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Protein

Caveolin-3

Gene

Cav3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae.By similarity

GO - Molecular functioni

  • alpha-tubulin binding Source: Ensembl
  • calcium channel regulator activity Source: Ensembl
  • connexin binding Source: GO_Central
  • enzyme binding Source: RGD
  • ion channel binding Source: BHF-UCL
  • nitric-oxide synthase binding Source: RGD
  • potassium channel inhibitor activity Source: BHF-UCL
  • protein-containing complex binding Source: Ensembl
  • protein-containing complex scaffold activity Source: RGD
  • protein C-terminus binding Source: Ensembl
  • sodium channel regulator activity Source: Ensembl
  • structural molecule activity Source: GO_Central

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-RNO-445355 Smooth Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-3
Gene namesi
Name:Cav3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 4

Organism-specific databases

RGDi2281 Cav3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 83CytoplasmicSequence analysisAdd BLAST83
Intramembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 151CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441421 – 151Caveolin-3Add BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki38Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3)By similarity

Post-translational modificationi

Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

PaxDbiP51638
PRIDEiP51638

PTM databases

iPTMnetiP51638
PhosphoSitePlusiP51638
SwissPalmiP51638

Expressioni

Tissue specificityi

Expressed predominantly in muscle.

Gene expression databases

BgeeiENSRNOG00000005798 Expressed in 7 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiP51638 RN

Interactioni

Subunit structurei

Homooligomer. Interacts with DYSF (By similarity). Interacts with DLG1 and KCNA5; forms a ternary complex (PubMed:15277200). Interacts with DAG1 (via its C-terminal); the interaction prevents binding of DAG1 with DMD. Interacts with TRIM72. Interacts with MUSK; may regulate MUSK signaling. Interacts with BVES. Interacts with CAVIN1, CAVIN2 and CAVIN4 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi247843, 4 interactors
CORUMiP51638
IntActiP51638, 1 interactor
MINTiP51638
STRINGi10116.ENSRNOP00000007601

Family & Domainsi

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiENOG410IXSQ Eukaryota
ENOG41121CB LUCA
GeneTreeiENSGT00390000014924
HOGENOMiHOG000036550
HOVERGENiHBG003422
InParanoidiP51638
KOiK12959
OMAiVKDIHFK
OrthoDBiEOG091G0M1R
PhylomeDBiP51638
TreeFamiTF315736

Family and domain databases

InterProiView protein in InterPro
IPR031091 CAV-3
IPR001612 Caveolin
IPR018361 Caveolin_CS
PANTHERiPTHR10844 PTHR10844, 1 hit
PTHR10844:SF16 PTHR10844:SF16, 1 hit
PfamiView protein in Pfam
PF01146 Caveolin, 1 hit
PROSITEiView protein in PROSITE
PS01210 CAVEOLIN, 1 hit

Sequencei

Sequence statusi: Complete.

P51638-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMTEEHTDLE ARIIKDIHCK EIDLVNRDPK NINEDIVKVD FEDVIAEPEG
60 70 80 90 100
TYSFDGVWRV SYTTFTVSKY WCYRLLSTLL GVPLALLWGF LFACISFCHI
110 120 130 140 150
WAVVPCIKSY LIEIQCISHI YSLCIRTFCN PLFAALGQVC SNIKVVLRRE

G
Length:151
Mass (Da):17,402
Last modified:October 1, 1996 - v1
Checksum:iA822A33EF9AA668F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31968 mRNA Translation: AAC52377.1
BC084692 mRNA Translation: AAH84692.1
RefSeqiNP_062028.1, NM_019155.2
UniGeneiRn.98191

Genome annotation databases

EnsembliENSRNOT00000007601; ENSRNOP00000007601; ENSRNOG00000005798
GeneIDi29161
KEGGirno:29161
UCSCiRGD:2281 rat

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U31968 mRNA Translation: AAC52377.1
BC084692 mRNA Translation: AAH84692.1
RefSeqiNP_062028.1, NM_019155.2
UniGeneiRn.98191

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi247843, 4 interactors
CORUMiP51638
IntActiP51638, 1 interactor
MINTiP51638
STRINGi10116.ENSRNOP00000007601

PTM databases

iPTMnetiP51638
PhosphoSitePlusiP51638
SwissPalmiP51638

Proteomic databases

PaxDbiP51638
PRIDEiP51638

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000007601; ENSRNOP00000007601; ENSRNOG00000005798
GeneIDi29161
KEGGirno:29161
UCSCiRGD:2281 rat

Organism-specific databases

CTDi859
RGDi2281 Cav3

Phylogenomic databases

eggNOGiENOG410IXSQ Eukaryota
ENOG41121CB LUCA
GeneTreeiENSGT00390000014924
HOGENOMiHOG000036550
HOVERGENiHBG003422
InParanoidiP51638
KOiK12959
OMAiVKDIHFK
OrthoDBiEOG091G0M1R
PhylomeDBiP51638
TreeFamiTF315736

Enzyme and pathway databases

ReactomeiR-RNO-445355 Smooth Muscle Contraction

Miscellaneous databases

PROiPR:P51638

Gene expression databases

BgeeiENSRNOG00000005798 Expressed in 7 organ(s), highest expression level in skeletal muscle tissue
GenevisibleiP51638 RN

Family and domain databases

InterProiView protein in InterPro
IPR031091 CAV-3
IPR001612 Caveolin
IPR018361 Caveolin_CS
PANTHERiPTHR10844 PTHR10844, 1 hit
PTHR10844:SF16 PTHR10844:SF16, 1 hit
PfamiView protein in Pfam
PF01146 Caveolin, 1 hit
PROSITEiView protein in PROSITE
PS01210 CAVEOLIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAV3_RAT
AccessioniPrimary (citable) accession number: P51638
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 137 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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