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Entry version 122 (08 May 2019)
Sequence version 1 (01 Oct 1996)
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Protein

Host cell factor 1

Gene

HCFC1

Organism
Mesocricetus auratus (Golden hamster)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in control of the cell cycle (PubMed:9087427). Also antagonizes transactivation by ZBTB17 and GABP2; represses ZBTB17 activation of the p15(INK4b) promoter and inhibits its ability to recruit p300 (By similarity). Coactivator for EGR2 and GABP2 (By similarity). Tethers the chromatin modifying Set1/Ash2 histone H3 'Lys-4' methyltransferase (H3K4me) and Sin3 histone deacetylase (HDAC) complexes (involved in the activation and repression of transcription respectively) together (By similarity). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (By similarity). Recruits KMT2E to E2F1 responsive promoters promoting transcriptional activation and thereby facilitates G1 to S phase transition (By similarity).By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionChromatin regulator
Biological processCell cycle

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HCFC1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMesocricetus auratus (Golden hamster)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10036 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeMesocricetus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000189706 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome assembly

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi134P → S: Causes temperature-sensitive cell cycle arrest in a Go-like state. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000166232 – 1432HCF N-terminal chain 6By similarityAdd BLAST1431
ChainiPRO_00000166242 – 1332HCF N-terminal chain 5By similarityAdd BLAST1331
ChainiPRO_00000166252 – 1304HCF N-terminal chain 4By similarityAdd BLAST1303
ChainiPRO_00000166262 – 1110HCF N-terminal chain 3By similarityAdd BLAST1109
ChainiPRO_00000166272 – 1081HCF N-terminal chain 2By similarityAdd BLAST1080
ChainiPRO_00000166282 – 1019HCF N-terminal chain 1By similarityAdd BLAST1018
ChainiPRO_00000166291020 – 2090HCF C-terminal chain 1By similarityAdd BLAST1071
ChainiPRO_00000166301082 – 2090HCF C-terminal chain 2By similarityAdd BLAST1009
ChainiPRO_00000166311111 – 2090HCF C-terminal chain 3By similarityAdd BLAST980
ChainiPRO_00000166321305 – 2090HCF C-terminal chain 4By similarityAdd BLAST786
ChainiPRO_00000166331333 – 2090HCF C-terminal chain 5By similarityAdd BLAST758
ChainiPRO_00000166341433 – 2090HCF C-terminal chain 6By similarityAdd BLAST658

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei6PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki105Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki163Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki244Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki282Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei288N6-acetyllysineBy similarity1
Cross-linki363Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei411PhosphoserineBy similarity1
Modified residuei504Omega-N-methylarginineBy similarity1
Modified residuei524Omega-N-methylarginineBy similarity1
Modified residuei598PhosphoserineBy similarity1
Modified residuei666PhosphoserineBy similarity1
Modified residuei669PhosphoserineBy similarity1
Modified residuei813N6-acetyllysineBy similarity1
Modified residuei1204PhosphoserineBy similarity1
Modified residuei1216Asymmetric dimethylarginineBy similarity1
Modified residuei1223PhosphoserineBy similarity1
Modified residuei1500PhosphothreonineBy similarity1
Modified residuei1506PhosphoserineBy similarity1
Modified residuei1559PhosphoserineBy similarity1
Modified residuei1826PhosphoserineBy similarity1
Cross-linki1862Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Cross-linki1863Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)By similarity
Modified residuei1893PhosphoserineBy similarity1
Modified residuei2060N6-acetyllysineBy similarity1
Cross-linki2079Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Proteolytically cleaved at one or several PPCE--THET sites within the HCF repeats. Cleavage is promoted by O-glycosylation (By similarity).By similarity
O-glycosylated. GlcNAcylation by OGT promotes proteolytic processing (By similarity).By similarity
Ubiquitinated. Lys-1862 and Lys-1863 are ubiquitinated both via 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. BAP1 mediated deubiquitination of 'Lys-48'-linked polyubiquitin chains; deubiquitination by BAP1 does not seem to stabilize the protein (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei1019 – 1020Cleavage; by autolysisBy similarity2
Sitei1081 – 1082Cleavage; by autolysisBy similarity2
Sitei1110 – 1111Cleavage; by autolysisBy similarity2
Sitei1304 – 1305Cleavage; by autolysisBy similarity2
Sitei1332 – 1333Cleavage; by autolysisBy similarity2
Sitei1432 – 1433Cleavage; by autolysisBy similarity2

Keywords - PTMi

Acetylation, Autocatalytic cleavage, Glycoprotein, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
P51611

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Composed predominantly of six polypeptides ranging from 110 to 150 kDa and a minor 300 kDa polypeptide. The majority of N- and C-terminal cleavage products remain tightly, albeit non-covalently, associated.

Interacts with POU2F1, CREB3, ZBTB17, EGR2, E2F4, CREBZF, SP1, GABP2, Sin3 HDAC complex (SIN3A, HDAC1, HDAC2, SUDS3), SAP30, SIN3B and FHL2.

Component of a MLL1 complex, composed of at least the core components KMT2A/MLL1, ASH2L, HCFC1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, DPY30, E2F6, HCFC2, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MEN1, MGA, KAT8, PELP1, PHF20, PRP31, RING2, RUVBL1, RUVBL2, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10.

Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1.

Interacts directly with THAP3 (via its HBM).

Interacts (via the Kelch-repeat domain) with THAP1 (via the HBM); the interaction recruits HCHC1 to the RRM1.

