GPC3

Functionⁱ

Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.1 Publication

GO - Molecular functionⁱ

peptidyl-dipeptidase inhibitor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17549790

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anatomical structure morphogenesis
Source: ProtInc
Traceable author statementⁱ
- 8589713
anterior/posterior axis specification Source: Ensembl
body morphogenesis Source: Ensembl
bone mineralization Source: Ensembl
branching involved in ureteric bud morphogenesis Source: Ensembl
cell proliferation involved in metanephros development Source: Ensembl
cellular protein metabolic process Source: Reactome
coronary vasculature development Source: Ensembl
embryonic hindlimb morphogenesis Source: Ensembl
glycosaminoglycan biosynthetic process Source: Reactome
glycosaminoglycan catabolic process Source: Reactome
lung development Source: Ensembl
mesenchymal cell proliferation involved in ureteric bud development Source: UniProtKB
mesonephric duct morphogenesis Source: Ensembl
negative regulation of canonical Wnt signaling pathway Source: Ensembl
negative regulation of epithelial cell proliferation Source: Ensembl
negative regulation of growth Source: Ensembl
negative regulation of smoothened signaling pathway Source: Ensembl
osteoclast differentiation Source: Ensembl
positive regulation of BMP signaling pathway Source: Ensembl
positive regulation of endocytosis Source: Ensembl
positive regulation of glucose import Source: Ensembl
positive regulation of protein catabolic process Source: Ensembl
positive regulation of smoothened signaling pathway Source: Ensembl
positive regulation of Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
post-translational protein modification Source: Reactome
response to bacterium Source: Ensembl
retinoid metabolic process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Protease inhibitor

Molecular function

Protease inhibitor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-2022928 HS-GAG biosynthesis R-HSA-2024096 HS-GAG degradation R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type R-HSA-3560801 Defective B3GAT3 causes JDSSDHD R-HSA-3656237 Defective EXT2 causes exostoses 2 R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-8957275 Post-translational protein phosphorylation R-HSA-975634 Retinoid metabolism and transport
SignaLinkⁱ	P51654
SIGNORⁱ	P51654

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glypican-3 Alternative name(s): GTR2-2 Intestinal protein OCI-5 MXR7 Cleaved into the following chain: Secreted glypican-3
Gene namesⁱ	Name:GPC3 Synonyms:OCI5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000147257.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4451 GPC3
MIMⁱ	300037 gene
neXtProtⁱ	NX_P51654

Keywords - Cellular componentⁱ

Cell membrane, Membrane, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Simpson-Golabi-Behmel syndrome 1 (SGBS1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA condition characterized by pre- and postnatal overgrowth (gigantism), facial dysmorphism and a variety of inconstant visceral and skeletal malformations. Characteristic dysmorphic features include macrocephaly with coarse, distinctive facies with a large protruding jaw, broad nasal bridge and cleft palate. Cardiac defects are frequent.

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2719
GeneReviewsⁱ	GPC3
MalaCards human disease database More...MalaCardsⁱ	GPC3
MIMⁱ	312870 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000147257
Orphanetⁱ	373 Simpson-Golabi-Behmel syndrome
PharmGKBⁱ	PA28832

Polymorphism and mutation databases

BioMutaⁱ	GPC3
DMDMⁱ	1708022

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
PropeptideⁱPRO_0000012310	? – 580	Removed in mature formSequence analysis
Signal peptideⁱ	1 – 24	Sequence analysisAdd BLAST	24
ChainⁱPRO_0000012309	25 – ?	Glypican-3
ChainⁱPRO_0000333844	25 – ?	Secreted glypican-3

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	124	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	241	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	352	Phosphoserine; by FAM20C1 Publication	1
Glycosylationⁱ	418	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	495	O-linked (Xyl...) (heparan sulfate) serineSequence analysis	1
Glycosylationⁱ	509	O-linked (Xyl...) (heparan sulfate) serineSequence analysis	1

Keywords - PTMⁱ

Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51654
PaxDbⁱ	P51654
PeptideAtlas More...PeptideAtlasⁱ	P51654
PRIDEⁱ	P51654
ProteomicsDBⁱ	56359
TopDownProteomicsⁱ	P51654-1 [P51654-1]

PTM databases

iPTMnetⁱ	P51654
PhosphoSitePlusⁱ	P51654

Expressionⁱ

Tissue specificityⁱ

Highly expressed in lung, liver and kidney.

