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UniProtKB - P51649 (SSDH_HUMAN)
Protein
Succinate-semialdehyde dehydrogenase, mitochondrial
Gene
ALDH5A1
Organism
Homo sapiens (Human)
Status
Functioni
Catalyzes one step in the degradation of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA).
1 PublicationCatalytic activityi
Activity regulationi
Redox-regulated. Inhibited under oxydizing conditions. Inhibited by hydrogen peroxide H2O2.1 Publication
: 4-aminobutanoate degradation Pathwayi
This protein is involved in the pathway 4-aminobutanoate degradation, which is part of Amino-acid degradation.4 PublicationsView all proteins of this organism that are known to be involved in the pathway 4-aminobutanoate degradation and in Amino-acid degradation.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 205 | Transition state stabilizerBy similarity | 1 | |
Binding sitei | 213 | SubstrateCombined sources1 Publication | 1 | |
Active sitei | 306 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Binding sitei | 306 | NADBy similarity | 1 | |
Binding sitei | 334 | SubstrateCombined sources1 Publication | 1 | |
Active sitei | 340 | NucleophilePROSITE-ProRule annotation | 1 | |
Binding sitei | 498 | SubstrateCombined sources1 Publication | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 202 – 204 | NADBy similarity | 3 | |
Nucleotide bindingi | 228 – 231 | NADCombined sources1 Publication | 4 | |
Nucleotide bindingi | 284 – 289 | NADCombined sources1 Publication | 6 | |
Nucleotide bindingi | 438 – 440 | NADBy similarity | 3 |
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- succinate-semialdehyde dehydrogenase (NAD+) activity Source: UniProtKB
GO - Biological processi
- central nervous system development Source: UniProtKB
- gamma-aminobutyric acid catabolic process Source: UniProtKB
- glutamate metabolic process Source: UniProtKB
- neurotransmitter catabolic process Source: UniProtKB
- post-embryonic development Source: Ensembl
- succinate metabolic process Source: UniProtKB
Keywordsi
Molecular function | Oxidoreductase |
Ligand | NAD |
Enzyme and pathway databases
BRENDAi | 1.2.1.24, 2681 |
PathwayCommonsi | P51649 |
Reactomei | R-HSA-916853, Degradation of GABA |
SABIO-RKi | P51649 |
SignaLinki | P51649 |
SIGNORi | P51649 |
UniPathwayi | UPA00733 |
Names & Taxonomyi
Protein namesi | Recommended name: Succinate-semialdehyde dehydrogenase, mitochondrialCurated (EC:1.2.1.244 Publications)Alternative name(s): Aldehyde dehydrogenase family 5 member A1 NAD(+)-dependent succinic semialdehyde dehydrogenase |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:408, ALDH5A1 |
MIMi | 610045, gene |
neXtProti | NX_P51649 |
VEuPathDBi | HostDB:ENSG00000112294 |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial matrix Source: Reactome
- mitochondrion Source: HPA
Keywords - Cellular componenti
MitochondrionPathology & Biotechi
Involvement in diseasei
Succinic semialdehyde dehydrogenase deficiency (SSADHD)3 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA rare inborn error of 4-aminobutyric acid (GABA) metabolism, which leads to accumulation of 4-hydroxybutyric acid in physiologic fluids of patients. The disease is clinically characterized by developmental delay, hypotonia, mental retardation, ataxia, seizures, hyperkinetic behavior, aggression, and sleep disturbances.
