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UniProtKB - P51617 (IRAK1_HUMAN)

Entry version 213 (02 Dec 2020)
Sequence version 2 (01 Dec 2000)
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Protein

Interleukin-1 receptor-associated kinase 1

Gene

IRAK1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. Involved in Toll-like receptor (TLR) and IL-1R signaling pathways. Is rapidly recruited by MYD88 to the receptor-signaling complex upon TLR activation. Association with MYD88 leads to IRAK1 phosphorylation by IRAK4 and subsequent autophosphorylation and kinase activation. Phosphorylates E3 ubiquitin ligases Pellino proteins (PELI1, PELI2 and PELI3) to promote pellino-mediated polyubiquitination of IRAK1. Then, the ubiquitin-binding domain of IKBKG/NEMO binds to polyubiquitinated IRAK1 bringing together the IRAK1-MAP3K7/TAK1-TRAF6 complex and the NEMO-IKKA-IKKB complex. In turn, MAP3K7/TAK1 activates IKKs (CHUK/IKKA and IKBKB/IKKB) leading to NF-kappa-B nuclear translocation and activation. Alternatively, phosphorylates TIRAP to promote its ubiquitination and subsequent degradation. Phosphorylates the interferon regulatory factor 7 (IRF7) to induce its activation and translocation to the nucleus, resulting in transcriptional activation of type I IFN genes, which drive the cell in an antiviral state. When sumoylated, translocates to the nucleus and phosphorylates STAT3.8 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Mg2+

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei239ATP1
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei340Proton acceptorPROSITE-ProRule annotation1
Binding sitei358ATPPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi218 – 226ATPPROSITE-ProRule annotation9
Nucleotide bindingi342 – 345ATPPROSITE-ProRule annotation4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionKinase, Serine/threonine-protein kinase, Transferase
Biological processHost-virus interaction, Immunity, Innate immunity
LigandATP-binding, Magnesium, Nucleotide-binding

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...BRENDAi		2.7.10.2, 2681

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P51617

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-1257604, PIP3 activates AKT signaling
R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-168638, NOD1/2 Signaling Pathway
R-HSA-209543, p75NTR recruits signalling complexes [P51617-1]
R-HSA-209560, NF-kB is activated and signals survival
R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-450302, activated TAK1 mediates p38 MAPK activation
R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8986944, Transcriptional Regulation by MECP2
R-HSA-9020702, Interleukin-1 signaling
R-HSA-937039, IRAK1 recruits IKK complex
R-HSA-975110, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975138, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975144, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-HSA-975155, MyD88 dependent cascade initiated on endosome
R-HSA-975871, MyD88 cascade initiated on plasma membrane

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		P51617

SIGNOR Signaling Network Open Resource

More...SIGNORi		P51617

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Interleukin-1 receptor-associated kinase 1 (EC:2.7.11.1)
Short name:
IRAK-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IRAK1
Synonyms:IRAK
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome X

Organism-specific databases

Eukaryotic Pathogen and Host Database Resources

More...EuPathDBi		HostDB:ENSG00000184216.11

Human Gene Nomenclature Database

More...HGNCi		HGNC:6112, IRAK1

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		300283, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P51617

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Lipid droplet, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi209T → A: Completely abolishes auto-phosphorylation in the kinase domain. 1 Publication1
Mutagenesisi239K → S: Loss of kinase activity. 1 Publication1
Mutagenesisi340D → N: Loss of kinase activity. 1 Publication1
Mutagenesisi387T → A: Loss of kinase activity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		3654

MalaCards human disease database

More...MalaCardsi		IRAK1

Open Targets

More...OpenTargetsi		ENSG00000184216

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		93552, Pediatric systemic lupus erythematosus
536, Systemic lupus erythematosus

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA29912

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P51617, Tchem

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL3357

Drug and drug target database

More...DrugBanki		DB12010, Fostamatinib

DrugCentral

More...DrugCentrali		P51617

IUPHAR/BPS Guide to PHARMACOLOGY

More...GuidetoPHARMACOLOGYi		2042

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		IRAK1

Domain mapping of disease mutations (DMDM)

More...DMDMi		8928535

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000860301 – 712Interleukin-1 receptor-associated kinase 1Add BLAST712

