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Protein

C-C chemokine receptor type 4

Gene

CCR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival.5 Publications

GO - Molecular functioni

  • C-C chemokine receptor activity Source: Ensembl
  • chemokine receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
SIGNORiP51679

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 4
Short name:
C-C CKR-4
Short name:
CC-CKR-4
Short name:
CCR-4
Short name:
CCR4
Alternative name(s):
K5-5
CD_antigen: CD194
Gene namesi
Name:CCR4
Synonyms:CMKBR4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000183813.6
HGNCiHGNC:1605 CCR4
MIMi604836 gene
neXtProtiNX_P51679

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 39ExtracellularSequence analysisAdd BLAST39
Transmembranei40 – 67Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini68 – 77CytoplasmicSequence analysis10
Transmembranei78 – 98Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini99 – 111ExtracellularSequence analysisAdd BLAST13
Transmembranei112 – 133Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini134 – 150CytoplasmicSequence analysisAdd BLAST17
Transmembranei151 – 175Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini176 – 206ExtracellularSequence analysisAdd BLAST31
Transmembranei207 – 226Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini227 – 242CytoplasmicSequence analysisAdd BLAST16
Transmembranei243 – 267Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini268 – 284ExtracellularSequence analysisAdd BLAST17
Transmembranei285 – 308Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini309 – 360CytoplasmicSequence analysisAdd BLAST52

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1233
OpenTargetsiENSG00000183813
PharmGKBiPA26169

Chemistry databases

ChEMBLiCHEMBL2414
GuidetoPHARMACOLOGYi61

Polymorphism and mutation databases

BioMutaiCCR4
DMDMi1705894

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692451 – 360C-C chemokine receptor type 4Add BLAST360

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi110 ↔ 187PROSITE-ProRule annotation
Glycosylationi183N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi194N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP51679
PeptideAtlasiP51679
PRIDEiP51679
ProteomicsDBi56366

PTM databases

iPTMnetiP51679
PhosphoSitePlusiP51679

Expressioni

Tissue specificityi

Predominantly expressed in the thymus, in peripheral blood leukocytes, including T-cells, mostly CD4+ cells, and basophils, and in platelets; at lower levels, in the spleen and in monocytes. Detected also in macrophages, IL-2-activated natural killer cells and skin-homing memory T-cells, mostly the ones expressing the cutaneous lymphocyte antigen (CLA). Expressed in brain microvascular and coronary artery endothelial cells.1 Publication

Gene expression databases

BgeeiENSG00000183813 Expressed in 49 organ(s), highest expression level in leukocyte
CleanExiHS_CCR4
ExpressionAtlasiP51679 baseline and differential
GenevisibleiP51679 HS

Organism-specific databases

HPAiHPA031613

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
CCL17Q925832EBI-7847466,EBI-16640146

Protein-protein interaction databases

BioGridi107638, 6 interactors
DIPiDIP-5848N
IntActiP51679, 3 interactors
MINTiP51679
STRINGi9606.ENSP00000332659

Chemistry databases

BindingDBiP51679

Structurei

3D structure databases

ProteinModelPortaliP51679
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118785
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP51679
KOiK04179
OMAiFFIMLMS
OrthoDBiEOG091G0B7A
PhylomeDBiP51679
TreeFamiTF330966

