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Protein

Estradiol 17-beta-dehydrogenase 2

Gene

Hsd17b2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH (By similarity).By similarity

Catalytic activityi

17-beta-estradiol + NAD(P)+ = estrone + NAD(P)H.
Testosterone + NAD+ = androstenedione + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei220SubstrateBy similarity1
Active sitei233Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi83 – 112NADBy similarityAdd BLAST30

GO - Molecular functioni

GO - Biological processi

  • androgen biosynthetic process Source: MGI
  • estrogen biosynthetic process Source: MGI
  • in utero embryonic development Source: MGI
  • placenta development Source: MGI
  • response to retinoic acid Source: MGI

Keywordsi

Molecular functionOxidoreductase
Biological processLipid biosynthesis, Lipid metabolism, Steroid biosynthesis
LigandNAD

Enzyme and pathway databases

ReactomeiR-MMU-193144 Estrogen biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Estradiol 17-beta-dehydrogenase 2 (EC:1.1.1.62)
Alternative name(s):
17-beta-hydroxysteroid dehydrogenase type 2
Short name:
17-beta-HSD 2
Testosterone 17-beta-dehydrogenase (EC:1.1.1.239)
Gene namesi
Name:Hsd17b2
Synonyms:Edh17b2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:1096386 Hsd17b2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei4 – 24Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL1914270

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000545711 – 381Estradiol 17-beta-dehydrogenase 2Add BLAST381

Proteomic databases

MaxQBiP51658
PaxDbiP51658
PeptideAtlasiP51658
PRIDEiP51658

PTM databases

iPTMnetiP51658
PhosphoSitePlusiP51658

Expressioni

Gene expression databases

BgeeiENSMUSG00000031844
CleanExiMM_HSD17B2
ExpressionAtlasiP51658 baseline and differential
GenevisibleiP51658 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034304

Chemistry databases

BindingDBiP51658

Structurei

3D structure databases

ProteinModelPortaliP51658
SMRiP51658
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1610 Eukaryota
ENOG410Y7FK LUCA
GeneTreeiENSGT00920000148940
HOVERGENiHBG005482
InParanoidiP51658
KOiK13368
OMAiQEDYGQD
OrthoDBiEOG091G0LMI
PhylomeDBiP51658
TreeFamiTF325617

Family and domain databases

InterProiView protein in InterPro
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR00081 GDHRDH
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

P51658-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPFASESAW LCLAAAAVLG GTLLCGCRSG RQLRSQAVCL AGLWGGACLL
60 70 80 90 100
SLSLLCTLFL LSVACFLLLY MSSSDQDLLP VDQKAVLVTG ADSGFGHGLA
110 120 130 140 150
KHLDKLGFTV FAGVLDKEGP GAEELRKHCS ERLSVLQMDV TKPEQIKDAH
160 170 180 190 200
SKVTEKIQDK GLWAVVNNAG VFHLPIDGEL IPMSIYRKCM AVNFFGTVEV
210 220 230 240 250
TKAFLPLLRK SKGRLVNVSS MGGTVPLQMT SAYAATKAAL TMFSTIIRQE
260 270 280 290 300
LDKWGVKVVT IKPGGFKTNI TGSQDIWDKM EKEILDHFSK DIQENYGQDY
310 320 330 340 350
VHTQKLIIPT LKERSNPDIT PVLRDIQHAI SARNPSSFYY PGRMAYLWVC
360 370 380
LAAYCPTSLL DYVIKKGFYP QPTPRALRTV H
Length:381
Mass (Da):41,836
Last modified:November 1, 1997 - v2
Checksum:i74A62797947E6086
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti36 – 37QA → RP in CAA64982 (Ref. 2) Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y09517 mRNA Translation: CAA70706.1
X95685 mRNA Translation: CAA64982.1
CCDSiCCDS40491.1
RefSeqiNP_032316.2, NM_008290.2
UniGeneiMm.276466

Genome annotation databases

EnsembliENSMUST00000034304; ENSMUSP00000034304; ENSMUSG00000031844
GeneIDi15486
KEGGimmu:15486
UCSCiuc009npf.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDHB2_MOUSE
AccessioniPrimary (citable) accession number: P51658
Secondary accession number(s): O08898
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: November 1, 1997
Last modified: June 20, 2018
This is version 149 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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