Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Neuronal membrane glycoprotein M6-a

Gene

GPM6A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNeurogenesis

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal membrane glycoprotein M6-a
Short name:
M6a
Gene namesi
Name:GPM6A
Synonyms:M6A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000150625.16
HGNCiHGNC:4460 GPM6A
MIMi601275 gene
neXtProtiNX_P51674

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 22CytoplasmicSequence analysisAdd BLAST22
Transmembranei23 – 43HelicalSequence analysisAdd BLAST21
Topological domaini44 – 84ExtracellularSequence analysisAdd BLAST41
Transmembranei85 – 105HelicalSequence analysisAdd BLAST21
Topological domaini106 – 127CytoplasmicSequence analysisAdd BLAST22
Transmembranei128 – 148HelicalSequence analysisAdd BLAST21
Topological domaini149 – 213ExtracellularBy similarityAdd BLAST65
Transmembranei214 – 234HelicalSequence analysisAdd BLAST21
Topological domaini235 – 278CytoplasmicSequence analysisAdd BLAST44

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2823
OpenTargetsiENSG00000150625
PharmGKBiPA28843

Polymorphism and mutation databases

BioMutaiGPM6A
DMDMi2506889

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001590181 – 278Neuronal membrane glycoprotein M6-aAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi174 ↔ 192By similarity
Glycosylationi208N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei256PhosphoserineBy similarity1
Modified residuei278PhosphothreonineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP51674
PeptideAtlasiP51674
PRIDEiP51674
ProteomicsDBi56364

PTM databases

iPTMnetiP51674
PhosphoSitePlusiP51674
SwissPalmiP51674

Expressioni

Gene expression databases

BgeeiENSG00000150625 Expressed in 194 organ(s), highest expression level in occipital lobe
CleanExiHS_GPM6A
ExpressionAtlasiP51674 baseline and differential
GenevisibleiP51674 HS

Organism-specific databases

HPAiHPA017338

Interactioni

Subunit structurei

Interacts with OPRM1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ZDHHC17Q8IUH55EBI-7187133,EBI-524753

Protein-protein interaction databases

BioGridi109084, 38 interactors
IntActiP51674, 3 interactors
MINTiP51674
STRINGi9606.ENSP00000280187

Structurei

3D structure databases

ProteinModelPortaliP51674
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the myelin proteolipid protein family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4800 Eukaryota
ENOG4110EPW LUCA
GeneTreeiENSGT00390000006915
HOGENOMiHOG000231338
HOVERGENiHBG000096
InParanoidiP51674
OMAiIAMIHYL
OrthoDBiEOG091G0IM5
PhylomeDBiP51674
TreeFamiTF315162

Family and domain databases

InterProiView protein in InterPro
IPR001614 Myelin_PLP
IPR018237 Myelin_PLP_CS
PANTHERiPTHR11683 PTHR11683, 1 hit
PfamiView protein in Pfam
PF01275 Myelin_PLP, 1 hit
PRINTSiPR00214 MYELINPLP
SMARTiView protein in SMART
SM00002 PLP, 1 hit
PROSITEiView protein in PROSITE
PS00575 MYELIN_PLP_1, 1 hit
PS01004 MYELIN_PLP_2, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 14 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P51674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEENMEEGQT QKGCFECCIK CLGGIPYASL IATILLYAGV ALFCGCGHEA
60 70 80 90 100
LSGTVNILQT YFEMARTAGD TLDVFTMIDI FKYVIYGIAA AFFVYGILLM
110 120 130 140 150
VEGFFTTGAI KDLYGDFKIT TCGRCVSAWF IMLTYLFMLA WLGVTAFTSL
160 170 180 190 200
PVYMYFNLWT ICRNTTLVEG ANLCLDLRQF GIVTIGEEKK ICTVSENFLR
210 220 230 240 250
MCESTELNMT FHLFIVALAG AGAAVIAMVH YLMVLSANWA YVKDACRMQK
260 270
YEDIKSKEEQ ELHDIHSTRS KERLNAYT
Length:278
Mass (Da):31,210
Last modified:November 1, 1997 - v2
Checksum:iDD0DB598C0E86B5D
GO
Isoform 2 (identifier: P51674-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MEENMEEGQTQK → MTDLE

Show »
Length:271
Mass (Da):30,364
Checksum:iAA2999D92620BD4A
GO
Isoform 3 (identifier: P51674-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-12: MEENMEEGQTQK → M

Note: No experimental confirmation available.
Show »
Length:267
Mass (Da):29,905
Checksum:i94DD2BD6AFADEA61
GO

Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6R9D2D6R9D2_HUMAN
Neuronal membrane glycoprotein M6-a
GPM6A
218Annotation score:
D6R9T7D6R9T7_HUMAN
Neuronal membrane glycoprotein M6-a
GPM6A
129Annotation score:
D6RDV7D6RDV7_HUMAN
Neuronal membrane glycoprotein M6-a
GPM6A
119Annotation score:
D6REJ8D6REJ8_HUMAN
Neuronal membrane glycoprotein M6-a
GPM6A
117Annotation score:
D6RB41D6RB41_HUMAN
Neuronal membrane glycoprotein M6-a
GPM6A
87Annotation score:
D6RBM6D6RBM6_HUMAN
Neuronal membrane glycoprotein M6-a
GPM6A
105Annotation score:
D6RFY0D6RFY0_HUMAN
Neuronal membrane glycoprotein M6-a
GPM6A
41Annotation score:
D6RBH3D6RBH3_HUMAN
Neuronal membrane glycoprotein M6-a
GPM6A
82Annotation score:
D6RAE4D6RAE4_HUMAN
Neuronal membrane glycoprotein M6-a
GPM6A
49Annotation score:
D6RFZ3D6RFZ3_HUMAN
Neuronal membrane glycoprotein M6-a
GPM6A
98Annotation score:
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti102E → A in AAB16889 (PubMed:8661015).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014895242V → L. Corresponds to variant dbSNP:rs1049820Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0451091 – 12MEENM…GQTQK → MTDLE in isoform 2. 1 PublicationAdd BLAST12
Alternative sequenceiVSP_0460981 – 12MEENM…GQTQK → M in isoform 3. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49958 mRNA Translation: BAA08712.1
AK299788 mRNA Translation: BAH13128.1
AK226176 mRNA No translation available.
AC093819 Genomic DNA No translation available.
AC097537 Genomic DNA No translation available.
AC110794 Genomic DNA No translation available.
BC022508 mRNA Translation: AAH22508.1
BC022528 mRNA Translation: AAH22528.1
U45956 mRNA Translation: AAB16889.1
CCDSiCCDS3824.1 [P51674-1]
CCDS54822.1 [P51674-3]
CCDS58936.1 [P51674-2]
RefSeqiNP_001248377.1, NM_001261448.1 [P51674-2]
NP_005268.1, NM_005277.4 [P51674-1]
NP_963885.1, NM_201591.2 [P51674-1]
NP_963886.1, NM_201592.2 [P51674-3]
UniGeneiHs.75819

Genome annotation databases

EnsembliENST00000280187; ENSP00000280187; ENSG00000150625 [P51674-1]
ENST00000393658; ENSP00000377268; ENSG00000150625 [P51674-1]
ENST00000506894; ENSP00000421578; ENSG00000150625 [P51674-3]
ENST00000515090; ENSP00000423984; ENSG00000150625 [P51674-2]
GeneIDi2823
KEGGihsa:2823
UCSCiuc003iuf.5 human [P51674-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D49958 mRNA Translation: BAA08712.1
AK299788 mRNA Translation: BAH13128.1
AK226176 mRNA No translation available.
AC093819 Genomic DNA No translation available.
AC097537 Genomic DNA No translation available.
AC110794 Genomic DNA No translation available.
BC022508 mRNA Translation: AAH22508.1
BC022528 mRNA Translation: AAH22528.1
U45956 mRNA Translation: AAB16889.1
CCDSiCCDS3824.1 [P51674-1]
CCDS54822.1 [P51674-3]
CCDS58936.1 [P51674-2]
RefSeqiNP_001248377.1, NM_001261448.1 [P51674-2]
NP_005268.1, NM_005277.4 [P51674-1]
NP_963885.1, NM_201591.2 [P51674-1]
NP_963886.1, NM_201592.2 [P51674-3]
UniGeneiHs.75819

3D structure databases

ProteinModelPortaliP51674
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109084, 38 interactors
IntActiP51674, 3 interactors
MINTiP51674
STRINGi9606.ENSP00000280187

PTM databases

iPTMnetiP51674
PhosphoSitePlusiP51674
SwissPalmiP51674

Polymorphism and mutation databases

BioMutaiGPM6A
DMDMi2506889

Proteomic databases

PaxDbiP51674
PeptideAtlasiP51674
PRIDEiP51674
ProteomicsDBi56364

Protocols and materials databases

DNASUi2823
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000280187; ENSP00000280187; ENSG00000150625 [P51674-1]
ENST00000393658; ENSP00000377268; ENSG00000150625 [P51674-1]
ENST00000506894; ENSP00000421578; ENSG00000150625 [P51674-3]
ENST00000515090; ENSP00000423984; ENSG00000150625 [P51674-2]
GeneIDi2823
KEGGihsa:2823
UCSCiuc003iuf.5 human [P51674-1]

Organism-specific databases

CTDi2823
DisGeNETi2823
EuPathDBiHostDB:ENSG00000150625.16
GeneCardsiGPM6A
HGNCiHGNC:4460 GPM6A
HPAiHPA017338
MIMi601275 gene
neXtProtiNX_P51674
OpenTargetsiENSG00000150625
PharmGKBiPA28843
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4800 Eukaryota
ENOG4110EPW LUCA
GeneTreeiENSGT00390000006915
HOGENOMiHOG000231338
HOVERGENiHBG000096
InParanoidiP51674
OMAiIAMIHYL
OrthoDBiEOG091G0IM5
PhylomeDBiP51674
TreeFamiTF315162

Miscellaneous databases

ChiTaRSiGPM6A human
GeneWikiiGPM6A
GenomeRNAii2823
PROiPR:P51674
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000150625 Expressed in 194 organ(s), highest expression level in occipital lobe
CleanExiHS_GPM6A
ExpressionAtlasiP51674 baseline and differential
GenevisibleiP51674 HS

Family and domain databases

InterProiView protein in InterPro
IPR001614 Myelin_PLP
IPR018237 Myelin_PLP_CS
PANTHERiPTHR11683 PTHR11683, 1 hit
PfamiView protein in Pfam
PF01275 Myelin_PLP, 1 hit
PRINTSiPR00214 MYELINPLP
SMARTiView protein in SMART
SM00002 PLP, 1 hit
PROSITEiView protein in PROSITE
PS00575 MYELIN_PLP_1, 1 hit
PS01004 MYELIN_PLP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPM6A_HUMAN
AccessioniPrimary (citable) accession number: P51674
Secondary accession number(s): B7Z642, E9PHI5, Q92602
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: September 12, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again