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Protein

C-C chemokine receptor type 3

Gene

CCR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for a C-C type chemokine. Binds to eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES and MIP-1 delta. Subsequently transduces a signal by increasing the intracellular calcium ions level. Alternative coreceptor with CD4 for HIV-1 infection.

Miscellaneous

Overexpression of CCR3 together with its ligands appears to be a characteristic of ulcerative colitis (UC). The production of CCR3 ligands by human colonic epithelial cells suggests further that the epithelium can play a role in modulating pathological T-cell-mediated mucosal inflammation (PubMed:21077277).1 Publication

GO - Molecular functioni

  • C-C chemokine binding Source: CAFA
  • C-C chemokine receptor activity Source: GO_Central
  • chemokine binding Source: GO_Central
  • chemokine receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
SIGNORiP51677

Names & Taxonomyi

Protein namesi
Recommended name:
C-C chemokine receptor type 3
Short name:
C-C CKR-3
Short name:
CC-CKR-3
Short name:
CCR-3
Short name:
CCR3
Short name:
CKR3
Alternative name(s):
Eosinophil eotaxin receptor
CD_antigen: CD193
Gene namesi
Name:CCR3
Synonyms:CMKBR3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000183625.14
HGNCiHGNC:1604 CCR3
MIMi601268 gene
neXtProtiNX_P51677

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 34ExtracellularSequence analysisAdd BLAST34
Transmembranei35 – 62Helical; Name=1Sequence analysisAdd BLAST28
Topological domaini63 – 72CytoplasmicSequence analysis10
Transmembranei73 – 93Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini94 – 107ExtracellularSequence analysisAdd BLAST14
Transmembranei108 – 129Helical; Name=3Sequence analysisAdd BLAST22
Topological domaini130 – 146CytoplasmicSequence analysisAdd BLAST17
Transmembranei147 – 171Helical; Name=4Sequence analysisAdd BLAST25
Topological domaini172 – 203ExtracellularSequence analysisAdd BLAST32
Transmembranei204 – 223Helical; Name=5Sequence analysisAdd BLAST20
Topological domaini224 – 239CytoplasmicSequence analysisAdd BLAST16
Transmembranei240 – 264Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini265 – 281ExtracellularSequence analysisAdd BLAST17
Transmembranei282 – 305Helical; Name=7Sequence analysisAdd BLAST24
Topological domaini306 – 355CytoplasmicSequence analysisAdd BLAST50

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1232
OpenTargetsiENSG00000183625
PharmGKBiPA26168

Chemistry databases

ChEMBLiCHEMBL3473
GuidetoPHARMACOLOGYi60

Polymorphism and mutation databases

BioMutaiCCR3
DMDMi1705892

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000692391 – 355C-C chemokine receptor type 3Add BLAST355

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi106 ↔ 183PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP51677
PeptideAtlasiP51677
PRIDEiP51677
ProteomicsDBi56365

PTM databases

PhosphoSitePlusiP51677

Expressioni

Tissue specificityi

In eosinophils as well as trace amounts in neutrophils and monocytes.

Gene expression databases

BgeeiENSG00000183625 Expressed in 47 organ(s), highest expression level in blood
CleanExiHS_CCR3
ExpressionAtlasiP51677 baseline and differential
GenevisibleiP51677 HS

Organism-specific databases

HPAiCAB003795

Interactioni

Subunit structurei

(Microbial infection) Interacts with HIV-1 protein Tat.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
CCL11P516712EBI-6625120,EBI-727357

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107637, 7 interactors
DIPiDIP-5846N
IntActiP51677, 1 interactor
STRINGi9606.ENSP00000441600

Chemistry databases

BindingDBiP51677

Structurei

3D structure databases

ProteinModelPortaliP51677
SMRiP51677
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150855
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP51677
KOiK04178
OMAiRCPSKKK
OrthoDBiEOG091G0B7A
PhylomeDBiP51677
TreeFamiTF330966