Related information in OMIMFeature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026199 | 93 | C → F in SSADHD; 3% of activity. 1 PublicationCorresponds to variant dbSNP:rs765561257EnsemblClinVar. | 1 | |
Natural variantiVAR_026200 | 176 | G → R in SSADHD; <1% of activity. 1 PublicationCorresponds to variant dbSNP:rs72552281EnsemblClinVar. | 1 | |
Natural variantiVAR_026201 | 223 | C → Y in SSADHD; 5% of activity. 1 PublicationCorresponds to variant dbSNP:rs72552282EnsemblClinVar. | 1 | |
Natural variantiVAR_026202 | 233 | T → M in SSADHD; 4% of activity. 1 PublicationCorresponds to variant dbSNP:rs1326526453Ensembl. | 1 | |
Natural variantiVAR_026203 | 255 | N → S in SSADHD; 17% of activity. 1 PublicationCorresponds to variant dbSNP:rs145087265EnsemblClinVar. | 1 | |
Natural variantiVAR_026204 | 268 | G → E in SSADHD; <1% of activity. 2 PublicationsCorresponds to variant dbSNP:rs375628463EnsemblClinVar. | 1 | |
Natural variantiVAR_026205 | 335 | N → K in SSADHD; 1% of activity. 1 PublicationCorresponds to variant dbSNP:rs72552283Ensembl. | 1 | |
Natural variantiVAR_026206 | 382 | P → L in SSADHD; 2% of activity. 1 Publication | 1 | |
Natural variantiVAR_026207 | 382 | P → Q in SSADHD. 1 Publication | 1 | |
Natural variantiVAR_026208 | 409 | G → D in SSADHD; <1% of activity. 2 PublicationsCorresponds to variant dbSNP:rs118203984EnsemblClinVar. | 1 | |
Natural variantiVAR_026209 | 487 | V → E in SSADHD. 1 Publication | 1 | |
Natural variantiVAR_026210 | 533 | G → R in SSADHD; <1% of activity. 1 PublicationCorresponds to variant dbSNP:rs72552284EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 213 | R → A: Reduces catalytic activity to less than 15% of wild-type. 1 Publication | 1 | |
Mutagenesisi | 334 | R → A: Reduces catalytic activity to less than 15% of wild-type. 1 Publication | 1 | |
Mutagenesisi | 342 | C → A: Loss of regulation by redox state. 1 Publication | 1 | |
Mutagenesisi | 498 | S → A: Reduces catalytic activity to less than 15% of wild-type. 1 Publication | 1 |
Keywords - Diseasei
Disease variantOrganism-specific databases
DisGeNETi | 7915 |
GeneReviewsi | ALDH5A1 |
MalaCardsi | ALDH5A1 |
MIMi | 271980, phenotype |
OpenTargetsi | ENSG00000112294 |
Orphaneti | 22, Succinic semialdehyde dehydrogenase deficiency |
PharmGKBi | PA24702 |
Miscellaneous databases
Pharosi | P51649, Tclin |
Chemistry databases
ChEMBLi | CHEMBL1911 |
DrugBanki | DB00534, Chlormerodrin DB00157, NADH DB09072, Sodium oxybate DB00139, Succinic acid DB00313, Valproic acid |
DrugCentrali | P51649 |
GuidetoPHARMACOLOGYi | 2466 |
Genetic variation databases
BioMutai | ALDH5A1 |
DMDMi | 7531278 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 47 | MitochondrionSequence analysisAdd BLAST | 47 | |
ChainiPRO_0000007184 | 48 – 535 | Succinate-semialdehyde dehydrogenase, mitochondrialAdd BLAST | 488 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 126 | N6-acetyllysine; alternateCombined sources | 1 | |
Modified residuei | 126 | N6-succinyllysine; alternateBy similarity | 1 | |
Modified residuei | 135 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 184 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 265 | N6-acetyllysine; alternateBy similarity | 1 | |
Modified residuei | 265 | N6-succinyllysine; alternateBy similarity | 1 | |
Disulfide bondi | 340 ↔ 342 | In inhibited form1 Publication | ||
Modified residuei | 365 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 402 | N6-succinyllysineBy similarity | 1 | |
Modified residuei | 411 | N6-acetyllysineBy similarity | 1 | |
Modified residuei | 499 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, Disulfide bond, PhosphoproteinProteomic databases
EPDi | P51649 |
jPOSTi | P51649 |
MassIVEi | P51649 |
PaxDbi | P51649 |
PeptideAtlasi | P51649 |
PRIDEi | P51649 |
ProteomicsDBi | 33829 56358 [P51649-1] |
PTM databases
GlyGeni | P51649, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P51649 |
PhosphoSitePlusi | P51649 |
SwissPalmi | P51649 |
Expressioni
Tissue specificityi
Brain, pancreas, heart, liver, skeletal muscle and kidney. Lower in placenta.
Gene expression databases
Bgeei | ENSG00000112294, Expressed in vastus lateralis and 232 other tissues |
ExpressionAtlasi | P51649, baseline and differential |
Genevisiblei | P51649, HS |
Organism-specific databases
HPAi | ENSG00000112294, Tissue enhanced (liver) |
Interactioni
Subunit structurei
Homotetramer.