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei66Phosphothreonine; by PKC/PRKCI1 Publication1
Modified residuei131PhosphoserineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki134Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki180Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei209Phosphothreonine; by IRAK41 Publication1
Modified residuei371PhosphoserineCombined sources1
Modified residuei375PhosphoserineCombined sources1
Modified residuei387Phosphothreonine1 Publication1
Modified residuei556PhosphoserineCombined sources1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Following recruitment on the activated receptor complex, phosphorylated on Thr-209, probably by IRAK4, resulting in a conformational change of the kinase domain, allowing further phosphorylations to take place. Thr-387 phosphorylation in the activation loop is required to achieve full enzymatic activity.4 Publications
Polyubiquitinated by TRAF6 after cell stimulation with IL-1-beta by PELI1, PELI2 and PELI3. Polyubiquitination occurs with polyubiquitin chains linked through 'Lys-63'. Ubiquitination promotes interaction with NEMO/IKBKG. Also sumoylated; leading to nuclear translocation.3 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		P51617

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		P51617

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P51617

MaxQB - The MaxQuant DataBase

More...MaxQBi		P51617

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P51617

PeptideAtlas

More...PeptideAtlasi		P51617

PRoteomics IDEntifications database

More...PRIDEi		P51617

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		56349 [P51617-1]
56350 [P51617-2]
56351 [P51617-3]
56352 [P51617-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P51617

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P51617

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform 1 and isoform 2 are ubiquitously expressed in all tissues examined, with isoform 1 being more strongly expressed than isoform 2.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000184216, Expressed in parotid gland and 238 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P51617, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P51617, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000184216, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer (By similarity).

Forms a complex with TRAF6, PELI1, IRAK4 and MYD88 (PubMed:16951688). Direct binding of SMAD6 to PELI1 prevents complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression (PubMed:16951688). The TRAF6-PELI1-IRAK4-MYD88 complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation (PubMed:16951688). Interaction with MYD88 recruits IRAK1 to the stimulated receptor complex (PubMed:9430229).

Interacts with TOLLIP; this interaction occurs in the cytosol prior to receptor activation (PubMed:10854325).

Interacts with IL1RL1 (PubMed:16286016).

Interacts with PELI1 and TRAF6 (PubMed:12496252).

Interacts (when polyubiquitinated) with IKBKG/NEMO (PubMed:18347055).

Interacts with RSAD2/viperin (By similarity).

Interacts with IRAK1BP1 (By similarity).

Interacts with PELI2 (By similarity).

Interacts with ZC3H12A; this interaction increases the interaction between ZC3H12A and IKBKB/IKKB (By similarity).

Interacts with IRAK4 (PubMed:11960013).

Interacts with PELI3 (PubMed:12874243).

Interacts with INAVA; the interaction takes place upon PRR stimulation (PubMed:28436939).

Interacts (via C-terminus) with NFATC4 (via N-terminus) (PubMed:18691762).

By similarity11 Publications

(Microbial infection) Interacts with mumps virus protein SH; this interaction inhibits downstream NF-kappa-B pathway activation.

1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		109863, 144 interactors

CORUM comprehensive resource of mammalian protein complexes

More...CORUMi		P51617

Database of interacting proteins

More...DIPi		DIP-397N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P51617

Protein interaction database and analysis system

More...IntActi		P51617, 86 interactors

Molecular INTeraction database

More...MINTi		P51617

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000358997

Chemistry databases

BindingDB database of measured binding affinities

More...BindingDBi		P51617

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P51617, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1712
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P51617

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 106DeathAdd BLAST80
Domaini212 – 521Protein kinasePROSITE-ProRule annotationAdd BLAST310

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni110 – 211ProST regionAdd BLAST102

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi649 – 655Poly-Ser7
Compositional biasi688 – 691Poly-Ser4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The ProST region is composed of many proline and serine residues (more than 20 of each) and some threonines. This region is the site of IRAK-1 hyperphosphorylation.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1187, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000160502

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000288_173_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P51617

Identification of Orthologs from Complete Genome Data

More...OMAi		TEDQYNF

Database of Orthologous Groups

More...OrthoDBi		684563at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P51617

