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Protein

Glypican-4

Gene

Gpc4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cell surface proteoglycan that bears heparan sulfate. May be involved in the development of kidney tubules and of the central nervous system.

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-1971475 A tetrasaccharide linker sequence is required for GAG synthesis
R-MMU-2022928 HS-GAG biosynthesis
R-MMU-2024096 HS-GAG degradation
R-MMU-975634 Retinoid metabolism and transport

Names & Taxonomyi

Protein namesi
Recommended name:
Glypican-4
Alternative name(s):
K-glypican
Cleaved into the following chain:
Gene namesi
Name:Gpc4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome X

Organism-specific databases

MGIiMGI:104902 Gpc4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001231719 – 529Glypican-4Add BLAST511
ChainiPRO_000033384819 – ?Secreted glypican-4
PropeptideiPRO_0000012318530 – 557Removed in mature formSequence analysisAdd BLAST28

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei357PhosphoserineBy similarity1
Glycosylationi494O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi498O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi500O-linked (Xyl...) (glycosaminoglycan) serineSequence analysis1
Glycosylationi514N-linked (GlcNAc...) asparagineSequence analysis1
Lipidationi529GPI-anchor amidated serineSequence analysis1

Keywords - PTMi

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQBiP51655
PaxDbiP51655
PeptideAtlasiP51655
PRIDEiP51655

PTM databases

iPTMnetiP51655
PhosphoSitePlusiP51655
SwissPalmiP51655

Expressioni

Tissue specificityi

Highly expressed in developing brain and kidney.

Gene expression databases

BgeeiENSMUSG00000031119
CleanExiMM_GPC4
GenevisibleiP51655 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi200014, 1 interactor
IntActiP51655, 1 interactor
MINTiP51655
STRINGi10090.ENSMUSP00000033450

Structurei

3D structure databases

ProteinModelPortaliP51655
SMRiP51655
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glypican family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG3821 Eukaryota
ENOG410XST2 LUCA
GeneTreeiENSGT00550000074430
HOGENOMiHOG000253003
HOVERGENiHBG003464
InParanoidiP51655
KOiK08110
OMAiQCPSEFE
OrthoDBiEOG091G06T6
PhylomeDBiP51655
TreeFamiTF105317

Family and domain databases

InterProiView protein in InterPro
IPR001863 Glypican
IPR031180 Glypican-4
IPR019803 Glypican_CS
PANTHERiPTHR10822 PTHR10822, 1 hit
PTHR10822:SF25 PTHR10822:SF25, 1 hit
PfamiView protein in Pfam
PF01153 Glypican, 1 hit
PROSITEiView protein in PROSITE
PS01207 GLYPICAN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51655-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARLGLLALL CTLAALSASL LAAELKSKSC SEVRRLYVSK GFNKNDAPLY
60 70 80 90 100
EINGDHLKIC PQDYTCCSQE MEEKYSLQSK DDFKTVVSEQ CNHLQAIFAS
110 120 130 140 150
RYKKFDEFFK ELLENAEKSL NDMFVKTYGH LYMQNSELFK DLFVELKRYY
160 170 180 190 200
VAGNVNLEEM LNDFWARLLE RMFRLVNSQY HFTDEYLECV SKYTEQLKPF
210 220 230 240 250
GDVPRKLKLQ VTRAFVAART FAQGLAVARD VVSKVSVVNP TAQCTHALLK
260 270 280 290 300
MIYCSHCRGL VTVKPCYNYC SNIMRGCLAN QGDLDFEWNN FIDAMLMVAE
310 320 330 340 350
RLEGPFNIES VMDPIDVKIS DAIMNMQDNS VQVSQKVFQG CGPPKPLPAG
360 370 380 390 400
RISRSISESA FSARFRPYHP EQRPTTAAGT SLDRLVTDVK EKLKQAKKFW
410 420 430 440 450
SSLPSTVCND ERMAAGNENE DDCWNGKGKS RYLFAVTGNG LANQGNNPEV
460 470 480 490 500
QVDTSKPDIL ILRQIMALRV MTSKMKNAYN GNDVDFFDIS DESSGEGSGS
510 520 530 540 550
GCEYQQCPSE FEYNATDHSG KSANEKADSA GGAHAEAKPY LLAALCILFL

AVQGEWR
Length:557
Mass (Da):62,586
Last modified:May 16, 2003 - v2
Checksum:iF216AA0FEF5ED840
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti537A → T in CAA58560 (PubMed:7657705).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83577 mRNA Translation: CAA58560.1
BC006622 mRNA Translation: AAH06622.1
CCDSiCCDS30124.1
PIRiA57050
RefSeqiNP_032176.2, NM_008150.2
UniGeneiMm.1528
Mm.478164
Mm.491492

Genome annotation databases

EnsembliENSMUST00000033450; ENSMUSP00000033450; ENSMUSG00000031119
GeneIDi14735
KEGGimmu:14735
UCSCiuc012hhb.1 mouse

Similar proteinsi

Entry informationi

Entry nameiGPC4_MOUSE
AccessioniPrimary (citable) accession number: P51655
Secondary accession number(s): Q923C8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: May 16, 2003
Last modified: June 20, 2018
This is version 142 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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