STAT5B

Functionⁱ

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. Positively regulates hematopoietic/erythroid differentiation.2 Publications

Caution

It was reported that dephosphorylation on tyrosine residues by PTPN2 would negatively regulate prolactin signaling pathway (PubMed:11773439). However, the corresponding article has been retracted (PubMed:24319783).1 Publication1 Publication

GO - Molecular functionⁱ

chromatin binding Source: UniProtKB
DNA-binding transcription factor activity
Source: ProtInc
Traceable author statementⁱ
- 8631883
DNA-binding transcription factor activity, RNA polymerase II-specific Source: NTNU_SB
glucocorticoid receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12552091
protein dimerization activity Source: UniProtKB
protein tyrosine kinase activity Source: Reactome
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
RNA polymerase II proximal promoter sequence-specific DNA binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

2-oxoglutarate metabolic process Source: BHF-UCL
allantoin metabolic process Source: BHF-UCL
cellular response to epidermal growth factor stimulus Source: UniProtKB
cellular response to growth factor stimulus Source: UniProtKB
cellular response to hormone stimulus
Source: BHF-UCL
Inferred from direct assayⁱ
- 12552091
citrate metabolic process Source: BHF-UCL
creatine metabolic process Source: BHF-UCL
creatinine metabolic process Source: BHF-UCL
cytokine-mediated signaling pathway Source: Reactome
development of secondary female sexual characteristics Source: Ensembl
development of secondary male sexual characteristics Source: Ensembl
fatty acid metabolic process Source: BHF-UCL
female pregnancy Source: Ensembl
interleukin-15-mediated signaling pathway Source: Reactome
interleukin-2-mediated signaling pathway Source: Reactome
interleukin-7-mediated signaling pathway Source: Reactome
interleukin-9-mediated signaling pathway Source: Reactome
isoleucine metabolic process Source: BHF-UCL
JAK-STAT cascade
Source: ProtInc
Traceable author statementⁱ
- 8631883
JAK-STAT cascade involved in growth hormone signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 12552091
lactation Source: Ensembl
lipid storage Source: Ensembl
luteinization Source: Ensembl
mast cell migration Source: Ensembl
natural killer cell differentiation Source: Ensembl
negative regulation of apoptotic process Source: Ensembl
negative regulation of erythrocyte differentiation Source: Ensembl
oxaloacetate metabolic process Source: BHF-UCL
Peyer's patch development Source: Ensembl
positive regulation of activated T cell proliferation Source: Ensembl
positive regulation of B cell differentiation Source: Ensembl
positive regulation of erythrocyte differentiation
Source: UniProtKB
Inferred from direct assayⁱ
- 20702587
positive regulation of gamma-delta T cell differentiation Source: Ensembl
positive regulation of inflammatory response Source: Ensembl
positive regulation of interleukin-2 biosynthetic process Source: Ensembl
positive regulation of mitotic cell cycle Source: Ensembl
positive regulation of multicellular organism growth Source: Ensembl
positive regulation of natural killer cell differentiation Source: Ensembl
positive regulation of natural killer cell mediated cytotoxicity Source: Ensembl
positive regulation of natural killer cell proliferation Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: UniProtKB
progesterone metabolic process Source: Ensembl
regulation of epithelial cell differentiation Source: Ensembl
regulation of multicellular organism growth Source: BHF-UCL
regulation of steroid metabolic process Source: Ensembl
regulation of transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 8631883
response to estradiol
Source: BHF-UCL
Inferred from direct assayⁱ
- 12552091
response to interleukin-4 Source: Ensembl
succinate metabolic process Source: BHF-UCL
taurine metabolic process Source: BHF-UCL
T cell differentiation in thymus Source: Ensembl
T cell homeostasis Source: Ensembl
valine metabolic process Source: BHF-UCL