2 PublicationsGO - Molecular functioni
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 113645, 45 interactors |
IntActi | P51649, 18 interactors |
MINTi | P51649 |
STRINGi | 9606.ENSP00000314649 |
Chemistry databases
BindingDBi | P51649 |
Miscellaneous databases
RNActi | P51649, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
AlphaFoldDBi | P51649 |
SMRi | P51649 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P51649 |
Family & Domainsi
Sequence similaritiesi
Belongs to the aldehyde dehydrogenase family.Curated
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG2451, Eukaryota |
GeneTreei | ENSGT00930000151038 |
HOGENOMi | CLU_005391_5_1_1 |
InParanoidi | P51649 |
OMAi | WHKLIEQ |
PhylomeDBi | P51649 |
TreeFami | TF352906 |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR010102, Succ_semiAld_DH |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
TIGRFAMsi | TIGR01780, SSADH, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: P51649-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MATCIWLRSC GARRLGSTFP GCRLRPRAGG LVPASGPAPG PAQLRCYAGR
60 70 80 90 100
LAGLSAALLR TDSFVGGRWL PAAATFPVQD PASGAALGMV ADCGVREARA
110 120 130 140 150
AVRAAYEAFC RWREVSAKER SSLLRKWYNL MIQNKDDLAR IITAESGKPL
160 170 180 190 200
KEAHGEILYS AFFLEWFSEE ARRVYGDIIH TPAKDRRALV LKQPIGVAAV
210 220 230 240 250
ITPWNFPSAM ITRKVGAALA AGCTVVVKPA EDTPFSALAL AELASQAGIP
260 270 280 290 300
SGVYNVIPCS RKNAKEVGEA ICTDPLVSKI SFTGSTTTGK ILLHHAANSV
310 320 330 340 350
KRVSMELGGL APFIVFDSAN VDQAVAGAMA SKFRNTGQTC VCSNQFLVQR
360 370 380 390 400
GIHDAFVKAF AEAMKKNLRV GNGFEEGTTQ GPLINEKAVE KVEKQVNDAV
410 420 430 440 450
SKGATVVTGG KRHQLGKNFF EPTLLCNVTQ DMLCTHEETF GPLAPVIKFD
460 470 480 490 500
TEEEAIAIAN AADVGLAGYF YSQDPAQIWR VAEQLEVGMV GVNEGLISSV
510 520 530
ECPFGGVKQS GLGREGSKYG IDEYLELKYV CYGGL
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9J8Q5 | C9J8Q5_HUMAN | Succinate-semialdehyde dehydrogenas... | ALDH5A1 | 507 | Annotation score: | ||
A0A5F9ZI23 | A0A5F9ZI23_HUMAN | Succinate-semialdehyde dehydrogenas... | ALDH5A1 | 408 | Annotation score: | ||
A0A5F9ZH05 | A0A5F9ZH05_HUMAN | Succinate-semialdehyde dehydrogenas... | ALDH5A1 | 99 | Annotation score: | ||
A0A5F9ZH98 | A0A5F9ZH98_HUMAN | Succinate-semialdehyde dehydrogenas... | ALDH5A1 | 229 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_026227 | 36 | G → R No effect on succinate-semialdehyde dehydrogenase activity. 2 PublicationsCorresponds to variant dbSNP:rs4646832EnsemblClinVar. | 1 | |
Natural variantiVAR_026199 | 93 | C → F in SSADHD; 3% of activity. 1 PublicationCorresponds to variant dbSNP:rs765561257EnsemblClinVar. | 1 | |
Natural variantiVAR_026200 | 176 | G → R in SSADHD; <1% of activity. 1 PublicationCorresponds to variant dbSNP:rs72552281EnsemblClinVar. | 1 | |
Natural variantiVAR_016758 | 180 | H → Y 83% of activity. 3 PublicationsCorresponds to variant dbSNP:rs2760118EnsemblClinVar. | 1 | |
Natural variantiVAR_016759 | 182 | P → L 48% of activity. 2 PublicationsCorresponds to variant dbSNP:rs3765310EnsemblClinVar. | 1 | |
Natural variantiVAR_026201 | 223 | C → Y in SSADHD; 5% of activity. 1 PublicationCorresponds to variant dbSNP:rs72552282EnsemblClinVar. | 1 | |
Natural variantiVAR_026202 | 233 | T → M in SSADHD; 4% of activity. 1 PublicationCorresponds to variant dbSNP:rs1326526453Ensembl. | 1 | |
