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UniProtKB - P51659 (DHB4_HUMAN)

Entry version 205 (16 Oct 2019)
Sequence version 3 (23 Jan 2007)
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Protein

Peroxisomal multifunctional enzyme type 2

Gene

HSD17B4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Bifunctional enzyme acting on the peroxisomal beta-oxidation pathway for fatty acids. Catalyzes the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids.2 Publications

Miscellaneous

The protein is found both as a full-length peptide and in a cleaved version.

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=10 µM for D-3-hydroxy-octanoyl-CoA1 Publication
  2. KM=13 µM for NAD1 Publication
  3. KM=2.7 µM for 3-ketooctanoyl-CoA1 Publication
  4. KM=5.4 µM for NADH1 Publication
  1. Vmax=8.8 µmol/min/mg enzyme1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid beta-oxidation

This protein is involved in the pathway fatty acid beta-oxidation, which is part of Lipid metabolism.
View all proteins of this organism that are known to be involved in the pathway fatty acid beta-oxidation and in Lipid metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei21NAD; via amide nitrogen1
Binding sitei40NAD1
Binding sitei99NAD; via carbonyl oxygen1
Binding sitei151SubstrateBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei164Proton acceptorPROSITE-ProRule annotation1
Binding sitei435(3R)-3-hydroxydecanoyl-CoABy similarity1
Binding sitei533(3R)-3-hydroxydecanoyl-CoA; via amide nitrogenBy similarity1
Binding sitei563(3R)-3-hydroxydecanoyl-CoA; via carbonyl oxygenBy similarity1
Binding sitei706Substrate1
Binding sitei724Substrate1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi13 – 37NADBy similarityAdd BLAST25
Nucleotide bindingi75 – 76NAD2
Nucleotide bindingi164 – 168NAD5
Nucleotide bindingi196 – 199NAD4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIsomerase, Lyase, Oxidoreductase
Biological processFatty acid metabolism, Lipid metabolism
LigandNAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:HS05792-MONOMER

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		4.2.1.119 2681

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-2046106 alpha-linolenic acid (ALA) metabolism
R-HSA-389887 Beta-oxidation of pristanoyl-CoA
R-HSA-390247 Beta-oxidation of very long chain fatty acids
R-HSA-9033241 Peroxisomal protein import
R-HSA-9033500 TYSND1 cleaves peroxisomal proteins

SABIO-RK: Biochemical Reaction Kinetics Database

More...SABIO-RKi		P51659

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00659

Chemistry databases

SwissLipids knowledge resource for lipid biology

More...SwissLipidsi		SLP:000000540

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxisomal multifunctional enzyme type 2
Short name:
MFE-2
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase 4
Short name:
17-beta-HSD 4
D-bifunctional protein
Short name:
DBP
Multifunctional protein 2
Short name:
MPF-2
Short chain dehydrogenase/reductase family 8C member 1
Cleaved into the following 2 chains:
(3R)-hydroxyacyl-CoA dehydrogenase (EC:1.1.1.n12)
Enoyl-CoA hydratase 2 (EC:4.2.1.107, EC:4.2.1.119)
Alternative name(s):
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HSD17B4
Synonyms:EDH17B4, SDR8C1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:5213 HSD17B4

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		601860 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P51659

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Peroxisome

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

D-bifunctional protein deficiency (DBPD)4 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionDisorder of peroxisomal fatty acid beta-oxidation.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03757616G → S in DBPD; no dehydrogenase activity. 2 PublicationsCorresponds to variant dbSNP:rs137853096EnsemblClinVar.1
Natural variantiVAR_065906106R → P in DBPD. 1 PublicationCorresponds to variant dbSNP:rs25640EnsemblClinVar.1
Natural variantiVAR_065908457N → Y in DBPD; the mutation leads to an unstable protein. 1 PublicationCorresponds to variant dbSNP:rs137853097EnsemblClinVar.1
Perrault syndrome 1 (PRLTS1)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA sex-influenced disorder characterized by sensorineural deafness in both males and females and ovarian dysgenesis in females. Some patients also have neurologic manifestations, including mild mental retardation and cerebellar and peripheral nervous system involvement.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_065907217Y → C in PRLTS1. 1 PublicationCorresponds to variant dbSNP:rs387906825EnsemblClinVar.1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi347Y → A: No hydratase activity. 1 Publication1
Mutagenesisi366E → A: No hydratase activity. 1 Publication1
Mutagenesisi370D → A: No effect. 1 Publication1
Mutagenesisi406H → A: No effect. 1 Publication1
Mutagenesisi408E → A: No effect. 1 Publication1
Mutagenesisi410Y → A: No effect. 1 Publication1
Mutagenesisi490D → A: No effect. 1 Publication1
Mutagenesisi505Y → A: Completely inactive. 1 Publication1
Mutagenesisi510D → A: No hydratase activity. 1 Publication1
Mutagenesisi515H → A: Completely inactive. 1 Publication1
Mutagenesisi517D → A: No effect. 1 Publication1
Mutagenesisi532H → A: No effect. 1 Publication1

