UniProtKB - P51617 (IRAK1_HUMAN)
Interleukin-1 receptor-associated kinase 1
IRAK1
Functioni
Catalytic activityi
Cofactori
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 239 | ATP | 1 | |
Active sitei | 340 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Binding sitei | 358 | ATPPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 218 – 226 | ATPPROSITE-ProRule annotation | 9 | |
Nucleotide bindingi | 342 – 345 | ATPPROSITE-ProRule annotation | 4 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- heat shock protein binding Source: Ensembl
- identical protein binding Source: UniProtKB
- kinase activity Source: MGI
- NF-kappaB-inducing kinase activity Source: ProtInc
- protein heterodimerization activity Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
- protein kinase activity Source: MGI
- protein serine/threonine kinase activity Source: UniProtKB
GO - Biological processi
- activation of MAPK activity Source: Reactome
- activation of NF-kappaB-inducing kinase activity Source: UniProtKB
- aging Source: Ensembl
- cellular response to heat Source: Ensembl
- cellular response to hypoxia Source: Ensembl
- cellular response to lipopolysaccharide Source: GO_Central
- cytokine-mediated signaling pathway Source: GO_Central
- innate immune response Source: GO_Central
- interleukin-1-mediated signaling pathway Source: BHF-UCL
- intracellular signal transduction Source: GO_Central
- JNK cascade Source: Reactome
- lipopolysaccharide-mediated signaling pathway Source: BHF-UCL
- MyD88-dependent toll-like receptor signaling pathway Source: BHF-UCL
- negative regulation of apoptotic process Source: Reactome
- negative regulation of NF-kappaB transcription factor activity Source: BHF-UCL
- nucleotide-binding oligomerization domain containing signaling pathway Source: Reactome
- positive regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
- positive regulation of leukocyte adhesion to vascular endothelial cell Source: ARUK-UCL
- positive regulation of MAP kinase activity Source: GO_Central
- positive regulation of NF-kappaB transcription factor activity Source: BHF-UCL
- positive regulation of NIK/NF-kappaB signaling Source: ARUK-UCL
- positive regulation of smooth muscle cell proliferation Source: Ensembl
- positive regulation of type I interferon production Source: BHF-UCL
- protein autophosphorylation Source: BHF-UCL
- protein phosphorylation Source: ProtInc
- regulation of cytokine-mediated signaling pathway Source: BHF-UCL
- response to interleukin-1 Source: BHF-UCL
- response to lipopolysaccharide Source: BHF-UCL
- toll-like receptor 2 signaling pathway Source: BHF-UCL
- toll-like receptor 4 signaling pathway Source: GO_Central
- toll-like receptor 9 signaling pathway Source: Reactome
- toll-like receptor signaling pathway Source: Reactome
- type I interferon signaling pathway Source: BHF-UCL
- viral process Source: UniProtKB-KW
Keywordsi
Molecular function | Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Host-virus interaction, Immunity, Innate immunity |
Ligand | ATP-binding, Magnesium, Nucleotide-binding |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P51617 |
Reactomei | R-HSA-1257604, PIP3 activates AKT signaling R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-209543, p75NTR recruits signalling complexes [P51617-1] R-HSA-209560, NF-kB is activated and signals survival R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-450302, activated TAK1 mediates p38 MAPK activation R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8986944, Transcriptional Regulation by MECP2 R-HSA-9020702, Interleukin-1 signaling R-HSA-937039, IRAK1 recruits IKK complex R-HSA-975110, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975138, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975144, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975155, MyD88 dependent cascade initiated on endosome R-HSA-975871, MyD88 cascade initiated on plasma membrane |
SignaLinki | P51617 |
SIGNORi | P51617 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:IRAK1 Synonyms:IRAK |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000184216.11 |
HGNCi | HGNC:6112, IRAK1 |
MIMi | 300283, gene |
neXtProti | NX_P51617 |
Subcellular locationi