Natural variantiVAR_026228 | 237 | A → S 65% of activity. 2 PublicationsCorresponds to variant dbSNP:rs62621664EnsemblClinVar. | 1 | |
Natural variantiVAR_026203 | 255 | N → S in SSADHD; 17% of activity. 1 PublicationCorresponds to variant dbSNP:rs145087265EnsemblClinVar. | 1 | |
Natural variantiVAR_026204 | 268 | G → E in SSADHD; <1% of activity. 2 PublicationsCorresponds to variant dbSNP:rs375628463EnsemblClinVar. | 1 | |
Natural variantiVAR_026205 | 335 | N → K in SSADHD; 1% of activity. 1 PublicationCorresponds to variant dbSNP:rs72552283Ensembl. | 1 | |
Natural variantiVAR_069047 | 372 | N → S1 Publication | 1 | |
Natural variantiVAR_026206 | 382 | P → L in SSADHD; 2% of activity. 1 Publication | 1 | |
Natural variantiVAR_026207 | 382 | P → Q in SSADHD. 1 Publication | 1 | |
Natural variantiVAR_026229 | 406 | V → I2 PublicationsCorresponds to variant dbSNP:rs143741652EnsemblClinVar. | 1 | |
Natural variantiVAR_026208 | 409 | G → D in SSADHD; <1% of activity. 2 PublicationsCorresponds to variant dbSNP:rs118203984EnsemblClinVar. | 1 | |
Natural variantiVAR_026209 | 487 | V → E in SSADHD. 1 Publication | 1 | |
Natural variantiVAR_026210 | 533 | G → R in SSADHD; <1% of activity. 1 PublicationCorresponds to variant dbSNP:rs72552284EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_045231 | 242 | E → EVNQGFLLDLDPLL in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11192 mRNA Translation: CAA72076.1 AJ427354 mRNA Translation: CAD20883.2 AJ427355 mRNA Translation: CAD20884.1 AK315380 mRNA Translation: BAG37773.1 AL031230 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55452.1 CH471087 Genomic DNA Translation: EAW55453.1 BC034321 mRNA Translation: AAH34321.1 L34820 mRNA Translation: AAA67057.1 |
CCDSi | CCDS4555.1 [P51649-1] CCDS4556.1 [P51649-2] |
PIRi | A55773 |
RefSeqi | NP_001071.1, NM_001080.3 [P51649-1] NP_733936.1, NM_170740.1 [P51649-2] |
Genome annotation databases
Ensembli | ENST00000348925.2; ENSP00000314649.3; ENSG00000112294.14 [P51649-2] ENST00000357578.8; ENSP00000350191.3; ENSG00000112294.14 |
GeneIDi | 7915 |
KEGGi | hsa:7915 |
MANE-Selecti | ENST00000357578.8; ENSP00000350191.3; NM_001080.3; NP_001071.1 |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Y11192 mRNA Translation: CAA72076.1 AJ427354 mRNA Translation: CAD20883.2 AJ427355 mRNA Translation: CAD20884.1 AK315380 mRNA Translation: BAG37773.1 AL031230 Genomic DNA No translation available. CH471087 Genomic DNA Translation: EAW55452.1 CH471087 Genomic DNA Translation: EAW55453.1 BC034321 mRNA Translation: AAH34321.1 L34820 mRNA Translation: AAA67057.1 |
CCDSi | CCDS4555.1 [P51649-1] CCDS4556.1 [P51649-2] |
PIRi | A55773 |
RefSeqi | NP_001071.1, NM_001080.3 [P51649-1] NP_733936.1, NM_170740.1 [P51649-2] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
2W8N | X-ray | 2.00 | A | 49-535 | [»] | |
2W8O | X-ray | 3.40 | A | 49-535 | [»] | |
2W8P | X-ray | 2.30 | A | 49-535 | [»] | |
2W8Q | X-ray | 2.40 | A | 49-535 | [»] | |
2W8R | X-ray | 2.40 | A | 49-535 | [»] | |
AlphaFoldDBi | P51649 | |||||
SMRi | P51649 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 113645, 45 interactors |
IntActi | P51649, 18 interactors |
MINTi | P51649 |
STRINGi | 9606.ENSP00000314649 |
