UniProtKB - P51679 (CCR4_HUMAN)
Protein
C-C chemokine receptor type 4
Gene
CCR4
Organism
Homo sapiens (Human)
Status
Functioni
High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.5 Publications
GO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- C-C chemokine receptor activity Source: GO_Central
- chemokine binding Source: GO_Central
- chemokine receptor activity Source: ProtInc
GO - Biological processi
- calcium-mediated signaling Source: GO_Central
- cell chemotaxis Source: GO_Central
- chemotaxis Source: GO_Central
- G protein-coupled receptor signaling pathway Source: Reactome
- homeostasis of number of cells Source: Ensembl
- immune response Source: GO_Central
- inflammatory response Source: ProtInc
- neuron migration Source: Ensembl
- positive regulation of cytosolic calcium ion concentration Source: GO_Central
- positive regulation of positive chemotaxis Source: Ensembl
- response to antibiotic Source: Ensembl
- response to bacterium Source: Ensembl
- response to radiation Source: Ensembl
- tolerance induction Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P51679 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P51679 |
Names & Taxonomyi
Protein namesi | Recommended name: C-C chemokine receptor type 4Short name: C-C CKR-4 Short name: CC-CKR-4 Short name: CCR-4 Short name: CCR4 Alternative name(s): K5-5 CD_antigen: CD194 |
Gene namesi | Name:CCR4 Synonyms:CMKBR4 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1605, CCR4 |
MIMi | 604836, gene |
neXtProti | NX_P51679 |
VEuPathDBi | HostDB:ENSG00000183813.6 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- external side of plasma membrane Source: GO_Central
- integral component of plasma membrane Source: ProtInc
- plasma membrane Source: HPA
Other locations
- neuronal cell body Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 39 | ExtracellularSequence analysisAdd BLAST | 39 | |
Transmembranei | 40 – 67 | Helical; Name=1Sequence analysisAdd BLAST | 28 | |
Topological domaini | 68 – 77 | CytoplasmicSequence analysis | 10 | |
Transmembranei | 78 – 98 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 99 – 111 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 112 – 133 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 134 – 150 | CytoplasmicSequence analysisAdd BLAST | 17 | |
Transmembranei | 151 – 175 | Helical; Name=4Sequence analysisAdd BLAST | 25 | |
Topological domaini | 176 – 206 | ExtracellularSequence analysisAdd BLAST | 31 | |
Transmembranei | 207 – 226 | Helical; Name=5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 227 – 242 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 243 – 267 | Helical; Name=6Sequence analysisAdd BLAST | 25 | |
Topological domaini | 268 – 284 | ExtracellularSequence analysisAdd BLAST | 17 | |
Transmembranei | 285 – 308 | Helical; Name=7Sequence analysisAdd BLAST | 24 | |
Topological domaini | 309 – 360 | CytoplasmicSequence analysisAdd BLAST | 52 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 1233 |
OpenTargetsi | ENSG00000183813 |
PharmGKBi | PA26169 |
Miscellaneous databases
Pharosi | P51679, Tclin |
Chemistry databases
ChEMBLi | CHEMBL2414 |
DrugBanki | DB15570, FLX475 DB12498, Mogamulizumab |
DrugCentrali | P51679 |
GuidetoPHARMACOLOGYi | 61 |
Genetic variation databases
BioMutai | CCR4 |
DMDMi | 1705894 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069245 | 1 – 360 | C-C chemokine receptor type 4Add BLAST | 360 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 110 ↔ 187 | PROSITE-ProRule annotation | ||
Glycosylationi | 183 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 194 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.1 Publication
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
MassIVEi | P51679 |
PaxDbi | P51679 |
PeptideAtlasi | P51679 |
PRIDEi | P51679 |
ProteomicsDBi | 56366 |
PTM databases
GlyGeni | P51679, 2 sites |
iPTMneti | P51679 |
PhosphoSitePlusi | P51679 |
Expressioni
Tissue specificityi
Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.1 Publication
Gene expression databases
Bgeei | ENSG00000183813, Expressed in leukocyte and 74 other tissues |
ExpressionAtlasi | P51679, baseline and differential |
Genevisiblei | P51679, HS |
Organism-specific databases
HPAi | ENSG00000183813, Group enriched (blood, lymphoid tissue) |
Interactioni
Binary interactionsi
Hide detailsGO - Molecular functioni
- C-C chemokine binding Source: GO_Central
- chemokine binding Source: GO_Central
Protein-protein interaction databases
BioGRIDi | 107638, 7 interactors |
DIPi | DIP-5848N |
IntActi | P51679, 33 interactors |
MINTi | P51679 |
STRINGi | 9606.ENSP00000332659 |
Chemistry databases
BindingDBi | P51679 |
Miscellaneous databases
RNActi | P51679, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214473 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P51679 |
OMAi | STVDHDL |
OrthoDBi | 900867at2759 |
PhylomeDBi | P51679 |
TreeFami | TF330966 |
Family and domain databases
