CCR4

Functionⁱ

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.5 Publications

GO - Molecular functionⁱ

C-C chemokine receptor activity Source: Ensembl
chemokine receptor activity
Source: ProtInc
Traceable author statementⁱ
- 7642634

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

chemotaxis
Source: ProtInc
Traceable author statementⁱ
- 7642634
G-protein coupled receptor signaling pathway Source: Reactome
homeostasis of number of cells Source: Ensembl
immune response
Source: ProtInc
Traceable author statementⁱ
- 7642634
inflammatory response
Source: ProtInc
Traceable author statementⁱ
- 7642634
neuron migration Source: Ensembl
positive regulation of cytosolic calcium ion concentration
Source: ProtInc
Traceable author statementⁱ
- 7642634
positive regulation of positive chemotaxis Source: Ensembl
response to antibiotic Source: Ensembl
response to bacterium Source: Ensembl
response to radiation Source: Ensembl
tolerance induction Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	P51679

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: C-C chemokine receptor type 4 Short name: C-C CKR-4 Short name: CC-CKR-4 Short name: CCR-4 Short name: CCR4 Alternative name(s): K5-5 CD_antigen: CD194
Gene namesⁱ	Name:CCR4 Synonyms:CMKBR4
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000183813.6
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1605 CCR4
MIMⁱ	604836 gene
neXtProtⁱ	NX_P51679

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 39	ExtracellularSequence analysisAdd BLAST	39
Transmembraneⁱ	40 – 67	Helical; Name=1Sequence analysisAdd BLAST	28
Topological domainⁱ	68 – 77	CytoplasmicSequence analysis	10
Transmembraneⁱ	78 – 98	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	99 – 111	ExtracellularSequence analysisAdd BLAST	13
Transmembraneⁱ	112 – 133	Helical; Name=3Sequence analysisAdd BLAST	22
Topological domainⁱ	134 – 150	CytoplasmicSequence analysisAdd BLAST	17
Transmembraneⁱ	151 – 175	Helical; Name=4Sequence analysisAdd BLAST	25
Topological domainⁱ	176 – 206	ExtracellularSequence analysisAdd BLAST	31
Transmembraneⁱ	207 – 226	Helical; Name=5Sequence analysisAdd BLAST	20
Topological domainⁱ	227 – 242	CytoplasmicSequence analysisAdd BLAST	16
Transmembraneⁱ	243 – 267	Helical; Name=6Sequence analysisAdd BLAST	25
Topological domainⁱ	268 – 284	ExtracellularSequence analysisAdd BLAST	17
Transmembraneⁱ	285 – 308	Helical; Name=7Sequence analysisAdd BLAST	24
Topological domainⁱ	309 – 360	CytoplasmicSequence analysisAdd BLAST	52

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1233
Open Targets More...OpenTargetsⁱ	ENSG00000183813
PharmGKBⁱ	PA26169

Chemistry databases

ChEMBLⁱ	CHEMBL2414
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	61

Polymorphism and mutation databases

BioMutaⁱ	CCR4
DMDMⁱ	1705894

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000069245	1 – 360	C-C chemokine receptor type 4Add BLAST		360

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	110 ↔ 187	PROSITE-ProRule annotation
Glycosylationⁱ	183	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	194	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.1 Publication

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P51679
PeptideAtlas More...PeptideAtlasⁱ	P51679
PRIDEⁱ	P51679
ProteomicsDBⁱ	56366

PTM databases

iPTMnetⁱ	P51679
PhosphoSitePlusⁱ	P51679

Expressionⁱ

Tissue specificityⁱ

Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000183813 Expressed in 49 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_CCR4
ExpressionAtlasⁱ	P51679 baseline and differential
Genevisibleⁱ	P51679 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA031613

HPAⁱ

HPA031613

Interactionⁱ

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CCL17	Q92583	2	EBI-7847466,EBI-16640146

With

Entry

#Exp.

