GPC3

Functionⁱ

Cell surface proteoglycan that bears heparan sulfate (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity).By similarity4 Publications

Miscellaneous

Used as a marker for hepatocellular carcinoma (HCC) as it is expressed in HCC but is not detectable in hepatocytes from normal or benign liver diseases (PubMed:12851874). When attached to the cell surface, stimulates the growth of HCC cells by increasing canonical Wnt signaling (PubMed:16024626). Cleavage is not required for stimulation of Wnt signaling or HCC growth (PubMed:16227623).3 Publications

GO - Molecular functionⁱ

peptidyl-dipeptidase inhibitor activity
Source: UniProtKB
Inferred from direct assayⁱ
- 17549790

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

anatomical structure morphogenesis
Source: ProtInc
Traceable author statementⁱ
- 8589713
anterior/posterior axis specification Source: Ensembl
body morphogenesis Source: Ensembl
bone mineralization Source: Ensembl
branching involved in ureteric bud morphogenesis Source: Ensembl
cell migration involved in gastrulation Source: UniProtKB
cell proliferation involved in kidney development Source: UniProtKB
cell proliferation involved in metanephros development Source: Ensembl
cellular protein metabolic process Source: Reactome
coronary vasculature development Source: UniProtKB
embryonic hindlimb morphogenesis Source: Ensembl
glycosaminoglycan biosynthetic process Source: Reactome
glycosaminoglycan catabolic process Source: Reactome
lung development Source: Ensembl
mesenchymal cell proliferation involved in ureteric bud development Source: UniProtKB
mesonephric duct morphogenesis Source: UniProtKB
negative regulation of canonical Wnt signaling pathway Source: Ensembl
negative regulation of epithelial cell proliferation Source: Ensembl
negative regulation of growth Source: Ensembl
negative regulation of smoothened signaling pathway Source: UniProtKB
osteoclast differentiation Source: Ensembl
positive regulation of BMP signaling pathway Source: Ensembl
positive regulation of canonical Wnt signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 24496449
positive regulation of endocytosis Source: UniProtKB
positive regulation of glucose import Source: Ensembl
positive regulation of protein catabolic process Source: UniProtKB
positive regulation of smoothened signaling pathway Source: Ensembl
positive regulation of Wnt signaling pathway, planar cell polarity pathway Source: Ensembl
post-translational protein modification Source: Reactome
regulation of canonical Wnt signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 14610063
regulation of non-canonical Wnt signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 14610063
response to bacterium Source: Ensembl
retinoid metabolic process Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Protease inhibitor

Molecular function

Protease inhibitor

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-2022928 HS-GAG biosynthesis R-HSA-2024096 HS-GAG degradation R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type R-HSA-3560801 Defective B3GAT3 causes JDSSDHD R-HSA-3656237 Defective EXT2 causes exostoses 2 R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-8957275 Post-translational protein phosphorylation R-HSA-975634 Retinoid metabolism and transport
SignaLinkⁱ	P51654
SIGNORⁱ	P51654

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glypican-3 Alternative name(s): GTR2-2 Intestinal protein OCI-5 MXR7 Cleaved into the following 2 chains: Glypican-3 alpha subunit1 Publication Glypican-3 beta subunit1 Publication
Gene namesⁱ	Name:GPC3 Synonyms:OCI5
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000147257.13
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:4451 GPC3
MIMⁱ	300037 gene
neXtProtⁱ	NX_P51654

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Simpson-Golabi-Behmel syndrome 1 (SGBS1)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA condition characterized by pre- and postnatal overgrowth (gigantism), facial dysmorphism and a variety of inconstant visceral and skeletal malformations. Characteristic dysmorphic features include macrocephaly with coarse, distinctive facies with a large protruding jaw, broad nasal bridge and cleft palate. Cardiac defects are frequent.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	355 – 358	RQYR → AQYA: Abolishes proteolytic processing. Abolishes interaction with WNT5A and ability to regulate Wnt signaling. Increases binding of hedgehog protein SHH to the PTC1 receptor and abolishes ability to inhibit hedgehog signaling. 3 Publications	4
Mutagenesisⁱ	355	R → A: No effect on proteolytic processing. 1 Publication	1
Mutagenesisⁱ	358	R → A: No effect on proteolytic processing. 1 Publication	1
Mutagenesisⁱ	371 – 374	KVLK → AVLA: No effect on proteolytic processing. 1 Publication	4
Mutagenesisⁱ	387 – 389	RRR → AAA: No effect on proteolytic processing. 1 Publication	3
Mutagenesisⁱ	394 – 396	KLK → ALA: No effect on proteolytic processing. 1 Publication	3