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1170546 Prolactin receptor signaling R-HSA-1266695 Interleukin-7 signaling R-HSA-1433557 Signaling by SCF-KIT R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants R-HSA-186763 Downstream signal transduction R-HSA-2586552 Signaling by Leptin R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-8854691 Interleukin-20 family signaling R-HSA-8983432 Interleukin-15 signaling R-HSA-8985947 Interleukin-9 signaling R-HSA-9020558 Interleukin-2 signaling R-HSA-9020958 Interleukin-21 signaling R-HSA-982772 Growth hormone receptor signaling
SignaLinkⁱ	P51692
SIGNORⁱ	P51692

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Signal transducer and activator of transcription 5B
Gene namesⁱ	Name:STAT5B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 17

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000173757.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11367 STAT5B
MIMⁱ	604260 gene
neXtProtⁱ	NX_P51692

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Growth hormone insensitivity with immunodeficiency (GHII)3 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disease characterized by short stature, growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, resistance to hexogeneous growth hormone therapy, and recurrent infections.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_018728	630	A → P in GHII; affects activation by growth hormone or interferon-gamma. 1 PublicationCorresponds to variant dbSNP:rs121908501EnsemblClinVar.		1
Natural variantⁱVAR_067368	646	F → S in GHII; transcriptionally inactive. 1 Publication		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	684	T → A: Abolishes interaction with INSR. 1 Publication		1
Mutagenesisⁱ	699	Y → F: Abolishes phosphorylation by HCK. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Dwarfism

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6777
MalaCards human disease database More...MalaCardsⁱ	STAT5B
MIMⁱ	245590 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000173757
Orphanetⁱ	520 Acute promyelocytic leukemia 220465 Laron syndrome with immunodeficiency
PharmGKBⁱ	PA36186

Chemistry databases

ChEMBLⁱ	CHEMBL5817
Drug and drug target database More...DrugBankⁱ	DB01254 Dasatinib

Polymorphism and mutation databases

BioMutaⁱ	STAT5B
DMDMⁱ	41019536

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000182429	1 – 787	Signal transducer and activator of transcription 5BAdd BLAST		787

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	90	PhosphotyrosineCombined sources	1
Modified residueⁱ	128	PhosphoserineCombined sources	1
Modified residueⁱ	193	PhosphoserineCombined sources	1
Modified residueⁱ	682	PhosphotyrosineBy similarity	1
Modified residueⁱ	699	Phosphotyrosine; by HCK, JAK and PTK62 Publications	1

Post-translational modificationⁱ

Tyrosine phosphorylated in response to signaling via activated KIT, resulting in translocation to the nucleus. Tyrosine phosphorylated in response to signaling via activated FLT3; wild-type FLT3 results in much weaker phosphorylation than constitutively activated mutant FLT3. Alternatively, can be phosphorylated by JAK2. Phosphorylation at Tyr-699 by PTK6 or HCK leads to an increase of its transcriptional activity.6 Publications

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P51692
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51692
PaxDbⁱ	P51692
PeptideAtlas More...PeptideAtlasⁱ	P51692
PRIDEⁱ	P51692
ProteomicsDBⁱ	56378

PTM databases

iPTMnetⁱ	P51692
PhosphoSitePlusⁱ	P51692

Miscellaneous databases

PMAP-CutDBⁱ	P51692

PMAP-CutDBⁱ

P51692

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000173757 Expressed in 234 organ(s), highest expression level in blood
CleanExⁱ	HS_STAT5B
ExpressionAtlasⁱ	P51692 baseline and differential
Genevisibleⁱ	P51692 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB004298 HPA042128 HPA049883 HPA051156

HPAⁱ

CAB004298
HPA042128
HPA049883
HPA051156

Interactionⁱ

Subunit structureⁱ

Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 (PubMed:12954634). Interacts with NMI (PubMed:9989503). Interacts with SOCS7 (PubMed:15677474). Interacts (via SH2 domain) with INSR (PubMed:9428692). Interacts with CPEB3; this inhibits STAT5B-mediated transcriptional activation (PubMed:20639532).By similarity5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
DNAJA3	Q96EY1	2	EBI-1186119,EBI-356767
NMI	Q13287	7	EBI-1186119,EBI-372942

