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Protein

C-C chemokine receptor type 9

Gene

CCR9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for chemokine SCYA25/TECK. Subsequently transduces a signal by increasing the intracellular calcium ions level.2 Publications
(Microbial infection) Alternative coreceptor with CD4 for HIV-1 infection.

Miscellaneous

EC50 of SCYA25/TECK for isoform 1 is lower than for isoform 2.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • C-C chemokine binding Source: GO_Central
  • C-C chemokine receptor activity Source: GO_Central
  • chemokine binding Source: GO_Central
  • chemokine receptor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P51686

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-C chemokine receptor type 9
Short name:
C-C CKR-9
Short name:
CC-CKR-9
Short name:
CCR-9
Alternative name(s):
G-protein coupled receptor 28
GPR-9-6
CD_antigen: CDw199
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCR9
Synonyms:GPR28
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000173585.15

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1610 CCR9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
604738 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P51686

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 48Extracellular1 PublicationAdd BLAST48
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei49 – 74Helical; Name=11 PublicationAdd BLAST26
Topological domaini75 – 85Cytoplasmic1 PublicationAdd BLAST11
Transmembranei86 – 109Helical; Name=21 PublicationAdd BLAST24
Topological domaini110 – 120Extracellular1 PublicationAdd BLAST11
Transmembranei121 – 150Helical; Name=31 PublicationAdd BLAST30
Topological domaini151 – 159Cytoplasmic1 Publication9
Transmembranei160 – 185Helical; Name=41 PublicationAdd BLAST26
Topological domaini186 – 208Extracellular1 PublicationAdd BLAST23
Transmembranei209 – 243Helical; Name=51 PublicationAdd BLAST35
Topological domaini244 – 248Cytoplasmic1 Publication5
Transmembranei249 – 283Helical; Name=61 PublicationAdd BLAST35
Topological domaini284 – 290Extracellular1 Publication7
Transmembranei291 – 321Helical; Name=71 PublicationAdd BLAST31
Topological domaini322 – 369CytoplasmicSequence analysis1 PublicationAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
10803

Open Targets

More...
OpenTargetsi
ENSG00000173585

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26174

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL5815

Drug and drug target database

More...
DrugBanki
DB05005 CCX282

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
66

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCR9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
114152781

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000692911 – 369C-C chemokine receptor type 9Add BLAST369

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi32N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi38 ↔ 2891 Publication
Disulfide bondi119 ↔ 198PROSITE-ProRule annotationCombined sources1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P51686

PeptideAtlas

More...
PeptideAtlasi
P51686

PRoteomics IDEntifications database

More...
PRIDEi
P51686

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56370
56371 [P51686-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P51686

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P51686

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the thymus and low in lymph nodes and spleen.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000173585 Expressed in 65 organ(s), highest expression level in thymus

CleanEx database of gene expression profiles

More...
CleanExi
HS_CCR9

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P51686 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P51686 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB006839

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-5884N

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000350256

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P51686

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1369
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P51686

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P51686

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3656 Eukaryota
ENOG410XRW9 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154012

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234122

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106917

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P51686

KEGG Orthology (KO)

More...
KOi
K04184

Identification of Orthologs from Complete Genome Data

More...
OMAi
TICTMVY

Database of Orthologous Groups

More...
OrthoDBi
EOG091G093O

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P51686

TreeFam database of animal gene trees

More...
TreeFami
TF330966

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004069 Chemokine_CCR9
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00657 CCCHEMOKINER
PR01531 CHEMOKINER9
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P51686-1) [UniParc]FASTAAdd to basket
Also known as: CCR9A

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTPTDFTSPI PNMADDYGSE STSSMEDYVN FNFTDFYCEK NNVRQFASHF
60 70 80 90 100
LPPLYWLVFI VGALGNSLVI LVYWYCTRVK TMTDMFLLNL AIADLLFLVT
110 120 130 140 150
LPFWAIAAAD QWKFQTFMCK VVNSMYKMNF YSCVLLIMCI SVDRYIAIAQ
160 170 180 190 200
AMRAHTWREK RLLYSKMVCF TIWVLAAALC IPEILYSQIK EESGIAICTM
210 220 230 240 250
VYPSDESTKL KSAVLTLKVI LGFFLPFVVM ACCYTIIIHT LIQAKKSSKH
260 270 280 290 300
KALKVTITVL TVFVLSQFPY NCILLVQTID AYAMFISNCA VSTNIDICFQ
310 320 330 340 350
VTQTIAFFHS CLNPVLYVFV GERFRRDLVK TLKNLGCISQ AQWVSFTRRE
360
GSLKLSSMLL ETTSGALSL
Length:369
Mass (Da):42,016
Last modified:September 5, 2006 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF27CEA0CFB66B44C
GO
Isoform 2 (identifier: P51686-2) [UniParc]FASTAAdd to basket
Also known as: CCR9B

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: Missing.

