UniProtKB - P51636 (CAV2_HUMAN)
Caveolin-2
CAV2
Functioni
GO - Molecular functioni
- D1 dopamine receptor binding Source: BHF-UCL
- molecular adaptor activity Source: GO_Central
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: MGI
- protein kinase binding Source: GO_Central
- protein-macromolecule adaptor activity Source: Ensembl
- scaffold protein binding Source: Ensembl
GO - Biological processi
- basement membrane organization Source: Ensembl
- caveola assembly Source: BHF-UCL
- cell differentiation Source: GO_Central
- endoplasmic reticulum organization Source: UniProtKB
- insulin receptor signaling pathway Source: BHF-UCL
- mitochondrion organization Source: UniProtKB
- negative regulation of endothelial cell proliferation Source: UniProtKB
- negative regulation of transforming growth factor beta receptor signaling pathway Source: Ensembl
- positive regulation by host of viral process Source: AgBase
- positive regulation by host of viral release from host cell Source: AgBase
- positive regulation of dopamine receptor signaling pathway Source: BHF-UCL
- positive regulation of endothelial cell proliferation Source: Ensembl
- positive regulation of GTPase activity Source: BHF-UCL
- positive regulation of MAPK cascade Source: BHF-UCL
- receptor-mediated endocytosis of virus by host cell Source: CACAO
- regulation of cytosolic calcium ion concentration Source: GO_Central
- regulation of mitotic nuclear division Source: BHF-UCL
- skeletal muscle fiber development Source: UniProtKB
- vesicle docking Source: BHF-UCL
- vesicle fusion Source: BHF-UCL
- vesicle organization Source: BHF-UCL
Enzyme and pathway databases
PathwayCommonsi | P51636 |
Reactomei | R-HSA-9009391, Extra-nuclear estrogen signaling |
SignaLinki | P51636 |
SIGNORi | P51636 |
Protein family/group databases
TCDBi | 8.A.104.1.11, the 5'-amp-activated protein kinase (ampk) family |
Names & Taxonomyi
Protein namesi | Recommended name: Caveolin-2 |
Gene namesi | Name:CAV2 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:1528, CAV2 |
MIMi | 601048, gene |
neXtProti | NX_P51636 |
VEuPathDBi | HostDB:ENSG00000105971.14 |
Subcellular locationi
Cytoplasm and Cytosol
Nucleus
Plasma membrane
Golgi apparatus
Other locations
Note: Potential hairpin-like structure in the membrane. Membrane protein of caveolae. Tyr-19-phosphorylated form is enriched at sites of cell-cell contact and is translocated to the nucleus in complex with MAPK1 in response to insulin (By similarity). Tyr-27-phosphorylated form is located both in the cytoplasm and plasma membrane. CAV1-mediated Ser-23-phosphorylated form locates to the plasma membrane. Ser-36-phosphorylated form resides in intracellular compartments.By similarity
Golgi apparatus
- Golgi apparatus Source: BHF-UCL
- Golgi membrane Source: UniProtKB-SubCell
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- caveola Source: BHF-UCL
- caveolar macromolecular signaling complex Source: Ensembl
- extrinsic component of cytoplasmic side of plasma membrane Source: BHF-UCL
- integral component of plasma membrane Source: MGI
- plasma membrane Source: BHF-UCL
Other locations
- acrosomal membrane Source: Ensembl
- cytoplasmic vesicle Source: MGI
- focal adhesion Source: Ensembl
- membrane Source: BHF-UCL
- membrane raft Source: HGNC-UCL
- perinuclear region of cytoplasm Source: BHF-UCL
- protein-containing complex Source: MGI
- transport vesicle Source: LIFEdb
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 86 | CytoplasmicSequence analysisAdd BLAST | 86 | |
Intramembranei | 87 – 107 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 108 – 162 | CytoplasmicSequence analysisAdd BLAST | 55 |
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Golgi apparatus, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 19 | Y → A: Greatly reduced Src-mediated phosphorylation and binding of RASA1, SRC and NCK1. Completely eliminates Src-mediated tyrosine phosphorylation and binding to RASA1, SRC and NCK1; when associated with A-27. 1 Publication | 1 | |
Mutagenesisi | 23 | S → A: Abolishes phosphorylation. 1 Publication | 1 | |
Mutagenesisi | 27 | Y → A: Greatly reduced Src-mediated phosphorylation and binding of RASA1, SRC and NCK1. Completely eliminates Src-mediated phosphorylation and binding of RASA1, SRC and NCK1; when associated with A-19. 1 Publication | 1 | |
Mutagenesisi | 36 | S → A: Abolishes phosphorylation. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 858 |
OpenTargetsi | ENSG00000105971 |
PharmGKBi | PA26108 |
Miscellaneous databases
Pharosi | P51636, Tbio |
Genetic variation databases
BioMutai | CAV2 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000004772 | 1 – 162 | Caveolin-2Add BLAST | 162 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 19 | Phosphotyrosine; by SRC2 Publications | 1 | |
Modified residuei | 20 | PhosphoserineBy similarity | 1 | |
Modified residuei | 23 | Phosphoserine1 Publication | 1 | |
Modified residuei | 27 | Phosphotyrosine; by SRC1 Publication | 1 | |
Modified residuei | 36 | Phosphoserine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
PhosphoproteinProteomic databases
EPDi | P51636 |
jPOSTi | P51636 |
MassIVEi | P51636 |
PaxDbi | P51636 |
PeptideAtlasi | P51636 |
PRIDEi | P51636 |
ProteomicsDBi | 56353 [P51636-1] 56354 [P51636-2] 56355 [P51636-3] |
PTM databases
iPTMneti | P51636 |
PhosphoSitePlusi | P51636 |
SwissPalmi | P51636 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000105971, Expressed in upper lobe of lung and 243 other tissues |
ExpressionAtlasi | P51636, baseline and differential |
Genevisiblei | P51636, HS |
Organism-specific databases
HPAi | ENSG00000105971, Low tissue specificity |
Interactioni
Subunit structurei
Monomer or homodimer.