Gene expression databases

Bgeeⁱ	ENSG00000147257 Expressed in 172 organ(s), highest expression level in kidney
CleanExⁱ	HS_GPC3
ExpressionAtlasⁱ	P51654 baseline and differential
Genevisibleⁱ	P51654 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA006316

HPAⁱ

HPA006316

Interactionⁱ

Subunit structureⁱ

Interacts with DPP4.1 Publication

Protein-protein interaction databases

BioGridⁱ	108983, 24 interactors
Database of interacting proteins More...DIPⁱ	DIP-61509N
IntActⁱ	P51654, 5 interactors
STRINGⁱ	9606.ENSP00000377836

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51654
SMRⁱ	P51654
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glypican family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3821 Eukaryota ENOG410XST2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074430
HOGENOMⁱ	HOG000049177
HOVERGENⁱ	HBG005896
InParanoidⁱ	P51654
KEGG Orthology (KO) More...KOⁱ	K08109
OMAⁱ	MNPGLPE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06T6
PhylomeDBⁱ	P51654
TreeFamⁱ	TF105317

Family and domain databases

InterProⁱ	View protein in InterPro IPR001863 Glypican IPR015501 Glypican-3 IPR019803 Glypican_CS
PANTHERⁱ	PTHR10822 PTHR10822, 1 hit PTHR10822:SF4 PTHR10822:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01153 Glypican, 1 hit
PROSITEⁱ	View protein in PROSITE PS01207 GLYPICAN, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.ⁱShow all

Isoform 1 (identifier: P51654-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGTVRTACL VVAMLLSLDF PGQAQPPPPP PDATCHQVRS FFQRLQPGLK 
        60         70         80         90        100
WVPETPVPGS DLQVCLPKGP TCCSRKMEEK YQLTARLNME QLLQSASMEL 
       110        120        130        140        150
KFLIIQNAAV FQEAFEIVVR HAKNYTNAMF KNNYPSLTPQ AFEFVGEFFT 
       160        170        180        190        200
DVSLYILGSD INVDDMVNEL FDSLFPVIYT QLMNPGLPDS ALDINECLRG 
       210        220        230        240        250
ARRDLKVFGN FPKLIMTQVS KSLQVTRIFL QALNLGIEVI NTTDHLKFSK 
       260        270        280        290        300
DCGRMLTRMW YCSYCQGLMM VKPCGGYCNV VMQGCMAGVV EIDKYWREYI 
       310        320        330        340        350
LSLEELVNGM YRIYDMENVL LGLFSTIHDS IQYVQKNAGK LTTTIGKLCA 
       360        370        380        390        400
HSQQRQYRSA YYPEDLFIDK KVLKVAHVEH EETLSSRRRE LIQKLKSFIS 
       410        420        430        440        450
FYSALPGYIC SHSPVAENDT LCWNGQELVE RYSQKAARNG MKNQFNLHEL 
       460        470        480        490        500
KMKGPEPVVS QIIDKLKHIN QLLRTMSMPK GRVLDKNLDE EGFESGDCGD 
       510        520        530        540        550
DEDECIGGSG DGMIKVKNQL RFLAELAYDL DVDDAPGNSQ QATPKDNEIS 
       560        570        580
TFHNLGNVHS PLKLLTSMAI SVVCFFFLVH

Length:580

Mass (Da):65,563

Last modified:October 1, 1996 - v1

Checksum:ⁱ19485B76D3CE15FC

GO

Isoform 2 (identifier: P51654-2) [UniParc]FASTA Add to basket

Also known as: Variant B

The sequence of this isoform differs from the canonical sequence as follows:
59-112: Missing.

