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Entry version 153 (25 May 2022)
Sequence version 2 (23 Jan 2007)
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Protein

Aldo-keto reductase family 1 member A1

Gene

Akr1a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids (By similarity) (PubMed:22820017, PubMed:25152401).

Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone (PubMed:22820017).

Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic (PubMed:8500767, PubMed:25152401).

Involved also in the detoxification of lipid-derived aldehydes like acrolein (PubMed:25152401).

Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs (By similarity).

Displays no reductase activity towards retinoids (By similarity).

By similarity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

kcat is 3.0 sec(-1) for D,L glyceraldehyde as substrate (PubMed:22820017). kcat is 3.0 sec(-1) for methylglyoxal as substrate (PubMed:22820017). kcat is 3.4 sec(-1) for 3-deoxyglucosone as substrate (PubMed:22820017). kcat is 3.1 sec(-1) for D-glucuronic acid as substrate (PubMed:22820017). kcat is 3.7 sec(-1) for D-glucurono-gamma-lactone acid as substrate (PubMed:22820017).1 Publication
  1. KM=2.9 mM for D,L glyceraldehyde1 Publication
  2. KM=1.8 mM for D-glucuronic acid1 Publication
  3. KM=0.31 mM for methylglyoxal1 Publication
  4. KM=0.63 mM for 3-deoxyglucosone1 Publication
  5. KM=11 mM for D-glucurono-gamma-lactone1 Publication
  6. KM=2.4 mM for acrolein1 Publication
  7. KM=0.260 mM for mevaldate1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei50Proton donorBy similarity1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei80Lowers pKa of active site TyrBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei113SubstrateBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi11 – 20NADPSequence analysis10
Nucleotide bindingi211 – 273NADPBy similarityAdd BLAST63

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processLipid metabolism
LigandNADP

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.1.1.2, 5301

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-RNO-156590, Glutathione conjugation
R-RNO-5661270, Formation of xylulose-5-phosphate

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
P51635

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Aldo-keto reductase family 1 member A1 (EC:1.1.1.22 Publications, EC:1.1.1.331 Publication, EC:1.1.1.3721 Publication, EC:1.1.1.541 Publication)
Alternative name(s):
3-DG-reducing enzyme1 Publication
Alcohol dehydrogenase [NADP(+)]
Aldehyde reductase1 Publication
Glucuronate reductase1 Publication (EC:1.1.1.191 Publication)
Glucuronolactone reductase1 Publication (EC:1.1.1.201 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Akr1a1
Synonyms:Alr
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiRattus norvegicus (Rat)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10116 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002494 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Rat genome database

More...
RGDi
68346, Akr1a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL3871

DrugCentral

More...
DrugCentrali
P51635

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001246202 – 325Aldo-keto reductase family 1 member A1Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylthreonine1 Publication1
Modified residuei4PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi23N-linked (Glc) (glycation) lysine1 Publication1
Modified residuei38PhosphoserineBy similarity1
Glycosylationi68N-linked (Glc) (glycation) lysine1 Publication1
Glycosylationi85N-linked (Glc) (glycation) lysine1 Publication1
Modified residuei127N6-acetyllysine; alternateBy similarity1
Modified residuei127N6-succinyllysine; alternateBy similarity1
Glycosylationi141N-linked (Glc) (glycation) lysine1 Publication1
Modified residuei145N6-succinyllysineBy similarity1
Glycosylationi153N-linked (Glc) (glycation) lysine1 Publication1
Modified residuei211PhosphoserineBy similarity1

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei13Not glycated1 Publication1
Sitei30Not glycated1 Publication1
Sitei34Not glycated1 Publication1
Sitei61Not glycated1 Publication1
Sitei80Not glycated1 Publication1
Sitei97Not glycated1 Publication1
Sitei127Not glycated1 Publication1
Sitei134Not glycated1 Publication1
Sitei145Not glycated1 Publication1
Sitei157Not glycated1 Publication1
Sitei240Not glycated1 Publication1
Sitei257Not glycated1 Publication1
Sitei263Not glycated1 Publication1
Sitei287Not glycated1 Publication1
Sitei294Not glycated1 Publication1
Sitei308Not glycated1 Publication1

Keywords - PTMi

Acetylation, Glycation, Glycoprotein, Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P51635

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P51635

PRoteomics IDEntifications database

More...
PRIDEi
P51635

2D gel databases

The World-2DPAGE database

More...
World-2DPAGEi
0004:P51635

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P51635

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P51635

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P51635

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSRNOG00000016727, Expressed in adult mammalian kidney and 21 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P51635, RN

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.