Interacts with CAV1; the interaction forms a stable heterooligomeric complex that is required for targeting to lipid rafts and for caveolae formation. Tyrosine phosphorylated forms do not form heterooligomers with the Tyr-19-phosphorylated form existing as a monomer or dimer, and the Tyr-27-form as a monomer only.
Interacts (tyrosine phosphorylated form) with the SH2 domain-containing proteins, RASA1, NCK1 and SRC.
Interacts (tyrosine phosphorylated form) with INSR, the interaction (Tyr-27-phosphorylated form) is increased on insulin stimulation.
Interacts (Tyr-19 phosphorylated form) with MAPK1 (phosphorylated form); the interaction, promoted by insulin, leads to nuclear location and MAPK1 activation.
Interacts with STAT3; the interaction is increased on insulin-induced tyrosine phosphorylation leading to STAT activation (By similarity).
By similarityBinary interactionsi
Hide detailsP51636
With | #Exp. | IntAct |
---|---|---|
CAV1 [Q03135] | 4 | EBI-603607,EBI-603614 |
EGFR [P00533] | 3 | EBI-603607,EBI-297353 |
SDCBP [O00560] | 3 | EBI-603607,EBI-727004 |
GO - Molecular functioni
- D1 dopamine receptor binding Source: BHF-UCL
- protein heterodimerization activity Source: Ensembl
- protein homodimerization activity Source: MGI
- protein kinase binding Source: GO_Central
- scaffold protein binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 107306, 80 interactors |
DIPi | DIP-34929N |
IntActi | P51636, 70 interactors |
MINTi | P51636 |
STRINGi | 9606.ENSP00000222693 |
Miscellaneous databases
RNActi | P51636, protein |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | ENOG502RZYX, Eukaryota |
GeneTreei | ENSGT00950000183006 |
HOGENOMi | CLU_2145024_0_0_1 |
InParanoidi | P51636 |
OMAi | CLHIWVV |
PhylomeDBi | P51636 |
TreeFami | TF315736 |
Family and domain databases
InterProi | View protein in InterPro IPR033306, CAV-2 IPR001612, Caveolin IPR018361, Caveolin_CS |
PANTHERi | PTHR10844, PTHR10844, 1 hit PTHR10844:SF3, PTHR10844:SF3, 1 hit |
Pfami | View protein in Pfam PF01146, Caveolin, 1 hit |
PROSITEi | View protein in PROSITE PS01210, CAVEOLIN, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
This entry describes 3 produced by isoformsialternative splicing and alternative initiation. AlignAdd to basketThis entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MGLETEKADV QLFMDDDSYS HHSGLEYADP EKFADSDQDR DPHRLNSHLK
60 70 80 90 100
LGFEDVIAEP VTTHSFDKVW ICSHALFEIS KYVMYKFLTV FLAIPLAFIA
110 120 130 140 150
GILFATLSCL HIWILMPFVK TCLMVLPSVQ TIWKSVTDVI IAPLCTSVGR
160
CFSSVSLQLS QD
The sequence of this isoform differs from the canonical sequence as follows:
1-13: Missing.
