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Protein

Ciliary neurotrophic factor

Gene

Cntf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, Growth factor
Biological processDifferentiation, Neurogenesis

Enzyme and pathway databases

ReactomeiR-MMU-6788467 IL-6-type cytokine receptor ligand interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Ciliary neurotrophic factor
Short name:
CNTF
Gene namesi
Name:Cntf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:88439 Cntf

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001495201 – 198Ciliary neurotrophic factorAdd BLAST198

Proteomic databases

PaxDbiP51642
PRIDEiP51642

PTM databases

iPTMnetiP51642
PhosphoSitePlusiP51642

Expressioni

Tissue specificityi

Nervous system.

Gene expression databases

BgeeiENSMUSG00000079415
ExpressionAtlasiP51642 baseline and differential
GenevisibleiP51642 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198795, 3 interactors
STRINGi10090.ENSMUSP00000108555

Structurei

3D structure databases

ProteinModelPortaliP51642
SMRiP51642
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CNTF family.Curated

Phylogenomic databases

eggNOGiENOG410IGEN Eukaryota
ENOG410YYIH LUCA
GeneTreeiENSGT00420000029890
HOGENOMiHOG000059605
HOVERGENiHBG005362
InParanoidiP51642
KOiK05420
OMAiKLWGLKV
OrthoDBiEOG091G0R1O
PhylomeDBiP51642
TreeFamiTF336237

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR000151 Ciliary_neurotrophic_fac_CNTF
PANTHERiPTHR15196 PTHR15196, 1 hit
PfamiView protein in Pfam
PF01110 CNTF, 1 hit
SUPFAMiSSF47266 SSF47266, 1 hit

Sequencei

Sequence statusi: Complete.

P51642-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAFAEQSPLT LHRRDLCSRS IWLARKIRSD LTALMESYVK HQGLNKNISL
60 70 80 90 100
DSVDGVPVAS TDRWSEMTEA ERLQENLQAY RTFQGMLTKL LEDQRVHFTP
110 120 130 140 150
TEGDFHQAIH TLTLQVSAFA YQLEELMALL EQKVPEKEAD GMPVTIGDGG
160 170 180 190
LFEKKLWGLK VLQELSQWTV RSIHDLRVIS SHHMGISAHE SHYGAKQM
Length:198
Mass (Da):22,587
Last modified:October 1, 1996 - v1
Checksum:i4EB03E7455653667
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U05342 mRNA Translation: AAA81912.1
BC027539 mRNA Translation: AAH27539.1
CCDSiCCDS29637.1
PIRiI48723
RefSeqiNP_740756.1, NM_170786.2
UniGeneiMm.290924

Genome annotation databases

EnsembliENSMUST00000112933; ENSMUSP00000108555; ENSMUSG00000079415
GeneIDi12803
KEGGimmu:12803
UCSCiuc008gun.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCNTF_MOUSE
AccessioniPrimary (citable) accession number: P51642
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: July 18, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

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