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Protein

Corticosteroid 11-beta-dehydrogenase isozyme 2

Gene

Hsd11b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.

Catalytic activityi

An 11-beta-hydroxysteroid + NAD+ = an 11-oxosteroid + NADH.

Activity regulationi

Inhibited by glycyrrhetinic acid, carbenoloxone and 11-alpha-OH-progesterone.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei219SubstrateBy similarity1
Active sitei232Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi82 – 111NADBy similarityAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

BRENDAi1.1.1.146 3474
1.1.1.B40 3474
ReactomeiR-MMU-194002 Glucocorticoid biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Corticosteroid 11-beta-dehydrogenase isozyme 2 (EC:1.1.1.-)
Alternative name(s):
11-beta-hydroxysteroid dehydrogenase type 2
Short name:
11-DH2
Short name:
11-beta-HSD2
NAD-dependent 11-beta-hydroxysteroid dehydrogenase
Gene namesi
Name:Hsd11b2
Synonyms:Hsd11k
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:104720 Hsd11b2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Microsome

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3490

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000546281 – 386Corticosteroid 11-beta-dehydrogenase isozyme 2Add BLAST386

Proteomic databases

MaxQBiP51661
PaxDbiP51661
PeptideAtlasiP51661
PRIDEiP51661

PTM databases

iPTMnetiP51661
PhosphoSitePlusiP51661

Expressioni

Tissue specificityi

Highly expressed in kidney. Also found in colon and small intestine. Not expressed in the adrenal gland.

Gene expression databases

BgeeiENSMUSG00000031891 Expressed in 175 organ(s), highest expression level in cortex of kidney
CleanExiMM_HSD11B2
GenevisibleiP51661 MM

Interactioni

Subunit structurei

Interacts with ligand-free cytoplasmic NR3C2.By similarity

Protein-protein interaction databases

BioGridi200431, 1 interactor
IntActiP51661, 3 interactors
MINTiP51661
STRINGi10090.ENSMUSP00000034363

Chemistry databases

BindingDBiP51661

Structurei

3D structure databases

ProteinModelPortaliP51661
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1610 Eukaryota
ENOG410Y7FK LUCA
GeneTreeiENSGT00930000150852
HOVERGENiHBG005482
InParanoidiP51661
KOiK00071
OMAiFPCLAAY
OrthoDBiEOG091G0LMI
PhylomeDBiP51661
TreeFamiTF325617

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

P51661-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERWPWPSGG AWLLVAARAL LQLLRSDLRL GRPLLAALAL LAALDWLCQR
60 70 80 90 100
LLPPPAALVV LAGAGWIALS RLARPPRLPV ATRAVLITGC DTGFGKETAK
110 120 130 140 150
KLDAMGFTVL ATVLDLNSPG ALELRDLCSP RLKLLQMDLT KAEDISRVLE
160 170 180 190 200
ITKAHTASTG LWGLVNNAGL NIVVADVELS PVATFRKCME VNFFGALELT
210 220 230 240 250
KGLLPLLRHS RGRIVTVGSP AGDMPYPCLA AYGTSKAAIA LLMDTFGCEL
260 270 280 290 300
LPWGIKVSII KPGCFKTDAV TNVNLWEKRK QLLLANIPRE LLQAYGEDYI
310 320 330 340 350
EHVHGQFLNS LRMALPDLSP VVDAIIDALL AAQPRSRYYP GRGLGLMYFI
360 370 380
HHYLPEGLRR CFLQNFFINH LLPRALRPGQ HGPAPA
Length:386
Mass (Da):42,187
Last modified:April 30, 2003 - v2
Checksum:i687FD253568487AB
GO

Sequence cautioni

The sequence CAA62219 differs from that shown. Reason: Frameshift at position 383.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49Q → L in AAC60711 (PubMed:7664690).Curated1
Sequence conflicti49Q → L in CAA62218 (PubMed:7664690).Curated1
Sequence conflicti52L → M in AAC60711 (PubMed:7664690).Curated1
Sequence conflicti52L → M in CAA62218 (PubMed:7664690).Curated1
Sequence conflicti178E → G in AAC60711 (PubMed:7664690).Curated1
Sequence conflicti178E → G in CAA62218 (PubMed:7664690).Curated1
Sequence conflicti216T → P in AAC60711 (PubMed:7664690).Curated1
Sequence conflicti216T → P in CAA62218 (PubMed:7664690).Curated1
Sequence conflicti265F → S in AAC60711 (PubMed:7664690).Curated1
Sequence conflicti265F → S in CAA62218 (PubMed:7664690).Curated1
Sequence conflicti268D → A in AAC60711 (PubMed:7664690).Curated1
Sequence conflicti268D → A in CAA62218 (PubMed:7664690).Curated1
Sequence conflicti297E → A in AAC60711 (PubMed:7664690).Curated1
Sequence conflicti297E → A in CAA62218 (PubMed:7664690).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79554
, S79550, S79551, S79552, S79553 Genomic DNA Translation: AAC60711.1 Frameshift.
X90646 Genomic DNA Translation: CAA62218.1
X90647 Genomic DNA Translation: CAA62219.1 Frameshift.
BC014753 mRNA Translation: AAH14753.1
CCDSiCCDS40460.1
PIRiS60188
RefSeqiNP_032315.2, NM_008289.2
UniGeneiMm.5079

Genome annotation databases

EnsembliENSMUST00000034363; ENSMUSP00000034363; ENSMUSG00000031891
GeneIDi15484
KEGGimmu:15484
UCSCiuc009nde.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S79554
, S79550, S79551, S79552, S79553 Genomic DNA Translation: AAC60711.1 Frameshift.
X90646 Genomic DNA Translation: CAA62218.1
X90647 Genomic DNA Translation: CAA62219.1 Frameshift.
BC014753 mRNA Translation: AAH14753.1
CCDSiCCDS40460.1
PIRiS60188
RefSeqiNP_032315.2, NM_008289.2
UniGeneiMm.5079

3D structure databases

ProteinModelPortaliP51661
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200431, 1 interactor
IntActiP51661, 3 interactors
MINTiP51661
STRINGi10090.ENSMUSP00000034363

Chemistry databases

BindingDBiP51661
ChEMBLiCHEMBL3490

PTM databases

iPTMnetiP51661
PhosphoSitePlusiP51661

Proteomic databases

MaxQBiP51661
PaxDbiP51661
PeptideAtlasiP51661
PRIDEiP51661

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034363; ENSMUSP00000034363; ENSMUSG00000031891
GeneIDi15484
KEGGimmu:15484
UCSCiuc009nde.1 mouse

Organism-specific databases

CTDi3291
MGIiMGI:104720 Hsd11b2

Phylogenomic databases

eggNOGiKOG1610 Eukaryota
ENOG410Y7FK LUCA
GeneTreeiENSGT00930000150852
HOVERGENiHBG005482
InParanoidiP51661
KOiK00071
OMAiFPCLAAY
OrthoDBiEOG091G0LMI
PhylomeDBiP51661
TreeFamiTF325617

Enzyme and pathway databases

BRENDAi1.1.1.146 3474
1.1.1.B40 3474
ReactomeiR-MMU-194002 Glucocorticoid biosynthesis

Miscellaneous databases

PROiPR:P51661
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031891 Expressed in 175 organ(s), highest expression level in cortex of kidney
CleanExiMM_HSD11B2
GenevisibleiP51661 MM

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiDHI2_MOUSE
AccessioniPrimary (citable) accession number: P51661
Secondary accession number(s): Q91WK3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 30, 2003
Last modified: November 7, 2018
This is version 150 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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