UniProtKB - P51672 (XCL1_RAT)
Protein
Lymphotactin
Gene
Xcl1
Organism
Rattus norvegicus (Rat)
Status
Functioni
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.By similarity
GO - Molecular functioni
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: RGD
- chemokine receptor binding Source: RGD
- protein homodimerization activity Source: RGD
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: RGD
- cell-cell signaling Source: RGD
- cellular response to interferon-gamma Source: GO_Central
- cellular response to interleukin-1 Source: GO_Central
- cellular response to interleukin-4 Source: RGD
- cellular response to transforming growth factor beta stimulus Source: RGD
- cellular response to tumor necrosis factor Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- chemotaxis Source: RGD
- G protein-coupled receptor signaling pathway Source: GO_Central
- inflammatory response Source: GO_Central
- killing of cells of other organism Source: RGD
- lymphocyte chemotaxis Source: GO_Central
- mature natural killer cell chemotaxis Source: RGD
- monocyte chemotaxis Source: GO_Central
- negative regulation of CD4-positive, alpha-beta T cell proliferation Source: RGD
- negative regulation of DNA-binding transcription factor activity Source: RGD
- negative regulation of interferon-gamma production Source: RGD
- negative regulation of interleukin-2 production Source: RGD
- negative regulation of T cell cytokine production Source: RGD
- negative regulation of T-helper 1 cell activation Source: RGD
- negative regulation of transcription, DNA-templated Source: RGD
- neutrophil chemotaxis Source: GO_Central
- positive regulation of B cell chemotaxis Source: RGD
- positive regulation of CD4-positive, alpha-beta T cell proliferation Source: RGD
- positive regulation of CD8-positive, alpha-beta T cell proliferation Source: RGD
- positive regulation of ERK1 and ERK2 cascade Source: GO_Central
- positive regulation of granzyme A production Source: RGD
- positive regulation of granzyme B production Source: RGD
- positive regulation of GTPase activity Source: GO_Central
- positive regulation of immunoglobulin production in mucosal tissue Source: RGD
- positive regulation of interleukin-10 production Source: RGD
- positive regulation of leukocyte chemotaxis Source: RGD
- positive regulation of natural killer cell chemotaxis Source: RGD
- positive regulation of neutrophil chemotaxis Source: RGD
- positive regulation of release of sequestered calcium ion into cytosol Source: RGD
- positive regulation of T cell chemotaxis Source: RGD
- positive regulation of T cell cytokine production Source: RGD
- positive regulation of T cell mediated cytotoxicity Source: RGD
- positive regulation of T-helper 1 cell cytokine production Source: RGD
- positive regulation of T-helper 2 cell cytokine production Source: RGD
- positive regulation of thymocyte migration Source: RGD
- positive regulation of transforming growth factor beta production Source: RGD
- regulation of inflammatory response Source: RGD
- release of sequestered calcium ion into cytosol Source: RGD
- response to virus Source: RGD
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis |
Enzyme and pathway databases
Reactomei | R-RNO-380108, Chemokine receptors bind chemokines R-RNO-416476, G alpha (q) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: LymphotactinAlternative name(s): C motif chemokine 1 Cytokine SCM-1 Small-inducible cytokine C1 |
Gene namesi | Name:Xcl1 Synonyms:Ltn, Scyc1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620452, Xcl1 |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: RGD
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000005250 | 22 – 114 | LymphotactinAdd BLAST | 93 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 32 ↔ 69 | Sequence analysis |
Keywords - PTMi
Disulfide bondProteomic databases
PaxDbi | P51672 |
PRIDEi | P51672 |
PTM databases
PhosphoSitePlusi | P51672 |
Interactioni
GO - Molecular functioni
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: RGD
- chemokine receptor binding Source: RGD
- protein homodimerization activity Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003976 |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine gamma family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S6ZP, Eukaryota |
InParanoidi | P51672 |
OrthoDBi | 1553663at2759 |
PhylomeDBi | P51672 |
Family and domain databases
CDDi | cd00271, Chemokine_C, 1 hit |
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR001811, Chemokine_IL8-like_dom IPR008105, Chemokine_XCL1/XCL2 IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit PTHR12015:SF101, PTHR12015:SF101, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR01731, LYMPHOTACTIN |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P51672-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLLLLTFLG VCCFAAWVVE GVGTEVLQES ICVSLRTQRL PVQKIKTYTI
60 70 80 90 100
KEGAMRAVIF VTKRGLRICA DPQAKWVKTA IKTVDGRASA SKSKAETIPT
110
QAQRSASTAV TLTG
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V6D4 | G3V6D4_RAT | Chemokine (C motif) ligand 1 | Xcl1 XCL1, rCG_46098 | 114 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U23377 mRNA Translation: AAA69478.1 |
RefSeqi | NP_599188.1, NM_134361.1 |
Genome annotation databases
GeneIDi | 171371 |
KEGGi | rno:171371 |
UCSCi | RGD:620452, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U23377 mRNA Translation: AAA69478.1 |
RefSeqi | NP_599188.1, NM_134361.1 |
3D structure databases
SMRi | P51672 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000003976 |
PTM databases
PhosphoSitePlusi | P51672 |
Proteomic databases
PaxDbi | P51672 |
PRIDEi | P51672 |
Genome annotation databases
GeneIDi | 171371 |
KEGGi | rno:171371 |
UCSCi | RGD:620452, rat |
Organism-specific databases
CTDi | 6375 |
RGDi | 620452, Xcl1 |
Phylogenomic databases
eggNOGi | ENOG502S6ZP, Eukaryota |
InParanoidi | P51672 |
OrthoDBi | 1553663at2759 |
PhylomeDBi | P51672 |
Enzyme and pathway databases
Reactomei | R-RNO-380108, Chemokine receptors bind chemokines R-RNO-416476, G alpha (q) signalling events |
Miscellaneous databases
PROi | PR:P51672 |
Family and domain databases
CDDi | cd00271, Chemokine_C, 1 hit |
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR001811, Chemokine_IL8-like_dom IPR008105, Chemokine_XCL1/XCL2 IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit PTHR12015:SF101, PTHR12015:SF101, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR01731, LYMPHOTACTIN |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | XCL1_RAT | |
Accessioni | P51672Primary (citable) accession number: P51672 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 117 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families