Nucleus
- Nucleus 1 Publication
Other locations
- Cytoplasm 1 Publication
- Lipid droplet By similarity
Note: Translocates to the nucleus when sumoylated. RSAD2/viperin recruits it to the lipid droplet (By similarity).By similarity
Cytosol
- cytosol Source: HPA
Endosome
- endosome membrane Source: Reactome
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: GO_Central
- lipid droplet Source: UniProtKB
- protein-containing complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, Lipid droplet, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 209 | T → A: Completely abolishes auto-phosphorylation in the kinase domain. 1 Publication | 1 | |
Mutagenesisi | 239 | K → S: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 340 | D → N: Loss of kinase activity. 1 Publication | 1 | |
Mutagenesisi | 387 | T → A: Loss of kinase activity. 1 Publication | 1 |
Organism-specific databases
DisGeNETi | 3654 |
MalaCardsi | IRAK1 |
OpenTargetsi | ENSG00000184216 |
Orphaneti | 93552, Pediatric systemic lupus erythematosus 536, Systemic lupus erythematosus |
PharmGKBi | PA29912 |
Miscellaneous databases
Pharosi | P51617, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3357 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | P51617 |
GuidetoPHARMACOLOGYi | 2042 |
Polymorphism and mutation databases
BioMutai | IRAK1 |
DMDMi | 8928535 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000086030 | 1 – 712 | Interleukin-1 receptor-associated kinase 1Add BLAST | 712 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 66 | Phosphothreonine; by PKC/PRKCI1 Publication | 1 | |
Modified residuei | 131 | PhosphoserineCombined sources | 1 | |
Cross-linki | 134 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Cross-linki | 180 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication | ||
Modified residuei | 209 | Phosphothreonine; by IRAK41 Publication | 1 | |
Modified residuei | 371 | PhosphoserineCombined sources | 1 | |
Modified residuei | 375 | PhosphoserineCombined sources | 1 | |
Modified residuei | 387 | Phosphothreonine1 Publication | 1 | |
Modified residuei | 556 | PhosphoserineCombined sources | 1 |
Post-translational modificationi
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P51617 |
jPOSTi | P51617 |
MassIVEi | P51617 |
MaxQBi | P51617 |
PaxDbi | P51617 |
PeptideAtlasi | P51617 |
PRIDEi | P51617 |
ProteomicsDBi | 56349 [P51617-1] 56350 [P51617-2] 56351 [P51617-3] 56352 [P51617-4] |
PTM databases
iPTMneti | P51617 |
PhosphoSitePlusi | P51617 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000184216, Expressed in parotid gland and 238 other tissues |
ExpressionAtlasi | P51617, baseline and differential |
Genevisiblei | P51617, HS |
Organism-specific databases
HPAi | ENSG00000184216, Low tissue specificity |
Interactioni
Subunit structurei
Homodimer (By similarity).
Forms a complex with TRAF6, PELI1, IRAK4 and MYD88 (PubMed:16951688). Direct binding of SMAD6 to PELI1 prevents complex formation and hence negatively regulates IL1R-TLR signaling and eventually NF-kappa-B-mediated gene expression (PubMed:16951688). The TRAF6-PELI1-IRAK4-MYD88 complex recruits MAP3K7/TAK1, TAB1 and TAB2 to mediate NF-kappa-B activation (PubMed:16951688). Interaction with MYD88 recruits IRAK1 to the stimulated receptor complex (PubMed:9430229).
Interacts with TOLLIP; this interaction occurs in the cytosol prior to receptor activation (PubMed:10854325).
Interacts with IL1RL1 (PubMed:16286016).
Interacts with PELI1 and TRAF6 (PubMed:12496252).
Interacts (when polyubiquitinated) with IKBKG/NEMO (PubMed:18347055).
Interacts with RSAD2/viperin (By similarity).
Interacts with IRAK1BP1 (By similarity).
Interacts with PELI2 (By similarity).
Interacts with ZC3H12A; this interaction increases the interaction between ZC3H12A and IKBKB/IKKB (By similarity).
Interacts with IRAK4 (PubMed:11960013).
Interacts with PELI3 (PubMed:12874243).
Interacts with INAVA; the interaction takes place upon PRR stimulation (PubMed:28436939).
Interacts (via C-terminus) with NFATC4 (via N-terminus) (PubMed:18691762).
By similarity11 Publications(Microbial infection) Interacts with mumps virus protein SH; this interaction inhibits downstream NF-kappa-B pathway activation.
