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Protein

C-C chemokine receptor type 5

Gene

Ccr5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity).By similarity

GO - Molecular functioni

  • actin binding Source: MGI
  • C-C chemokine binding Source: BHF-UCL
  • C-C chemokine receptor activity Source: MGI
  • chemokine (C-C motif) ligand 5 binding Source: MGI
  • protein kinase binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 5
Short name:
C-C CKR-5
Short name:
CC-CKR-5
Short name:
CCR-5
Alternative name(s):
MIP-1 alpha receptor
CD_antigen: CD195
Gene namesi
Name:Ccr5
Synonyms:Cmkbr5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107182 Ccr5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 32ExtracellularSequence analysisAdd BLAST32
Transmembranei33 – 60Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini61 – 70CytoplasmicSequence analysis10
Transmembranei71 – 91Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini92 – 104ExtracellularSequence analysisAdd BLAST13
Transmembranei105 – 126Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini127 – 143CytoplasmicSequence analysisAdd BLAST17
Transmembranei144 – 168Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini169 – 200ExtracellularSequence analysisAdd BLAST32
Transmembranei201 – 220Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini221 – 237CytoplasmicSequence analysisAdd BLAST17
Transmembranei238 – 262Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini263 – 279ExtracellularSequence analysisAdd BLAST17
Transmembranei280 – 303Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini304 – 354CytoplasmicSequence analysisAdd BLAST51

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3676

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692691 – 354C-C chemokine receptor type 5Add BLAST354

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6O-linked (GalNAc...) serineBy similarity1
Modified residuei10SulfotyrosineSequence analysis1
Modified residuei12SulfotyrosineSequence analysis1
Modified residuei16SulfotyrosineSequence analysis1
Disulfide bondi22 ↔ 271By similarity
Disulfide bondi103 ↔ 180PROSITE-ProRule annotation
Lipidationi323S-palmitoyl cysteineBy similarity1
Lipidationi326S-palmitoyl cysteineBy similarity1
Modified residuei338Phosphoserine; by BARK1By similarity1
Modified residuei339Phosphoserine; by BARK1By similarity1
Modified residuei344Phosphoserine; by BARK1By similarity1
Modified residuei351Phosphoserine; by BARK1By similarity1

Post-translational modificationi

Sulfated on at least 2 of the N-terminal tyrosines. Sulfation is required for efficient binding of the chemokines, CCL3 and CCL4 (By similarity).By similarity
O-glycosylated, but not N-glycosylated. Ser-6 appears to be the major site. Also sialylated glycans present which contribute to chemokine binding (By similarity).By similarity
Palmitoylation in the C-terminal is important for cell surface expression.By similarity
Phosphorylation on serine residues in the C-terminal is stimulated by binding CC chemokines especially by APO-RANTES.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, Phosphoprotein, Sulfation

Proteomic databases

EPDiP51682
MaxQBiP51682
PaxDbiP51682
PRIDEiP51682

PTM databases

iPTMnetiP51682
PhosphoSitePlusiP51682

Expressioni

Gene expression databases

BgeeiENSMUSG00000079227 Expressed in 131 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_CCR5
ExpressionAtlasiP51682 baseline and differential
GenevisibleiP51682 MM

Interactioni

Subunit structurei

Interacts with PRAF2. Efficient ligand binding to CCL3/MIP-1alpha and CCL4/MIP-1beta requires sulfation, O-glycosylation and sialic acid modifications. Glycosylation on Ser-6 is required for efficient binding of CCL4. Interacts with GRK2. Interacts with ARRB1 and ARRB2. Interacts with CNIH4.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP51682, 4 interactors
STRINGi10090.ENSMUSP00000107069

Chemistry databases

BindingDBiP51682

Structurei

3D structure databases

ProteinModelPortaliP51682
SMRiP51682
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118785
HOVERGENiHBG106917
InParanoidiP51682
KOiK04180
OMAiFGNTMCQ
OrthoDBiEOG091G0B7A
TreeFamiTF330966

Family and domain databases

InterProiView protein in InterPro
IPR002240 Chemokine_CCR5
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01110 CHEMOKINER5
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

P51682-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDFQGSVPTY SYDIDYGMSA PCQKINVKQI AAQLLPPLYS LVFIFGFVGN
60 70 80 90 100
MMVFLILISC KKLKSVTDIY LLNLAISDLL FLLTLPFWAH YAANEWVFGN
110 120 130 140 150
IMCKVFTGLY HIGYFGGIFF IILLTIDRYL AIVHAVFALK VRTVNFGVIT
160 170 180 190 200
SVVTWAVAVF ASLPEIIFTR SQKEGFHYTC SPHFPHTQYH FWKSFQTLKM
210 220 230 240 250
VILSLILPLL VMVICYSGIL HTLFRCRNEK KRHRAVRLIF AIMIVYFLFW
260 270 280 290 300
TPYNIVLLLT TFQEFFGLNN CSSSNRLDQA MQATETLGMT HCCLNPVIYA
310 320 330 340 350
FVGEKFRSYL SVFFRKHMVK RFCKRCSIFQ QDNPDRASSV YTRSTGEHEV