GO - Molecular functionⁱ

glucocorticoid receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 12552091
protein dimerization activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	112654, 59 interactors
CORUMⁱ	P51692
IntActⁱ	P51692, 39 interactors
Molecular INTeraction database More...MINTⁱ	P51692
STRINGⁱ	9606.ENSP00000293328

Chemistry databases

BindingDBⁱ

P51692

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51692
SMRⁱ	P51692
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	589 – 686	SH2PROSITE-ProRule annotationAdd BLAST		98

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	232 – 321	Required for interaction with NMI1 PublicationAdd BLAST		90

Sequence similaritiesⁱ

Belongs to the transcription factor STAT family.Curated

Keywords - Domainⁱ

SH2 domain

Phylogenomic databases

eggNOGⁱ	KOG3667 Eukaryota ENOG410XPN8 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119236
HOVERGENⁱ	HBG107486
InParanoidⁱ	P51692
KEGG Orthology (KO) More...KOⁱ	K11224
OMAⁱ	TIWQNRQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G03O3
PhylomeDBⁱ	P51692
TreeFamⁱ	TF318648

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10420 SH2_STAT5b, 1 hit
Gene3Dⁱ	1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR008967 p53-like_TF_DNA-bd IPR000980 SH2 IPR036860 SH2_dom_sf IPR001217 STAT IPR035858 STAT5a/5b IPR035886 STAT5b_SH2 IPR036535 STAT_N_sf IPR013800 STAT_TF_alpha IPR015988 STAT_TF_coiled-coil IPR013801 STAT_TF_DNA-bd IPR012345 STAT_TF_DNA-bd_N IPR013799 STAT_TF_prot_interaction
PANTHERⁱ	PTHR11801 PTHR11801, 1 hit PTHR11801:SF39 PTHR11801:SF39, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00017 SH2, 1 hit PF01017 STAT_alpha, 1 hit PF02864 STAT_bind, 1 hit PF02865 STAT_int, 1 hit
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00964 STAT_int, 1 hit
SUPFAMⁱ	SSF47655 SSF47655, 1 hit SSF48092 SSF48092, 1 hit SSF49417 SSF49417, 1 hit SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P51692-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAVWIQAQQL QGEALHQMQA LYGQHFPIEV RHYLSQWIES QAWDSVDLDN 
        60         70         80         90        100
PQENIKATQL LEGLVQELQK KAEHQVGEDG FLLKIKLGHY ATQLQNTYDR 
       110        120        130        140        150
CPMELVRCIR HILYNEQRLV REANNGSSPA GSLADAMSQK HLQINQTFEE 
       160        170        180        190        200
LRLVTQDTEN ELKKLQQTQE YFIIQYQESL RIQAQFGPLA QLSPQERLSR 
       210        220        230        240        250
ETALQQKQVS LEAWLQREAQ TLQQYRVELA EKHQKTLQLL RKQQTIILDD 
       260        270        280        290        300
ELIQWKRRQQ LAGNGGPPEG SLDVLQSWCE KLAEIIWQNR QQIRRAEHLC 
       310        320        330        340        350
QQLPIPGPVE EMLAEVNATI TDIISALVTS TFIIEKQPPQ VLKTQTKFAA 
       360        370        380        390        400
TVRLLVGGKL NVHMNPPQVK ATIISEQQAK SLLKNENTRN DYSGEILNNC 
       410        420        430        440        450
CVMEYHQATG TLSAHFRNMS LKRIKRSDRR GAESVTEEKF TILFESQFSV 
       460        470        480        490        500
GGNELVFQVK TLSLPVVVIV HGSQDNNATA TVLWDNAFAE PGRVPFAVPD 
       510        520        530        540        550
KVLWPQLCEA LNMKFKAEVQ SNRGLTKENL VFLAQKLFNN SSSHLEDYSG 
       560        570        580        590        600
LSVSWSQFNR ENLPGRNYTF WQWFDGVMEV LKKHLKPHWN DGAILGFVNK 
       610        620        630        640        650
QQAHDLLINK PDGTFLLRFS DSEIGGITIA WKFDSQERMF WNLMPFTTRD 
       660        670        680        690        700
FSIRSLADRL GDLNYLIYVF PDRPKDEVYS KYYTPVPCES ATAKAVDGYV 
       710        720        730        740        750
KPQIKQVVPE FVNASADAGG GSATYMDQAP SPAVCPQAHY NMYPQNPDSV 
       760        770        780 
LDTDGDFDLE DTMDVARRVE ELLGRPMDSQ WIPHAQS