1 PublicationBinary interactionsi
Hide detailsP51617
GO - Molecular functioni
- heat shock protein binding Source: Ensembl
- identical protein binding Source: UniProtKB
- protein heterodimerization activity Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 109863, 144 interactors |
CORUMi | P51617 |
DIPi | DIP-397N |
ELMi | P51617 |
IntActi | P51617, 86 interactors |
MINTi | P51617 |
STRINGi | 9606.ENSP00000358997 |
Chemistry databases
BindingDBi | P51617 |
Miscellaneous databases
RNActi | P51617, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P51617 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 27 – 106 | DeathAdd BLAST | 80 | |
Domaini | 212 – 521 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 310 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 110 – 211 | ProST regionAdd BLAST | 102 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 649 – 655 | Poly-Ser | 7 | |
Compositional biasi | 688 – 691 | Poly-Ser | 4 |
Domaini
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1187, Eukaryota |
GeneTreei | ENSGT00940000160502 |
HOGENOMi | CLU_000288_173_1_1 |
InParanoidi | P51617 |
OMAi | TEDQYNF |
OrthoDBi | 684563at2759 |
PhylomeDBi | P51617 |
TreeFami | TF328924 |
Family and domain databases
CDDi | cd08794, Death_IRAK1, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR035533, Death_IRAK1 IPR035536, IRAK1 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24419:SF1, PTHR24419:SF1, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAGGPGPGEP AAPGAQHFLY EVPPWVMCRF YKVMDALEPA DWCQFAALIV
60 70 80 90 100
RDQTELRLCE RSGQRTASVL WPWINRNARV ADLVHILTHL QLLRARDIIT
110 120 130 140 150
AWHPPAPLPS PGTTAPRPSS IPAPAEAEAW SPRKLPSSAS TFLSPAFPGS
160 170 180 190 200
QTHSGPELGL VPSPASLWPP PPSPAPSSTK PGPESSVSLL QGARPFPFCW
210 220 230 240 250
PLCEISRGTH NFSEELKIGE GGFGCVYRAV MRNTVYAVKR LKENADLEWT
260 270 280 290 300
AVKQSFLTEV EQLSRFRHPN IVDFAGYCAQ NGFYCLVYGF LPNGSLEDRL
310 320 330 340 350
HCQTQACPPL SWPQRLDILL GTARAIQFLH QDSPSLIHGD IKSSNVLLDE
360 370 380 390 400
RLTPKLGDFG LARFSRFAGS SPSQSSMVAR TQTVRGTLAY LPEEYIKTGR
410 420 430 440 450
LAVDTDTFSF GVVVLETLAG QRAVKTHGAR TKYLKDLVEE EAEEAGVALR
460 470 480 490 500
STQSTLQAGL AADAWAAPIA MQIYKKHLDP RPGPCPPELG LGLGQLACCC
510 520 530 540 550
LHRRAKRRPP MTQVYERLEK LQAVVAGVPG HSEAASCIPP SPQENSYVSS
560 570 580 590 600
TGRAHSGAAP WQPLAAPSGA SAQAAEQLQR GPNQPVESDE SLGGLSAALR
610 620 630 640 650
SWHLTPSCPL DPAPLREAGC PQGDTAGESS WGSGPGSRPT AVEGLALGSS
660 670 680 690 700
ASSSSEPPQI IINPARQKMV QKLALYEDGA LDSLQLLSSS SLPGLGLEQD
710
RQGPEESDEF QS
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH7C1F0 | H7C1F0_HUMAN | Interleukin-1 receptor-associated k... | IRAK1 | 234 | Annotation score: | ||
D3YTB5 | D3YTB5_HUMAN | Interleukin-1 receptor-associated k... | IRAK1 | 708 | Annotation score: | ||
H7C224 | H7C224_HUMAN | Interleukin-1 receptor-associated k... | IRAK1 | 392 | Annotation score: | ||
H7C2I6 | H7C2I6_HUMAN | Interleukin-1 receptor-associated k... | IRAK1 | 276 | Annotation score: | ||
F8WAB6 | F8WAB6_HUMAN | Interleukin-1 receptor-associated k... | IRAK1 | 339 | Annotation score: | ||
H7C3C1 | H7C3C1_HUMAN | Interleukin-1 receptor-associated k... | IRAK1 | 218 | Annotation score: | ||
H7C3G8 | H7C3G8_HUMAN | Interleukin-1 receptor-associated k... | IRAK1 | 212 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_051629 | 194 | R → H. Corresponds to variant dbSNP:rs11465830EnsemblClinVar. | 1 | |
Natural variantiVAR_051630 | 196 | F → S1 PublicationCorresponds to variant dbSNP:rs1059702Ensembl. | 1 | |
Natural variantiVAR_051631 | 203 | C → S. Corresponds to variant dbSNP:rs10127175EnsemblClinVar. | 1 | |
Natural variantiVAR_040573 | 398 | T → M1 PublicationCorresponds to variant dbSNP:rs56340948Ensembl. | 1 | |
