CAV2

Functionⁱ

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation. The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells. Positive regulator of cellular mitogenesis of the MAPK signaling pathway. Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression (By similarity).By similarity2 Publications

GO - Molecular functionⁱ

D1 dopamine receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15569306
protein binding, bridging Source: Ensembl
protein-containing complex scaffold activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein heterodimerization activity Source: Ensembl
protein homodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 8552590
protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
scaffold protein binding Source: Ensembl
structural molecule activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

caveola assembly
Source: BHF-UCL
Inferred from direct assayⁱ
- 12743374
cell differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
endoplasmic reticulum organization Source: UniProtKB
insulin receptor signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 20455999
mitochondrion organization Source: UniProtKB
negative regulation of endothelial cell proliferation Source: UniProtKB
negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
positive regulation by host of viral process
Source: AgBase
Inferred from mutant phenotypeⁱ
- 25556234
positive regulation by host of viral release from host cell
Source: AgBase
Inferred from mutant phenotypeⁱ
- 25556234
positive regulation of dopamine receptor signaling pathway
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 15569306
positive regulation of endothelial cell proliferation Source: Ensembl
positive regulation of GTPase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 8552590
positive regulation of MAPK cascade
Source: BHF-UCL
Inferred from direct assayⁱ
- 20455999
protein complex oligomerization Source: Ensembl
receptor-mediated endocytosis of virus by host cell
Source: CACAO
Inferred from genetic interactionⁱ
- 21047970
regulation of mitotic nuclear division
Source: BHF-UCL
Inferred from expression patternⁱ
- 18081315
skeletal muscle fiber development Source: UniProtKB
vesicle docking
Source: BHF-UCL
Inferred from direct assayⁱ
- 12743374
vesicle fusion
Source: BHF-UCL
Inferred from direct assayⁱ
- 12743374
vesicle organization
Source: BHF-UCL
Inferred from direct assayⁱ
- 12743374

View the complete GO annotation on QuickGO ...

Enzyme and pathway databases

SignaLinkⁱ	P51636
SIGNORⁱ	P51636

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Caveolin-2
Gene namesⁱ	Name:CAV2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000105971.14
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:1528 CAV2
MIMⁱ	601048 gene
neXtProtⁱ	NX_P51636

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 86	CytoplasmicSequence analysisAdd BLAST	86
Intramembraneⁱ	87 – 107	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	108 – 162	CytoplasmicSequence analysisAdd BLAST	55

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasm, Golgi apparatus, Membrane, Nucleus

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	19	Y → A: Greatly reduced Src-mediated phosphorylation and binding of RASA1, SRC and NCK1. Completely eliminates Src-mediated tyrosine phosphorylation and binding to RASA1, SRC and NCK1; when associated with A-27. 1 Publication	1
Mutagenesisⁱ	23	S → A: Abolishes phosphorylation. 1 Publication	1
Mutagenesisⁱ	27	Y → A: Greatly reduced Src-mediated phosphorylation and binding of RASA1, SRC and NCK1. Completely eliminates Src-mediated phosphorylation and binding of RASA1, SRC and NCK1; when associated with A-19. 1 Publication	1
Mutagenesisⁱ	36	S → A: Abolishes phosphorylation. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	858
Open Targets More...OpenTargetsⁱ	ENSG00000105971
PharmGKBⁱ	PA26108

Polymorphism and mutation databases

BioMutaⁱ	CAV2

BioMutaⁱ

CAV2

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000004772	1 – 162	Caveolin-2Add BLAST		162

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	19	Phosphotyrosine; by SRC2 Publications	1
Modified residueⁱ	20	PhosphoserineBy similarity	1
Modified residueⁱ	23	Phosphoserine1 Publication	1
Modified residueⁱ	27	Phosphotyrosine; by SRC1 Publication	1
Modified residueⁱ	36	Phosphoserine1 Publication	1