Family and domain databases

InterProiView protein in InterPro
IPR002238 Chemokine_CCR3
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01108 CHEMOKINER3
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P51677-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTTSLDTVET FGTTSYYDDV GLLCEKADTR ALMAQFVPPL YSLVFTVGLL
60 70 80 90 100
GNVVVVMILI KYRRLRIMTN IYLLNLAISD LLFLVTLPFW IHYVRGHNWV
110 120 130 140 150
FGHGMCKLLS GFYHTGLYSE IFFIILLTID RYLAIVHAVF ALRARTVTFG
160 170 180 190 200
VITSIVTWGL AVLAALPEFI FYETEELFEE TLCSALYPED TVYSWRHFHT
210 220 230 240 250
LRMTIFCLVL PLLVMAICYT GIIKTLLRCP SKKKYKAIRL IFVIMAVFFI
260 270 280 290 300
FWTPYNVAIL LSSYQSILFG NDCERSKHLD LVMLVTEVIA YSHCCMNPVI
310 320 330 340 350
YAFVGERFRK YLRHFFHRHL LMHLGRYIPF LPSEKLERTS SVSPSTAEPE

LSIVF
Length:355
Mass (Da):41,044
Last modified:October 1, 1996 - v1
Checksum:iE95DCD7A6C643874
GO
Isoform 2 (identifier: P51677-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MPFGIRMLLRAHKPGSSRRSEM

Note: Gene prediction based on EST data.
Show »
Length:376
Mass (Da):43,453
Checksum:i422D094FF3497FE4
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8TDP5Q8TDP5_HUMAN
C-C chemokine receptor type 3
CCR3
80Annotation score:
Q8TDP4Q8TDP4_HUMAN
C-C chemokine receptor type 3
CCR3
21Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81 – 82LL → QG in AAL85630 (PubMed:12079287).Curated2
Sequence conflicti205I → V in BAG53863 (PubMed:14702039).Curated1
Sequence conflicti276S → T in AAB09726 (PubMed:8676064).Curated1
Sequence conflicti276S → T in BAA86964 (PubMed:11196669).Curated1
Sequence conflicti277K → R in BAG53863 (PubMed:14702039).Curated1
Sequence conflicti349P → R in BAG53863 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02006721G → D. Corresponds to variant dbSNP:rs4987125Ensembl.1
Natural variantiVAR_04938239P → L. Corresponds to variant dbSNP:rs5742906Ensembl.1
Natural variantiVAR_010668218C → S Polymorphism found in about 7% of the population. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0467041M → MPFGIRMLLRAHKPGSSRRS EM in isoform 2. Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28694 mRNA Translation: AAC50469.1
U51241 Genomic DNA Translation: AAB16831.1
U49727 Genomic DNA Translation: AAB09726.1
AF026535 mRNA Translation: AAB82589.1
AB023887 Genomic DNA Translation: BAA86964.1
AF262301 mRNA Translation: AAL85630.1
AF247361 Genomic DNA Translation: AAL85154.1
AY221092 Genomic DNA Translation: AAO65970.2
EF064760 Genomic DNA Translation: ABK41943.1
AK123050 mRNA Translation: BAG53863.1
AC104439 Genomic DNA No translation available.
BC110297 mRNA Translation: AAI10298.1
BC130318 mRNA Translation: AAI30319.1
BC130320 mRNA Translation: AAI30321.1
CCDSiCCDS2738.1 [P51677-1]
CCDS54574.1 [P51677-2]
PIRiG02436
RefSeqiNP_001828.1, NM_001837.3 [P51677-1]
NP_847898.1, NM_178328.1 [P51677-2]
NP_847899.1, NM_178329.2 [P51677-1]
XP_006713023.1, XM_006712960.3 [P51677-1]
XP_011531637.1, XM_011533335.2 [P51677-1]
UniGeneiHs.506190