TreeFam database of animal gene trees

More...TreeFami		TF328924

Family and domain databases

Conserved Domains Database

More...CDDi		cd08794, Death_IRAK1, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR035533, Death_IRAK1
IPR035536, IRAK1
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS

The PANTHER Classification System

More...PANTHERi		PTHR24419:SF1, PTHR24419:SF1, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00531, Death, 1 hit
PF00069, Pkinase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00220, S_TKc, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47986, SSF47986, 1 hit
SSF56112, SSF56112, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P51617-1) [UniParc]FASTAAdd to basket
Also known as: a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAGGPGPGEP AAPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV 
        60         70         80         90        100
RDQTELRLCE RSGQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT 
       110        120        130        140        150
AWHPPAPLPS PGTTAPRPSS IPAPAEAEAW SPRKLPSSAS TFLSPAFPGS 
       160        170        180        190        200
QTHSGPELGL VPSPASLWPP PPSPAPSSTK PGPESSVSLL QGARPFPFCW 
       210        220        230        240        250
PLCEISRGTH NFSEELKIGE GGFGCVYRAV MRNTVYAVKR LKENADLEWT 
       260        270        280        290        300
AVKQSFLTEV EQLSRFRHPN IVDFAGYCAQ NGFYCLVYGF LPNGSLEDRL 
       310        320        330        340        350
HCQTQACPPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE 
       360        370        380        390        400
RLTPKLGDFG LARFSRFAGS SPSQSSMVAR TQTVRGTLAY LPEEYIKTGR 
       410        420        430        440        450
LAVDTDTFSF GVVVLETLAG QRAVKTHGAR TKYLKDLVEE EAEEAGVALR 
       460        470        480        490        500
STQSTLQAGL AADAWAAPIA MQIYKKHLDP RPGPCPPELG LGLGQLACCC 
       510        520        530        540        550
LHRRAKRRPP MTQVYERLEK LQAVVAGVPG HSEAASCIPP SPQENSYVSS 
       560        570        580        590        600
TGRAHSGAAP WQPLAAPSGA SAQAAEQLQR GPNQPVESDE SLGGLSAALR 
       610        620        630        640        650
SWHLTPSCPL DPAPLREAGC PQGDTAGESS WGSGPGSRPT AVEGLALGSS 
       660        670        680        690        700
ASSSSEPPQI IINPARQKMV QKLALYEDGA LDSLQLLSSS SLPGLGLEQD 
       710 
RQGPEESDEF QS
Length:712
Mass (Da):76,537
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA7ADED75D3A3981D
GO
Isoform 2 (identifier: P51617-2) [UniParc]FASTAAdd to basket
Also known as: b

The sequence of this isoform differs from the canonical sequence as follows:
     513-542: Missing.

Note: Inactive.Curated
Show »
Length:682
Mass (Da):73,421
Checksum:i687C7EB6064FA918
GO
Isoform 3 (identifier: P51617-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     45-45: F → FGGWRRAAGGREARGLLAPTPDAPRPA
     478-492: Missing.
     513-542: Missing.

Show »
Length:693
Mass (Da):74,560
Checksum:iD744A32E997E1246
GO
Isoform 4 (identifier: P51617-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     435-513: Missing.