« Hide

        10         20         30         40         50
MAGTVRTACL VVAMLLSLDF PGQAQPPPPP PDATCHQVRS FFQRLQPGLK 
        60         70         80         90        100
WVPETPVPEA FEIVVRHAKN YTNAMFKNNY PSLTPQAFEF VGEFFTDVSL 
       110        120        130        140        150
YILGSDINVD DMVNELFDSL FPVIYTQLMN PGLPDSALDI NECLRGARRD 
       160        170        180        190        200
LKVFGNFPKL IMTQVSKSLQ VTRIFLQALN LGIEVINTTD HLKFSKDCGR 
       210        220        230        240        250
MLTRMWYCSY CQGLMMVKPC GGYCNVVMQG CMAGVVEIDK YWREYILSLE 
       260        270        280        290        300
ELVNGMYRIY DMENVLLGLF STIHDSIQYV QKNAGKLTTT IGKLCAHSQQ 
       310        320        330        340        350
RQYRSAYYPE DLFIDKKVLK VAHVEHEETL SSRRRELIQK LKSFISFYSA 
       360        370        380        390        400
LPGYICSHSP VAENDTLCWN GQELVERYSQ KAARNGMKNQ FNLHELKMKG 
       410        420        430        440        450
PEPVVSQIID KLKHINQLLR TMSMPKGRVL DKNLDEEGFE SGDCGDDEDE 
       460        470        480        490        500
CIGGSGDGMI KVKNQLRFLA ELAYDLDVDD APGNSQQATP KDNEISTFHN 
       510        520 
LGNVHSPLKL LTSMAISVVC FFFLVH

Show »

Length:526

Mass (Da):59,475

Checksum:ⁱA0858770AF739C17

GO

Isoform 3 (identifier: P51654-3) [UniParc]FASTA Add to basket

Also known as: Variant C

The sequence of this isoform differs from the canonical sequence as follows:
344-344: T → TETEKKIWHFKYPIFFLCIGLDLQ

« Hide

        10         20         30         40         50
MAGTVRTACL VVAMLLSLDF PGQAQPPPPP PDATCHQVRS FFQRLQPGLK 
        60         70         80         90        100
WVPETPVPGS DLQVCLPKGP TCCSRKMEEK YQLTARLNME QLLQSASMEL 
       110        120        130        140        150
KFLIIQNAAV FQEAFEIVVR HAKNYTNAMF KNNYPSLTPQ AFEFVGEFFT 
       160        170        180        190        200
DVSLYILGSD INVDDMVNEL FDSLFPVIYT QLMNPGLPDS ALDINECLRG 
       210        220        230        240        250
ARRDLKVFGN FPKLIMTQVS KSLQVTRIFL QALNLGIEVI NTTDHLKFSK 
       260        270        280        290        300
DCGRMLTRMW YCSYCQGLMM VKPCGGYCNV VMQGCMAGVV EIDKYWREYI 
       310        320        330        340        350
LSLEELVNGM YRIYDMENVL LGLFSTIHDS IQYVQKNAGK LTTTETEKKI 
       360        370        380        390        400
WHFKYPIFFL CIGLDLQIGK LCAHSQQRQY RSAYYPEDLF IDKKVLKVAH 
       410        420        430        440        450
VEHEETLSSR RRELIQKLKS FISFYSALPG YICSHSPVAE NDTLCWNGQE 
       460        470        480        490        500
LVERYSQKAA RNGMKNQFNL HELKMKGPEP VVSQIIDKLK HINQLLRTMS 
       510        520        530        540        550
MPKGRVLDKN LDEEGFESGD CGDDEDECIG GSGDGMIKVK NQLRFLAELA 
       560        570        580        590        600
YDLDVDDAPG NSQQATPKDN EISTFHNLGN VHSPLKLLTS MAISVVCFFF 

LVH

Show »