Show »
Length:357
Mass (Da):40,713
Checksum:i96982E0B922F6B31
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JWC0C9JWC0_HUMAN
C-C chemokine receptor type 9
CCR9
107Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH95516 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_02920892I → V. Corresponds to variant dbSNP:rs45530037Ensembl.1
Natural variantiVAR_020068284M → V. Corresponds to variant dbSNP:rs12721497Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0202861 – 12Missing in isoform 2. 3 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ132337 mRNA Translation: CAB43477.1
AF145439 mRNA Translation: AAF66699.1
AF145440 mRNA Translation: AAF66700.1
U45982 Genomic DNA Translation: AAA93319.1
AY242127 Genomic DNA Translation: AAO92294.1
BC069678 mRNA Translation: AAH69678.1
BC095516 mRNA Translation: AAH95516.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2732.1 [P51686-1]
CCDS2733.1 [P51686-2]

NCBI Reference Sequences

More...
RefSeqi
NP_001243298.1, NM_001256369.1 [P51686-2]
NP_006632.2, NM_006641.3 [P51686-2]
NP_112477.1, NM_031200.2 [P51686-1]
XP_011531614.1, XM_011533312.2 [P51686-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.225946

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000355983; ENSP00000348260; ENSG00000173585 [P51686-2]
ENST00000357632; ENSP00000350256; ENSG00000173585 [P51686-1]
ENST00000395963; ENSP00000379292; ENSG00000173585 [P51686-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
10803

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:10803

UCSC genome browser

More...
UCSCi
uc003coz.3 human [P51686-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CC chemokine receptors entry

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ132337 mRNA Translation: CAB43477.1
AF145439 mRNA Translation: AAF66699.1
AF145440 mRNA Translation: AAF66700.1
U45982 Genomic DNA Translation: AAA93319.1
AY242127 Genomic DNA Translation: AAO92294.1
BC069678 mRNA Translation: AAH69678.1
BC095516 mRNA Translation: AAH95516.1 Different initiation.
CCDSiCCDS2732.1 [P51686-1]
CCDS2733.1 [P51686-2]
RefSeqiNP_001243298.1, NM_001256369.1 [P51686-2]
NP_006632.2, NM_006641.3 [P51686-2]
NP_112477.1, NM_031200.2 [P51686-1]
XP_011531614.1, XM_011533312.2 [P51686-1]
UniGeneiHs.225946

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5LWEX-ray2.80A/B24-341[»]
ProteinModelPortaliP51686
SMRiP51686
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5884N
STRINGi9606.ENSP00000350256

Chemistry databases

BindingDBiP51686
ChEMBLiCHEMBL5815
DrugBankiDB05005 CCX282
GuidetoPHARMACOLOGYi66

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP51686
PhosphoSitePlusiP51686

Polymorphism and mutation databases

BioMutaiCCR9
DMDMi114152781

Proteomic databases

PaxDbiP51686
PeptideAtlasiP51686
PRIDEiP51686
ProteomicsDBi56370
56371 [P51686-2]

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
10803
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355983; ENSP00000348260; ENSG00000173585 [P51686-2]
ENST00000357632; ENSP00000350256; ENSG00000173585 [P51686-1]
ENST00000395963; ENSP00000379292; ENSG00000173585 [P51686-2]
GeneIDi10803
KEGGihsa:10803
UCSCiuc003coz.3 human [P51686-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10803
DisGeNETi10803
EuPathDBiHostDB:ENSG00000173585.15

GeneCards: human genes, protein and diseases

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GeneCardsi
CCR9
HGNCiHGNC:1610 CCR9
HPAiCAB006839
MIMi604738 gene
neXtProtiNX_P51686
OpenTargetsiENSG00000173585
PharmGKBiPA26174

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00940000154012
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP51686
KOiK04184
OMAiTICTMVY
OrthoDBiEOG091G093O
PhylomeDBiP51686
TreeFamiTF330966

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
SIGNORiP51686

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
CCR9

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
10803

Protein Ontology

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PROi
PR:P51686

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000173585 Expressed in 65 organ(s), highest expression level in thymus
CleanExiHS_CCR9
ExpressionAtlasiP51686 baseline and differential
GenevisibleiP51686 HS

Family and domain databases

InterProiView protein in InterPro
IPR004069 Chemokine_CCR9
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01531 CHEMOKINER9
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCR9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51686
Secondary accession number(s): Q4VBM3, Q549E0, Q9UQQ6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: September 5, 2006
Last modified: December 5, 2018
This is version 161 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  5. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  8. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
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