Show »
Length:633
Mass (Da):68,022
Checksum:i419926E55C935F38
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C1F0H7C1F0_HUMAN
Interleukin-1 receptor-associated k...
IRAK1
234Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YTB5D3YTB5_HUMAN
Interleukin-1 receptor-associated k...
IRAK1
708Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C224H7C224_HUMAN
Interleukin-1 receptor-associated k...
IRAK1
392Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C2I6H7C2I6_HUMAN
Interleukin-1 receptor-associated k...
IRAK1
276Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F8WAB6F8WAB6_HUMAN
Interleukin-1 receptor-associated k...
IRAK1
339Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3C1H7C3C1_HUMAN
Interleukin-1 receptor-associated k...
IRAK1
218Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C3G8H7C3G8_HUMAN
Interleukin-1 receptor-associated k...
IRAK1
212Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051629194R → H. Corresponds to variant dbSNP:rs11465830EnsemblClinVar.1
Natural variantiVAR_051630196F → S1 PublicationCorresponds to variant dbSNP:rs1059702Ensembl.1
Natural variantiVAR_051631203C → S. Corresponds to variant dbSNP:rs10127175EnsemblClinVar.1
Natural variantiVAR_040573398T → M1 PublicationCorresponds to variant dbSNP:rs56340948Ensembl.1
Natural variantiVAR_040574412V → M in a glioblastoma multiforme sample; somatic mutation. 1 Publication1
Natural variantiVAR_040575421Q → H in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_040576532S → L2 PublicationsCorresponds to variant dbSNP:rs1059703Ensembl.1
Natural variantiVAR_040577619G → S1 PublicationCorresponds to variant dbSNP:rs34112487Ensembl.1
Natural variantiVAR_040578625T → M1 PublicationCorresponds to variant dbSNP:rs35638718EnsemblClinVar.1
Natural variantiVAR_040579638R → W1 PublicationCorresponds to variant dbSNP:rs56082801Ensembl.1
Natural variantiVAR_040580690S → G in a lung adenocarcinoma sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01184945F → FGGWRRAAGGREARGLLAPT PDAPRPA in isoform 3. 1 Publication1
Alternative sequenceiVSP_041950435 – 513Missing in isoform 4. 2 PublicationsAdd BLAST79
Alternative sequenceiVSP_011850478 – 492Missing in isoform 3. 1 PublicationAdd BLAST15
Alternative sequenceiVSP_011851513 – 542Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST30

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L76191 mRNA Translation: AAC41949.1
AF030876 Genomic DNA Translation: AAC08756.1
AF346607 mRNA Translation: AAK62888.1
DQ054788 mRNA Translation: AAY88246.1
U52112 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72762.1
CH471172 Genomic DNA Translation: EAW72763.1
CH471172 Genomic DNA Translation: EAW72764.1
CH471172 Genomic DNA Translation: EAW72765.1
BC054000 mRNA Translation: AAH54000.1
BC014963 mRNA Translation: AAH14963.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS14740.1 [P51617-1]
CCDS35443.1 [P51617-4]
CCDS35444.1 [P51617-2]

Protein sequence database of the Protein Information Resource

More...PIRi		G02512

NCBI Reference Sequences

More...RefSeqi		NP_001020413.1, NM_001025242.1 [P51617-2]
NP_001020414.1, NM_001025243.1 [P51617-4]
NP_001560.2, NM_001569.3 [P51617-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000369974; ENSP00000358991; ENSG00000184216 [P51617-4]
ENST00000369980; ENSP00000358997; ENSG00000184216 [P51617-1]
ENST00000393687; ENSP00000377291; ENSG00000184216 [P51617-2]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3654

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:3654

UCSC genome browser

More...UCSCi		uc004fjr.2, human [P51617-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76191 mRNA Translation: AAC41949.1
AF030876 Genomic DNA Translation: AAC08756.1
AF346607 mRNA Translation: AAK62888.1
DQ054788 mRNA Translation: AAY88246.1
U52112 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72762.1
CH471172 Genomic DNA Translation: EAW72763.1
CH471172 Genomic DNA Translation: EAW72764.1
CH471172 Genomic DNA Translation: EAW72765.1
BC054000 mRNA Translation: AAH54000.1
BC014963 mRNA Translation: AAH14963.1
CCDSiCCDS14740.1 [P51617-1]
CCDS35443.1 [P51617-4]
CCDS35444.1 [P51617-2]
PIRiG02512
RefSeqiNP_001020413.1, NM_001025242.1 [P51617-2]
NP_001020414.1, NM_001025243.1 [P51617-4]
NP_001560.2, NM_001569.3 [P51617-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
6BFNX-ray2.26A/B194-530[»]
SMRiP51617
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi109863, 144 interactors
CORUMiP51617
DIPiDIP-397N
ELMiP51617
IntActiP51617, 86 interactors
MINTiP51617
STRINGi9606.ENSP00000358997

Chemistry databases

BindingDBiP51617
ChEMBLiCHEMBL3357
DrugBankiDB12010, Fostamatinib
DrugCentraliP51617
GuidetoPHARMACOLOGYi2042

