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UniProtKB - P51684 (CCR6_HUMAN)

Entry version 184 (13 Feb 2019)
Sequence version 2 (15 Jul 1998)
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Protein

C-C chemokine receptor type 6

Gene

CCR6

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for the C-C type chemokine CCL20 (PubMed:9169459). Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels (PubMed:20068036). Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins (PubMed:25585877). Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity (PubMed:25122636). Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects (PubMed:20068036). The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma (PubMed:21376174). CCR6 is essential for the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for the normal migration of Th17 cells in Peyers-patches and other related tissue sites of the intestine and plays a role in regulating effector T-cell balance and distribution in inflamed intestine. Plays an important role in the coordination of early thymocyte precursor migration events important for normal subsequent thymocyte precursor development, but is not required for the formation of normal thymic natural regulatory T-cells (nTregs). Required for optimal differentiation of DN2 and DN3 thymocyte precursors. Essential for B-cell localization in the subepithelial dome of Peyers-patches and for efficient B-cell isotype switching to IgA in the Peyers-patches. Essential for appropriate anatomical distribution of memory B-cells in the spleen and for the secondary recall response of memory B-cells (By similarity). Positively regulates sperm motility and chemotaxis via its binding to CCL20 (PubMed:23765988).2 PublicationsBy similarity4 Publications

Caution

It is uncertain whether Met-1 or Met-6 is the initiator.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • C-C chemokine binding Source: UniProtKB
  • C-C chemokine receptor activity Source: UniProtKB
  • chemokine binding Source: GO_Central
  • chemokine receptor activity Source: ProtInc
  • signaling receptor activity Source: ProtInc
View the complete GO annotation on QuickGO ...

GO - Biological processi

View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1461957 Beta defensins
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C-C chemokine receptor type 6
Short name:
C-C CKR-6
Short name:
CC-CKR-6
Short name:
CCR-6
Alternative name(s):
Chemokine receptor-like 3
Short name:
CKR-L3
DRY6
G-protein coupled receptor 29
GPR-CY4
Short name:
GPRCY4
LARC receptor
CD_antigen: CD196
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCR6
Synonyms:CKRL3, CMKBR6, GPR29, STRL22
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		HostDB:ENSG00000112486.14

Human Gene Nomenclature Database

More...HGNCi		HGNC:1607 CCR6

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601835 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P51684

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 47ExtracellularSequence analysisAdd BLAST47
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei48 – 74Helical; Name=1Sequence analysisAdd BLAST27
Topological domaini75 – 83CytoplasmicSequence analysis9
Transmembranei84 – 104Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini105 – 119ExtracellularSequence analysisAdd BLAST15
Transmembranei120 – 141Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini142 – 159CytoplasmicSequence analysisAdd BLAST18
Transmembranei160 – 180Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini181 – 211ExtracellularSequence analysisAdd BLAST31
Transmembranei212 – 238Helical; Name=5Sequence analysisAdd BLAST27
Topological domaini239 – 254CytoplasmicSequence analysisAdd BLAST16
Transmembranei255 – 279Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini280 – 303ExtracellularSequence analysisAdd BLAST24
Transmembranei304 – 321Helical; Name=7Sequence analysisAdd BLAST18
Topological domaini322 – 374CytoplasmicSequence analysisAdd BLAST53

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi36C → A: No loss of calcium flux but loss of chemotaxis in response to CCL20 stimulation. No effect on cell surface expression. 1 Publication1
Mutagenesisi36C → D or G: Loss of calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression. 1 Publication1
Mutagenesisi36C → S: No loss of calcium flux but loss of chemotaxis in response to CCL20 stimulation, impaired CCL20-binding and no effect on cell surface expression; when associated with or without S-288. Loss of calcium flux in response to CCL20 stimulation and significant reduction in cell surface expression; when associated with S-118; S-197 and S-288. 1 Publication1
Mutagenesisi57C → S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression. 1 Publication1
Mutagenesisi118C → S: Loss of calcium flux and chemotaxis in response to CCL20 stimulation, impaired CCL20-binding and significant reduction in cell surface expression; when associated with or without S-197. Loss of calcium flux in response to CCL20 stimulation and significant reduction in cell surface expression; when associated with S-36; S-197 and S-288. 1 Publication1
Mutagenesisi131C → S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression. 1 Publication1
Mutagenesisi138C → S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression. 1 Publication1
Mutagenesisi168C → S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression. 1 Publication1
Mutagenesisi197C → S: Loss of calcium flux and chemotaxis in response to CCL20 stimulation, impaired CCL20-binding and significant reduction in cell surface expression; when associated with or without S-118. Loss of calcium flux in response to CCL20 stimulation and significant reduction in cell surface expression; when associated with S-36; S-118 and S-288. 1 Publication1
Mutagenesisi233C → S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression. 1 Publication1
Mutagenesisi266C → S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression. 1 Publication1
Mutagenesisi288C → A, G or R: No loss of calcium flux but loss of chemotaxis in response to CCL20 stimulation. No effect on cell surface expression. 1 Publication1
Mutagenesisi288C → S: No loss of calcium flux but loss of chemotaxis in response to CCL20 stimulation, impaired CCL20-binding and no effect on cell surface expression; when associated with or without S-36. Loss of calcium flux in response to CCL20 stimulation and significant reduction in cell surface expression; when associated with S-36; S-118 and S-197. 1 Publication1
Mutagenesisi309C → S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression. 1 Publication1
Mutagenesisi310C → S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on cell surface expression. 1 Publication1
Mutagenesisi336C → S: Reduced calcium flux and chemotaxis in response to CCL20 stimulation, and reduced CCL20-binding. No effect on cell surface expression. 1 Publication1
Mutagenesisi348C → S: No effect on calcium flux and chemotaxis in response to CCL20 stimulation. No effect on CCL20-binding and cell surface expression. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		1235

