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Entry version 158 (13 Feb 2019)
Sequence version 1 (01 Oct 1996)
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Protein

C-C chemokine receptor type 8

Gene

CCR8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the chemokine CCL1/SCYA1/I-309. May regulate monocyte chemotaxis and thymic cell line apoptosis. Alternative coreceptor with CD4 for HIV-1 infection.4 Publications

Caution

Was originally thought to be a receptor for SCYA3 and SCYA17.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • C-C chemokine binding Source: GO_Central
  • C-C chemokine receptor activity Source: GO_Central
  • chemokine binding Source: GO_Central
  • chemokine receptor activity Source: ProtInc
  • coreceptor activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P51685

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-C chemokine receptor type 8
Short name:
C-C CKR-8
Short name:
CC-CKR-8
Short name:
CCR-8
Alternative name(s):
CC chemokine receptor CHEMR1
CMKBRL2
Chemokine receptor-like 1
Short name:
CKR-L1
GPR-CY6
Short name:
GPRCY6
TER1
CD_antigen: CDw198
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCR8
Synonyms:CKRL1, CMKBR8, CMKBRL2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000179934.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:1609 CCR8

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601834 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P51685

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei36 – 63Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini64 – 73CytoplasmicSequence analysis10
Transmembranei74 – 93Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini94 – 107ExtracellularSequence analysisAdd BLAST14
Transmembranei108 – 129Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini130 – 146CytoplasmicSequence analysisAdd BLAST17
Transmembranei147 – 171Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini172 – 202ExtracellularSequence analysisAdd BLAST31
Transmembranei203 – 222Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini223 – 238CytoplasmicSequence analysisAdd BLAST16
Transmembranei239 – 263Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini264 – 280ExtracellularSequence analysisAdd BLAST17
Transmembranei281 – 304Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini305 – 355CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
1237

Open Targets

More...
OpenTargetsi
ENSG00000179934

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA26173

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4596

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
65

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCR8

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1707884

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000692881 – 355C-C chemokine receptor type 8Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P51685

PeptideAtlas

More...
PeptideAtlasi
P51685

PRoteomics IDEntifications database

More...
PRIDEi
P51685

ProteomicsDB human proteome resource

More...
ProteomicsDBi
56369

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P51685

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P51685

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000179934 Expressed in 18 organ(s), highest expression level in leukocyte

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P51685 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P51685 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA042383

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-5836N

Protein interaction database and analysis system

More...
IntActi
P51685, 13 interactors

Molecular INTeraction database

More...
MINTi
P51685

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000326432

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P51685

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P51685

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P51685

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IJ9D Eukaryota
ENOG410YUBT LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153388

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234122

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG106917

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P51685

KEGG Orthology (KO)

More...
KOi
K04183

Identification of Orthologs from Complete Genome Data

More...
OMAi
MFFITLM

Database of Orthologous Groups

More...
OrthoDBi
900867at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P51685

TreeFam database of animal gene trees

More...
TreeFami
TF330966

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004068 Chemokine_CCR8
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00657 CCCHEMOKINER
PR01530 CHEMOKINER8
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: P51685-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDYTLDLSVT TVTDYYYPDI FSSPCDAELI QTNGKLLLAV FYCLLFVFSL
60 70 80 90 100
LGNSLVILVL VVCKKLRSIT DVYLLNLALS DLLFVFSFPF QTYYLLDQWV
110 120 130 140 150
FGTVMCKVVS GFYYIGFYSS MFFITLMSVD RYLAVVHAVY ALKVRTIRMG
160 170 180 190 200
TTLCLAVWLT AIMATIPLLV FYQVASEDGV LQCYSFYNQQ TLKWKIFTNF
210 220 230 240 250
KMNILGLLIP FTIFMFCYIK ILHQLKRCQN HNKTKAIRLV LIVVIASLLF
260 270 280 290 300
WVPFNVVLFL TSLHSMHILD GCSISQQLTY ATHVTEIISF THCCVNPVIY
310 320 330 340 350
AFVGEKFKKH LSEIFQKSCS QIFNYLGRQM PRESCEKSSS CQQHSSRSSS

VDYIL
Length:355
Mass (Da):40,844
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBC14A153CF695361
GO
Isoform 2 (identifier: P51685-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: MDYTLDLSVT...LLFVFSFPFQ → MRNLFRQM