By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
P51635, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10116.ENSRNOP00000023072

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P51635

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
P51635

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P51635

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aldo/keto reductase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1577, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000156539

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_023205_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P51635

Identification of Orthologs from Complete Genome Data

More...
OMAi
WRHPDEP

Database of Orthologous Groups

More...
OrthoDBi
1016440at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P51635

TreeFam database of animal gene trees

More...
TreeFami
TF106492

Family and domain databases

Conserved Domains Database

More...
CDDi
cd19106, AKR_AKR1A1-4, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.100, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020471, AKR
IPR044481, AKR1A
IPR018170, Aldo/ket_reductase_CS
IPR023210, NADP_OxRdtase_dom
IPR036812, NADP_OxRdtase_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00248, Aldo_ket_red, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000097, AKR, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00069, ALDKETRDTASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51430, SSF51430, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00798, ALDOKETO_REDUCTASE_1, 1 hit
PS00062, ALDOKETO_REDUCTASE_2, 1 hit
PS00063, ALDOKETO_REDUCTASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P51635-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTASSVLLHT GQKMPLIGLG TWKSEPGQVK AAIKYALSVG YRHIDCASVY
60 70 80 90 100
GNETEIGEAL KESVGAGKAV PREELFVTSK LWNTKHHPED VEPAVRKTLA
110 120 130 140 150
DLQLEYLDLY LMHWPYAFER GDNPFPKNAD GTVKYDSTHY KETWKALEAL
160 170 180 190 200
VAKGLVKALG LSNFSSRQID DVLSVASVRP AVLQVECHPY LAQNELIAHC
210 220 230 240 250
QARGLEVTAY SPLGSSDRAW RHPDEPVLLE EPVVLALAEK HGRSPAQILL
260 270 280 290 300
RWQVQRKVIC IPKSITPSRI LQNIQVFDFT FSPEEMKQLD ALNKNWRYIV
310 320
PMITVDGKRV PRDAGHPLYP FNDPY
Length:325
Mass (Da):36,506
Last modified:January 23, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF95573B7411884DA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A8I5ZT45A0A8I5ZT45_RAT
Aldo-keto reductase family 1 member...
Akr1a1
314Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A8I6AVC9A0A8I6AVC9_RAT
Aldo-keto reductase family 1 member...
Akr1a1
299Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D10854 mRNA Translation: BAA01627.1
BC059133 mRNA Translation: AAH59133.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JN0629

NCBI Reference Sequences

More...
RefSeqi
NP_112262.1, NM_031000.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSRNOT00000023072; ENSRNOP00000023072; ENSRNOG00000016727

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
78959

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
rno:78959

UCSC genome browser

More...
UCSCi
RGD:68346, rat

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10854 mRNA Translation: BAA01627.1
BC059133 mRNA Translation: AAH59133.1
PIRiJN0629
RefSeqiNP_112262.1, NM_031000.3

3D structure databases

AlphaFoldDBiP51635
SMRiP51635
ModBaseiSearch...

Protein-protein interaction databases

IntActiP51635, 1 interactor
STRINGi10116.ENSRNOP00000023072

Chemistry databases

BindingDBiP51635
ChEMBLiCHEMBL3871
DrugCentraliP51635

PTM databases

iPTMnetiP51635
PhosphoSitePlusiP51635
SwissPalmiP51635

2D gel databases

World-2DPAGEi0004:P51635

Proteomic databases

jPOSTiP51635
PaxDbiP51635
PRIDEiP51635

Genome annotation databases

EnsembliENSRNOT00000023072; ENSRNOP00000023072; ENSRNOG00000016727
GeneIDi78959
KEGGirno:78959
UCSCiRGD:68346, rat

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10327
RGDi68346, Akr1a1

Phylogenomic databases

eggNOGiKOG1577, Eukaryota
GeneTreeiENSGT00940000156539
HOGENOMiCLU_023205_0_0_1
InParanoidiP51635
OMAiWRHPDEP
OrthoDBi1016440at2759
PhylomeDBiP51635
TreeFamiTF106492

Enzyme and pathway databases

BRENDAi1.1.1.2, 5301
ReactomeiR-RNO-156590, Glutathione conjugation
R-RNO-5661270, Formation of xylulose-5-phosphate
SABIO-RKiP51635

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P51635

Gene expression databases

BgeeiENSRNOG00000016727, Expressed in adult mammalian kidney and 21 other tissues
GenevisibleiP51635, RN

Family and domain databases

CDDicd19106, AKR_AKR1A1-4, 1 hit
Gene3Di3.20.20.100, 1 hit
InterProiView protein in InterPro
IPR020471, AKR
IPR044481, AKR1A
IPR018170, Aldo/ket_reductase_CS
IPR023210, NADP_OxRdtase_dom
IPR036812, NADP_OxRdtase_dom_sf
PfamiView protein in Pfam
PF00248, Aldo_ket_red, 1 hit
PIRSFiPIRSF000097, AKR, 1 hit
PRINTSiPR00069, ALDKETRDTASE
SUPFAMiSSF51430, SSF51430, 1 hit
PROSITEiView protein in PROSITE
PS00798, ALDOKETO_REDUCTASE_1, 1 hit
PS00062, ALDOKETO_REDUCTASE_2, 1 hit
PS00063, ALDOKETO_REDUCTASE_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAK1A1_RAT
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51635
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: May 25, 2022
This is version 153 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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