Natural variantiVAR_040574 | 412 | V → M in a glioblastoma multiforme sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_040575 | 421 | Q → H in a breast pleomorphic lobular carcinoma sample; somatic mutation. 1 Publication | 1 | |
Natural variantiVAR_040576 | 532 | S → L2 PublicationsCorresponds to variant dbSNP:rs1059703Ensembl. | 1 | |
Natural variantiVAR_040577 | 619 | G → S1 PublicationCorresponds to variant dbSNP:rs34112487Ensembl. | 1 | |
Natural variantiVAR_040578 | 625 | T → M1 PublicationCorresponds to variant dbSNP:rs35638718EnsemblClinVar. | 1 | |
Natural variantiVAR_040579 | 638 | R → W1 PublicationCorresponds to variant dbSNP:rs56082801Ensembl. | 1 | |
Natural variantiVAR_040580 | 690 | S → G in a lung adenocarcinoma sample; somatic mutation. 1 Publication | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_011849 | 45 | F → FGGWRRAAGGREARGLLAPT PDAPRPA in isoform 3. 1 Publication | 1 | |
Alternative sequenceiVSP_041950 | 435 – 513 | Missing in isoform 4. 2 PublicationsAdd BLAST | 79 | |
Alternative sequenceiVSP_011850 | 478 – 492 | Missing in isoform 3. 1 PublicationAdd BLAST | 15 | |
Alternative sequenceiVSP_011851 | 513 – 542 | Missing in isoform 2 and isoform 3. 2 PublicationsAdd BLAST | 30 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L76191 mRNA Translation: AAC41949.1 AF030876 Genomic DNA Translation: AAC08756.1 AF346607 mRNA Translation: AAK62888.1 DQ054788 mRNA Translation: AAY88246.1 U52112 Genomic DNA No translation available. CH471172 Genomic DNA Translation: EAW72762.1 CH471172 Genomic DNA Translation: EAW72763.1 CH471172 Genomic DNA Translation: EAW72764.1 CH471172 Genomic DNA Translation: EAW72765.1 BC054000 mRNA Translation: AAH54000.1 BC014963 mRNA Translation: AAH14963.1 |
CCDSi | CCDS14740.1 [P51617-1] CCDS35443.1 [P51617-4] CCDS35444.1 [P51617-2] |
PIRi | G02512 |
RefSeqi | NP_001020413.1, NM_001025242.1 [P51617-2] NP_001020414.1, NM_001025243.1 [P51617-4] NP_001560.2, NM_001569.3 [P51617-1] |
Genome annotation databases
Ensembli | ENST00000369974; ENSP00000358991; ENSG00000184216 [P51617-4] ENST00000369980; ENSP00000358997; ENSG00000184216 [P51617-1] ENST00000393687; ENSP00000377291; ENSG00000184216 [P51617-2] |
GeneIDi | 3654 |
KEGGi | hsa:3654 |
UCSCi | uc004fjr.2, human [P51617-1] |
Keywords - Coding sequence diversityi
Alternative splicing, PolymorphismSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L76191 mRNA Translation: AAC41949.1 AF030876 Genomic DNA Translation: AAC08756.1 AF346607 mRNA Translation: AAK62888.1 DQ054788 mRNA Translation: AAY88246.1 U52112 Genomic DNA No translation available. CH471172 Genomic DNA Translation: EAW72762.1 CH471172 Genomic DNA Translation: EAW72763.1 CH471172 Genomic DNA Translation: EAW72764.1 CH471172 Genomic DNA Translation: EAW72765.1 BC054000 mRNA Translation: AAH54000.1 BC014963 mRNA Translation: AAH14963.1 |
CCDSi | CCDS14740.1 [P51617-1] CCDS35443.1 [P51617-4] CCDS35444.1 [P51617-2] |
PIRi | G02512 |
RefSeqi | NP_001020413.1, NM_001025242.1 [P51617-2] NP_001020414.1, NM_001025243.1 [P51617-4] NP_001560.2, NM_001569.3 [P51617-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6BFN | X-ray | 2.26 | A/B | 194-530 | [»] | |
SMRi | P51617 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 109863, 144 interactors |
CORUMi | P51617 |
DIPi | DIP-397N |
ELMi | P51617 |
IntActi | P51617, 86 interactors |
MINTi | P51617 |
STRINGi | 9606.ENSP00000358997 |
Chemistry databases
BindingDBi | P51617 |
ChEMBLi | CHEMBL3357 |
DrugBanki | DB12010, Fostamatinib |
DrugCentrali | P51617 |
GuidetoPHARMACOLOGYi | 2042 |
PTM databases
iPTMneti | P51617 |
PhosphoSitePlusi | P51617 |
Polymorphism and mutation databases
BioMutai | IRAK1 |
DMDMi | 8928535 |