STGL
Length:354
Mass (Da):40,785
Last modified:July 27, 2011 - v3
Checksum:iD91F50EC9C956795
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q3E5E9Q3E5_MOUSE
C-C chemokine receptor type 5
Ccr5
123Annotation score:
E9Q351E9Q351_MOUSE
C-C chemokine receptor type 5
Ccr5
54Annotation score:
A0A1L1SS26A0A1L1SS26_MOUSE
C-C chemokine receptor type 5
Ccr5
15Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3F → L in CAA63867 (PubMed:8662890).Curated1
Sequence conflicti62K → R in AAC53386 (PubMed:9343222).Curated1
Sequence conflicti66V → M in AAC53386 (PubMed:9343222).Curated1
Sequence conflicti80L → F in CAA63867 (PubMed:8662890).Curated1
Sequence conflicti145N → I in AAB71183 (PubMed:9261347).Curated1
Sequence conflicti160F → S in AAC53386 (PubMed:9343222).Curated1
Sequence conflicti185P → L in AAC53386 (PubMed:9343222).Curated1
Sequence conflicti190H → Y in AAB37273 (Ref. 3) Curated1
Sequence conflicti208P → S in AAC52454 (PubMed:8631787).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti11S → I. 1
Natural varianti97V → I. 1
Natural varianti109L → V. 1
Natural varianti156A → V. 1
Natural varianti213V → I. 1
Natural varianti318M → I. 1
Natural varianti337A → V. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47036 mRNA Translation: AAC52454.1
X94151 mRNA Translation: CAA63867.1
U68565 Genomic DNA Translation: AAB37273.1
U83327 Genomic DNA Translation: AAC53386.1
AF022990 Genomic DNA Translation: AAC53389.1
AF019772 Genomic DNA Translation: AAB71183.1
D83648 mRNA Translation: BAA12024.1
AK141906 mRNA Translation: BAE24879.1
AK154595 mRNA Translation: BAE32698.1
AK155628 mRNA Translation: BAE33354.1
AK155867 mRNA Translation: BAE33471.1
CH466671 Genomic DNA Translation: EDL37177.1
BC103574 mRNA Translation: AAI03575.1
BC103586 mRNA Translation: AAI03587.1
BC103587 mRNA Translation: AAI03588.1
CCDSiCCDS40821.1
RefSeqiNP_034047.2, NM_009917.5
UniGeneiMm.14302

Genome annotation databases

EnsembliENSMUST00000111442; ENSMUSP00000107069; ENSMUSG00000079227
GeneIDi12774
KEGGimmu:12774
UCSCiuc009shd.2 mouse

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47036 mRNA Translation: AAC52454.1
X94151 mRNA Translation: CAA63867.1
U68565 Genomic DNA Translation: AAB37273.1
U83327 Genomic DNA Translation: AAC53386.1
AF022990 Genomic DNA Translation: AAC53389.1
AF019772 Genomic DNA Translation: AAB71183.1
D83648 mRNA Translation: BAA12024.1
AK141906 mRNA Translation: BAE24879.1
AK154595 mRNA Translation: BAE32698.1
AK155628 mRNA Translation: BAE33354.1
AK155867 mRNA Translation: BAE33471.1
CH466671 Genomic DNA Translation: EDL37177.1
BC103574 mRNA Translation: AAI03575.1
BC103586 mRNA Translation: AAI03587.1
BC103587 mRNA Translation: AAI03588.1
CCDSiCCDS40821.1
RefSeqiNP_034047.2, NM_009917.5
UniGeneiMm.14302

3D structure databases

ProteinModelPortaliP51682
SMRiP51682
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP51682, 4 interactors
STRINGi10090.ENSMUSP00000107069

Chemistry databases

BindingDBiP51682
ChEMBLiCHEMBL3676

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP51682
PhosphoSitePlusiP51682

Proteomic databases

EPDiP51682
MaxQBiP51682
PaxDbiP51682
PRIDEiP51682

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000111442; ENSMUSP00000107069; ENSMUSG00000079227
GeneIDi12774
KEGGimmu:12774
UCSCiuc009shd.2 mouse

Organism-specific databases

CTDi1234
MGIiMGI:107182 Ccr5

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118785
HOVERGENiHBG106917
InParanoidiP51682
KOiK04180
OMAiFGNTMCQ
OrthoDBiEOG091G0B7A
TreeFamiTF330966

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

PROiPR:P51682
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079227 Expressed in 131 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_CCR5
ExpressionAtlasiP51682 baseline and differential
GenevisibleiP51682 MM

Family and domain databases

InterProiView protein in InterPro
IPR002240 Chemokine_CCR5
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01110 CHEMOKINER5
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCR5_MOUSE
AccessioniPrimary (citable) accession number: P51682
Secondary accession number(s): O35313
, O35891, P97308, P97405, Q3ZAZ8, Q61867
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 157 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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