Note: No experimental confirmation available.
Show »
Length:272
Mass (Da):31,622
Checksum:i1A78F1429FE3A4A3
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
C9JIP9C9JIP9_HUMAN
C-C chemokine receptor type 8
CCR8
118Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_04938427A → G1 PublicationCorresponds to variant dbSNP:rs2853699Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0563401 – 91MDYTL…SFPFQ → MRNLFRQM in isoform 2. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z79782 Genomic DNA Translation: CAB02142.1
Y08456 Genomic DNA Translation: CAA69712.1
U45983 Genomic DNA Translation: AAB61962.1
AF005210 mRNA Translation: AAB62547.1
U62556 Genomic DNA Translation: AAB05542.1
D49919 mRNA Translation: BAA23387.1
AY016370 Genomic DNA Translation: AAK08628.1
AK314957 mRNA Translation: BAG37461.1
AC104850 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64577.1
BC069067 mRNA Translation: AAH69067.1
BC074743 mRNA Translation: AAH74743.1
BC107152 mRNA Translation: AAI07153.1
BC107159 mRNA Translation: AAI07160.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS2684.1 [P51685-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
JC5067

NCBI Reference Sequences

More...
RefSeqi
NP_005192.1, NM_005201.3 [P51685-1]

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.113222

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000326306; ENSP00000326432; ENSG00000179934 [P51685-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
1237

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:1237

UCSC genome browser

More...
UCSCi
uc010hhr.3 human [P51685-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z79782 Genomic DNA Translation: CAB02142.1
Y08456 Genomic DNA Translation: CAA69712.1
U45983 Genomic DNA Translation: AAB61962.1
AF005210 mRNA Translation: AAB62547.1
U62556 Genomic DNA Translation: AAB05542.1
D49919 mRNA Translation: BAA23387.1
AY016370 Genomic DNA Translation: AAK08628.1
AK314957 mRNA Translation: BAG37461.1
AC104850 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64577.1
BC069067 mRNA Translation: AAH69067.1
BC074743 mRNA Translation: AAH74743.1
BC107152 mRNA Translation: AAI07153.1
BC107159 mRNA Translation: AAI07160.1
CCDSiCCDS2684.1 [P51685-1]
PIRiJC5067
RefSeqiNP_005192.1, NM_005201.3 [P51685-1]
UniGeneiHs.113222

3D structure databases

ProteinModelPortaliP51685
SMRiP51685
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5836N
IntActiP51685, 13 interactors
MINTiP51685
STRINGi9606.ENSP00000326432

Chemistry databases

BindingDBiP51685
ChEMBLiCHEMBL4596
GuidetoPHARMACOLOGYi65

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP51685
PhosphoSitePlusiP51685

Polymorphism and mutation databases

BioMutaiCCR8
DMDMi1707884

Proteomic databases

PaxDbiP51685
PeptideAtlasiP51685
PRIDEiP51685
ProteomicsDBi56369

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
1237
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000326306; ENSP00000326432; ENSG00000179934 [P51685-1]
GeneIDi1237
KEGGihsa:1237
UCSCiuc010hhr.3 human [P51685-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
1237
DisGeNETi1237
EuPathDBiHostDB:ENSG00000179934.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCR8
HGNCiHGNC:1609 CCR8
HPAiHPA042383
MIMi601834 gene
neXtProtiNX_P51685
OpenTargetsiENSG00000179934
PharmGKBiPA26173

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IJ9D Eukaryota
ENOG410YUBT LUCA
GeneTreeiENSGT00940000153388
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP51685
KOiK04183
OMAiMFFITLM
OrthoDBi900867at2759
PhylomeDBiP51685
TreeFamiTF330966

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
SIGNORiP51685

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
CCR8_(gene)

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
1237

Protein Ontology

More...
PROi
PR:P51685

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000179934 Expressed in 18 organ(s), highest expression level in leukocyte
ExpressionAtlasiP51685 baseline and differential
GenevisibleiP51685 HS

Family and domain databases

InterProiView protein in InterPro
IPR004068 Chemokine_CCR8
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01530 CHEMOKINER8
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCR8_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51685
Secondary accession number(s): B2RC64
, Q3KNQ8, Q3KNR3, Q9BYX5
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 13, 2019
This is version 158 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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