Keywords - Diseaseⁱ

Disease mutation

Organism-specific databases

DisGeNET More...DisGeNETⁱ	2719
GeneReviewsⁱ	GPC3
MalaCards human disease database More...MalaCardsⁱ	GPC3
MIMⁱ	312870 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000147257
Orphanetⁱ	654 Nephroblastoma 373 Simpson-Golabi-Behmel syndrome
PharmGKBⁱ	PA28832

Polymorphism and mutation databases

BioMutaⁱ	GPC3
DMDMⁱ	1708022

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
Signal peptideⁱ	1 – 24	1 PublicationAdd BLAST	24
ChainⁱPRO_0000445410	25 – 358	Glypican-3 alpha subunit1 PublicationAdd BLAST	334
ChainⁱPRO_0000445411	359 – 554	Glypican-3 beta subunit1 PublicationAdd BLAST	196
PropeptideⁱPRO_0000012310	555 – 580	Removed in mature formSequence analysisAdd BLAST	26

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	25	Pyrrolidone carboxylic acid1 Publication	1
Disulfide bondⁱ	35 ↔ 72	By similarity
Disulfide bondⁱ	65 ↔ 262	By similarity
Disulfide bondⁱ	73 ↔ 265	By similarity
Glycosylationⁱ	124	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	197 ↔ 349	By similarity
Glycosylationⁱ	241	N-linked (GlcNAc...) asparagine1 Publication	1
Disulfide bondⁱ	252 ↔ 285	By similarity
Disulfide bondⁱ	274 ↔ 422	Interchain (between alpha and beta chains)By similarity
Disulfide bondⁱ	278 ↔ 410	Interchain (between alpha and beta chains)By similarity
Modified residueⁱ	352	Phosphoserine; by FAM20C1 Publication	1
Glycosylationⁱ	418	N-linked (GlcNAc...) asparagine1 Publication	1
Glycosylationⁱ	495	O-linked (Xyl...) (heparan sulfate) serineSequence analysis	1
Glycosylationⁱ	509	O-linked (Xyl...) (heparan sulfate) serineSequence analysis	1
Lipidationⁱ	554	GPI-anchor amidated asparagineSequence analysis	1

Post-translational modificationⁱ

O-glycosylated; contains heparan sulfate.1 Publication

Cleaved intracellularly by a furin-like convertase to generate 2 subunits, alpha and beta, which remain associated through disulfide bonds and are associated with the cell surface via the GPI-anchor (PubMed:14610063). This processing is essential for its role in inhibition of hedgehog signaling (PubMed:25653284). A second proteolytic event may result in cleavage of the protein on the cell surface, separating it from the GPI-anchor and leading to its shedding from the cell surface (PubMed:14610063).2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	358 – 359	Cleavage2 Publications		2

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, GPI-anchor, Heparan sulfate, Lipoprotein, Phosphoprotein, Proteoglycan, Pyrrolidone carboxylic acid

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51654
PaxDbⁱ	P51654
PeptideAtlas More...PeptideAtlasⁱ	P51654
PRIDEⁱ	P51654
ProteomicsDBⁱ	56359
TopDownProteomicsⁱ	P51654-1 [P51654-1]

PTM databases

iPTMnetⁱ	P51654
PhosphoSitePlusⁱ	P51654

Expressionⁱ

Tissue specificityⁱ

Highly expressed in lung, liver and kidney.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000147257 Expressed in 172 organ(s), highest expression level in kidney
CleanExⁱ	HS_GPC3
ExpressionAtlasⁱ	P51654 baseline and differential
Genevisibleⁱ	P51654 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA006316