InterProi | View protein in InterPro IPR002239, Chemokine_CCR4 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR10489:SF608, PTHR10489:SF608, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR01109, CHEMOKINER4 PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P51679-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNPTDIADTT LDESIYSNYY LYESIPKPCT KEGIKAFGEL FLPPLYSLVF
60 70 80 90 100
VFGLLGNSVV VLVLFKYKRL RSMTDVYLLN LAISDLLFVF SLPFWGYYAA
110 120 130 140 150
DQWVFGLGLC KMISWMYLVG FYSGIFFVML MSIDRYLAIV HAVFSLRART
160 170 180 190 200
LTYGVITSLA TWSVAVFASL PGFLFSTCYT ERNHTYCKTK YSLNSTTWKV
210 220 230 240 250
LSSLEINILG LVIPLGIMLF CYSMIIRTLQ HCKNEKKNKA VKMIFAVVVL
260 270 280 290 300
FLGFWTPYNI VLFLETLVEL EVLQDCTFER YLDYAIQATE TLAFVHCCLN
310 320 330 340 350
PIIYFFLGEK FRKYILQLFK TCRGLFVLCQ YCGLLQIYSA DTPSSSYTQS
360
TMDHDLHDAL
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_010669 | 130 | L → V1 Publication | 1 | |
Natural variantiVAR_010670 | 178 | C → S1 PublicationCorresponds to variant dbSNP:rs753825374Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X85740 mRNA Translation: CAA59743.1 AB023888 Genomic DNA Translation: BAA86965.1 AB023889 Genomic DNA Translation: BAA86966.1 AB023890 Genomic DNA Translation: BAA86967.1 AB023891 Genomic DNA Translation: BAA86968.1 AB023892 Genomic DNA Translation: BAA86969.1 AY322539 Genomic DNA Translation: AAP84352.1 BC069139 mRNA Translation: AAH69139.1 BC071751 mRNA Translation: AAH71751.1 BC074935 mRNA Translation: AAH74935.1 |
CCDSi | CCDS2656.1 |
PIRi | A57160 |
RefSeqi | NP_005499.1, NM_005508.4 XP_016861176.1, XM_017005687.1 |
Genome annotation databases
Ensembli | ENST00000330953; ENSP00000332659; ENSG00000183813 |
GeneIDi | 1233 |
KEGGi | hsa:1233 |
UCSCi | uc003cfg.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia CC chemokine receptors entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X85740 mRNA Translation: CAA59743.1 AB023888 Genomic DNA Translation: BAA86965.1 AB023889 Genomic DNA Translation: BAA86966.1 AB023890 Genomic DNA Translation: BAA86967.1 AB023891 Genomic DNA Translation: BAA86968.1 AB023892 Genomic DNA Translation: BAA86969.1 AY322539 Genomic DNA Translation: AAP84352.1 BC069139 mRNA Translation: AAH69139.1 BC071751 mRNA Translation: AAH71751.1 BC074935 mRNA Translation: AAH74935.1 |
CCDSi | CCDS2656.1 |
PIRi | A57160 |
RefSeqi | NP_005499.1, NM_005508.4 XP_016861176.1, XM_017005687.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 107638, 7 interactors |
DIPi | DIP-5848N |
IntActi | P51679, 33 interactors |
MINTi | P51679 |
STRINGi | 9606.ENSP00000332659 |
Chemistry databases
BindingDBi | P51679 |
ChEMBLi | CHEMBL2414 |
DrugBanki | DB15570, FLX475 DB12498, Mogamulizumab |
DrugCentrali | P51679 |
GuidetoPHARMACOLOGYi | 61 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P51679, 2 sites |
iPTMneti | P51679 |
PhosphoSitePlusi | P51679 |
Genetic variation databases
BioMutai | CCR4 |
DMDMi | 1705894 |
Proteomic databases
MassIVEi | P51679 |
PaxDbi | P51679 |
PeptideAtlasi | P51679 |
PRIDEi | P51679 |
ProteomicsDBi | 56366 |
Protocols and materials databases
ABCDi | P51679, 1 sequenced antibody |
Antibodypediai | 11668, 739 antibodies |
DNASUi | 1233 |
Genome annotation databases
Ensembli | ENST00000330953; ENSP00000332659; ENSG00000183813 |
GeneIDi | 1233 |
KEGGi | hsa:1233 |
UCSCi | uc003cfg.2, human |
Organism-specific databases
CTDi | 1233 |
DisGeNETi | 1233 |
GeneCardsi | CCR4 |
HGNCi | HGNC:1605, CCR4 |
HPAi | ENSG00000183813, Group enriched (blood, lymphoid tissue) |
MIMi | 604836, gene |
neXtProti | NX_P51679 |
OpenTargetsi | ENSG00000183813 |
PharmGKBi | PA26169 |
VEuPathDBi | HostDB:ENSG00000183813.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214473 |
HOGENOMi | CLU_009579_8_3_1 |
InParanoidi | P51679 |
OMAi | STVDHDL |
OrthoDBi | 900867at2759 |
PhylomeDBi | P51679 |
TreeFami | TF330966 |
Enzyme and pathway databases
PathwayCommonsi | P51679 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events |
SIGNORi | P51679 |
Miscellaneous databases
BioGRID-ORCSi | 1233, 5 hits in 874 CRISPR screens |
GeneWikii | CCR4 |
GenomeRNAii | 1233 |
Pharosi | P51679, Tclin |
PROi | PR:P51679 |
RNActi | P51679, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000183813, Expressed in leukocyte and 74 other tissues |
ExpressionAtlasi | P51679, baseline and differential |
Genevisiblei | P51679, HS |
Family and domain databases
InterProi | View protein in InterPro IPR002239, Chemokine_CCR4 IPR000355, Chemokine_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR10489:SF608, PTHR10489:SF608, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00657, CCCHEMOKINER PR01109, CHEMOKINER4 PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCR4_HUMAN | |
Accessioni | P51679Primary (citable) accession number: P51679 Secondary accession number(s): Q9ULY6, Q9ULY7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 174 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries - Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families