IntAct

Notes

CCL17

Q92583

2

EBI-7847466,EBI-16640146

Protein-protein interaction databases

BioGridⁱ	107638, 6 interactors
Database of interacting proteins More...DIPⁱ	DIP-5848N
IntActⁱ	P51679, 3 interactors
Molecular INTeraction database More...MINTⁱ	P51679
STRINGⁱ	9606.ENSP00000332659

Chemistry databases

BindingDBⁱ

P51679

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51679
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118785
HOGENOMⁱ	HOG000234122
HOVERGENⁱ	HBG106917
InParanoidⁱ	P51679
KEGG Orthology (KO) More...KOⁱ	K04179
OMAⁱ	FFIMLMS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0B7A
PhylomeDBⁱ	P51679
TreeFamⁱ	TF330966

Family and domain databases

InterProⁱ	View protein in InterPro IPR002239 Chemokine_CCR4 IPR000355 Chemokine_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR10489:SF608 PTHR10489:SF608, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00657 CCCHEMOKINER PR01109 CHEMOKINER4 PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P51679-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNPTDIADTT LDESIYSNYY LYESIPKPCT KEGIKAFGEL FLPPLYSLVF 
        60         70         80         90        100
VFGLLGNSVV VLVLFKYKRL RSMTDVYLLN LAISDLLFVF SLPFWGYYAA 
       110        120        130        140        150
DQWVFGLGLC KMISWMYLVG FYSGIFFVML MSIDRYLAIV HAVFSLRART 
       160        170        180        190        200
LTYGVITSLA TWSVAVFASL PGFLFSTCYT ERNHTYCKTK YSLNSTTWKV 
       210        220        230        240        250
LSSLEINILG LVIPLGIMLF CYSMIIRTLQ HCKNEKKNKA VKMIFAVVVL 
       260        270        280        290        300
FLGFWTPYNI VLFLETLVEL EVLQDCTFER YLDYAIQATE TLAFVHCCLN 
       310        320        330        340        350
PIIYFFLGEK FRKYILQLFK TCRGLFVLCQ YCGLLQIYSA DTPSSSYTQS 
       360
TMDHDLHDAL

Length:360

Mass (Da):41,403

Last modified:October 1, 1996 - v1

Checksum:ⁱ51EBE12AD1FAFABF

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_010669	130	L → V1 Publication		1
Natural variantⁱVAR_010670	178	C → S1 PublicationCorresponds to variant dbSNP:rs753825374Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X85740 mRNA Translation: CAA59743.1 AB023888 Genomic DNA Translation: BAA86965.1 AB023889 Genomic DNA Translation: BAA86966.1 AB023890 Genomic DNA Translation: BAA86967.1 AB023891 Genomic DNA Translation: BAA86968.1 AB023892 Genomic DNA Translation: BAA86969.1 AY322539 Genomic DNA Translation: AAP84352.1 BC069139 mRNA Translation: AAH69139.1 BC071751 mRNA Translation: AAH71751.1 BC074935 mRNA Translation: AAH74935.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2656.1
PIRⁱ	A57160
NCBI Reference Sequences More...RefSeqⁱ	NP_005499.1, NM_005508.4 XP_016861176.1, XM_017005687.1
UniGeneⁱ	Hs.184926

Genome annotation databases

Ensemblⁱ	ENST00000330953; ENSP00000332659; ENSG00000183813
GeneIDⁱ	1233
KEGGⁱ	hsa:1233
UCSC genome browser More...UCSCⁱ	uc003cfg.2 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P51679	Chemokine (C-C motif) receptor 4		HUMAN		360	UniRef100_P51679
C-C motif chemokine receptor 4		PANTR		360
Uncharacterized protein		PANPA		360
C-C motif chemokine receptor 4		Pan troglodytes verus		360
C-C motif chemokine receptor 4		GORGO		360

Protein	Similar proteins		Species	Score	Length	Source
P51679	Chemokine (C-C motif) receptor 4		HUMAN		360	UniRef90_P51679
C-C motif chemokine receptor 4		PANTR		360
Uncharacterized protein		PANPA		360
C-C motif chemokine receptor 4		Pan troglodytes verus		360
C-C motif chemokine receptor 4		GORGO		360
+34

