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Protein

Eotaxin

Gene

CCL11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3.

GO - Molecular functioni

  • CCR3 chemokine receptor binding Source: CAFA
  • chemokine activity Source: UniProtKB
  • protein dimerization activity Source: CAFA
  • receptor ligand activity Source: CAFA

GO - Biological processi

  • actin filament organization Source: Ensembl
  • antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
  • branching involved in mammary gland duct morphogenesis Source: Ensembl
  • cell adhesion Source: ProtInc
  • cellular calcium ion homeostasis Source: ProtInc
  • cellular response to interferon-gamma Source: GO_Central
  • cellular response to interleukin-1 Source: GO_Central
  • cellular response to tumor necrosis factor Source: GO_Central
  • chemokine-mediated signaling pathway Source: GO_Central
  • chemotaxis Source: ProtInc
  • chronic inflammatory response Source: Ensembl
  • cytokine-mediated signaling pathway Source: Reactome
  • cytoskeleton organization Source: UniProtKB
  • eosinophil chemotaxis Source: UniProtKB
  • ERK1 and ERK2 cascade Source: Ensembl
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • inflammatory response Source: ProtInc
  • killing of cells of other organism Source: UniProtKB
  • lymphocyte chemotaxis Source: GO_Central
  • mammary duct terminal end bud growth Source: Ensembl
  • mast cell chemotaxis Source: Ensembl
  • monocyte chemotaxis Source: GO_Central
  • neutrophil chemotaxis Source: GO_Central
  • positive regulation of actin filament polymerization Source: BHF-UCL
  • positive regulation of angiogenesis Source: Ensembl
  • positive regulation of cell migration Source: BHF-UCL
  • positive regulation of endothelial cell proliferation Source: BHF-UCL
  • positive regulation of ERK1 and ERK2 cascade Source: GO_Central
  • positive regulation of GTPase activity Source: BHF-UCL
  • protein phosphorylation Source: ProtInc
  • regulation of cell shape Source: UniProtKB
  • response to interleukin-13 Source: Ensembl
  • response to interleukin-4 Source: Ensembl
  • response to radiation Source: ProtInc
  • response to virus Source: ProtInc
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-HSA-6785807 Interleukin-4 and 13 signaling
SIGNORiP51671

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Eosinophil chemotactic protein
Small-inducible cytokine A11
Gene namesi
Name:CCL11
Synonyms:SCYA11
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000172156.3
HGNCiHGNC:10610 CCL11
MIMi601156 gene
neXtProtiNX_P51671

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6356
MalaCardsiCCL11
OpenTargetsiENSG00000172156
PharmGKBiPA35543

Chemistry databases

ChEMBLiCHEMBL3286077
DrugBankiDB05429 CAT-213

Polymorphism and mutation databases

BioMutaiCCL11
DMDMi1706661

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000000519524 – 97EotaxinAdd BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 57
Disulfide bondi33 ↔ 73
Glycosylationi94O-linked (GalNAc...) threonine1 Publication1

Post-translational modificationi

O-linked glycan consists of a Gal-GalNAc disaccharide which is modified with up to 2 sialic acid residues.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51671
PRIDEiP51671
ProteomicsDBi56363

PTM databases

iPTMnetiP51671
PhosphoSitePlusiP51671

Miscellaneous databases

PMAP-CutDBiP51671

Expressioni

Inductioni

Induced by TNF, IL1A/interleukin-1 alpha and IFNG/IFN-gamma.

Gene expression databases

BgeeiENSG00000172156
CleanExiHS_CCL11
ExpressionAtlasiP51671 baseline and differential
GenevisibleiP51671 HS

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • CCR3 chemokine receptor binding Source: CAFA
  • chemokine activity Source: UniProtKB
  • protein dimerization activity Source: CAFA
  • receptor ligand activity Source: CAFA

Protein-protein interaction databases

BioGridi112259, 3 interactors
DIPiDIP-5858N
IntActiP51671, 4 interactors
MINTiP51671
STRINGi9606.ENSP00000302234

Chemistry databases

BindingDBiP51671

Structurei

Secondary structure

197
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi26 – 29Combined sources4
Turni43 – 45Combined sources3
Beta strandi46 – 52Combined sources7
Beta strandi55 – 59Combined sources5
Beta strandi61 – 66Combined sources6
Beta strandi67 – 70Combined sources4
Beta strandi71 – 74Combined sources4
Helixi79 – 91Combined sources13

3D structure databases

DisProtiDP00641
ProteinModelPortaliP51671
SMRiP51671
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP51671

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036686
HOVERGENiHBG017871
InParanoidiP51671
KOiK16597
OMAiGSKCPQK
OrthoDBiEOG091G14KV
PhylomeDBiP51671
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51671-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVSAALLWL LLIAAAFSPQ GLAGPASVPT TCCFNLANRK IPLQRLESYR
60 70 80 90
RITSGKCPQK AVIFKTKLAK DICADPKKKW VQDSMKYLDQ KSPTPKP
Length:97
Mass (Da):10,732
Last modified:October 1, 1996 - v1
Checksum:iB433C30FDA4C71A7
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0016347L → P. 1
Natural variantiVAR_00163523A → T. Corresponds to variant dbSNP:rs1129844Ensembl.1
Natural variantiVAR_00163651R → S. 1
Natural variantiVAR_00163779K → R. 1
Natural variantiVAR_04870586K → T. Corresponds to variant dbSNP:rs34262946Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46573 mRNA Translation: AAA98957.1
U34780 Genomic DNA Translation: AAC50369.1
D49372 mRNA Translation: BAA08370.1
Z69291 mRNA Translation: CAA93258.1
Z75668 mRNA Translation: CAA99997.1
Z75669 mRNA Translation: CAA99998.1
U46572 Genomic DNA Translation: AAC51297.1
Z92709 Genomic DNA Translation: CAB07027.1
BC017850 mRNA Translation: AAH17850.1
CCDSiCCDS11279.1
PIRiJC4912
RefSeqiNP_002977.1, NM_002986.2
UniGeneiHs.54460

Genome annotation databases

EnsembliENST00000305869; ENSP00000302234; ENSG00000172156
GeneIDi6356
KEGGihsa:6356

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiCCL11_HUMAN
AccessioniPrimary (citable) accession number: P51671
Secondary accession number(s): P50877, Q92490, Q92491
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 176 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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