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Protein

Caveolin-3

Gene

Cav3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (PubMed:19380584). Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (By similarity).By similarity1 Publication

GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-MMU-445355 Smooth Muscle Contraction

Names & Taxonomyi

Protein namesi
Recommended name:
Caveolin-3Imported
Alternative name(s):
M-caveolin
Gene namesi
Name:Cav3Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107570 Cav3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 83CytoplasmicSequence analysisAdd BLAST83
Intramembranei84 – 104HelicalSequence analysisAdd BLAST21
Topological domaini105 – 151CytoplasmicSequence analysisAdd BLAST47

Keywords - Cellular componenti

Cell membrane, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi27R → Q: Results in aberrent localization of TRIM72 and defects in membrane repair. 1 Publication1
Mutagenesisi105P → L: Dominant-negative mutant that induces defects in membrane repair. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001441411 – 151Caveolin-3Add BLAST151

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki38Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO3)By similarity

Post-translational modificationi

Sumoylation with SUMO3 by PIAS4 may reduce agonist-induced internalization and desensitization of adrenergic receptor ABRD2.By similarity

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiP51637
PaxDbiP51637
PeptideAtlasiP51637
PRIDEiP51637

PTM databases

iPTMnetiP51637
PhosphoSitePlusiP51637

Expressioni

Tissue specificityi

Expressed predominantly in muscle.1 Publication

Gene expression databases

BgeeiENSMUSG00000062694 Expressed in 95 organ(s), highest expression level in triceps surae
CleanExiMM_CAV3
GenevisibleiP51637 MM

Interactioni

Subunit structurei

Homooligomer. Interacts with DYSF. Interacts with DLG1 and KCNA5; forms a ternary complex. Interacts with DAG1 (via its C-terminal); the interaction prevents binding of DAG1 with DMD (By similarity). Interacts with TRIM72 (PubMed:19380584). Interacts with MUSK; may regulate MUSK signaling (PubMed:19940021). Interacts with BVES (PubMed:24066022). Interacts with CAVIN1, CAVIN2 and CAVIN4 (By similarity).By similarity3 Publications

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198516, 8 interactors
CORUMiP51637
DIPiDIP-31069N
IntActiP51637, 343 interactors
MINTiP51637
STRINGi10090.ENSMUSP00000074922

Structurei

3D structure databases

ProteinModelPortaliP51637
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni64 – 114Required for interaction with DAG1By similarityAdd BLAST51

Sequence similaritiesi

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGiENOG410IXSQ Eukaryota
ENOG41121CB LUCA
GeneTreeiENSGT00390000014924
HOGENOMiHOG000036550
HOVERGENiHBG003422
InParanoidiP51637
KOiK12959
OMAiVKDIHFK
OrthoDBiEOG091G0M1R
PhylomeDBiP51637
TreeFamiTF315736

Family and domain databases

InterProiView protein in InterPro
IPR031091 CAV-3
IPR001612 Caveolin
IPR018361 Caveolin_CS
PANTHERiPTHR10844 PTHR10844, 1 hit
PTHR10844:SF16 PTHR10844:SF16, 1 hit
PfamiView protein in Pfam
PF01146 Caveolin, 1 hit
PROSITEiView protein in PROSITE
PS01210 CAVEOLIN, 1 hit

Sequencei

Sequence statusi: Complete.

P51637-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MMTEEHTDLE ARIIKDIHCK EIDLVNRDPK NINEDIVKVD FEDVIAEPEG
60 70 80 90 100
TYSFDGVWKV SFTTFTVSKY WCYRLLSTLL GVPLALLWGF LFACISFCHI
110 120 130 140 150
WAVVPCIKSY LIEIQCISHI YSLCIRTFCN PLFAALGQVC SNIKVVLRRE

G
Length:151
Mass (Da):17,358
Last modified:October 1, 1996 - v1
Checksum:i7C1A181010CC60F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36579 mRNA Translation: AAC52352.1
BC024383 mRNA Translation: AAH24383.1
CCDSiCCDS20406.1
PIRiS68222
RefSeqiNP_031643.1, NM_007617.3
UniGeneiMm.3924

Genome annotation databases

EnsembliENSMUST00000075477; ENSMUSP00000074922; ENSMUSG00000062694
GeneIDi12391
KEGGimmu:12391
UCSCiuc009dea.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U36579 mRNA Translation: AAC52352.1
BC024383 mRNA Translation: AAH24383.1
CCDSiCCDS20406.1
PIRiS68222
RefSeqiNP_031643.1, NM_007617.3
UniGeneiMm.3924

3D structure databases

ProteinModelPortaliP51637
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198516, 8 interactors
CORUMiP51637
DIPiDIP-31069N
IntActiP51637, 343 interactors
MINTiP51637
STRINGi10090.ENSMUSP00000074922

PTM databases

iPTMnetiP51637
PhosphoSitePlusiP51637

Proteomic databases

MaxQBiP51637
PaxDbiP51637
PeptideAtlasiP51637
PRIDEiP51637

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000075477; ENSMUSP00000074922; ENSMUSG00000062694
GeneIDi12391
KEGGimmu:12391
UCSCiuc009dea.1 mouse

Organism-specific databases

CTDi859
MGIiMGI:107570 Cav3

Phylogenomic databases

eggNOGiENOG410IXSQ Eukaryota
ENOG41121CB LUCA
GeneTreeiENSGT00390000014924
HOGENOMiHOG000036550
HOVERGENiHBG003422
InParanoidiP51637
KOiK12959
OMAiVKDIHFK
OrthoDBiEOG091G0M1R
PhylomeDBiP51637
TreeFamiTF315736

Enzyme and pathway databases

ReactomeiR-MMU-445355 Smooth Muscle Contraction

Miscellaneous databases

PROiPR:P51637
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062694 Expressed in 95 organ(s), highest expression level in triceps surae
CleanExiMM_CAV3
GenevisibleiP51637 MM

Family and domain databases

InterProiView protein in InterPro
IPR031091 CAV-3
IPR001612 Caveolin
IPR018361 Caveolin_CS
PANTHERiPTHR10844 PTHR10844, 1 hit
PTHR10844:SF16 PTHR10844:SF16, 1 hit
PfamiView protein in Pfam
PF01146 Caveolin, 1 hit
PROSITEiView protein in PROSITE
PS01210 CAVEOLIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCAV3_MOUSE
AccessioniPrimary (citable) accession number: P51637
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: September 12, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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