Length:787

Mass (Da):89,866

Last modified:January 16, 2004 - v2

Checksum:ⁱAA2F1CAB20955ACA

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	C9J4I3	C9J4I3_HUMAN		Signal transducer and activator of ... Signal transducer and activator of transcription 5B	STAT5B	156	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	230	A → P in AAC50491 (Ref. 2) Curated		1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_052074	130	A → V. Corresponds to variant dbSNP:rs2277619Ensembl.	1
Natural variantⁱVAR_018728	630	A → P in GHII; affects activation by growth hormone or interferon-gamma. 1 PublicationCorresponds to variant dbSNP:rs121908501EnsemblClinVar.	1
Natural variantⁱVAR_067368	646	F → S in GHII; transcriptionally inactive. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U48730 mRNA Translation: AAC50485.2 U47686 mRNA Translation: AAC50491.1 AJ412888 AJ412899 Genomic DNA Translation: CAD19638.1 BC065227 mRNA Translation: AAH65227.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS11423.1
NCBI Reference Sequences More...RefSeqⁱ	NP_036580.2, NM_012448.3
UniGeneⁱ	Hs.595276

Genome annotation databases

Ensemblⁱ	ENST00000293328; ENSP00000293328; ENSG00000173757
GeneIDⁱ	6777
KEGGⁱ	hsa:6777
UCSC genome browser More...UCSCⁱ	uc002hzh.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P51692	Signal transducer and activator of transcription 5B		MOUSE		786	UniRef90_P42232
Signal transducer and activator of transcription 5A		PIG		799
Signal transducer and activator of transcription 5A		SHEEP		794
Signal transducer and activator of transcription 5A		HUMAN		794
Signal transducer and activator of transcription 5A		BOVIN		794
+345

Protein	Similar proteins		Species	Score	Length	Source
P51692	Signal transducer and activator of transcription 5B		MOUSE		786	UniRef50_P42232
Signal transducer and activator of transcription 5A		PIG		799
Signal transducer and activator of transcription 5A		SHEEP		794
Signal transducer and activator of transcription 5A		BOVIN		794
Signal transducer and activator of transcription 5A		HUMAN		794
+579

Cross-referencesⁱ

Web resourcesⁱ

STAT5Bbase

STAT5B mutation db

Wikipedia

STAT5 entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U48730 mRNA Translation: AAC50485.2 U47686 mRNA Translation: AAC50491.1 AJ412888 AJ412899 Genomic DNA Translation: CAD19638.1 BC065227 mRNA Translation: AAH65227.1
CCDSⁱ	CCDS11423.1
RefSeqⁱ	NP_036580.2, NM_012448.3
UniGeneⁱ	Hs.595276

3D structure databases

ProteinModelPortalⁱ	P51692
SMRⁱ	P51692
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112654, 59 interactors
CORUMⁱ	P51692
IntActⁱ	P51692, 39 interactors
MINTⁱ	P51692
STRINGⁱ	9606.ENSP00000293328

Chemistry databases

BindingDBⁱ	P51692
ChEMBLⁱ	CHEMBL5817
DrugBankⁱ	DB01254 Dasatinib

PTM databases

iPTMnetⁱ	P51692
PhosphoSitePlusⁱ	P51692

Polymorphism and mutation databases

BioMutaⁱ	STAT5B
DMDMⁱ	41019536

Proteomic databases

EPDⁱ	P51692
MaxQBⁱ	P51692
PaxDbⁱ	P51692
PeptideAtlasⁱ	P51692
PRIDEⁱ	P51692
ProteomicsDBⁱ	56378

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6777
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000293328; ENSP00000293328; ENSG00000173757
GeneIDⁱ	6777
KEGGⁱ	hsa:6777
UCSCⁱ	uc002hzh.4 human