Keywords - Diseasei

Deafness, Disease mutation

Organism-specific databases

DisGeNET

More...DisGeNETi		3295

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		HSD17B4

MalaCards human disease database

More...MalaCardsi		HSD17B4
MIMi233400 phenotype
261515 phenotype

Open Targets

More...OpenTargetsi		ENSG00000133835

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		300 Bifunctional enzyme deficiency
2855 Perrault syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29481

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P51659

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5814

Drug and drug target database

More...DrugBanki		DB03192 3r-Hydroxydecanoyl-Coa
DB00157 NADH

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		HSD17B4

Domain mapping of disease mutations (DMDM)

More...DMDMi		1706396

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000545831 – 736Peroxisomal multifunctional enzyme type 2Add BLAST736
ChainiPRO_00004000821 – 311(3R)-hydroxyacyl-CoA dehydrogenaseAdd BLAST311
ChainiPRO_0000400083312 – 736Enoyl-CoA hydratase 2Add BLAST425

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei46N6-acetyllysine; alternateBy similarity1
Modified residuei46N6-succinyllysine; alternateBy similarity1
Modified residuei52PhosphoserineCombined sources1
Modified residuei57N6-succinyllysineBy similarity1
Modified residuei68N6-succinyllysineBy similarity1
Modified residuei84N6-succinyllysineBy similarity1
Modified residuei265PhosphothreonineCombined sources1
Modified residuei275N6-succinyllysineBy similarity1
Modified residuei304PhosphoserineCombined sources1
Modified residuei309PhosphoserineCombined sources1
Modified residuei356N6-succinyllysineBy similarity1
Modified residuei424N6-succinyllysineBy similarity1
Modified residuei565N6-acetyllysineCombined sources1
Modified residuei579N6-succinyllysineBy similarity1
Modified residuei663N6-succinyllysineBy similarity1
Modified residuei669N6-acetyllysineCombined sources1
Modified residuei707N6-acetyllysineCombined sources1
Modified residuei725N6-succinyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

The CPTAC Assay portal

More...CPTACi		CPTAC-389
CPTAC-390

Encyclopedia of Proteome Dynamics

More...EPDi		P51659

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P51659

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P51659

MaxQB - The MaxQuant DataBase

More...MaxQBi		P51659

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P51659

PeptideAtlas

More...PeptideAtlasi		P51659

PRoteomics IDEntifications database

More...PRIDEi		P51659

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		19165
27834
56360 [P51659-1]

Consortium for Top Down Proteomics

More...TopDownProteomicsi		P51659-1 [P51659-1]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P51659

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P51659

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P51659

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Present in many tissues with highest concentrations in liver, heart, prostate and testis.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000133835 Expressed in 233 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P51659 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P51659 HS

Organism-specific databases

Human Protein Atlas

More...HPAi		HPA021302
HPA021311
HPA021479

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

2 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		109528, 56 interactors

Protein interaction database and analysis system

More...IntActi		P51659, 44 interactors

Molecular INTeraction database

More...MINTi		P51659

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000420914

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1736
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P51659

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...EvolutionaryTracei		P51659

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini484 – 600MaoC-likeAdd BLAST117
Domaini624 – 736SCP2Add BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 305(3R)-hydroxyacyl-CoA dehydrogenaseAdd BLAST305
Regioni322 – 622Enoyl-CoA hydratase 2Add BLAST301
Regioni406 – 407(3R)-3-hydroxydecanoyl-CoA bindingBy similarity2
Regioni510 – 515(3R)-3-hydroxydecanoyl-CoA bindingBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi734 – 736Microbody targeting signalSequence analysis3

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1206 Eukaryota
COG2030 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000158343

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000170895

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P51659

KEGG Orthology (KO)

More...KOi		K12405

Identification of Orthologs from Complete Genome Data

More...OMAi		CTQAAFP

Database of Orthologous Groups

More...OrthoDBi		1120431at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P51659