Protein	Similar proteins		Species	Score	Length	Source
P51679	C-C chemokine receptor type 4		CANLF		360	UniRef50_P51679
C-C chemokine receptor type 4		MOUSE		360
Chemokine (C-C motif) receptor 4		HUMAN		360
C-C motif chemokine receptor 4		PANTR		360
Uncharacterized protein		PANPA		360
+170

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X85740 mRNA Translation: CAA59743.1 AB023888 Genomic DNA Translation: BAA86965.1 AB023889 Genomic DNA Translation: BAA86966.1 AB023890 Genomic DNA Translation: BAA86967.1 AB023891 Genomic DNA Translation: BAA86968.1 AB023892 Genomic DNA Translation: BAA86969.1 AY322539 Genomic DNA Translation: AAP84352.1 BC069139 mRNA Translation: AAH69139.1 BC071751 mRNA Translation: AAH71751.1 BC074935 mRNA Translation: AAH74935.1
CCDSⁱ	CCDS2656.1
PIRⁱ	A57160
RefSeqⁱ	NP_005499.1, NM_005508.4 XP_016861176.1, XM_017005687.1
UniGeneⁱ	Hs.184926

3D structure databases

ProteinModelPortalⁱ	P51679
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107638, 6 interactors
DIPⁱ	DIP-5848N
IntActⁱ	P51679, 3 interactors
MINTⁱ	P51679
STRINGⁱ	9606.ENSP00000332659

Chemistry databases

BindingDBⁱ	P51679
ChEMBLⁱ	CHEMBL2414
GuidetoPHARMACOLOGYⁱ	61

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P51679
PhosphoSitePlusⁱ	P51679

Polymorphism and mutation databases

BioMutaⁱ	CCR4
DMDMⁱ	1705894

Proteomic databases

PaxDbⁱ	P51679
PeptideAtlasⁱ	P51679
PRIDEⁱ	P51679
ProteomicsDBⁱ	56366

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1233
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000330953; ENSP00000332659; ENSG00000183813
GeneIDⁱ	1233
KEGGⁱ	hsa:1233
UCSCⁱ	uc003cfg.2 human

Organism-specific databases

CTDⁱ	1233
DisGeNETⁱ	1233
EuPathDBⁱ	HostDB:ENSG00000183813.6
GeneCardsⁱ	CCR4
HGNCⁱ	HGNC:1605 CCR4
HPAⁱ	HPA031613
MIMⁱ	604836 gene
neXtProtⁱ	NX_P51679
OpenTargetsⁱ	ENSG00000183813
PharmGKBⁱ	PA26169
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
GeneTreeⁱ	ENSGT00760000118785
HOGENOMⁱ	HOG000234122
HOVERGENⁱ	HBG106917
InParanoidⁱ	P51679
KOⁱ	K04179
OMAⁱ	FFIMLMS
OrthoDBⁱ	EOG091G0B7A
PhylomeDBⁱ	P51679
TreeFamⁱ	TF330966

Enzyme and pathway databases

Reactomeⁱ	R-HSA-380108 Chemokine receptors bind chemokines R-HSA-418594 G alpha (i) signalling events
SIGNORⁱ	P51679

Miscellaneous databases

GeneWikiⁱ	CCR4
GenomeRNAiⁱ	1233
Protein Ontology More...PROⁱ	PR:P51679
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000183813 Expressed in 49 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_CCR4
ExpressionAtlasⁱ	P51679 baseline and differential
Genevisibleⁱ	P51679 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR002239 Chemokine_CCR4 IPR000355 Chemokine_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR10489:SF608 PTHR10489:SF608, 1 hit
Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00657 CCCHEMOKINER PR01109 CHEMOKINER4 PR00237 GPCRRHODOPSN
SMARTⁱ	View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCR4_HUMAN
Accessionⁱ	P51679Primary (citable) accession number: P51679 Secondary accession number(s): Q9ULY6, Q9ULY7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	September 12, 2018
	This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
SIMILARITY comments
Index of protein domains and families
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P51679 (CCR4_HUMAN)

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C-C chemokine receptor type 4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