HPAⁱ

HPA006316

Interactionⁱ

Subunit structureⁱ

Heterodimer; disulfide-linked (PubMed:14610063). Cleavage by a furin-like convertase results in production of alpha and beta chains which form a disulfide-linked heterodimer (PubMed:14610063). Interacts with DPP4 (PubMed:17549790). Interacts with FGF2 (By similarity). Interacts with WNT5A (PubMed:14610063). Also interacts with WNT3A and WNT7B (PubMed:16227623). Interacts with hedgehog protein SHH; the heparan sulfate chains are not required for the interaction (By similarity). Also interacts with hedgehog protein IHH (By similarity). Interacts with CD81 (By similarity). Interacts with Wnt receptors FZD4, FZD7 and FZD8; the heparan sulfate chains are required for the interaction (PubMed:24496449).By similarity4 Publications

Protein-protein interaction databases

BioGridⁱ	108983, 24 interactors
Database of interacting proteins More...DIPⁱ	DIP-61509N
IntActⁱ	P51654, 5 interactors
STRINGⁱ	9606.ENSP00000377836

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51654
SMRⁱ	P51654
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the glypican family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	KOG3821 Eukaryota ENOG410XST2 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074430
HOGENOMⁱ	HOG000049177
HOVERGENⁱ	HBG005896
InParanoidⁱ	P51654
KEGG Orthology (KO) More...KOⁱ	K08109
OMAⁱ	PGYVCSH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06T6
PhylomeDBⁱ	P51654
TreeFamⁱ	TF105317

Family and domain databases

InterProⁱ	View protein in InterPro IPR001863 Glypican IPR015501 Glypican-3 IPR019803 Glypican_CS
PANTHERⁱ	PTHR10822 PTHR10822, 1 hit PTHR10822:SF4 PTHR10822:SF4, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01153 Glypican, 1 hit
PROSITEⁱ	View protein in PROSITE PS01207 GLYPICAN, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform 1 (identifier: P51654-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAGTVRTACL VVAMLLSLDF PGQAQPPPPP PDATCHQVRS FFQRLQPGLK 
        60         70         80         90        100
WVPETPVPGS DLQVCLPKGP TCCSRKMEEK YQLTARLNME QLLQSASMEL 
       110        120        130        140        150
KFLIIQNAAV FQEAFEIVVR HAKNYTNAMF KNNYPSLTPQ AFEFVGEFFT 
       160        170        180        190        200
DVSLYILGSD INVDDMVNEL FDSLFPVIYT QLMNPGLPDS ALDINECLRG 
       210        220        230        240        250
ARRDLKVFGN FPKLIMTQVS KSLQVTRIFL QALNLGIEVI NTTDHLKFSK 
       260        270        280        290        300
DCGRMLTRMW YCSYCQGLMM VKPCGGYCNV VMQGCMAGVV EIDKYWREYI 
       310        320        330        340        350
LSLEELVNGM YRIYDMENVL LGLFSTIHDS IQYVQKNAGK LTTTIGKLCA 
       360        370        380        390        400
HSQQRQYRSA YYPEDLFIDK KVLKVAHVEH EETLSSRRRE LIQKLKSFIS 
       410        420        430        440        450
FYSALPGYIC SHSPVAENDT LCWNGQELVE RYSQKAARNG MKNQFNLHEL 
       460        470        480        490        500
KMKGPEPVVS QIIDKLKHIN QLLRTMSMPK GRVLDKNLDE EGFESGDCGD 
       510        520        530        540        550
DEDECIGGSG DGMIKVKNQL RFLAELAYDL DVDDAPGNSQ QATPKDNEIS 
       560        570        580
TFHNLGNVHS PLKLLTSMAI SVVCFFFLVH

Length:580

Mass (Da):65,563

Last modified:October 1, 1996 - v1

Checksum:ⁱ19485B76D3CE15FC

GO

Isoform 2 (identifier: P51654-2) [UniParc]FASTA Add to basket

Also known as: Variant B

The sequence of this isoform differs from the canonical sequence as follows:
59-112: Missing.

