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Protein

C-C chemokine receptor type 4

Gene

Ccr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival.1 Publication

GO - Molecular functioni

  • C-C chemokine binding Source: GO_Central
  • C-C chemokine receptor activity Source: MGI
  • chemokine binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 4
Short name:
C-C CKR-4
Short name:
CC-CKR-4
Short name:
CCR-4
Short name:
CCR4
Alternative name(s):
CD_antigen: CD194
Gene namesi
Name:Ccr4
Synonyms:Cmkbr4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:107824 Ccr4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 67Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini68 – 77CytoplasmicSequence analysis10
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 111ExtracellularSequence analysisAdd BLAST13
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 150CytoplasmicSequence analysisAdd BLAST17
Transmembranei151 – 175Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini176 – 206ExtracellularSequence analysisAdd BLAST31
Transmembranei207 – 226Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini227 – 242CytoplasmicSequence analysisAdd BLAST16
Transmembranei243 – 267Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini268 – 284ExtracellularSequence analysisAdd BLAST17
Transmembranei285 – 308Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini309 – 360CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5410
GuidetoPHARMACOLOGYi61

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692461 – 360C-C chemokine receptor type 4Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi2N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP51680
PRIDEiP51680

PTM databases

PhosphoSitePlusiP51680

Expressioni

Tissue specificityi

Expressed in the thymus, macrophages and T- and B-cells.

Developmental stagei

Low expression at 7.5 dpc and 12.5 dpc in the yolk sac.

Gene expression databases

BgeeiENSMUSG00000047898 Expressed in 32 organ(s), highest expression level in spinal cord
CleanExiMM_CCR4
ExpressionAtlasiP51680 baseline and differential
GenevisibleiP51680 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiP51680, 3 interactors
STRINGi10090.ENSMUSP00000062677

Chemistry databases

BindingDBiP51680

Structurei

3D structure databases

ProteinModelPortaliP51680
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi343 – 346Poly-Ser4

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150855
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP51680
KOiK04179
OMAiKFRKYIV
OrthoDBiEOG091G0B7A
TreeFamiTF330966

Family and domain databases

InterProiView protein in InterPro
IPR002239 Chemokine_CCR4
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR10489:SF608 PTHR10489:SF608, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01109 CHEMOKINER4
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P51680-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNATEVTDTT QDETVYNSYY FYESMPKPCT KEGIKAFGEV FLPPLYSLVF
60 70 80 90 100
LLGLFGNSVV VLVLFKYKRL KSMTDVYLLN LAISDLLFVL SLPFWGYYAA
110 120 130 140 150
DQWVFGLGLC KIVSWMYLVG FYSGIFFIML MSIDRYLAIV HAVFSLKART
160 170 180 190 200
LTYGVITSLI TWSVAVFASL PGLLFSTCYT EHNHTYCKTQ YSVNSTTWKV
210 220 230 240 250
LSSLEINVLG LLIPLGIMLF CYSMIIRTLQ HCKNEKKNRA VRMIFAVVVL
260 270 280 290 300
FLGFWTPYNV VLFLETLVEL EVLQDCTLER YLDYAIQATE TLAFIHCCLN
310 320 330 340 350
PVIYFFLGEK FRKYITQLFR TCRGPLVLCK HCDFLQVYSA DMSSSSYTQS
360
TVDHDFRDAL
Length:360
Mass (Da):41,408
Last modified:July 27, 2011 - v2
Checksum:i8FA760951BE2002B
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1STS0A0A1L1STS0_MOUSE
C-C chemokine receptor type 4
Ccr4
32Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4T → I in AAA92582 (PubMed:9192769).Curated1
Sequence conflicti145S → T in AAA92582 (PubMed:9192769).Curated1
Sequence conflicti181E → Q in AAA92582 (PubMed:9192769).Curated1
Sequence conflicti205E → D in AAA92582 (PubMed:9192769).Curated1
Sequence conflicti221C → W in CAA62372 (PubMed:8573157).Curated1
Sequence conflicti241V → L in AAA92582 (PubMed:9192769).Curated1
Sequence conflicti246A → G in CAA62372 (PubMed:8573157).Curated1
Sequence conflicti293A → G in CAA62372 (PubMed:8573157).Curated1
Sequence conflicti311F → S in AAA92582 (PubMed:9192769).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90862 mRNA Translation: CAA62372.1
U15208 mRNA Translation: AAA92582.1
CH466587 Genomic DNA Translation: EDL09307.1
CH466587 Genomic DNA Translation: EDL09308.1
BC117041 mRNA Translation: AAI17042.1
BC119171 mRNA Translation: AAI19172.1
CCDSiCCDS23594.1
PIRiJC4587
RefSeqiNP_034046.2, NM_009916.2
XP_006511996.1, XM_006511933.2
XP_006511997.1, XM_006511934.3
XP_011241235.1, XM_011242933.2
UniGeneiMm.1337

Genome annotation databases

EnsembliENSMUST00000054414; ENSMUSP00000062677; ENSMUSG00000047898
ENSMUST00000215425; ENSMUSP00000150002; ENSMUSG00000047898
GeneIDi12773
KEGGimmu:12773
UCSCiuc009rxo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90862 mRNA Translation: CAA62372.1
U15208 mRNA Translation: AAA92582.1
CH466587 Genomic DNA Translation: EDL09307.1
CH466587 Genomic DNA Translation: EDL09308.1
BC117041 mRNA Translation: AAI17042.1
BC119171 mRNA Translation: AAI19172.1
CCDSiCCDS23594.1
PIRiJC4587
RefSeqiNP_034046.2, NM_009916.2
XP_006511996.1, XM_006511933.2
XP_006511997.1, XM_006511934.3
XP_011241235.1, XM_011242933.2
UniGeneiMm.1337

3D structure databases

ProteinModelPortaliP51680
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP51680, 3 interactors
STRINGi10090.ENSMUSP00000062677

Chemistry databases

BindingDBiP51680
ChEMBLiCHEMBL5410
GuidetoPHARMACOLOGYi61

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP51680

Proteomic databases

PaxDbiP51680
PRIDEiP51680

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054414; ENSMUSP00000062677; ENSMUSG00000047898
ENSMUST00000215425; ENSMUSP00000150002; ENSMUSG00000047898
GeneIDi12773
KEGGimmu:12773
UCSCiuc009rxo.2 mouse

Organism-specific databases

CTDi1233
MGIiMGI:107824 Ccr4

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150855
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP51680
KOiK04179
OMAiKFRKYIV
OrthoDBiEOG091G0B7A
TreeFamiTF330966

Enzyme and pathway databases

ReactomeiR-MMU-380108 Chemokine receptors bind chemokines
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

ChiTaRSiNoct mouse
PROiPR:P51680
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000047898 Expressed in 32 organ(s), highest expression level in spinal cord
CleanExiMM_CCR4
ExpressionAtlasiP51680 baseline and differential
GenevisibleiP51680 MM

Family and domain databases

InterProiView protein in InterPro
IPR002239 Chemokine_CCR4
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR10489:SF608 PTHR10489:SF608, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01109 CHEMOKINER4
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCR4_MOUSE
AccessioniPrimary (citable) accession number: P51680
Secondary accession number(s): Q14A03
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: July 27, 2011
Last modified: November 7, 2018
This is version 152 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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