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Protein

Sulfite oxidase, mitochondrial

Gene

SUOX

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: sulfur metabolism

This protein is involved in the pathway sulfur metabolism, which is part of Energy metabolism.
View all proteins of this organism that are known to be involved in the pathway sulfur metabolism and in Energy metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi118Iron (heme axial ligand)1
Metal bindingi143Iron (heme axial ligand)1
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei145Heme b1 Publication1
Binding sitei147Heme b1 Publication1
Metal bindingi264MolybdenumBy similarity1
Binding sitei322MolybdopterinBy similarity1
Binding sitei361MolybdopterinBy similarity1
Binding sitei366MolybdopterinBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • heme binding Source: GO_Central
  • molybdenum ion binding Source: InterPro
  • molybdopterin cofactor binding Source: GO_Central
  • sulfite oxidase activity Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
LigandHeme, Iron, Metal-binding, Molybdenum

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS06627-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.8.3.1 2681

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-1614517 Sulfide oxidation to sulfate

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P51687

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00096

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sulfite oxidase, mitochondrial (EC:1.8.3.1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SUOX
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000139531.12

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11460 SUOX

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
606887 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P51687

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Sulfite oxidase deficiency, isolated (ISOD)5 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA life-threatening, autosomal recessive neurometabolic disorder characterized by severe neurological impairment. Classic ISOD manifests in the first few hours to days of life and is characterized by intractable seizures, feeding difficulties, rapidly progressive encephalopathy, microcephaly, and profound intellectual disability. Children usually die during the first few months of life. Mild ISOD manifests in infancy or early childhood and is characterized by ectopia lentis that is variably present, developmental delay and regression, movement disorder characterized by dystonia and choreoathetosis, ataxia, and rarely acute hemiplegia due to metabolic stroke.
See also OMIM:272300
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_002200217R → Q in ISOD; 2% of activity. 3 PublicationsCorresponds to variant dbSNP:rs121908007EnsemblClinVar.1
Natural variantiVAR_015724258I → L in ISOD. 1 Publication1
Natural variantiVAR_002201265A → D in ISOD. 2 PublicationsCorresponds to variant dbSNP:rs121908008EnsemblClinVar.1
Natural variantiVAR_015725268R → Q in ISOD. 1 PublicationCorresponds to variant dbSNP:rs1041681662Ensembl.1
Natural variantiVAR_015726362G → S in ISOD. 1 PublicationCorresponds to variant dbSNP:rs757559168Ensembl.1
Natural variantiVAR_015727366R → H in ISOD. 1 PublicationCorresponds to variant dbSNP:rs776690106Ensembl.1
Natural variantiVAR_015728379K → R in ISOD. 1 PublicationCorresponds to variant dbSNP:rs777114729Ensembl.1
Natural variantiVAR_015729396Q → R in ISOD. 1 Publication1
Natural variantiVAR_002202427S → Y in ISOD. 2 Publications1
Natural variantiVAR_015730450W → R in ISOD. 1 Publication1
Natural variantiVAR_002203530G → D in ISOD. 1 PublicationCorresponds to variant dbSNP:rs121908009EnsemblClinVar.1

Keywords - Diseasei

Disease mutation, Epilepsy, Mental retardation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6821

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SUOX

MalaCards human disease database

More...
MalaCardsi
SUOX
MIMi272300 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000139531

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
99731 Isolated sulfite oxidase deficiency

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA36250

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SUOX

Domain mapping of disease mutations (DMDM)

More...
DMDMi
152031695

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a transit peptide.<p><a href='/help/transit' target='_top'>More...</a></p>Transit peptidei1 – 79MitochondrionBy similarityAdd BLAST79
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000648180 – 545Sulfite oxidase, mitochondrialAdd BLAST466

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei123PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
P51687

MaxQB - The MaxQuant DataBase

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MaxQBi
P51687

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P51687

PeptideAtlas

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PeptideAtlasi
P51687

PRoteomics IDEntifications database

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PRIDEi
P51687

ProteomicsDB human proteome resource

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ProteomicsDBi
56372

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P51687

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P51687

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000139531 Expressed in 206 organ(s), highest expression level in right lobe of liver

CleanEx database of gene expression profiles

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CleanExi
HS_SUOX

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P51687 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P51687 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA038208
HPA038209

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.By similarity

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
NUP62P371985EBI-3921347,EBI-347978

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112690, 10 interactors

Protein interaction database and analysis system

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IntActi
P51687, 77 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000266971

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1545
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P51687

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P51687

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P51687

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini82 – 161Cytochrome b5 heme-bindingPROSITE-ProRule annotationAdd BLAST80

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni165 – 174HingeBy similarity10
Regioni175 – 401Moco domainBy similarityAdd BLAST227
Regioni215 – 219Molybdopterin-bindingBy similarity5
Regioni377 – 379Molybdopterin-bindingBy similarity3
Regioni402 – 538HomodimerizationBy similarityAdd BLAST137

Keywords - Domaini

Transit peptide

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0535 Eukaryota
KOG4576 Eukaryota
COG2041 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003749

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000252609

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG017865

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P51687

KEGG Orthology (KO)