Length:603

Mass (Da):68,414

Checksum:ⁱ1930C0382E91AF60

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation
	H0Y3U6	H0Y3U6_HUMAN		Glypican-3 Glypican-3	GPC3	256	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_021385	296	W → R in SGBS1. 1 PublicationCorresponds to variant dbSNP:rs104894854EnsemblClinVar.		1
Natural variantⁱVAR_069139	429	V → M1 PublicationCorresponds to variant dbSNP:rs11539789EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046117	59 – 112	Missing in isoform 2. 1 PublicationAdd BLAST		54
Alternative sequenceⁱVSP_046703	344	T → TETEKKIWHFKYPIFFLCIG LDLQ in isoform 3. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U50410 mRNA Translation: AAA93471.1 L47124 Genomic DNA Translation: AAA98131.1 L47125 mRNA Translation: AAA98132.1 L47176 mRNA Translation: AAB58806.1 Z37987 mRNA Translation: CAA86069.1 DQ349136 mRNA Translation: ABC72125.1 DQ349138 mRNA Translation: ABC72127.1 AL008712 Z99570 Genomic DNA Translation: CAI43110.1 AL009174 Z99570 Genomic DNA Translation: CAI42761.1 Z99570 AL009174 Genomic DNA Translation: CAI42277.1 AL034401 Genomic DNA No translation available. AL662851 Genomic DNA No translation available. Z97196 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11771.1 AF003529 Genomic DNA Translation: AAB87062.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14638.1 [P51654-1] CCDS55495.1 [P51654-2] CCDS55496.1 [P51654-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001158089.1, NM_001164617.1 [P51654-3] NP_001158091.1, NM_001164619.1 [P51654-2] NP_004475.1, NM_004484.3 [P51654-1]
UniGeneⁱ	Hs.644108

Genome annotation databases

Ensemblⁱ	ENST00000370818; ENSP00000359854; ENSG00000147257 [P51654-1] ENST00000394299; ENSP00000377836; ENSG00000147257 [P51654-3] ENST00000631057; ENSP00000486325; ENSG00000147257 [P51654-2]
GeneIDⁱ	2719
KEGGⁱ	hsa:2719
UCSC genome browser More...UCSCⁱ	uc004exe.4 human [P51654-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P51654	Glypican 3 isoform 2		HUMAN		580	UniRef100_P51654
Glypican 3		RHIBE		334
UPI00083C43F4		RHIBE		306

Protein	Similar proteins		Species	Score	Length	Source
P51654	Glypican-3		MOUSE		579	UniRef90_Q8CFZ4
Glypican-3		RAT		597
Glypican-3		PANTR		580
Glypican 3 (Fragment)		MUSPF		608
Uncharacterized protein (Fragment)		AILME		112
+111
P51654-2	Glypican 3		PROCO		526	UniRef90_P51654-2
Glypican 3		SAIBB		526
Glypican 3		MACMU		526
Glypican 3		MACFA		526
Glypican 3		CALJA		526
+30
P51654-3	Glypican 3		PAPAN		603	UniRef90_P51654-3
Glypican 3		MANLE		603
glypican-3 isoform X2		ERIEU		603
Glypican 3		MACFA		603
Glypican 3		GORGO		603
+22

Protein	Similar proteins		Species	Score	Length	Source
P51654	Glypican-3		MOUSE		579	UniRef50_Q8CFZ4
Glypican-3		RAT		597
Glypican-3		PANTR		580
Glypican 3 (Fragment)		MUSPF		608
Uncharacterized protein (Fragment)		AILME		112
+205
P51654-2	glypican-3 isoform X3		Enhydra lutris kenyoni		526	UniRef50_P51654-2
Glypican 3		SAIBB		526
GPC3 isoform 4		PANTR		526
Glypican 3		PANPA		526
glypican-3 isoform X3		Florida manatee		526
+49
P51654-3	Glypican 3		GORGO		603	UniRef50_P51654-3
Glypican 3		MACFA		603
GPC3 isoform 2		PANTR		603
Glypican 3		PANPA		603
Glypican 3		PAPAN		603
+36

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U50410 mRNA Translation: AAA93471.1 L47124 Genomic DNA Translation: AAA98131.1 L47125 mRNA Translation: AAA98132.1 L47176 mRNA Translation: AAB58806.1 Z37987 mRNA Translation: CAA86069.1 DQ349136 mRNA Translation: ABC72125.1 DQ349138 mRNA Translation: ABC72127.1 AL008712 Z99570 Genomic DNA Translation: CAI43110.1 AL009174 Z99570 Genomic DNA Translation: CAI42761.1 Z99570 AL009174 Genomic DNA Translation: CAI42277.1 AL034401 Genomic DNA No translation available. AL662851 Genomic DNA No translation available. Z97196 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11771.1 AF003529 Genomic DNA Translation: AAB87062.1
CCDSⁱ	CCDS14638.1 [P51654-1] CCDS55495.1 [P51654-2] CCDS55496.1 [P51654-3]
RefSeqⁱ	NP_001158089.1, NM_001164617.1 [P51654-3] NP_001158091.1, NM_001164619.1 [P51654-2] NP_004475.1, NM_004484.3 [P51654-1]
UniGeneⁱ	Hs.644108

