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Protein

C-C motif chemokine 9

Gene

Ccl9

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Monokine with inflammatory, pyrogenic and chemokinetic properties. Circulates at high concentrations in the blood of healthy animals. Binding to a high-affinity receptor activates calcium release in neutrophils. It also inhibits colony formation of bone marrow myeloid immature progenitors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events
R-MMU-444473 Formyl peptide receptors bind formyl peptides and many other ligands

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 9
Alternative name(s):
CCF18
Macrophage inflammatory protein 1-gamma
Short name:
MIP-1-gamma
Macrophage inflammatory protein-related protein 2
Short name:
MRP-2
Small-inducible cytokine A9
Cleaved into the following 3 chains:
Gene namesi
Name:Ccl9
Synonyms:Mrp2, Scya10, Scya9
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:104533 Ccl9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000519222 – 122C-C motif chemokine 9Add BLAST101
ChainiPRO_000004186550 – 122CCL9(29-101)Add BLAST73
ChainiPRO_000004186651 – 122CCL9(30-101)Add BLAST72
ChainiPRO_000004186752 – 122CCL9(31-101)Add BLAST71

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi57 ↔ 80By similarity
Disulfide bondi58 ↔ 96By similarity
Disulfide bondi67 ↔ 107By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP51670
PeptideAtlasiP51670
PRIDEiP51670

PTM databases

iPTMnetiP51670
PhosphoSitePlusiP51670

Expressioni

Tissue specificityi

Expressed mainly in the liver, lung, and the thymus, although some expression has been detected in a wide variety of tissues except brain.

Inductioni

By interleukin-4; in the bone marrow macrophage.

Gene expression databases

BgeeiENSMUSG00000019122 Expressed in 157 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_CCL9
ExpressionAtlasiP51670 baseline and differential
GenevisibleiP51670 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-5921N
STRINGi10090.ENSMUSP00000019266

Structurei

3D structure databases

ProteinModelPortaliP51670
SMRiP51670
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J4DG Eukaryota
ENOG4111C2C LUCA
GeneTreeiENSGT00910000144306
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiP51670
KOiK22671
OMAiSQSIPCS
OrthoDBiEOG091G14Y2
PhylomeDBiP51670
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51670-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKPFHTALSF LILTTALGIW AQITHATETK EVQSSLKAQQ GLEIEMFHMG
60 70 80 90 100
FQDSSDCCLS YNSRIQCSRF IGYFPTSGGC TRPGIIFISK RGFQVCANPS
110 120
DRRVQRCIER LEQNSQPRTY KQ
Length:122
Mass (Da):13,871
Last modified:October 1, 1996 - v1
Checksum:i9075F1FFEEFD30F7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113Q → K in AAB02198 (PubMed:8597875).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49513 mRNA Translation: AAB02198.1
U15209 mRNA Translation: AAA92583.1
U19482 mRNA Translation: AAB17120.1
AF128195 mRNA Translation: AAF22536.1
AF128196 mRNA Translation: AAF22537.1
AF128197 mRNA Translation: AAF22538.1
AF128198 mRNA Translation: AAF22539.1
AF128199 mRNA Translation: AAF22540.1
AF128200 mRNA Translation: AAF22541.1
AF128201 mRNA Translation: AAF22542.1
AF128202 mRNA Translation: AAF22543.1
AF128203 mRNA Translation: AAF22544.1
AF128204 mRNA Translation: AAF22545.1
AB051897 Genomic DNA Translation: BAB18730.1
AL596122 Genomic DNA Translation: CAI25133.1
CCDSiCCDS25170.1
RefSeqiNP_035468.1, NM_011338.2
UniGeneiMm.416125

Genome annotation databases

EnsembliENSMUST00000019266; ENSMUSP00000019266; ENSMUSG00000019122
GeneIDi20308
KEGGimmu:20308
UCSCiuc007kpj.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U49513 mRNA Translation: AAB02198.1
U15209 mRNA Translation: AAA92583.1
U19482 mRNA Translation: AAB17120.1
AF128195 mRNA Translation: AAF22536.1
AF128196 mRNA Translation: AAF22537.1
AF128197 mRNA Translation: AAF22538.1
AF128198 mRNA Translation: AAF22539.1
AF128199 mRNA Translation: AAF22540.1
AF128200 mRNA Translation: AAF22541.1
AF128201 mRNA Translation: AAF22542.1
AF128202 mRNA Translation: AAF22543.1
AF128203 mRNA Translation: AAF22544.1
AF128204 mRNA Translation: AAF22545.1
AB051897 Genomic DNA Translation: BAB18730.1
AL596122 Genomic DNA Translation: CAI25133.1
CCDSiCCDS25170.1
RefSeqiNP_035468.1, NM_011338.2
UniGeneiMm.416125

3D structure databases

ProteinModelPortaliP51670
SMRiP51670
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5921N
STRINGi10090.ENSMUSP00000019266

PTM databases

iPTMnetiP51670
PhosphoSitePlusiP51670

Proteomic databases

PaxDbiP51670
PeptideAtlasiP51670
PRIDEiP51670

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000019266; ENSMUSP00000019266; ENSMUSG00000019122
GeneIDi20308
KEGGimmu:20308
UCSCiuc007kpj.1 mouse

Organism-specific databases

CTDi20308
MGIiMGI:104533 Ccl9

Phylogenomic databases

eggNOGiENOG410J4DG Eukaryota
ENOG4111C2C LUCA
GeneTreeiENSGT00910000144306
HOGENOMiHOG000036685
HOVERGENiHBG017871
InParanoidiP51670
KOiK22671
OMAiSQSIPCS
OrthoDBiEOG091G14Y2
PhylomeDBiP51670
TreeFamiTF334888

Enzyme and pathway databases

ReactomeiR-MMU-416476 G alpha (q) signalling events
R-MMU-418594 G alpha (i) signalling events
R-MMU-444473 Formyl peptide receptors bind formyl peptides and many other ligands

Miscellaneous databases

PROiPR:P51670
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019122 Expressed in 157 organ(s), highest expression level in bone marrow macrophage
CleanExiMM_CCL9
ExpressionAtlasiP51670 baseline and differential
GenevisibleiP51670 MM

Family and domain databases

InterProiView protein in InterPro
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL9_MOUSE
AccessioniPrimary (citable) accession number: P51670
Secondary accession number(s): Q5QNW2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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