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KOi
K00387

Identification of Orthologs from Complete Genome Data

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OMAi
AVGNAKW

Database of Orthologous Groups

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OrthoDBi
EOG091G0DBF

Database for complete collections of gene phylogenies

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PhylomeDBi
P51687

TreeFam database of animal gene trees

More...
TreeFami
TF300905

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.10.120.10, 1 hit
3.90.420.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS
IPR014756 Ig_E-set
IPR005066 MoCF_OxRdtse_dimer
IPR008335 Mopterin_OxRdtase_euk
IPR000572 OxRdtase_Mopterin-bd_dom
IPR036374 OxRdtase_Mopterin-bd_sf
IPR022407 OxRdtase_Mopterin_BS

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00173 Cyt-b5, 1 hit
PF03404 Mo-co_dimer, 1 hit
PF00174 Oxidored_molyb, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00363 CYTOCHROMEB5
PR00407 EUMOPTERIN

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01117 Cyt-b5, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55856 SSF55856, 1 hit
SSF56524 SSF56524, 1 hit
SSF81296 SSF81296, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit
PS00559 MOLYBDOPTERIN_EUK, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P51687-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLLLHRAVVL RLQQACRLKS IPSRICIQAC STNDSFQPQR PSLTFSGDNS
60 70 80 90 100
STQGWRVMGT LLGLGAVLAY QDHRCRAAQE STHIYTKEEV SSHTSPETGI
110 120 130 140 150
WVTLGSEVFD VTEFVDLHPG GPSKLMLAAG GPLEPFWALY AVHNQSHVRE
160 170 180 190 200
LLAQYKIGEL NPEDKVAPTV ETSDPYADDP VRHPALKVNS QRPFNAEPPP
210 220 230 240 250
ELLTENYITP NPIFFTRNHL PVPNLDPDTY RLHVVGAPGG QSLSLSLDDL
260 270 280 290 300
HNFPRYEITV TLQCAGNRRS EMTQVKEVKG LEWRTGAIST ARWAGARLCD
310 320 330 340 350
VLAQAGHQLC ETEAHVCFEG LDSDPTGTAY GASIPLARAM DPEAEVLLAY
360 370 380 390 400
EMNGQPLPRD HGFPVRVVVP GVVGARHVKW LGRVSVQPEE SYSHWQRRDY
410 420 430 440 450
KGFSPSVDWE TVDFDSAPSI QELPVQSAIT EPRDGETVES GEVTIKGYAW
460 470 480 490 500
SGGGRAVIRV DVSLDGGLTW QVAKLDGEEQ RPRKAWAWRL WQLKAPVPAG
510 520 530 540
QKELNIVCKA VDDGYNVQPD TVAPIWNLRG VLSNAWHRVH VYVSP
Length:545
Mass (Da):60,283
Last modified:July 10, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i39B842C55D39E11F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8VVW9F8VVW9_HUMAN
Sulfite oxidase, mitochondrial
SUOX
161Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VPA2F8VPA2_HUMAN
Sulfite oxidase, mitochondrial
SUOX
121Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VX56F8VX56_HUMAN
Sulfite oxidase, mitochondrial
SUOX
104Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8VRK9F8VRK9_HUMAN
Sulfite oxidase, mitochondrial
SUOX
42Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA74886 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAL08048 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_002200217R → Q in ISOD; 2% of activity. 3 PublicationsCorresponds to variant dbSNP:rs121908007EnsemblClinVar.1
Natural variantiVAR_015724258I → L in ISOD. 1 Publication1
Natural variantiVAR_002201265A → D in ISOD. 2 PublicationsCorresponds to variant dbSNP:rs121908008EnsemblClinVar.1
Natural variantiVAR_015725268R → Q in ISOD. 1 PublicationCorresponds to variant dbSNP:rs1041681662Ensembl.1
Natural variantiVAR_015726362G → S in ISOD. 1 PublicationCorresponds to variant dbSNP:rs757559168Ensembl.1
Natural variantiVAR_015727366R → H in ISOD. 1 PublicationCorresponds to variant dbSNP:rs776690106Ensembl.1
Natural variantiVAR_015728379K → R in ISOD. 1 PublicationCorresponds to variant dbSNP:rs777114729Ensembl.1
Natural variantiVAR_015729396Q → R in ISOD. 1 Publication1
Natural variantiVAR_002202427S → Y in ISOD. 2 Publications1
Natural variantiVAR_015730450W → R in ISOD. 1 Publication1
Natural variantiVAR_002203530G → D in ISOD. 1 PublicationCorresponds to variant dbSNP:rs121908009EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
L31573 mRNA Translation: AAA74886.1 Different initiation.
BC065193 mRNA Translation: AAH65193.2
AY056018 Genomic DNA Translation: AAL08048.1 Different initiation.

