UniProtKB - P51658 (DHB2_MOUSE)
Protein
Estradiol 17-beta-dehydrogenase 2
Gene
Hsd17b2
Organism
Mus musculus (Mouse)
Status
Functioni
Capable of catalyzing the interconversion of testosterone and androstenedione, as well as estradiol and estrone. Also has 20-alpha-HSD activity. Uses NADH while EDH17B3 uses NADPH.By similarity
Catalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 220 | SubstrateBy similarity | 1 | |
Active sitei | 233 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 83 – 112 | NADBy similarityAdd BLAST | 30 |
GO - Molecular functioni
- estradiol 17-beta-dehydrogenase activity Source: MGI
- testosterone dehydrogenase (NAD+) activity Source: MGI
GO - Biological processi
- androgen biosynthetic process Source: MGI
- estrogen biosynthetic process Source: MGI
- in utero embryonic development Source: MGI
- placenta development Source: MGI
- response to retinoic acid Source: MGI
Keywordsi
Molecular function | Oxidoreductase |
Biological process | Lipid biosynthesis, Lipid metabolism, Steroid biosynthesis |
Ligand | NAD |
Enzyme and pathway databases
Reactomei | R-MMU-193144, Estrogen biosynthesis |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Hsd17b2 Synonyms:Edh17b2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1096386, Hsd17b2 |
Subcellular locationi
Other locations
- Membrane Curated; Single-pass type II membrane protein Curated
Other locations
- integral component of membrane Source: UniProtKB-KW
- intracellular membrane-bounded organelle Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 4 – 24 | Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000054571 | 1 – 381 | Estradiol 17-beta-dehydrogenase 2Add BLAST | 381 |
Proteomic databases
jPOSTi | P51658 |
MaxQBi | P51658 |
PaxDbi | P51658 |
PeptideAtlasi | P51658 |
PRIDEi | P51658 |
PTM databases
iPTMneti | P51658 |
PhosphoSitePlusi | P51658 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000031844, Expressed in placenta labyrinth and 111 other tissues |
ExpressionAtlasi | P51658, baseline and differential |
Genevisiblei | P51658, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034304 |
Chemistry databases
BindingDBi | P51658 |
Miscellaneous databases
RNActi | P51658, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the short-chain dehydrogenases/reductases (SDR) family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1610, Eukaryota |
GeneTreei | ENSGT00940000160204 |
HOGENOMi | CLU_010194_2_0_1 |
InParanoidi | P51658 |
OMAi | PFAFYAP |
OrthoDBi | 1313182at2759 |
PhylomeDBi | P51658 |
TreeFami | TF325617 |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P51658-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSPFASESAW LCLAAAAVLG GTLLCGCRSG RQLRSQAVCL AGLWGGACLL
60 70 80 90 100
SLSLLCTLFL LSVACFLLLY MSSSDQDLLP VDQKAVLVTG ADSGFGHGLA
110 120 130 140 150
KHLDKLGFTV FAGVLDKEGP GAEELRKHCS ERLSVLQMDV TKPEQIKDAH
160 170 180 190 200
SKVTEKIQDK GLWAVVNNAG VFHLPIDGEL IPMSIYRKCM AVNFFGTVEV
210 220 230 240 250
TKAFLPLLRK SKGRLVNVSS MGGTVPLQMT SAYAATKAAL TMFSTIIRQE
260 270 280 290 300
LDKWGVKVVT IKPGGFKTNI TGSQDIWDKM EKEILDHFSK DIQENYGQDY
310 320 330 340 350
VHTQKLIIPT LKERSNPDIT PVLRDIQHAI SARNPSSFYY PGRMAYLWVC
360 370 380
LAAYCPTSLL DYVIKKGFYP QPTPRALRTV H
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1D5RLD6 | A0A1D5RLD6_MOUSE | Estradiol 17-beta-dehydrogenase 2 | Hsd17b2 | 124 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 36 – 37 | QA → RP in CAA64982 (Ref. 2) Curated | 2 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09517 mRNA Translation: CAA70706.1 X95685 mRNA Translation: CAA64982.1 |
CCDSi | CCDS40491.1 |
RefSeqi | NP_032316.2, NM_008290.2 |
Genome annotation databases
Ensembli | ENSMUST00000034304; ENSMUSP00000034304; ENSMUSG00000031844 |
GeneIDi | 15486 |
KEGGi | mmu:15486 |
UCSCi | uc009npf.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y09517 mRNA Translation: CAA70706.1 X95685 mRNA Translation: CAA64982.1 |
CCDSi | CCDS40491.1 |
RefSeqi | NP_032316.2, NM_008290.2 |
3D structure databases
SMRi | P51658 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000034304 |
Chemistry databases
BindingDBi | P51658 |
ChEMBLi | CHEMBL1914270 |
GuidetoPHARMACOLOGYi | 3094 |
PTM databases
iPTMneti | P51658 |
PhosphoSitePlusi | P51658 |
Proteomic databases
jPOSTi | P51658 |
MaxQBi | P51658 |
PaxDbi | P51658 |
PeptideAtlasi | P51658 |
PRIDEi | P51658 |
Protocols and materials databases
Antibodypediai | 16980, 300 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000034304; ENSMUSP00000034304; ENSMUSG00000031844 |
GeneIDi | 15486 |
KEGGi | mmu:15486 |
UCSCi | uc009npf.1, mouse |
Organism-specific databases
CTDi | 3294 |
MGIi | MGI:1096386, Hsd17b2 |
Phylogenomic databases
eggNOGi | KOG1610, Eukaryota |
GeneTreei | ENSGT00940000160204 |
HOGENOMi | CLU_010194_2_0_1 |
InParanoidi | P51658 |
OMAi | PFAFYAP |
OrthoDBi | 1313182at2759 |
PhylomeDBi | P51658 |
TreeFami | TF325617 |
Enzyme and pathway databases
Reactomei | R-MMU-193144, Estrogen biosynthesis |
Miscellaneous databases
BioGRID-ORCSi | 15486, 5 hits in 19 CRISPR screens |
ChiTaRSi | Hsd17b2, mouse |
PROi | PR:P51658 |
RNActi | P51658, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031844, Expressed in placenta labyrinth and 111 other tissues |
ExpressionAtlasi | P51658, baseline and differential |
Genevisiblei | P51658, MM |
Family and domain databases
InterProi | View protein in InterPro IPR036291, NAD(P)-bd_dom_sf IPR020904, Sc_DH/Rdtase_CS IPR002347, SDR_fam |
Pfami | View protein in Pfam PF00106, adh_short, 1 hit |
PRINTSi | PR00081, GDHRDH PR00080, SDRFAMILY |
SUPFAMi | SSF51735, SSF51735, 1 hit |
PROSITEi | View protein in PROSITE PS00061, ADH_SHORT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | DHB2_MOUSE | |
Accessioni | P51658Primary (citable) accession number: P51658 Secondary accession number(s): O08898 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 163 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families