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketE9PCT3 | E9PCT3_HUMAN | Caveolin | CAV2 | 113 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_012071 | 130 | Q → E. Corresponds to variant dbSNP:rs8940Ensembl. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_018696 | 1 – 13 | Missing in isoform Beta. CuratedAdd BLAST | 13 | |
Alternative sequenceiVSP_038114 | 51 – 112 | LGFED…SCLHI → DFNAFCKDLPNGSAFSADNM EECDRCYHCSIVYERRTMLL FCQPATEPGLNTWTPGLEIG IL in isoform C. 1 PublicationAdd BLAST | 62 | |
Alternative sequenceiVSP_038115 | 113 – 162 | Missing in isoform C. 1 PublicationAdd BLAST | 50 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF035752 mRNA Translation: AAB88492.1 AJ133269 Genomic DNA Translation: CAB63653.1 BT007051 mRNA Translation: AAP35700.1 BC005256 mRNA Translation: AAH05256.1 AJ242718 Genomic DNA Translation: CAB65090.1 AK310786 mRNA No translation available. CH236947 Genomic DNA Translation: EAL24361.1 |
CCDSi | CCDS5765.1 [P51636-3] CCDS5766.1 [P51636-1] |
RefSeqi | NP_001193676.1, NM_001206747.1 [P51636-2] NP_001193677.1, NM_001206748.1 NP_001224.1, NM_001233.4 [P51636-1] NP_937855.1, NM_198212.2 [P51636-3] |
Genome annotation databases
Ensembli | ENST00000222693; ENSP00000222693; ENSG00000105971 [P51636-1] ENST00000343213; ENSP00000345679; ENSG00000105971 [P51636-3] |
GeneIDi | 858 |
KEGGi | hsa:858 |
UCSCi | uc003vie.4, human [P51636-1] |
Keywords - Coding sequence diversityi
Alternative initiation, Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia Caveolin entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF035752 mRNA Translation: AAB88492.1 AJ133269 Genomic DNA Translation: CAB63653.1 BT007051 mRNA Translation: AAP35700.1 BC005256 mRNA Translation: AAH05256.1 AJ242718 Genomic DNA Translation: CAB65090.1 AK310786 mRNA No translation available. CH236947 Genomic DNA Translation: EAL24361.1 |
CCDSi | CCDS5765.1 [P51636-3] CCDS5766.1 [P51636-1] |
RefSeqi | NP_001193676.1, NM_001206747.1 [P51636-2] NP_001193677.1, NM_001206748.1 NP_001224.1, NM_001233.4 [P51636-1] NP_937855.1, NM_198212.2 [P51636-3] |
3D structure databases
SMRi | P51636 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107306, 80 interactors |
DIPi | DIP-34929N |
IntActi | P51636, 70 interactors |
MINTi | P51636 |
STRINGi | 9606.ENSP00000222693 |
Protein family/group databases
TCDBi | 8.A.104.1.11, the 5'-amp-activated protein kinase (ampk) family |
PTM databases
iPTMneti | P51636 |
PhosphoSitePlusi | P51636 |
SwissPalmi | P51636 |
Genetic variation databases
BioMutai | CAV2 |
Proteomic databases
EPDi | P51636 |
jPOSTi | P51636 |
MassIVEi | P51636 |
PaxDbi | P51636 |
PeptideAtlasi | P51636 |
PRIDEi | P51636 |
ProteomicsDBi | 56353 [P51636-1] 56354 [P51636-2] 56355 [P51636-3] |
Protocols and materials databases
Antibodypediai | 4606, 415 antibodies |
DNASUi | 858 |
Genome annotation databases
Ensembli | ENST00000222693; ENSP00000222693; ENSG00000105971 [P51636-1] ENST00000343213; ENSP00000345679; ENSG00000105971 [P51636-3] |
GeneIDi | 858 |
KEGGi | hsa:858 |
UCSCi | uc003vie.4, human [P51636-1] |
Organism-specific databases
CTDi | 858 |
DisGeNETi | 858 |
GeneCardsi | CAV2 |
HGNCi | HGNC:1528, CAV2 |
HPAi | ENSG00000105971, Low tissue specificity |
MIMi | 601048, gene |
neXtProti | NX_P51636 |
OpenTargetsi | ENSG00000105971 |
PharmGKBi | PA26108 |
VEuPathDBi | HostDB:ENSG00000105971.14 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502RZYX, Eukaryota |
GeneTreei | ENSGT00950000183006 |
HOGENOMi | CLU_2145024_0_0_1 |
InParanoidi | P51636 |
OMAi | CLHIWVV |
PhylomeDBi | P51636 |
TreeFami | TF315736 |
Enzyme and pathway databases
PathwayCommonsi | P51636 |
Reactomei | R-HSA-9009391, Extra-nuclear estrogen signaling |
SignaLinki | P51636 |
SIGNORi | P51636 |
Miscellaneous databases
BioGRID-ORCSi | 858, 8 hits in 996 CRISPR screens |
ChiTaRSi | CAV2, human |
GeneWikii | Caveolin_2 |
GenomeRNAii | 858 |
Pharosi | P51636, Tbio |
PROi | PR:P51636 |
RNActi | P51636, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000105971, Expressed in upper lobe of lung and 243 other tissues |
ExpressionAtlasi | P51636, baseline and differential |
Genevisiblei | P51636, HS |
Family and domain databases
InterProi | View protein in InterPro IPR033306, CAV-2 IPR001612, Caveolin IPR018361, Caveolin_CS |
PANTHERi | PTHR10844, PTHR10844, 1 hit PTHR10844:SF3, PTHR10844:SF3, 1 hit |
Pfami | View protein in Pfam PF01146, Caveolin, 1 hit |
PROSITEi | View protein in PROSITE PS01210, CAVEOLIN, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CAV2_HUMAN | |
Accessioni | P51636Primary (citable) accession number: P51636 Secondary accession number(s): A4D0U2, Q9UGM7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | July 15, 1999 | |
Last modified: | April 7, 2021 | |
This is version 196 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- UniProtKB entry view manual
User manual for the UniProtKB entry view - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families