« Hide

        10         20         30         40         50
MAGTVRTACL VVAMLLSLDF PGQAQPPPPP PDATCHQVRS FFQRLQPGLK 
        60         70         80         90        100
WVPETPVPEA FEIVVRHAKN YTNAMFKNNY PSLTPQAFEF VGEFFTDVSL 
       110        120        130        140        150
YILGSDINVD DMVNELFDSL FPVIYTQLMN PGLPDSALDI NECLRGARRD 
       160        170        180        190        200
LKVFGNFPKL IMTQVSKSLQ VTRIFLQALN LGIEVINTTD HLKFSKDCGR 
       210        220        230        240        250
MLTRMWYCSY CQGLMMVKPC GGYCNVVMQG CMAGVVEIDK YWREYILSLE 
       260        270        280        290        300
ELVNGMYRIY DMENVLLGLF STIHDSIQYV QKNAGKLTTT IGKLCAHSQQ 
       310        320        330        340        350
RQYRSAYYPE DLFIDKKVLK VAHVEHEETL SSRRRELIQK LKSFISFYSA 
       360        370        380        390        400
LPGYICSHSP VAENDTLCWN GQELVERYSQ KAARNGMKNQ FNLHELKMKG 
       410        420        430        440        450
PEPVVSQIID KLKHINQLLR TMSMPKGRVL DKNLDEEGFE SGDCGDDEDE 
       460        470        480        490        500
CIGGSGDGMI KVKNQLRFLA ELAYDLDVDD APGNSQQATP KDNEISTFHN 
       510        520 
LGNVHSPLKL LTSMAISVVC FFFLVH

Show »

Length:526

Mass (Da):59,475

Checksum:ⁱA0858770AF739C17

GO

Isoform 3 (identifier: P51654-3) [UniParc]FASTA Add to basket

Also known as: Variant C

The sequence of this isoform differs from the canonical sequence as follows:
344-344: T → TETEKKIWHFKYPIFFLCIGLDLQ

« Hide

        10         20         30         40         50
MAGTVRTACL VVAMLLSLDF PGQAQPPPPP PDATCHQVRS FFQRLQPGLK 
        60         70         80         90        100
WVPETPVPGS DLQVCLPKGP TCCSRKMEEK YQLTARLNME QLLQSASMEL 
       110        120        130        140        150
KFLIIQNAAV FQEAFEIVVR HAKNYTNAMF KNNYPSLTPQ AFEFVGEFFT 
       160        170        180        190        200
DVSLYILGSD INVDDMVNEL FDSLFPVIYT QLMNPGLPDS ALDINECLRG 
       210        220        230        240        250
ARRDLKVFGN FPKLIMTQVS KSLQVTRIFL QALNLGIEVI NTTDHLKFSK 
       260        270        280        290        300
DCGRMLTRMW YCSYCQGLMM VKPCGGYCNV VMQGCMAGVV EIDKYWREYI 
       310        320        330        340        350
LSLEELVNGM YRIYDMENVL LGLFSTIHDS IQYVQKNAGK LTTTETEKKI 
       360        370        380        390        400
WHFKYPIFFL CIGLDLQIGK LCAHSQQRQY RSAYYPEDLF IDKKVLKVAH 
       410        420        430        440        450
VEHEETLSSR RRELIQKLKS FISFYSALPG YICSHSPVAE NDTLCWNGQE 
       460        470        480        490        500
LVERYSQKAA RNGMKNQFNL HELKMKGPEP VVSQIIDKLK HINQLLRTMS 
       510        520        530        540        550
MPKGRVLDKN LDEEGFESGD CGDDEDECIG GSGDGMIKVK NQLRFLAELA 
       560        570        580        590        600
YDLDVDDAPG NSQQATPKDN EISTFHNLGN VHSPLKLLTS MAISVVCFFF 

LVH

Show »