Post-translational modificationⁱ

Phosphorylated on serine and tyrosine residues. CAV1 promotes phosphorylation on Ser-23 which then targets the complex to the plasma membrane, lipid rafts and caveolae. Phosphorylation on Ser-36 appears to modulate mitosis in endothelial cells (By similarity). Phosphorylation on both Tyr-19 and Tyr-27 is required for insulin-induced 'Ser-727' phosphorylation of STAT3 and its activation. Phosphorylation on Tyr-19 is required for insulin-induced phosphorylation of MAPK1 and DNA binding of STAT3. Tyrosine phosphorylation is induced by both EGF and insulin (By similarity).By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	P51636
PaxDbⁱ	P51636
PeptideAtlas More...PeptideAtlasⁱ	P51636
PRIDEⁱ	P51636
ProteomicsDBⁱ	56353 56354 [P51636-2] 56355 [P51636-3]

PTM databases

iPTMnetⁱ	P51636
PhosphoSitePlusⁱ	P51636
SwissPalmⁱ	P51636

Expressionⁱ

Tissue specificityⁱ

Expressed in endothelial cells, smooth muscle cells, skeletal myoblasts and fibroblasts.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000105971 Expressed in 235 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_CAV2
ExpressionAtlasⁱ	P51636 baseline and differential
Genevisibleⁱ	P51636 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB013488 HPA044810

HPAⁱ

CAB013488
HPA044810

Interactionⁱ

Subunit structureⁱ

Monomer or homodimer. Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only. Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC. Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation. Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation. Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
CAV1	Q03135	2	EBI-603607,EBI-603614

With

Entry

#Exp.

IntAct

Notes

CAV1

Q03135

2

EBI-603607,EBI-603614

GO - Molecular functionⁱ

D1 dopamine receptor binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 15569306
protein binding, bridging Source: Ensembl
protein-containing complex scaffold activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein heterodimerization activity Source: Ensembl
protein homodimerization activity
Source: MGI
Inferred from direct assayⁱ
- 8552590
protein kinase binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
scaffold protein binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	107306, 11 interactors
Database of interacting proteins More...DIPⁱ	DIP-34929N
IntActⁱ	P51636, 8 interactors
Molecular INTeraction database More...MINTⁱ	P51636
STRINGⁱ	9606.ENSP00000222693

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51636
SMRⁱ	P51636
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the caveolin family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IFFB Eukaryota ENOG4111STF LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000014924
HOGENOMⁱ	HOG000036550
HOVERGENⁱ	HBG003422
InParanoidⁱ	P51636
KEGG Orthology (KO) More...KOⁱ	K12958
OMAⁱ	HLKVGFE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0M1R
PhylomeDBⁱ	P51636
TreeFamⁱ	TF315736

Family and domain databases

InterProⁱ	View protein in InterPro IPR033306 CAV-2 IPR001612 Caveolin IPR018361 Caveolin_CS
PANTHERⁱ	PTHR10844 PTHR10844, 1 hit PTHR10844:SF3 PTHR10844:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF01146 Caveolin, 1 hit
PROSITEⁱ	View protein in PROSITE PS01210 CAVEOLIN, 1 hit

Sequences (3+)ⁱ

Sequence statusⁱ: Complete.

This entry describes 3 isoformsⁱ produced by alternative splicing and alternative initiation. Align Add to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show all Align All

Isoform Alpha (identifier: P51636-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGLETEKADV QLFMDDDSYS HHSGLEYADP EKFADSDQDR DPHRLNSHLK 
        60         70         80         90        100
LGFEDVIAEP VTTHSFDKVW ICSHALFEIS KYVMYKFLTV FLAIPLAFIA 
       110        120        130        140        150
GILFATLSCL HIWILMPFVK TCLMVLPSVQ TIWKSVTDVI IAPLCTSVGR 
       160 
CFSSVSLQLS QD

Length:162

Mass (Da):18,291

Last modified:July 15, 1999 - v2

Checksum:ⁱ89FDEDA861330B87

GO

Isoform Beta (identifier: P51636-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-13: Missing.

« Hide

        10         20         30         40         50
MDDDSYSHHS GLEYADPEKF ADSDQDRDPH RLNSHLKLGF EDVIAEPVTT 
        60         70         80         90        100
HSFDKVWICS HALFEISKYV MYKFLTVFLA IPLAFIAGIL FATLSCLHIW 
       110        120        130        140 
ILMPFVKTCL MVLPSVQTIW KSVTDVIIAP LCTSVGRCFS SVSLQLSQD

Note: Produced by alternative initiation.