Proteomic databases
EPDi | P51617 |
jPOSTi | P51617 |
MassIVEi | P51617 |
MaxQBi | P51617 |
PaxDbi | P51617 |
PeptideAtlasi | P51617 |
PRIDEi | P51617 |
ProteomicsDBi | 56349 [P51617-1] 56350 [P51617-2] 56351 [P51617-3] 56352 [P51617-4] |
Protocols and materials databases
Antibodypediai | 3845, 994 antibodies |
DNASUi | 3654 |
Genome annotation databases
Ensembli | ENST00000369974; ENSP00000358991; ENSG00000184216 [P51617-4] ENST00000369980; ENSP00000358997; ENSG00000184216 [P51617-1] ENST00000393687; ENSP00000377291; ENSG00000184216 [P51617-2] |
GeneIDi | 3654 |
KEGGi | hsa:3654 |
UCSCi | uc004fjr.2, human [P51617-1] |
Organism-specific databases
CTDi | 3654 |
DisGeNETi | 3654 |
EuPathDBi | HostDB:ENSG00000184216.11 |
GeneCardsi | IRAK1 |
HGNCi | HGNC:6112, IRAK1 |
HPAi | ENSG00000184216, Low tissue specificity |
MalaCardsi | IRAK1 |
MIMi | 300283, gene |
neXtProti | NX_P51617 |
OpenTargetsi | ENSG00000184216 |
Orphaneti | 93552, Pediatric systemic lupus erythematosus 536, Systemic lupus erythematosus |
PharmGKBi | PA29912 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1187, Eukaryota |
GeneTreei | ENSGT00940000160502 |
HOGENOMi | CLU_000288_173_1_1 |
InParanoidi | P51617 |
OMAi | TEDQYNF |
OrthoDBi | 684563at2759 |
PhylomeDBi | P51617 |
TreeFami | TF328924 |
Enzyme and pathway databases
BRENDAi | 2.7.10.2, 2681 |
PathwayCommonsi | P51617 |
Reactomei | R-HSA-1257604, PIP3 activates AKT signaling R-HSA-166058, MyD88:MAL(TIRAP) cascade initiated on plasma membrane R-HSA-168638, NOD1/2 Signaling Pathway R-HSA-209543, p75NTR recruits signalling complexes [P51617-1] R-HSA-209560, NF-kB is activated and signals survival R-HSA-445989, TAK1 activates NFkB by phosphorylation and activation of IKKs complex R-HSA-450302, activated TAK1 mediates p38 MAPK activation R-HSA-450321, JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 R-HSA-6811558, PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling R-HSA-8986944, Transcriptional Regulation by MECP2 R-HSA-9020702, Interleukin-1 signaling R-HSA-937039, IRAK1 recruits IKK complex R-HSA-975110, TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling R-HSA-975138, TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation R-HSA-975144, IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation R-HSA-975155, MyD88 dependent cascade initiated on endosome R-HSA-975871, MyD88 cascade initiated on plasma membrane |
SignaLinki | P51617 |
SIGNORi | P51617 |
Miscellaneous databases
BioGRID-ORCSi | 3654, 11 hits in 504 CRISPR screens |
ChiTaRSi | IRAK1, human |
GeneWikii | IRAK1 |
GenomeRNAii | 3654 |
Pharosi | P51617, Tchem |
PROi | PR:P51617 |
RNActi | P51617, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000184216, Expressed in parotid gland and 238 other tissues |
ExpressionAtlasi | P51617, baseline and differential |
Genevisiblei | P51617, HS |
Family and domain databases
CDDi | cd08794, Death_IRAK1, 1 hit |
InterProi | View protein in InterPro IPR011029, DEATH-like_dom_sf IPR000488, Death_domain IPR035533, Death_IRAK1 IPR035536, IRAK1 IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS |
PANTHERi | PTHR24419:SF1, PTHR24419:SF1, 1 hit |
Pfami | View protein in Pfam PF00531, Death, 1 hit PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF47986, SSF47986, 1 hit SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IRAK1_HUMAN | |
Accessioni | P51617Primary (citable) accession number: P51617 Secondary accession number(s): D3DWW3 Q96RL2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | December 1, 2000 | |
Last modified: | December 2, 2020 | |
This is version 213 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Human and mouse protein kinases
Human and mouse protein kinases: classification and index