S., Kenner L., Rulicke T., Dong A., Ravichandran M.

    , Brown P.J., Audette G.F., Rauscher S., Dhe-Paganon S., Moriggl R., Gunning P.T.
    Nat Commun 10:2517-2517(2019) [PubMed] [Europe PMC] [Abstract]
• protein dimerization activity Source: UniProtKB
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• cellular response to epidermal growth factor stimulus Source: UniProtKB
• cellular response to growth factor stimulus Source: UniProtKB
• cellular response to hormone stimulus Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2."
    Leung K.C., Doyle N., Ballesteros M., Sjogren K., Watts C.K., Low T.H., Leong G.M., Ross R.J., Ho K.K.
    Proc Natl Acad Sci U S A 100:1016-1021(2003) [PubMed] [Europe PMC] [Abstract]
• cytokine-mediated signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• defense response Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• development of secondary female sexual characteristics Source: Ensembl
• development of secondary male sexual characteristics Source: Ensembl
• female pregnancy Source: Ensembl
• growth hormone receptor signaling pathway via JAK-STAT Source: BHF-UCLInferred from direct assayⁱ
  • "Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2."
    Leung K.C., Doyle N., Ballesteros M., Sjogren K., Watts C.K., Low T.H., Leong G.M., Ross R.J., Ho K.K.
    Proc Natl Acad Sci U S A 100:1016-1021(2003) [PubMed] [Europe PMC] [Abstract]
• interleukin-15-mediated signaling pathway Source: Reactome
• interleukin-2-mediated signaling pathway Source: Reactome
• interleukin-7-mediated signaling pathway Source: Reactome
• interleukin-9-mediated signaling pathway Source: Reactome
• lactation Source: Ensembl
• lipid storage Source: Ensembl
• luteinization Source: Ensembl
• mast cell migration Source: Ensembl
• natural killer cell differentiation Source: Ensembl
• negative regulation of apoptotic process Source: Ensembl
• negative regulation of erythrocyte differentiation Source: Ensembl
• Peyer's patch development Source: Ensembl
• positive regulation of activated T cell proliferation Source: Ensembl
• positive regulation of B cell differentiation Source: Ensembl
• positive regulation of erythrocyte differentiation Source: UniProtKBInferred from direct assayⁱ
  • Ref.25

    "ZFP36L1 negatively regulates erythroid differentiation of CD34+ hematopoietic stem cells by interfering with the Stat5b pathway."
    Vignudelli T., Selmi T., Martello A., Parenti S., Grande A., Gemelli C., Zanocco-Marani T., Ferrari S.
    Mol. Biol. Cell 21:3340-3351(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• positive regulation of gamma-delta T cell differentiation Source: Ensembl
• positive regulation of inflammatory response Source: Ensembl
• positive regulation of interleukin-2 production Source: Ensembl
• positive regulation of mitotic cell cycle Source: Ensembl
• positive regulation of multicellular organism growth Source: Ensembl
• positive regulation of natural killer cell differentiation Source: Ensembl
• positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
• positive regulation of natural killer cell proliferation Source: Ensembl
• positive regulation of transcription by RNA polymerase II Source: UniProtKB
• progesterone metabolic process Source: Ensembl
• receptor signaling pathway via JAK-STAT Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of cell population proliferation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of epithelial cell differentiation Source: Ensembl
• regulation of multicellular organism growth Source: BHF-UCL
• regulation of steroid metabolic process Source: Ensembl
• regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• response to estradiol Source: BHF-UCLInferred from direct assayⁱ
  • "Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2."
    Leung K.C., Doyle N., Ballesteros M., Sjogren K., Watts C.K., Low T.H., Leong G.M., Ross R.J., Ho K.K.
    Proc Natl Acad Sci U S A 100:1016-1021(2003) [PubMed] [Europe PMC] [Abstract]
• response to interleukin-4 Source: Ensembl
• response to peptide hormone Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• taurine metabolic process Source: BHF-UCL
• T cell differentiation in thymus Source: Ensembl
• T cell homeostasis Source: Ensembl

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseaseⁱ

Mutagenesis

Keywords - Diseaseⁱ

Organism-specific databases

Miscellaneous databases

Chemistry databases

Genetic variation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• glucocorticoid receptor binding Source: BHF-UCLInferred from physical interactionⁱ
  • "Estrogen inhibits GH signaling by suppressing GH-induced JAK2 phosphorylation, an effect mediated by SOCS-2."
    Leung K.C., Doyle N., Ballesteros M., Sjogren K., Watts C.K., Low T.H., Leong G.M., Ross R.J., Ho K.K.
    Proc Natl Acad Sci U S A 100:1016-1021(2003) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: IntActInferred from physical interactionⁱ
  • "Structural and functional consequences of the STAT5B^N642H driver mutation."
    de Araujo E.D., Erdogan F., Neubauer H.A., Meneksedag-Erol D., Manaswiyoungkul P., Eram M.S., Seo H.S., Qadree A.K., Israelian J., Orlova A., Suske T., Pham H.T.T., Boersma A., Tangermann S., Kenner L., Rulicke T., Dong A., Ravichandran M.

    , Brown P.J., Audette G.F., Rauscher S., Dhe-Paganon S., Moriggl R., Gunning P.T.
    Nat Commun 10:2517-2517(2019) [PubMed] [Europe PMC] [Abstract]
• protein dimerization activity Source: UniProtKB

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

        10         20         30         40         50
MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSVDLDN 
        60         70         80         90        100
PQENIKATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR 
       110        120        130        140        150
CPMELVRCIR HILYNEQRLV REANNGSSPA GSLADAMSQK HLQINQTFEE 
       160        170        180        190        200
LRLVTQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFGPLA QLSPQERLSR 
       210        220        230        240        250
ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD 
       260        270        280        290        300
ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 
       310        320        330        340        350
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA 
       360        370        380        390        400
TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC 
       410        420        430        440        450
CVMEYHQATG TLSAHFRNMS LKRIKRSDRR GAESVTEEKF TILFESQFSV 
       460        470        480        490        500
GGNELVFQVK TLSLPVVVIV HGSQDNNATA TVLWDNAFAE PGRVPFAVPD 
       510        520        530        540        550
KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN SSSHLEDYSG 
       560        570        580        590        600
LSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK 
       610        620        630        640        650
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD 
       660        670        680        690        700
FSIRSLADRL GDLNYLIYVF PDRPKDEVYS KYYTPVPCES ATAKAVDGYV 
       710        720        730        740        750
KPQIKQVVPE FVNASADAGG GSATYMDQAP SPAVCPQAHY NMYPQNPDSV 
       760        770        780 
LDTDGDFDLE DTMDVARRVE ELLGRPMDSQ WIPHAQS               

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Genetic variation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 17
   Human chromosome 17: entries, gene names and cross-references to MIM
2. Human entries with genetic variants
   List of human entries with genetic variants
3. Human variants curated from literature reports
   Index of human variants curated from literature reports
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
6. SIMILARITY comments
   Index of protein domains and families