The Consensus CDS (CCDS) project

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CCDSi
CCDS8901.2

Protein sequence database of the Protein Information Resource

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PIRi
S55874

NCBI Reference Sequences

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RefSeqi
NP_000447.2, NM_000456.2
NP_001027558.1, NM_001032386.1
NP_001027559.1, NM_001032387.1
XP_016875396.1, XM_017019907.1
XP_016875397.1, XM_017019908.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.558403

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000266971; ENSP00000266971; ENSG00000139531
ENST00000356124; ENSP00000348440; ENSG00000139531
ENST00000394109; ENSP00000377668; ENSG00000139531
ENST00000394115; ENSP00000377674; ENSG00000139531
ENST00000548274; ENSP00000450245; ENSG00000139531
ENST00000550065; ENSP00000450264; ENSG00000139531

Database of genes from NCBI RefSeq genomes

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GeneIDi
6821

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6821

UCSC genome browser

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UCSCi
uc001six.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L31573 mRNA Translation: AAA74886.1 Different initiation.
BC065193 mRNA Translation: AAH65193.2
AY056018 Genomic DNA Translation: AAL08048.1 Different initiation.
CCDSiCCDS8901.2
PIRiS55874
RefSeqiNP_000447.2, NM_000456.2
NP_001027558.1, NM_001032386.1
NP_001027559.1, NM_001032387.1
XP_016875396.1, XM_017019907.1
XP_016875397.1, XM_017019908.1
UniGeneiHs.558403

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MJ4X-ray1.20A79-160[»]
ProteinModelPortaliP51687
SMRiP51687
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112690, 10 interactors
IntActiP51687, 77 interactors
STRINGi9606.ENSP00000266971

PTM databases

iPTMnetiP51687
PhosphoSitePlusiP51687

Polymorphism and mutation databases

BioMutaiSUOX
DMDMi152031695

Proteomic databases

EPDiP51687
MaxQBiP51687
PaxDbiP51687
PeptideAtlasiP51687
PRIDEiP51687
ProteomicsDBi56372

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266971; ENSP00000266971; ENSG00000139531
ENST00000356124; ENSP00000348440; ENSG00000139531
ENST00000394109; ENSP00000377668; ENSG00000139531
ENST00000394115; ENSP00000377674; ENSG00000139531
ENST00000548274; ENSP00000450245; ENSG00000139531
ENST00000550065; ENSP00000450264; ENSG00000139531
GeneIDi6821
KEGGihsa:6821
UCSCiuc001six.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6821
DisGeNETi6821
EuPathDBiHostDB:ENSG00000139531.12

GeneCards: human genes, protein and diseases

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GeneCardsi
SUOX
GeneReviewsiSUOX
HGNCiHGNC:11460 SUOX
HPAiHPA038208
HPA038209
MalaCardsiSUOX
MIMi272300 phenotype
606887 gene
neXtProtiNX_P51687
OpenTargetsiENSG00000139531
Orphaneti99731 Isolated sulfite oxidase deficiency
PharmGKBiPA36250

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG0535 Eukaryota
KOG4576 Eukaryota
COG2041 LUCA
GeneTreeiENSGT00390000003749
HOGENOMiHOG000252609
HOVERGENiHBG017865
InParanoidiP51687
KOiK00387
OMAiAVGNAKW
OrthoDBiEOG091G0DBF
PhylomeDBiP51687
TreeFamiTF300905

Enzyme and pathway databases

UniPathwayi
UPA00096

BioCyciMetaCyc:HS06627-MONOMER
BRENDAi1.8.3.1 2681
ReactomeiR-HSA-1614517 Sulfide oxidation to sulfate
SABIO-RKiP51687

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SUOX human
EvolutionaryTraceiP51687

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Sulfite_oxidase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6821

Protein Ontology

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PROi
PR:P51687

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000139531 Expressed in 206 organ(s), highest expression level in right lobe of liver
CleanExiHS_SUOX
ExpressionAtlasiP51687 baseline and differential
GenevisibleiP51687 HS

Family and domain databases

Gene3Di3.10.120.10, 1 hit
3.90.420.10, 1 hit
InterProiView protein in InterPro
IPR001199 Cyt_B5-like_heme/steroid-bd
IPR036400 Cyt_B5-like_heme/steroid_sf
IPR018506 Cyt_B5_heme-BS
IPR014756 Ig_E-set
IPR005066 MoCF_OxRdtse_dimer
IPR008335 Mopterin_OxRdtase_euk
IPR000572 OxRdtase_Mopterin-bd_dom
IPR036374 OxRdtase_Mopterin-bd_sf
IPR022407 OxRdtase_Mopterin_BS
PfamiView protein in Pfam
PF00173 Cyt-b5, 1 hit
PF03404 Mo-co_dimer, 1 hit
PF00174 Oxidored_molyb, 1 hit
PRINTSiPR00363 CYTOCHROMEB5
PR00407 EUMOPTERIN
SMARTiView protein in SMART
SM01117 Cyt-b5, 1 hit
SUPFAMiSSF55856 SSF55856, 1 hit
SSF56524 SSF56524, 1 hit
SSF81296 SSF81296, 1 hit
PROSITEiView protein in PROSITE
PS00191 CYTOCHROME_B5_1, 1 hit
PS50255 CYTOCHROME_B5_2, 1 hit
PS00559 MOLYBDOPTERIN_EUK, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSUOX_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51687
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 10, 2007
Last modified: December 5, 2018
This is version 192 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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