TreeFam database of animal gene trees

More...TreeFami		TF105656

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.30.1050.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR029069 HotDog_dom_sf
IPR039569 MaoC-like_dehydrat_N
IPR002539 MaoC-like_dom
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR003033 SCP2_sterol-bd_dom
IPR036527 SCP2_sterol-bd_dom_sf
IPR002347 SDR_fam

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00106 adh_short, 1 hit
PF13452 MaoC_dehydrat_N, 1 hit
PF01575 MaoC_dehydratas, 1 hit
PF02036 SCP2, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00081 GDHRDH
PR00080 SDRFAMILY

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51735 SSF51735, 1 hit
SSF54637 SSF54637, 2 hits
SSF55718 SSF55718, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00061 ADH_SHORT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 14 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P51659-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

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MGSPLRFDGR VVLVTGAGAG LGRAYALAFA ERGALVVVND LGGDFKGVGK 
        60         70         80         90        100
GSLAADKVVE EIRRRGGKAV ANYDSVEEGE KVVKTALDAF GRIDVVVNNA 
       110        120        130        140        150
GILRDRSFAR ISDEDWDIIH RVHLRGSFQV TRAAWEHMKK QKYGRIIMTS 
       160        170        180        190        200
SASGIYGNFG QANYSAAKLG LLGLANSLAI EGRKSNIHCN TIAPNAGSRM 
       210        220        230        240        250
TQTVMPEDLV EALKPEYVAP LVLWLCHESC EENGGLFEVG AGWIGKLRWE 
       260        270        280        290        300
RTLGAIVRQK NHPMTPEAVK ANWKKICDFE NASKPQSIQE STGSIIEVLS 
       310        320        330        340        350
KIDSEGGVSA NHTSRATSTA TSGFAGAIGQ KLPPFSYAYT ELEAIMYALG 
       360        370        380        390        400
VGASIKDPKD LKFIYEGSSD FSCLPTFGVI IGQKSMMGGG LAEIPGLSIN 
       410        420        430        440        450
FAKVLHGEQY LELYKPLPRA GKLKCEAVVA DVLDKGSGVV IIMDVYSYSE 
       460        470        480        490        500
KELICHNQFS LFLVGSGGFG GKRTSDKVKV AVAIPNRPPD AVLTDTTSLN 
       510        520        530        540        550
QAALYRLSGD WNPLHIDPNF ASLAGFDKPI LHGLCTFGFS ARRVLQQFAD 
       560        570        580        590        600
NDVSRFKAIK ARFAKPVYPG QTLQTEMWKE GNRIHFQTKV QETGDIVISN 
       610        620        630        640        650
AYVDLAPTSG TSAKTPSEGG KLQSTFVFEE IGRRLKDIGP EVVKKVNAVF 
       660        670        680        690        700
EWHITKGGNI GAKWTIDLKS GSGKVYQGPA KGAADTTIIL SDEDFMEVVL 
       710        720        730 
GKLDPQKAFF SGRLKARGNI MLSQKLQMIL KDYAKL
Length:736
Mass (Da):79,686
Last modified:January 23, 2007 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7B11E02483328BCE
GO
Isoform 2 (identifier: P51659-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-38: MGSPLRFDGR...FAERGALVVV → MVILEAPHLL...ISQCRFFVSM

Note: No experimental confirmation available.
Show »
Length:761
Mass (Da):83,025
Checksum:i246D60646BD2C7A8
GO
Isoform 3 (identifier: P51659-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     20-37: Missing.

Note: No experimental confirmation available.
Show »
Length:718
Mass (Da):77,870
Checksum:i79C506BC0D73B5C2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 14 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G5E9S2G5E9S2_HUMAN
Hydroxysteroid (17-beta) dehydrogen...
HSD17B4 hCG_37330
596Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ER27E7ER27_HUMAN
Peroxisomal multifunctional enzyme ...
HSD17B4
500Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7ET17E7ET17_HUMAN
Peroxisomal multifunctional enzyme ...
HSD17B4
599Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EWE5E7EWE5_HUMAN
Peroxisomal multifunctional enzyme ...
HSD17B4
712Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YD50A0A2R8YD50_HUMAN
Peroxisomal multifunctional enzyme ...
HSD17B4
711Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7L2A0A2R8Y7L2_HUMAN
Peroxisomal multifunctional enzyme ...
HSD17B4
589Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8Y7W2A0A2R8Y7W2_HUMAN
Peroxisomal multifunctional enzyme ...
HSD17B4
105Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E7EPL9E7EPL9_HUMAN
Peroxisomal multifunctional enzyme ...
HSD17B4
474Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YDT8A0A2R8YDT8_HUMAN
Peroxisomal multifunctional enzyme ...
HSD17B4
166Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A2R8YF39A0A2R8YF39_HUMAN
Peroxisomal multifunctional enzyme ...
HSD17B4
50Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
There are more potential isoformsShow all