Family and domain databases

InterProiView protein in InterPro
IPR002239 Chemokine_CCR4
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR10489:SF608 PTHR10489:SF608, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01109 CHEMOKINER4
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P51679-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNPTDIADTT LDESIYSNYY LYESIPKPCT KEGIKAFGEL FLPPLYSLVF
60 70 80 90 100
VFGLLGNSVV VLVLFKYKRL RSMTDVYLLN LAISDLLFVF SLPFWGYYAA
110 120 130 140 150
DQWVFGLGLC KMISWMYLVG FYSGIFFVML MSIDRYLAIV HAVFSLRART
160 170 180 190 200
LTYGVITSLA TWSVAVFASL PGFLFSTCYT ERNHTYCKTK YSLNSTTWKV
210 220 230 240 250
LSSLEINILG LVIPLGIMLF CYSMIIRTLQ HCKNEKKNKA VKMIFAVVVL
260 270 280 290 300
FLGFWTPYNI VLFLETLVEL EVLQDCTFER YLDYAIQATE TLAFVHCCLN
310 320 330 340 350
PIIYFFLGEK FRKYILQLFK TCRGLFVLCQ YCGLLQIYSA DTPSSSYTQS
360
TMDHDLHDAL
Length:360
Mass (Da):41,403
Last modified:October 1, 1996 - v1
Checksum:i51EBE12AD1FAFABF
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_010669130L → V1 Publication1
Natural variantiVAR_010670178C → S1 PublicationCorresponds to variant dbSNP:rs753825374Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85740 mRNA Translation: CAA59743.1
AB023888 Genomic DNA Translation: BAA86965.1
AB023889 Genomic DNA Translation: BAA86966.1
AB023890 Genomic DNA Translation: BAA86967.1
AB023891 Genomic DNA Translation: BAA86968.1
AB023892 Genomic DNA Translation: BAA86969.1
AY322539 Genomic DNA Translation: AAP84352.1
BC069139 mRNA Translation: AAH69139.1
BC071751 mRNA Translation: AAH71751.1
BC074935 mRNA Translation: AAH74935.1
CCDSiCCDS2656.1
PIRiA57160
RefSeqiNP_005499.1, NM_005508.4
XP_016861176.1, XM_017005687.1
UniGeneiHs.184926

Genome annotation databases

EnsembliENST00000330953; ENSP00000332659; ENSG00000183813
GeneIDi1233
KEGGihsa:1233
UCSCiuc003cfg.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X85740 mRNA Translation: CAA59743.1
AB023888 Genomic DNA Translation: BAA86965.1
AB023889 Genomic DNA Translation: BAA86966.1
AB023890 Genomic DNA Translation: BAA86967.1
AB023891 Genomic DNA Translation: BAA86968.1
AB023892 Genomic DNA Translation: BAA86969.1
AY322539 Genomic DNA Translation: AAP84352.1
BC069139 mRNA Translation: AAH69139.1
BC071751 mRNA Translation: AAH71751.1
BC074935 mRNA Translation: AAH74935.1
CCDSiCCDS2656.1
PIRiA57160
RefSeqiNP_005499.1, NM_005508.4
XP_016861176.1, XM_017005687.1
UniGeneiHs.184926

3D structure databases

ProteinModelPortaliP51679
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107638, 6 interactors
DIPiDIP-5848N
IntActiP51679, 3 interactors
MINTiP51679
STRINGi9606.ENSP00000332659

Chemistry databases

BindingDBiP51679
ChEMBLiCHEMBL2414
GuidetoPHARMACOLOGYi61

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP51679
PhosphoSitePlusiP51679

Polymorphism and mutation databases

BioMutaiCCR4
DMDMi1705894

Proteomic databases

PaxDbiP51679
PeptideAtlasiP51679
PRIDEiP51679
ProteomicsDBi56366

Protocols and materials databases

DNASUi1233
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330953; ENSP00000332659; ENSG00000183813
GeneIDi1233
KEGGihsa:1233
UCSCiuc003cfg.2 human

Organism-specific databases

CTDi1233
DisGeNETi1233
EuPathDBiHostDB:ENSG00000183813.6
GeneCardsiCCR4
HGNCiHGNC:1605 CCR4
HPAiHPA031613
MIMi604836 gene
neXtProtiNX_P51679
OpenTargetsiENSG00000183813
PharmGKBiPA26169
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118785
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP51679
KOiK04179
OMAiFFIMLMS
OrthoDBiEOG091G0B7A
PhylomeDBiP51679
TreeFamiTF330966

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
SIGNORiP51679

Miscellaneous databases

GeneWikiiCCR4
GenomeRNAii1233
PROiPR:P51679
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183813 Expressed in 49 organ(s), highest expression level in leukocyte
CleanExiHS_CCR4
ExpressionAtlasiP51679 baseline and differential
GenevisibleiP51679 HS

Family and domain databases

InterProiView protein in InterPro
IPR002239 Chemokine_CCR4
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR10489:SF608 PTHR10489:SF608, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01109 CHEMOKINER4
PR00237 GPCRRHODOPSN
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCR4_HUMAN
AccessioniPrimary (citable) accession number: P51679
Secondary accession number(s): Q9ULY6, Q9ULY7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 155 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  5. SIMILARITY comments
    Index of protein domains and families
  6. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  7. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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