Show »

Length:149

Mass (Da):16,829

Checksum:ⁱ0706B574F5E1AAD8

GO

Isoform C (identifier: P51636-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
51-112: LGFEDVIAEP...LFATLSCLHI → DFNAFCKDLP...WTPGLEIGIL
113-162: Missing.

« Hide

        10         20         30         40         50
MGLETEKADV QLFMDDDSYS HHSGLEYADP EKFADSDQDR DPHRLNSHLK 
        60         70         80         90        100
DFNAFCKDLP NGSAFSADNM EECDRCYHCS IVYERRTMLL FCQPATEPGL 
       110 
NTWTPGLEIG IL

Note: Produced by alternative splicing.

Show »

Length:112

Mass (Da):12,780

Checksum:ⁱ7C60DC5ABD6B0105

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	E9PCT3	E9PCT3_HUMAN		Caveolin Caveolin	CAV2	113	Annotation score:

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_012071	130	Q → E. Corresponds to variant dbSNP:rs8940Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_018696	1 – 13	Missing in isoform Beta. CuratedAdd BLAST	13
Alternative sequenceⁱVSP_038114	51 – 112	LGFED…SCLHI → DFNAFCKDLPNGSAFSADNM EECDRCYHCSIVYERRTMLL FCQPATEPGLNTWTPGLEIG IL in isoform C. 1 PublicationAdd BLAST	62
Alternative sequenceⁱVSP_038115	113 – 162	Missing in isoform C. 1 PublicationAdd BLAST	50

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF035752 mRNA Translation: AAB88492.1 AJ133269 Genomic DNA Translation: CAB63653.1 BT007051 mRNA Translation: AAP35700.1 BC005256 mRNA Translation: AAH05256.1 AJ242718 Genomic DNA Translation: CAB65090.1 AK310786 mRNA No translation available. CH236947 Genomic DNA Translation: EAL24361.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5765.1 [P51636-3] CCDS5766.1 [P51636-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_001193676.1, NM_001206747.1 [P51636-2] NP_001193677.1, NM_001206748.1 NP_001224.1, NM_001233.4 [P51636-1] NP_937855.1, NM_198212.2 [P51636-3]
UniGeneⁱ	Hs.212332 Hs.603096

Genome annotation databases

Ensemblⁱ	ENST00000222693; ENSP00000222693; ENSG00000105971 [P51636-1] ENST00000343213; ENSP00000345679; ENSG00000105971 [P51636-3]
GeneIDⁱ	858
KEGGⁱ	hsa:858
UCSC genome browser More...UCSCⁱ	uc003vie.4 human [P51636-1]

Keywords - Coding sequence diversityⁱ

Alternative initiation, Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P51636	Caveolin-2		PANTR		162	UniRef100_P51636
Caveolin (Fragment)		HUMAN		162
Caveolin		PANPA		162
Caveolin		PANTR		162
Isoform Beta of Caveolin-2		HUMAN		149
+2

Protein	Similar proteins		Species	Score	Length	Source
P51636	Caveolin-2		PANTR		162	UniRef90_P51636
Caveolin-2		AOTNA		162
Caveolin-2		ATEGE		162
Caveolin-2		CALJA		162
Caveolin-2		CHLAE		162
+31
P51636-3	CAV2 isoform 2		PANTR		112	UniRef90_P51636-3
Uncharacterized protein		PANPA		112
Uncharacterized protein		MACMU		112
Uncharacterized protein		MACFA		112
Uncharacterized protein		MACNE		112
+11

Protein	Similar proteins		Species	Score	Length	Source
P51636	Caveolin-2		PANTR		162	UniRef50_P51636
Caveolin-2		CHLAE		162
Caveolin-2		COLGU		162
Caveolin-2		PAPAN		162
Caveolin-2		SAIBB		162
+136
P51636-3	Uncharacterized protein		MACMU		112	UniRef50_P51636-3
Uncharacterized protein		MACFA		112
Uncharacterized protein		MACNE		112
CAV2 isoform 2		PANTR		112
Uncharacterized protein		PANPA		112
+30