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti587Q → R in BAG60363 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03757616G → S in DBPD; no dehydrogenase activity. 2 PublicationsCorresponds to variant dbSNP:rs137853096EnsemblClinVar.1
Natural variantiVAR_05230990F → L. Corresponds to variant dbSNP:rs28943588EnsemblClinVar.1
Natural variantiVAR_014872106R → H2 PublicationsCorresponds to variant dbSNP:rs25640EnsemblClinVar.1
Natural variantiVAR_065906106R → P in DBPD. 1 PublicationCorresponds to variant dbSNP:rs25640EnsemblClinVar.1
Natural variantiVAR_052310140K → N. Corresponds to variant dbSNP:rs28943589EnsemblClinVar.1
Natural variantiVAR_065907217Y → C in PRLTS1. 1 PublicationCorresponds to variant dbSNP:rs387906825EnsemblClinVar.1
Natural variantiVAR_024625292T → S. Corresponds to variant dbSNP:rs1143650EnsemblClinVar.1
Natural variantiVAR_052311427A → V. Corresponds to variant dbSNP:rs28943590EnsemblClinVar.1
Natural variantiVAR_065908457N → Y in DBPD; the mutation leads to an unstable protein. 1 PublicationCorresponds to variant dbSNP:rs137853097EnsemblClinVar.1
Natural variantiVAR_052312491A → T. Corresponds to variant dbSNP:rs28943591EnsemblClinVar.1
Natural variantiVAR_014873511W → R1 PublicationCorresponds to variant dbSNP:rs11539471EnsemblClinVar.1
Natural variantiVAR_014874559I → V2 PublicationsCorresponds to variant dbSNP:rs11205EnsemblClinVar.1
Natural variantiVAR_052313606A → S. Corresponds to variant dbSNP:rs15228Ensembl.1
Natural variantiVAR_052314687T → I. Corresponds to variant dbSNP:rs28943592EnsemblClinVar.1
Natural variantiVAR_052315728M → V. Corresponds to variant dbSNP:rs28943594EnsemblClinVar.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0461521 – 38MGSPL…ALVVV → MVILEAPHLLRRKEPETPGL SSRIGPSLCPGFCRKRSVSC CFQNLCNNPMEKIISQCRFF VSM in isoform 2. 1 PublicationAdd BLAST38
Alternative sequenceiVSP_04615320 – 37Missing in isoform 3. 1 PublicationAdd BLAST18

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X87176 mRNA Translation: CAA60643.1
AF057740
, AF057720, AF057721, AF057722, AF057723, AF057724, AF057725, AF057726, AF057727, AF057728, AF057729, AF057730, AF057731, AF057732, AF057733, AF057734, AF057735, AF057736, AF057737, AF057738, AF057739 Genomic DNA Translation: AAD08652.1
AK298075 mRNA Translation: BAG60363.1
AK301212 mRNA Translation: BAG62787.1
AC024564 Genomic DNA No translation available.
BC003098 mRNA Translation: AAH03098.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS4126.1 [P51659-1]
CCDS56378.1 [P51659-3]
CCDS56379.1 [P51659-2]

Protein sequence database of the Protein Information Resource

More...PIRi		S59136

NCBI Reference Sequences

More...RefSeqi		NP_000405.1, NM_000414.3 [P51659-1]
NP_001186220.1, NM_001199291.2 [P51659-2]
NP_001186221.1, NM_001199292.1 [P51659-3]
NP_001278956.1, NM_001292027.1
NP_001278957.1, NM_001292028.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000414835; ENSP00000411960; ENSG00000133835 [P51659-2]
ENST00000510025; ENSP00000424940; ENSG00000133835 [P51659-1]
ENST00000515320; ENSP00000424613; ENSG00000133835 [P51659-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3295