Length:603

Mass (Da):68,414

Checksum:ⁱ1930C0382E91AF60

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	H0Y3U6	H0Y3U6_HUMAN		Glypican-3 Glypican-3	GPC3	256	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_021385	296	W → R in SGBS1. 1 PublicationCorresponds to variant dbSNP:rs104894854EnsemblClinVar.		1
Natural variantⁱVAR_069139	429	V → M1 PublicationCorresponds to variant dbSNP:rs11539789EnsemblClinVar.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046117	59 – 112	Missing in isoform 2. 1 PublicationAdd BLAST		54
Alternative sequenceⁱVSP_046703	344	T → TETEKKIWHFKYPIFFLCIG LDLQ in isoform 3. 1 Publication		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U50410 mRNA Translation: AAA93471.1 L47124 Genomic DNA Translation: AAA98131.1 L47125 mRNA Translation: AAA98132.1 L47176 mRNA Translation: AAB58806.1 Z37987 mRNA Translation: CAA86069.1 DQ349136 mRNA Translation: ABC72125.1 DQ349138 mRNA Translation: ABC72127.1 AL008712 Z99570 Genomic DNA Translation: CAI43110.1 AL009174 Z99570 Genomic DNA Translation: CAI42761.1 Z99570 AL009174 Genomic DNA Translation: CAI42277.1 AL034401 Genomic DNA No translation available. AL662851 Genomic DNA No translation available. Z97196 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11771.1 AF003529 Genomic DNA Translation: AAB87062.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14638.1 [P51654-1] CCDS55495.1 [P51654-2] CCDS55496.1 [P51654-3]
NCBI Reference Sequences More...RefSeqⁱ	NP_001158089.1, NM_001164617.1 [P51654-3] NP_001158091.1, NM_001164619.1 [P51654-2] NP_004475.1, NM_004484.3 [P51654-1]
UniGeneⁱ	Hs.644108

Genome annotation databases

Ensemblⁱ	ENST00000370818; ENSP00000359854; ENSG00000147257 [P51654-1] ENST00000394299; ENSP00000377836; ENSG00000147257 [P51654-3] ENST00000631057; ENSP00000486325; ENSG00000147257 [P51654-2]
GeneIDⁱ	2719
KEGGⁱ	hsa:2719
UCSC genome browser More...UCSCⁱ	uc004exe.4 human [P51654-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P51654	Glypican 3 isoform 2		HUMAN		580	UniRef100_P51654
Uncharacterized protein		RHIBE		334
UPI00083C43F4		RHIBE		306

Protein	Similar proteins		Species	Score	Length	Source
P51654	Glypican-3		RAT		597	UniRef90_P51654
Glypican-3		PANTR		580
Glypican-3		MOUSE		579
Glypican 3 isoform 2		HUMAN		580
Uncharacterized protein		RHIBE		334
+113
P51654-2	Uncharacterized protein		PROCO		526	UniRef90_P51654-2
Glypican 3		SAIBB		526
Uncharacterized protein		MACMU		526
Uncharacterized protein		MACFA		526
Uncharacterized protein		CALJA		526
+32
P51654-3	Uncharacterized protein		PAPAN		603	UniRef90_P51654-3
Uncharacterized protein		MANLE		603
Glypican 3		GORGO		603
Uncharacterized protein		MACMU		603
Uncharacterized protein		COLAP		603
+22

Protein	Similar proteins		Species	Score	Length	Source
P51654	Glypican-3		RAT		597	UniRef50_P51654
Glypican-3		PANTR		580
Glypican-3		MOUSE		579
Glypican 3 isoform 2		HUMAN		580
Uncharacterized protein		RHIBE		334
+223
P51654-2	glypican-3 isoform X3		Enhydra lutris kenyoni		526	UniRef50_P51654-2
Glypican 3		SAIBB		526
GPC3 isoform 4		PANTR		526
Uncharacterized protein		PANPA		526
glypican-3 isoform X3		Florida manatee		526
+49
P51654-3	Glypican 3		GORGO		603	UniRef50_P51654-3
Uncharacterized protein		PAPAN		603
Uncharacterized protein		MANLE		603
Uncharacterized protein		MACMU		603
GPC3 isoform 2		PONAB		603
+51

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U50410 mRNA Translation: AAA93471.1 L47124 Genomic DNA Translation: AAA98131.1 L47125 mRNA Translation: AAA98132.1 L47176 mRNA Translation: AAB58806.1 Z37987 mRNA Translation: CAA86069.1 DQ349136 mRNA Translation: ABC72125.1 DQ349138 mRNA Translation: ABC72127.1 AL008712 Z99570 Genomic DNA Translation: CAI43110.1 AL009174 Z99570 Genomic DNA Translation: CAI42761.1 Z99570 AL009174 Genomic DNA Translation: CAI42277.1 AL034401 Genomic DNA No translation available. AL662851 Genomic DNA No translation available. Z97196 Genomic DNA No translation available. CH471107 Genomic DNA Translation: EAX11771.1 AF003529 Genomic DNA Translation: AAB87062.1
CCDSⁱ	CCDS14638.1 [P51654-1] CCDS55495.1 [P51654-2] CCDS55496.1 [P51654-3]
RefSeqⁱ	NP_001158089.1, NM_001164617.1 [P51654-3] NP_001158091.1, NM_001164619.1 [P51654-2] NP_004475.1, NM_004484.3 [P51654-1]
UniGeneⁱ	Hs.644108