3D structure databases

ProteinModelPortalⁱ	P51654
SMRⁱ	P51654
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108983, 24 interactors
DIPⁱ	DIP-61509N
IntActⁱ	P51654, 5 interactors
STRINGⁱ	9606.ENSP00000377836

PTM databases

iPTMnetⁱ	P51654
PhosphoSitePlusⁱ	P51654

Polymorphism and mutation databases

BioMutaⁱ	GPC3
DMDMⁱ	1708022

Proteomic databases

MaxQBⁱ	P51654
PaxDbⁱ	P51654
PeptideAtlasⁱ	P51654
PRIDEⁱ	P51654
ProteomicsDBⁱ	56359
TopDownProteomicsⁱ	P51654-1 [P51654-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2719
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000370818; ENSP00000359854; ENSG00000147257 [P51654-1] ENST00000394299; ENSP00000377836; ENSG00000147257 [P51654-3] ENST00000631057; ENSP00000486325; ENSG00000147257 [P51654-2]
GeneIDⁱ	2719
KEGGⁱ	hsa:2719
UCSCⁱ	uc004exe.4 human [P51654-1]

Organism-specific databases

CTDⁱ	2719
DisGeNETⁱ	2719
EuPathDBⁱ	HostDB:ENSG00000147257.13
GeneCardsⁱ	GPC3
GeneReviewsⁱ	GPC3
HGNCⁱ	HGNC:4451 GPC3
HPAⁱ	HPA006316
MalaCardsⁱ	GPC3
MIMⁱ	300037 gene 312870 phenotype
neXtProtⁱ	NX_P51654
OpenTargetsⁱ	ENSG00000147257
Orphanetⁱ	373 Simpson-Golabi-Behmel syndrome
PharmGKBⁱ	PA28832
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3821 Eukaryota ENOG410XST2 LUCA
GeneTreeⁱ	ENSGT00550000074430
HOGENOMⁱ	HOG000049177
HOVERGENⁱ	HBG005896
InParanoidⁱ	P51654
KOⁱ	K08109
OMAⁱ	MNPGLPE
OrthoDBⁱ	EOG091G06T6
PhylomeDBⁱ	P51654
TreeFamⁱ	TF105317

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-2022928 HS-GAG biosynthesis R-HSA-2024096 HS-GAG degradation R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type R-HSA-3560801 Defective B3GAT3 causes JDSSDHD R-HSA-3656237 Defective EXT2 causes exostoses 2 R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-8957275 Post-translational protein phosphorylation R-HSA-975634 Retinoid metabolism and transport
SignaLinkⁱ	P51654
SIGNORⁱ	P51654

Miscellaneous databases

ChiTaRSⁱ	GPC3 human
GeneWikiⁱ	Glypican_3
GenomeRNAiⁱ	2719
Protein Ontology More...PROⁱ	PR:P51654
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000147257 Expressed in 172 organ(s), highest expression level in kidney
CleanExⁱ	HS_GPC3
ExpressionAtlasⁱ	P51654 baseline and differential
Genevisibleⁱ	P51654 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001863 Glypican IPR015501 Glypican-3 IPR019803 Glypican_CS
PANTHERⁱ	PTHR10822 PTHR10822, 1 hit PTHR10822:SF4 PTHR10822:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF01153 Glypican, 1 hit
PROSITEⁱ	View protein in PROSITE PS01207 GLYPICAN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GPC3_HUMAN
Accessionⁱ	P51654Primary (citable) accession number: P51654 Secondary accession number(s): C9JLE3 , G3V1R0, Q2L880, Q2L882
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	September 12, 2018
	This is version 171 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P51654 (GPC3_HUMAN)

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Glypican-3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Golgi apparatus

Lysosome

Plasma Membrane

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Keywords - Diseasei

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Computationally mapped potential isoform sequencesi

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Computationally mapped potential isoform sequencesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