Cross-referencesⁱ

Web resourcesⁱ

Wikipedia

Caveolin entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AF035752 mRNA Translation: AAB88492.1 AJ133269 Genomic DNA Translation: CAB63653.1 BT007051 mRNA Translation: AAP35700.1 BC005256 mRNA Translation: AAH05256.1 AJ242718 Genomic DNA Translation: CAB65090.1 AK310786 mRNA No translation available. CH236947 Genomic DNA Translation: EAL24361.1
CCDSⁱ	CCDS5765.1 [P51636-3] CCDS5766.1 [P51636-1]
RefSeqⁱ	NP_001193676.1, NM_001206747.1 [P51636-2] NP_001193677.1, NM_001206748.1 NP_001224.1, NM_001233.4 [P51636-1] NP_937855.1, NM_198212.2 [P51636-3]
UniGeneⁱ	Hs.212332 Hs.603096

3D structure databases

ProteinModelPortalⁱ	P51636
SMRⁱ	P51636
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107306, 11 interactors
DIPⁱ	DIP-34929N
IntActⁱ	P51636, 8 interactors
MINTⁱ	P51636
STRINGⁱ	9606.ENSP00000222693

PTM databases

iPTMnetⁱ	P51636
PhosphoSitePlusⁱ	P51636
SwissPalmⁱ	P51636

Polymorphism and mutation databases

BioMutaⁱ	CAV2

BioMutaⁱ

CAV2

Proteomic databases

EPDⁱ	P51636
PaxDbⁱ	P51636
PeptideAtlasⁱ	P51636
PRIDEⁱ	P51636
ProteomicsDBⁱ	56353 56354 [P51636-2] 56355 [P51636-3]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	858
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000222693; ENSP00000222693; ENSG00000105971 [P51636-1] ENST00000343213; ENSP00000345679; ENSG00000105971 [P51636-3]
GeneIDⁱ	858
KEGGⁱ	hsa:858
UCSCⁱ	uc003vie.4 human [P51636-1]

Organism-specific databases

CTDⁱ	858
DisGeNETⁱ	858
EuPathDBⁱ	HostDB:ENSG00000105971.14
GeneCardsⁱ	CAV2
HGNCⁱ	HGNC:1528 CAV2
HPAⁱ	CAB013488 HPA044810
MIMⁱ	601048 gene
neXtProtⁱ	NX_P51636
OpenTargetsⁱ	ENSG00000105971
PharmGKBⁱ	PA26108
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IFFB Eukaryota ENOG4111STF LUCA
GeneTreeⁱ	ENSGT00390000014924
HOGENOMⁱ	HOG000036550
HOVERGENⁱ	HBG003422
InParanoidⁱ	P51636
KOⁱ	K12958
OMAⁱ	HLKVGFE
OrthoDBⁱ	EOG091G0M1R
PhylomeDBⁱ	P51636
TreeFamⁱ	TF315736

Enzyme and pathway databases

SignaLinkⁱ	P51636
SIGNORⁱ	P51636

Miscellaneous databases

ChiTaRSⁱ	CAV2 human
GeneWikiⁱ	Caveolin_2
GenomeRNAiⁱ	858
Protein Ontology More...PROⁱ	PR:P51636
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000105971 Expressed in 235 organ(s), highest expression level in upper lobe of lung
CleanExⁱ	HS_CAV2
ExpressionAtlasⁱ	P51636 baseline and differential
Genevisibleⁱ	P51636 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR033306 CAV-2 IPR001612 Caveolin IPR018361 Caveolin_CS
PANTHERⁱ	PTHR10844 PTHR10844, 1 hit PTHR10844:SF3 PTHR10844:SF3, 1 hit
Pfamⁱ	View protein in Pfam PF01146 Caveolin, 1 hit
PROSITEⁱ	View protein in PROSITE PS01210 CAVEOLIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CAV2_HUMAN
Accessionⁱ	P51636Primary (citable) accession number: P51636 Secondary accession number(s): A4D0U2, Q9UGM7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	July 15, 1999
	Last modified:	November 7, 2018
	This is version 177 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P51636 (CAV2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Caveolin-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Golgi apparatus

Nucleus

Plasma membrane

Other locations

Golgi apparatus

Nucleus

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