3D structure databases

ProteinModelPortalⁱ	P51654
SMRⁱ	P51654
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	108983, 24 interactors
DIPⁱ	DIP-61509N
IntActⁱ	P51654, 5 interactors
STRINGⁱ	9606.ENSP00000377836

PTM databases

iPTMnetⁱ	P51654
PhosphoSitePlusⁱ	P51654

Polymorphism and mutation databases

BioMutaⁱ	GPC3
DMDMⁱ	1708022

Proteomic databases

MaxQBⁱ	P51654
PaxDbⁱ	P51654
PeptideAtlasⁱ	P51654
PRIDEⁱ	P51654
ProteomicsDBⁱ	56359
TopDownProteomicsⁱ	P51654-1 [P51654-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	2719
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000370818; ENSP00000359854; ENSG00000147257 [P51654-1] ENST00000394299; ENSP00000377836; ENSG00000147257 [P51654-3] ENST00000631057; ENSP00000486325; ENSG00000147257 [P51654-2]
GeneIDⁱ	2719
KEGGⁱ	hsa:2719
UCSCⁱ	uc004exe.4 human [P51654-1]

Organism-specific databases

CTDⁱ	2719
DisGeNETⁱ	2719
EuPathDBⁱ	HostDB:ENSG00000147257.13
GeneCardsⁱ	GPC3
GeneReviewsⁱ	GPC3
HGNCⁱ	HGNC:4451 GPC3
HPAⁱ	HPA006316
MalaCardsⁱ	GPC3
MIMⁱ	300037 gene 312870 phenotype
neXtProtⁱ	NX_P51654
OpenTargetsⁱ	ENSG00000147257
Orphanetⁱ	654 Nephroblastoma 373 Simpson-Golabi-Behmel syndrome
PharmGKBⁱ	PA28832
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3821 Eukaryota ENOG410XST2 LUCA
GeneTreeⁱ	ENSGT00550000074430
HOGENOMⁱ	HOG000049177
HOVERGENⁱ	HBG005896
InParanoidⁱ	P51654
KOⁱ	K08109
OMAⁱ	PGYVCSH
OrthoDBⁱ	EOG091G06T6
PhylomeDBⁱ	P51654
TreeFamⁱ	TF105317

Enzyme and pathway databases

Reactomeⁱ	R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis R-HSA-2022928 HS-GAG biosynthesis R-HSA-2024096 HS-GAG degradation R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type R-HSA-3560801 Defective B3GAT3 causes JDSSDHD R-HSA-3656237 Defective EXT2 causes exostoses 2 R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 R-HSA-8957275 Post-translational protein phosphorylation R-HSA-975634 Retinoid metabolism and transport
SignaLinkⁱ	P51654
SIGNORⁱ	P51654

Miscellaneous databases

ChiTaRSⁱ	GPC3 human
GeneWikiⁱ	Glypican_3
GenomeRNAiⁱ	2719
Protein Ontology More...PROⁱ	PR:P51654
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000147257 Expressed in 172 organ(s), highest expression level in kidney
CleanExⁱ	HS_GPC3
ExpressionAtlasⁱ	P51654 baseline and differential
Genevisibleⁱ	P51654 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001863 Glypican IPR015501 Glypican-3 IPR019803 Glypican_CS
PANTHERⁱ	PTHR10822 PTHR10822, 1 hit PTHR10822:SF4 PTHR10822:SF4, 1 hit
Pfamⁱ	View protein in Pfam PF01153 Glypican, 1 hit
PROSITEⁱ	View protein in PROSITE PS01207 GLYPICAN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	GPC3_HUMAN
Accessionⁱ	P51654Primary (citable) accession number: P51654 Secondary accession number(s): C9JLE3 , G3V1R0, Q2L880, Q2L882
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	November 7, 2018
	This is version 173 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM

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UniProtKB - P51654 (GPC3_HUMAN)

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Glypican-3

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Functionⁱ

GO - Molecular functionⁱ

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