We will be switching to the new UniProt website on Tuesday, June 28. Please explore and share your feedback.
Take me to UniProt BETA
UniProtKB - P51651 (GPR6_RAT)
Protein
G-protein coupled receptor 6
Gene
Gpr6
Organism
Rattus norvegicus (Rat)
Status
Functioni
Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons.
1 PublicationGO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- sphingosine-1-phosphate receptor activity Source: RGD
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: GO_Central
- G protein-coupled receptor signaling pathway Source: RGD
- positive regulation of cytosolic calcium ion concentration Source: RGD
- regulation of metabolic process Source: GO_Central
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: G-protein coupled receptor 6Alternative name(s): Sphingosine 1-phosphate receptor GPR6 |
Gene namesi | Name:Gpr6 Synonyms:Cnl3 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 70939, Gpr6 |
Subcellular locationi
Plasma membrane
- Cell membrane Curated; Multi-pass membrane protein Curated
Note: Detected in the intracellular compartments. It is currently unclear whether this is a cell surface or intracellular receptor (By similarity).By similarity
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 75 | ExtracellularSequence analysisAdd BLAST | 75 | |
Transmembranei | 76 – 95 | Helical; Name=1Sequence analysisAdd BLAST | 20 | |
Topological domaini | 96 – 107 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 108 – 131 | Helical; Name=2Sequence analysisAdd BLAST | 24 | |
Topological domaini | 132 – 143 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 144 – 165 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 166 – 186 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 187 – 206 | Helical; Name=4Sequence analysisAdd BLAST | 20 | |
Topological domaini | 207 – 231 | ExtracellularSequence analysisAdd BLAST | 25 | |
Transmembranei | 232 – 250 | Helical; Name=5Sequence analysisAdd BLAST | 19 | |
Topological domaini | 251 – 278 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 279 – 305 | Helical; Name=6Sequence analysisAdd BLAST | 27 | |
Topological domaini | 306 – 310 | ExtracellularSequence analysis | 5 | |
Transmembranei | 311 – 332 | Helical; Name=7Sequence analysisAdd BLAST | 22 | |
Topological domaini | 333 – 363 | CytoplasmicSequence analysisAdd BLAST | 31 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069516 | 1 – 363 | G-protein coupled receptor 6Add BLAST | 363 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 2 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 9 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 52 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Lipidationi | 346 | S-palmitoyl cysteineBy similarity | 1 | |
Modified residuei | 357 | PhosphoserineSequence analysis | 1 | |
Modified residuei | 359 | PhosphoserineSequence analysis | 1 | |
Modified residuei | 361 | PhosphoserineSequence analysis | 1 |
Keywords - PTMi
Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
PaxDbi | P51651 |
PTM databases
GlyGeni | P51651, 3 sites |
iPTMneti | P51651 |
PhosphoSitePlusi | P51651 |
Expressioni
Tissue specificityi
Expressed in the brain, with a prominent distribution in striatum.1 Publication
Developmental stagei
Abundantly expressed in granule neurons at all developmental stages.1 Publication
Gene expression databases
Bgeei | ENSRNOG00000049580, Expressed in brain and 7 other tissues |
Genevisiblei | P51651, RN |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 28 – 51 | DisorderedSequence analysisAdd BLAST | 24 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214392 |
HOGENOMi | CLU_065071_0_0_1 |
InParanoidi | P51651 |
OMAi | YCVVGDP |
OrthoDBi | 903801at2759 |
PhylomeDBi | P51651 |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001151, GPR6 IPR000723, GPR_3/6/12_orphan |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00649, GPR6ORPHANR PR00644, GPRORPHANR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
P51651-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MNASAAALNE SQVVAVAAEG AAAAATAAGT PDTSEWGPPA ASAALGGGGG
60 70 80 90 100
PNGSLELSSQ LPAGPSGLLL SAVNPWDVLL CVSGTVIAGE NALVVALIAS
110 120 130 140 150
TPALRTPMFV LVGSLATADL LAGCGLILHF VFQYVVPSET VSLLMVGFLV
160 170 180 190 200
ASFAASVSSL LAITVDRYLS LYNALTYYSR RTLLGVHLLL AATWTVSLGL
210 220 230 240 250
GLLPVLGWNC LADRASCSVV RPLTRSHVAL LSTSFFVVFG IMLHLYVRIC
260 270 280 290 300
QVVWRHAHQI ALQQHCLAPP HLAATRKGVG TLAVVLGTFG ASWLPFAIYC
310 320 330 340 350
VVGSQEDPAI YTYATLLPAT YNSMINPIIY AFRNQEIQRA LWLLFCGCFQ
360
SKVPFRSRSP SEV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12006 mRNA Translation: AAA21870.1 AF064706 mRNA Translation: AAC16886.1 |
PIRi | S48697 |
RefSeqi | NP_113994.1, NM_031806.1 |
Genome annotation databases
Ensembli | ENSRNOT00000073276; ENSRNOP00000067254; ENSRNOG00000049580 |
GeneIDi | 83683 |
KEGGi | rno:83683 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U12006 mRNA Translation: AAA21870.1 AF064706 mRNA Translation: AAC16886.1 |
PIRi | S48697 |
RefSeqi | NP_113994.1, NM_031806.1 |
3D structure databases
AlphaFoldDBi | P51651 |
SMRi | P51651 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000067254 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P51651, 3 sites |
iPTMneti | P51651 |
PhosphoSitePlusi | P51651 |
Proteomic databases
PaxDbi | P51651 |
Genome annotation databases
Ensembli | ENSRNOT00000073276; ENSRNOP00000067254; ENSRNOG00000049580 |
GeneIDi | 83683 |
KEGGi | rno:83683 |
Organism-specific databases
CTDi | 2830 |
RGDi | 70939, Gpr6 |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01000000214392 |
HOGENOMi | CLU_065071_0_0_1 |
InParanoidi | P51651 |
OMAi | YCVVGDP |
OrthoDBi | 903801at2759 |
PhylomeDBi | P51651 |
Miscellaneous databases
PROi | PR:P51651 |
Gene expression databases
Bgeei | ENSRNOG00000049580, Expressed in brain and 7 other tissues |
Genevisiblei | P51651, RN |
Family and domain databases
InterProi | View protein in InterPro IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM IPR001151, GPR6 IPR000723, GPR_3/6/12_orphan |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00237, GPCRRHODOPSN PR00649, GPR6ORPHANR PR00644, GPRORPHANR |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GPR6_RAT | |
Accessioni | P51651Primary (citable) accession number: P51651 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families