PTM databases

iPTMnetiP51617
PhosphoSitePlusiP51617

Polymorphism and mutation databases

BioMutaiIRAK1
DMDMi8928535

Proteomic databases

EPDiP51617
jPOSTiP51617
MassIVEiP51617
MaxQBiP51617
PaxDbiP51617
PeptideAtlasiP51617
PRIDEiP51617
ProteomicsDBi56349 [P51617-1]
56350 [P51617-2]
56351 [P51617-3]
56352 [P51617-4]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		3845, 994 antibodies

The DNASU plasmid repository

More...DNASUi		3654

Genome annotation databases

EnsembliENST00000369974; ENSP00000358991; ENSG00000184216 [P51617-4]
ENST00000369980; ENSP00000358997; ENSG00000184216 [P51617-1]
ENST00000393687; ENSP00000377291; ENSG00000184216 [P51617-2]
GeneIDi3654
KEGGihsa:3654
UCSCiuc004fjr.2, human [P51617-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		3654
DisGeNETi3654
EuPathDBiHostDB:ENSG00000184216.11

GeneCards: human genes, protein and diseases

More...GeneCardsi		IRAK1
HGNCiHGNC:6112, IRAK1
HPAiENSG00000184216, Low tissue specificity
MalaCardsiIRAK1
MIMi300283, gene
neXtProtiNX_P51617
OpenTargetsiENSG00000184216
Orphaneti93552, Pediatric systemic lupus erythematosus
536, Systemic lupus erythematosus
PharmGKBiPA29912

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG1187, Eukaryota
GeneTreeiENSGT00940000160502
HOGENOMiCLU_000288_173_1_1
InParanoidiP51617
OMAiTEDQYNF
OrthoDBi684563at2759
PhylomeDBiP51617
TreeFamiTF328924

Enzyme and pathway databases

BRENDAi2.7.10.2, 2681
PathwayCommonsiP51617
ReactomeiR-HSA-1257604, PIP3 activates AKT signaling
R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane
R-HSA-168638, NOD1/2 Signaling Pathway
R-HSA-209543, p75NTR recruits signalling complexes [P51617-1]
R-HSA-209560, NF-kB is activated and signals survival
R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex
R-HSA-450302, activated TAK1 mediates p38 MAPK activation
R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
R-HSA-8986944, Transcriptional Regulation by MECP2
R-HSA-9020702, Interleukin-1 signaling
R-HSA-937039, IRAK1 recruits IKK complex
R-HSA-975110, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
R-HSA-975138, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
R-HSA-975144, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
R-HSA-975155, MyD88 dependent cascade initiated on endosome
R-HSA-975871, MyD88 cascade initiated on plasma membrane
SignaLinkiP51617
SIGNORiP51617

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		3654, 11 hits in 504 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		IRAK1, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		IRAK1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		3654
PharosiP51617, Tchem

Protein Ontology

More...PROi		PR:P51617
RNActiP51617, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000184216, Expressed in parotid gland and 238 other tissues
ExpressionAtlasiP51617, baseline and differential
GenevisibleiP51617, HS

Family and domain databases

CDDicd08794, Death_IRAK1, 1 hit
InterProiView protein in InterPro
IPR011029, DEATH-like_dom_sf
IPR000488, Death_domain
IPR035533, Death_IRAK1
IPR035536, IRAK1
IPR011009, Kinase-like_dom_sf
IPR000719, Prot_kinase_dom
IPR017441, Protein_kinase_ATP_BS
IPR008271, Ser/Thr_kinase_AS
PANTHERiPTHR24419:SF1, PTHR24419:SF1, 1 hit
PfamiView protein in Pfam
PF00531, Death, 1 hit
PF00069, Pkinase, 1 hit
SMARTiView protein in SMART
SM00220, S_TKc, 1 hit
SUPFAMiSSF47986, SSF47986, 1 hit
SSF56112, SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107, PROTEIN_KINASE_ATP, 1 hit
PS50011, PROTEIN_KINASE_DOM, 1 hit
PS00108, PROTEIN_KINASE_ST, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIRAK1_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51617
Secondary accession number(s): D3DWW3
, D3DWW4, Q7Z5V4, Q96C06, Q96RL2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: December 1, 2000
Last modified: December 2, 2020
This is version 213 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  6. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  7. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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