MalaCards human disease database

More...MalaCardsi		CCR6

Open Targets

More...OpenTargetsi		ENSG00000112486

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		220393 Diffuse cutaneous systemic sclerosis
220402 Limited cutaneous systemic sclerosis

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA26171

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL4423

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		63

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		CCR6

Domain mapping of disease mutations (DMDM)

More...DMDMi		2851567

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000692861 – 374C-C chemokine receptor type 6Add BLAST374

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi7N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi23N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi118 ↔ 1971 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P51684

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P51684

PeptideAtlas

More...PeptideAtlasi		P51684

PRoteomics IDEntifications database

More...PRIDEi		P51684

ProteomicsDB human proteome resource

More...ProteomicsDBi		56368

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P51684

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P51684

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Sperm. Mainly localized in the tail and in the postacrosomal region but is also found in the midpiece and basal region in a small percentage of sperm cells. Reduced levels found in the sperms of asthenozoospermia and leukocytospermia patients (at protein level). Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.3 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

By IL2/interleukin-2.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000112486 Expressed in 57 organ(s), highest expression level in leukocyte

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P51684 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P51684 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		CAB006820
HPA014488

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		107640, 70 interactors

Database of interacting proteins

More...DIPi		DIP-5865N

Protein interaction database and analysis system

More...IntActi		P51684, 1 interactor

Molecular INTeraction database

More...MINTi		P51684

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000339393

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P51684

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		P51684

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG410IKPR Eukaryota
ENOG410XSP7 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153132

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000234122

The HOVERGEN Database of Homologous Vertebrate Genes

More...HOVERGENi		HBG106917

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P51684

KEGG Orthology (KO)

More...KOi		K04181

Identification of Orthologs from Complete Genome Data

More...OMAi		IMKDLWC

Database of Orthologous Groups

More...OrthoDBi		981680at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P51684

TreeFam database of animal gene trees

More...TreeFami		TF330966

Family and domain databases

Conserved Domains Database

More...CDDi		cd15172 7tmA_CCR6, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR004067 Chemokine_CCR6
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM

The PANTHER Classification System

More...PANTHERi		PTHR10489:SF611 PTHR10489:SF611, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00657 CCCHEMOKINER
PR01529 CHEMOKINER6
PR00237 GPCRRHODOPSN

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P51684-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGESMNFSD VFDSSEDYFV SVNTSYYSVD SEMLLCSLQE VRQFSRLFVP 
        60         70         80         90        100
IAYSLICVFG LLGNILVVIT FAFYKKARSM TDVYLLNMAI ADILFVLTLP 
       110        120        130        140        150
FWAVSHATGA WVFSNATCKL LKGIYAINFN CGMLLLTCIS MDRYIAIVQA 
       160        170        180        190        200
TKSFRLRSRT LPRSKIICLV VWGLSVIISS STFVFNQKYN TQGSDVCEPK 
       210        220        230        240        250
YQTVSEPIRW KLLMLGLELL FGFFIPLMFM IFCYTFIVKT LVQAQNSKRH 
       260        270        280        290        300
KAIRVIIAVV LVFLACQIPH NMVLLVTAAN LGKMNRSCQS EKLIGYTKTV 
       310        320        330        340        350
TEVLAFLHCC LNPVLYAFIG QKFRNYFLKI LKDLWCVRRK YKSSGFSCAG 
       360        370 
RYSENISRQT SETADNDNAS SFTM
Length:374
Mass (Da):42,494
Last modified:July 15, 1998 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD7F963534E990BC4
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2R8YFT5A0A2R8YFT5_HUMAN
C-C chemokine receptor type 6
CCR6
155Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAB02144 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti60G → A in AAB06949 (Ref. 4) Curated1
Sequence conflicti74Y → N in AAB06949 (Ref. 4) Curated1
Sequence conflicti86L → V in AAB06949 (Ref. 4) Curated1
Sequence conflicti164S → T in AAC51124 (PubMed:9070937).Curated1
Sequence conflicti164S → T in AAC51125 (PubMed:9070937).Curated1
Sequence conflicti182T → S in AAB06949 (Ref. 4) Curated1
Sequence conflicti192Q → L in AAB06949 (Ref. 4) Curated1
Sequence conflicti206E → V in AAB06949 (Ref. 4) Curated1
Sequence conflicti225I → F in AAB06949 (Ref. 4) Curated1
Sequence conflicti370 – 374SSFTM → VVLHYVIES in AAB06949 (Ref. 4) Curated5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U45984 Genomic DNA Translation: AAB62714.1
Z79784 Genomic DNA Translation: CAB02144.1 Different initiation.
U60000 mRNA Translation: AAB06949.1
U68030 mRNA Translation: AAC51124.1
U68032 Genomic DNA Translation: AAC51125.1
AY242126 mRNA Translation: AAO92293.1
AL121935 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47506.1
CH471051 Genomic DNA Translation: EAW47507.1
BC037960 mRNA Translation: AAH37960.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS5298.1