Genome annotation databases

EnsembliENST00000357422; ENSP00000350003; ENSG00000183625 [P51677-1]
ENST00000395940; ENSP00000379271; ENSG00000183625 [P51677-1]
ENST00000395942; ENSP00000379273; ENSG00000183625 [P51677-1]
ENST00000545097; ENSP00000441600; ENSG00000183625 [P51677-2]
GeneIDi1232
KEGGihsa:1232
UCSCiuc003cpg.3 human [P51677-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

CC chemokine receptors entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28694 mRNA Translation: AAC50469.1
U51241 Genomic DNA Translation: AAB16831.1
U49727 Genomic DNA Translation: AAB09726.1
AF026535 mRNA Translation: AAB82589.1
AB023887 Genomic DNA Translation: BAA86964.1
AF262301 mRNA Translation: AAL85630.1
AF247361 Genomic DNA Translation: AAL85154.1
AY221092 Genomic DNA Translation: AAO65970.2
EF064760 Genomic DNA Translation: ABK41943.1
AK123050 mRNA Translation: BAG53863.1
AC104439 Genomic DNA No translation available.
BC110297 mRNA Translation: AAI10298.1
BC130318 mRNA Translation: AAI30319.1
BC130320 mRNA Translation: AAI30321.1
CCDSiCCDS2738.1 [P51677-1]
CCDS54574.1 [P51677-2]
PIRiG02436
RefSeqiNP_001828.1, NM_001837.3 [P51677-1]
NP_847898.1, NM_178328.1 [P51677-2]
NP_847899.1, NM_178329.2 [P51677-1]
XP_006713023.1, XM_006712960.3 [P51677-1]
XP_011531637.1, XM_011533335.2 [P51677-1]
UniGeneiHs.506190

3D structure databases

ProteinModelPortaliP51677
SMRiP51677
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107637, 7 interactors
DIPiDIP-5846N
IntActiP51677, 1 interactor
STRINGi9606.ENSP00000441600

Chemistry databases

BindingDBiP51677
ChEMBLiCHEMBL3473
GuidetoPHARMACOLOGYi60

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP51677

Polymorphism and mutation databases

BioMutaiCCR3
DMDMi1705892

Proteomic databases

PaxDbiP51677
PeptideAtlasiP51677
PRIDEiP51677
ProteomicsDBi56365

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000357422; ENSP00000350003; ENSG00000183625 [P51677-1]
ENST00000395940; ENSP00000379271; ENSG00000183625 [P51677-1]
ENST00000395942; ENSP00000379273; ENSG00000183625 [P51677-1]
ENST00000545097; ENSP00000441600; ENSG00000183625 [P51677-2]
GeneIDi1232
KEGGihsa:1232
UCSCiuc003cpg.3 human [P51677-1]

Organism-specific databases

CTDi1232
DisGeNETi1232
EuPathDBiHostDB:ENSG00000183625.14
GeneCardsiCCR3
HGNCiHGNC:1604 CCR3
HPAiCAB003795
MIMi601268 gene
neXtProtiNX_P51677
OpenTargetsiENSG00000183625
PharmGKBiPA26168
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00930000150855
HOGENOMiHOG000234122
HOVERGENiHBG106917
InParanoidiP51677
KOiK04178
OMAiRCPSKKK
OrthoDBiEOG091G0B7A
PhylomeDBiP51677
TreeFamiTF330966

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-418594 G alpha (i) signalling events
SIGNORiP51677

Miscellaneous databases

ChiTaRSiCCR3 human
GenomeRNAii1232
PROiPR:P51677
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183625 Expressed in 47 organ(s), highest expression level in blood
CleanExiHS_CCR3
ExpressionAtlasiP51677 baseline and differential
GenevisibleiP51677 HS

Family and domain databases

InterProiView protein in InterPro
IPR002238 Chemokine_CCR3
IPR000355 Chemokine_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00657 CCCHEMOKINER
PR01108 CHEMOKINER3
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCR3_HUMAN
AccessioniPrimary (citable) accession number: P51677
Secondary accession number(s): B3KVQ1
, F5GWL6, Q15748, Q2YDB9, Q86WD2, Q8TDP6, Q9ULY8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  7. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
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Main funding by: National Institutes of Health

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