Chemistry databases
BindingDBi | P51649 |
ChEMBLi | CHEMBL1911 |
DrugBanki | DB00534, Chlormerodrin DB00157, NADH DB09072, Sodium oxybate DB00139, Succinic acid DB00313, Valproic acid |
DrugCentrali | P51649 |
GuidetoPHARMACOLOGYi | 2466 |
PTM databases
GlyGeni | P51649, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P51649 |
PhosphoSitePlusi | P51649 |
SwissPalmi | P51649 |
Genetic variation databases
BioMutai | ALDH5A1 |
DMDMi | 7531278 |
Proteomic databases
EPDi | P51649 |
jPOSTi | P51649 |
MassIVEi | P51649 |
PaxDbi | P51649 |
PeptideAtlasi | P51649 |
PRIDEi | P51649 |
ProteomicsDBi | 33829 56358 [P51649-1] |
Protocols and materials databases
Antibodypediai | 25307, 450 antibodies from 34 providers |
DNASUi | 7915 |
Genome annotation databases
Ensembli | ENST00000348925.2; ENSP00000314649.3; ENSG00000112294.14 [P51649-2] ENST00000357578.8; ENSP00000350191.3; ENSG00000112294.14 |
GeneIDi | 7915 |
KEGGi | hsa:7915 |
MANE-Selecti | ENST00000357578.8; ENSP00000350191.3; NM_001080.3; NP_001071.1 |
Organism-specific databases
CTDi | 7915 |
DisGeNETi | 7915 |
GeneCardsi | ALDH5A1 |
GeneReviewsi | ALDH5A1 |
HGNCi | HGNC:408, ALDH5A1 |
HPAi | ENSG00000112294, Tissue enhanced (liver) |
MalaCardsi | ALDH5A1 |
MIMi | 271980, phenotype 610045, gene |
neXtProti | NX_P51649 |
OpenTargetsi | ENSG00000112294 |
Orphaneti | 22, Succinic semialdehyde dehydrogenase deficiency |
PharmGKBi | PA24702 |
VEuPathDBi | HostDB:ENSG00000112294 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG2451, Eukaryota |
GeneTreei | ENSGT00930000151038 |
HOGENOMi | CLU_005391_5_1_1 |
InParanoidi | P51649 |
OMAi | WHKLIEQ |
PhylomeDBi | P51649 |
TreeFami | TF352906 |
Enzyme and pathway databases
UniPathwayi | UPA00733 |
BRENDAi | 1.2.1.24, 2681 |
PathwayCommonsi | P51649 |
Reactomei | R-HSA-916853, Degradation of GABA |
SABIO-RKi | P51649 |
SignaLinki | P51649 |
SIGNORi | P51649 |
Miscellaneous databases
BioGRID-ORCSi | 7915, 7 hits in 1077 CRISPR screens |
ChiTaRSi | ALDH5A1, human |
EvolutionaryTracei | P51649 |
GeneWikii | Aldehyde_dehydrogenase_5_family,_member_A1 |
GenomeRNAii | 7915 |
Pharosi | P51649, Tclin |
PROi | PR:P51649 |
RNActi | P51649, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000112294, Expressed in vastus lateralis and 232 other tissues |
ExpressionAtlasi | P51649, baseline and differential |
Genevisiblei | P51649, HS |
Family and domain databases
Gene3Di | 3.40.309.10, 1 hit 3.40.605.10, 1 hit |
InterProi | View protein in InterPro IPR016161, Ald_DH/histidinol_DH IPR016163, Ald_DH_C IPR016160, Ald_DH_CS_CYS IPR029510, Ald_DH_CS_GLU IPR016162, Ald_DH_N IPR015590, Aldehyde_DH_dom IPR010102, Succ_semiAld_DH |
Pfami | View protein in Pfam PF00171, Aldedh, 1 hit |
SUPFAMi | SSF53720, SSF53720, 1 hit |
TIGRFAMsi | TIGR01780, SSADH, 1 hit |
PROSITEi | View protein in PROSITE PS00070, ALDEHYDE_DEHYDR_CYS, 1 hit PS00687, ALDEHYDE_DEHYDR_GLU, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | SSDH_HUMAN | |
Accessioni | P51649Primary (citable) accession number: P51649 Secondary accession number(s): B2RD26 Q8N3W6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | May 30, 2000 | |
Last modified: | May 25, 2022 | |
This is version 202 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families