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3295

UCSC genome browser

More...UCSCi		uc003ksj.4 human [P51659-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X87176 mRNA Translation: CAA60643.1
AF057740
, AF057720, AF057721, AF057722, AF057723, AF057724, AF057725, AF057726, AF057727, AF057728, AF057729, AF057730, AF057731, AF057732, AF057733, AF057734, AF057735, AF057736, AF057737, AF057738, AF057739 Genomic DNA Translation: AAD08652.1
AK298075 mRNA Translation: BAG60363.1
AK301212 mRNA Translation: BAG62787.1
AC024564 Genomic DNA No translation available.
BC003098 mRNA Translation: AAH03098.1
CCDSiCCDS4126.1 [P51659-1]
CCDS56378.1 [P51659-3]
CCDS56379.1 [P51659-2]
PIRiS59136
RefSeqiNP_000405.1, NM_000414.3 [P51659-1]
NP_001186220.1, NM_001199291.2 [P51659-2]
NP_001186221.1, NM_001199292.1 [P51659-3]
NP_001278956.1, NM_001292027.1
NP_001278957.1, NM_001292028.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1IKTX-ray1.75A618-736[»]
1S9CX-ray3.00A/B/C/D/E/F/G/H/I/J/K/L318-615[»]
1ZBQX-ray2.71A/B/C/D/E/F1-304[»]
SMRiP51659
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi109528, 56 interactors
IntActiP51659, 44 interactors
MINTiP51659
STRINGi9606.ENSP00000420914

Chemistry databases

ChEMBLiCHEMBL5814
DrugBankiDB03192 3r-Hydroxydecanoyl-Coa
DB00157 NADH
SwissLipidsiSLP:000000540

PTM databases

iPTMnetiP51659
PhosphoSitePlusiP51659
SwissPalmiP51659

Polymorphism and mutation databases

BioMutaiHSD17B4
DMDMi1706396

Proteomic databases

CPTACiCPTAC-389
CPTAC-390
EPDiP51659
jPOSTiP51659
MassIVEiP51659
MaxQBiP51659
PaxDbiP51659
PeptideAtlasiP51659
PRIDEiP51659
ProteomicsDBi19165
27834
56360 [P51659-1]
TopDownProteomicsiP51659-1 [P51659-1]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		3295

Genome annotation databases

EnsembliENST00000414835; ENSP00000411960; ENSG00000133835 [P51659-2]
ENST00000510025; ENSP00000424940; ENSG00000133835 [P51659-1]
ENST00000515320; ENSP00000424613; ENSG00000133835 [P51659-3]
GeneIDi3295
KEGGihsa:3295
UCSCiuc003ksj.4 human [P51659-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3295
DisGeNETi3295

GeneCards: human genes, protein and diseases

More...GeneCardsi		HSD17B4
GeneReviewsiHSD17B4
HGNCiHGNC:5213 HSD17B4
HPAiHPA021302
HPA021311
HPA021479
MalaCardsiHSD17B4
MIMi233400 phenotype
261515 phenotype
601860 gene
neXtProtiNX_P51659
OpenTargetsiENSG00000133835
Orphaneti300 Bifunctional enzyme deficiency
2855 Perrault syndrome
PharmGKBiPA29481

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1206 Eukaryota
COG2030 LUCA
GeneTreeiENSGT00940000158343
HOGENOMiHOG000170895
InParanoidiP51659
KOiK12405
OMAiCTQAAFP
OrthoDBi1120431at2759
PhylomeDBiP51659
TreeFamiTF105656

Enzyme and pathway databases

UniPathwayiUPA00659
BioCyciMetaCyc:HS05792-MONOMER
BRENDAi4.2.1.119 2681
ReactomeiR-HSA-193368 Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol
R-HSA-2046106 alpha-linolenic acid (ALA) metabolism
R-HSA-389887 Beta-oxidation of pristanoyl-CoA
R-HSA-390247 Beta-oxidation of very long chain fatty acids
R-HSA-9033241 Peroxisomal protein import
R-HSA-9033500 TYSND1 cleaves peroxisomal proteins
SABIO-RKiP51659

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		HSD17B4 human
EvolutionaryTraceiP51659

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		HSD17B4

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3295
PharosiP51659

Protein Ontology

More...PROi		PR:P51659

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000133835 Expressed in 233 organ(s), highest expression level in corpus callosum
ExpressionAtlasiP51659 baseline and differential
GenevisibleiP51659 HS

Family and domain databases

Gene3Di3.30.1050.10, 1 hit
InterProiView protein in InterPro
IPR029069 HotDog_dom_sf
IPR039569 MaoC-like_dehydrat_N
IPR002539 MaoC-like_dom
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR003033 SCP2_sterol-bd_dom
IPR036527 SCP2_sterol-bd_dom_sf
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PF13452 MaoC_dehydrat_N, 1 hit
PF01575 MaoC_dehydratas, 1 hit
PF02036 SCP2, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
SSF54637 SSF54637, 2 hits
SSF55718 SSF55718, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDHB4_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51659
Secondary accession number(s): B4DNV1
, B4DVS5, E9PB82, F5HE57
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: October 16, 2019
This is version 205 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  7. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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