Protein sequence database of the Protein Information Resource

More...PIRi		JC5068

NCBI Reference Sequences

More...RefSeqi		NP_004358.2, NM_004367.5
NP_113597.2, NM_031409.3

UniGene gene-oriented nucleotide sequence clusters

More...UniGenei		Hs.46468

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000341935; ENSP00000343952; ENSG00000112486
ENST00000349984; ENSP00000339393; ENSG00000112486
ENST00000400926; ENSP00000383715; ENSG00000112486
ENST00000643861; ENSP00000493637; ENSG00000112486

Database of genes from NCBI RefSeq genomes

More...GeneIDi		1235

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:1235

UCSC genome browser

More...UCSCi		uc003qvm.5 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U45984 Genomic DNA Translation: AAB62714.1
Z79784 Genomic DNA Translation: CAB02144.1 Different initiation.
U60000 mRNA Translation: AAB06949.1
U68030 mRNA Translation: AAC51124.1
U68032 Genomic DNA Translation: AAC51125.1
AY242126 mRNA Translation: AAO92293.1
AL121935 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW47506.1
CH471051 Genomic DNA Translation: EAW47507.1
BC037960 mRNA Translation: AAH37960.1
CCDSiCCDS5298.1
PIRiJC5068
RefSeqiNP_004358.2, NM_004367.5
NP_113597.2, NM_031409.3
UniGeneiHs.46468

3D structure databases

ProteinModelPortaliP51684
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107640, 70 interactors
DIPiDIP-5865N
IntActiP51684, 1 interactor
MINTiP51684
STRINGi9606.ENSP00000339393

Chemistry databases

BindingDBiP51684
ChEMBLiCHEMBL4423
GuidetoPHARMACOLOGYi63

Protein family/group databases

Information system for G protein-coupled receptors (GPCRs)

More...GPCRDBi		Search...

PTM databases

iPTMnetiP51684
PhosphoSitePlusiP51684

Polymorphism and mutation databases

BioMutaiCCR6
DMDMi2851567

Proteomic databases

jPOSTiP51684
PaxDbiP51684
PeptideAtlasiP51684
PRIDEiP51684
ProteomicsDBi56368

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		1235
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000341935; ENSP00000343952; ENSG00000112486
ENST00000349984; ENSP00000339393; ENSG00000112486
ENST00000400926; ENSP00000383715; ENSG00000112486
ENST00000643861; ENSP00000493637; ENSG00000112486
GeneIDi1235
KEGGihsa:1235
UCSCiuc003qvm.5 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1235
DisGeNETi1235
EuPathDBiHostDB:ENSG00000112486.14

GeneCards: human genes, protein and diseases

More...GeneCardsi		CCR6
HGNCiHGNC:1607 CCR6
HPAiCAB006820
HPA014488
MalaCardsiCCR6
MIMi601835 gene
neXtProtiNX_P51684
OpenTargetsiENSG00000112486
Orphaneti220393 Diffuse cutaneous systemic sclerosis
220402 Limited cutaneous systemic sclerosis
PharmGKBiPA26171

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG410IKPR Eukaryota
ENOG410XSP7 LUCA
GeneTreeiENSGT00940000153132
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP51684
KOiK04181
OMAiIMKDLWC
OrthoDBi981680at2759
PhylomeDBiP51684
TreeFamiTF330966

Enzyme and pathway databases

ReactomeiR-HSA-1461957 Beta defensins
R-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		CCR6 human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		C-C_chemokine_receptor_type_6

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		1235

Protein Ontology

More...PROi		PR:P51684

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000112486 Expressed in 57 organ(s), highest expression level in leukocyte
ExpressionAtlasiP51684 baseline and differential
GenevisibleiP51684 HS

Family and domain databases

CDDicd15172 7tmA_CCR6, 1 hit
InterProiView protein in InterPro
IPR004067 Chemokine_CCR6
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR10489:SF611 PTHR10489:SF611, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01529 CHEMOKINER6
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCCR6_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51684
Secondary accession number(s): E1P5C6, P78553, Q92846
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 15, 1998
Last modified: February 13, 2019
This is version 184 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. SIMILARITY comments
    Index of protein domains and families
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  5. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
UniProt is an ELIXIR core data resource
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