Organism-specific databases

CTDⁱ	6777
DisGeNETⁱ	6777
EuPathDBⁱ	HostDB:ENSG00000173757.9
GeneCardsⁱ	STAT5B
HGNCⁱ	HGNC:11367 STAT5B
HPAⁱ	CAB004298 HPA042128 HPA049883 HPA051156
MalaCardsⁱ	STAT5B
MIMⁱ	245590 phenotype 604260 gene
neXtProtⁱ	NX_P51692
OpenTargetsⁱ	ENSG00000173757
Orphanetⁱ	520 Acute promyelocytic leukemia 220465 Laron syndrome with immunodeficiency
PharmGKBⁱ	PA36186
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3667 Eukaryota ENOG410XPN8 LUCA
GeneTreeⁱ	ENSGT00760000119236
HOVERGENⁱ	HBG107486
InParanoidⁱ	P51692
KOⁱ	K11224
OMAⁱ	TIWQNRQ
OrthoDBⁱ	EOG091G03O3
PhylomeDBⁱ	P51692
TreeFamⁱ	TF318648

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1170546 Prolactin receptor signaling R-HSA-1266695 Interleukin-7 signaling R-HSA-1433557 Signaling by SCF-KIT R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants R-HSA-186763 Downstream signal transduction R-HSA-2586552 Signaling by Leptin R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling R-HSA-8854691 Interleukin-20 family signaling R-HSA-8983432 Interleukin-15 signaling R-HSA-8985947 Interleukin-9 signaling R-HSA-9020558 Interleukin-2 signaling R-HSA-9020958 Interleukin-21 signaling R-HSA-982772 Growth hormone receptor signaling
SignaLinkⁱ	P51692
SIGNORⁱ	P51692

Miscellaneous databases

ChiTaRSⁱ	STAT5B human
GeneWikiⁱ	STAT5B
GenomeRNAiⁱ	6777
PMAP-CutDBⁱ	P51692
Protein Ontology More...PROⁱ	PR:P51692
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000173757 Expressed in 234 organ(s), highest expression level in blood
CleanExⁱ	HS_STAT5B
ExpressionAtlasⁱ	P51692 baseline and differential
Genevisibleⁱ	P51692 HS

Family and domain databases

CDDⁱ	cd10420 SH2_STAT5b, 1 hit
Gene3Dⁱ	1.10.532.10, 1 hit 2.60.40.630, 1 hit 3.30.505.10, 1 hit
InterProⁱ	View protein in InterPro IPR008967 p53-like_TF_DNA-bd IPR000980 SH2 IPR036860 SH2_dom_sf IPR001217 STAT IPR035858 STAT5a/5b IPR035886 STAT5b_SH2 IPR036535 STAT_N_sf IPR013800 STAT_TF_alpha IPR015988 STAT_TF_coiled-coil IPR013801 STAT_TF_DNA-bd IPR012345 STAT_TF_DNA-bd_N IPR013799 STAT_TF_prot_interaction
PANTHERⁱ	PTHR11801 PTHR11801, 1 hit PTHR11801:SF39 PTHR11801:SF39, 1 hit
Pfamⁱ	View protein in Pfam PF00017 SH2, 1 hit PF01017 STAT_alpha, 1 hit PF02864 STAT_bind, 1 hit PF02865 STAT_int, 1 hit
SMARTⁱ	View protein in SMART SM00252 SH2, 1 hit SM00964 STAT_int, 1 hit
SUPFAMⁱ	SSF47655 SSF47655, 1 hit SSF48092 SSF48092, 1 hit SSF49417 SSF49417, 1 hit SSF55550 SSF55550, 1 hit
PROSITEⁱ	View protein in PROSITE PS50001 SH2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	STA5B_HUMAN
Accessionⁱ	P51692Primary (citable) accession number: P51692 Secondary accession number(s): Q8WWS8
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	January 16, 2004
	Last modified:	November 7, 2018
	This is version 190 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 17
Human chromosome 17: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P51692 (STA5B_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Signal transducer and activator of transcription 5B

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Other locations

Cytosol

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