Interacts directly with OGT; the interaction, which requires the HCFC1 cleavage site domain, glycosylates and promotes the proteolytic processing of HCFC1 and retains OGT in the nucleus.

Component of the SET1 complex, at least composed of the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L, CXXC1, HCFC1 and DPY30.

Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.

Part of a complex composed at least of ASCL2, EMSY, HCFC1, HSPA8, CCAR2, MATR3, MKI67, RBBP5, TUBB2A, WDR5 and ZNF335; this complex may have a histone H3-specific methyltransferase activity.

Interacts with TET2 and TET3.

Interacts with HCFC1R1.

Interacts with THAP11.

Interacts (via Kelch domain) with KMT2E (via HBM motif).

Interacts with E2F1.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10036.XP_005086983.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P51611

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati44 – 89Kelch 1Add BLAST46
Repeati93 – 140Kelch 2Add BLAST48
Repeati148 – 194Kelch 3Add BLAST47
Repeati217 – 265Kelch 4Add BLAST49
Repeati266 – 313Kelch 5Add BLAST48
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini366 – 469Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST104
Repeati1010 – 1035HCF repeat 1Add BLAST26
Repeati1072 – 1097HCF repeat 2Add BLAST26
Repeati1101 – 1126HCF repeat 3Add BLAST26
Repeati1157 – 1182HCF repeat 4; degenerateAdd BLAST26
Repeati1295 – 1320HCF repeat 5Add BLAST26
Repeati1323 – 1348HCF repeat 6Add BLAST26
Repeati1358 – 1383HCF repeat 7; degenerateAdd BLAST26
Repeati1423 – 1448HCF repeat 8Add BLAST26
Domaini1853 – 1943Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST91
Domaini1945 – 2061Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST117

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni500 – 550Required for interaction with OGTBy similarityAdd BLAST51
Regioni610 – 722Interaction with SIN3ABy similarityAdd BLAST113
Regioni750 – 902Interaction with ZBTB17By similarityAdd BLAST153
Regioni813 – 912Interaction with GABP2By similarityAdd BLAST100

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The HCF repeat is a highly specific proteolytic cleavage signal.By similarity
The kelch repeats fold into a 6-bladed kelch beta-propeller called the beta-propeller domain which mediates interaction with HCFC1R1.By similarity

Keywords - Domaini

Kelch repeat, Repeat

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
416932at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 2 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.120.10.80, 2 hits
2.60.40.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR037854 HCFC1
IPR013783 Ig-like_fold
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1

The PANTHER Classification System

More...
PANTHERi
PTHR46003:SF3 PTHR46003:SF3, 3 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01344 Kelch_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF117281 SSF117281, 1 hit
SSF49265 SSF49265, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P51611-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASAVSPANL PAVLLQPRWK RVVGWSGPVP RPRHGHRAVA IKELIVVFGG
60 70 80 90 100
GNEGIVDELH VYNTATNQWF IPAVRGDIPP GCAAYGFVCD GTRLLVFGGM
110 120 130 140 150
VEYGKYSNDL YELQASRWEW KRLKAKTPKN GPPPCPRLGH SFSLVGNKCY
160 170 180 190 200
LFGGLANDSE DPKNNIPRYL NDLYILELRP GSGVVAWDIP ITYGVLPPPR
210 220 230 240 250
ESHTAVVYTE KDNKKSKLVI YGGMSGCRLG DLWTLDIETL TWNKPSLSGV
260 270 280 290 300
APLPRSLHSA TTIGNKMYVF GGWVPLVMDD VKVATHEKEW KCTNTLACLN
310 320 330 340 350
LDTMAWETIL MDTLEDNIPR ARAGHCAVAI NTRLYIWSGR DGYRKAWNNQ
360 370 380 390 400
VCCKDLWYLE TEKPPPPARV QLVRANTNSL EVSWGAVATA DSYLLQLQKY
410 420 430 440 450
DIPATAATAT SPTPNPVPSV PANPPKSPAP AAAAPAVQPL TQVGITLVPQ
460 470 480 490 500
AAAAPPSTTT IQVLPTVPGS SISVPTAARA QGVPAVLKVT GPQATTGTPL
510 520 530 540 550
VTMRPAGQAG KAPVTVTSLP ASVRMVVPTQ SAQGTVIGSN PQMSGMAALA
560 570 580 590 600
AAAAATQKIP PSSAPTVLSV PAGTTIVKTV AVTPGTTTLP ATVKVASSPV
610 620 630 640 650
MVSNPATRML KTAAAQVGTS VSSAANTSTR PIITVHKSGT VTVAQQAQVV
660 670 680 690 700
TTVVGGVTKT ITLVKSPISV PGGSALISNL GKVMSVVQTK PVQTSAVTGQ
710 720 730 740 750
ASTGPVTQII QTKGPLPAGT ILKLVTSADG KPTTIITTTQ ASGAGSKPTI
760 770 780 790 800
LGISSVSPST TKPGTTTIIK TIPMSAIITQ AGATGVTSTP GIKSPITIIT
810 820 830 840 850
TKVMTSGTGA PAKIITAVPK IATGHGQQGV TQVVLKGAPG QPGAILRTVP
860 870 880 890 900
MSGVRLVTPV TVSAVKPAVT TLVVKGTTGV TTLGTVTGTV STSLAGAGAH
910 920 930 940 950
STSASLATPI TTLGTIATLS SQVINPTAIT VSAAQTTLTA AGGLTTPTIT
960 970 980 990 1000
MQPVSQPTQV TLITAPSGVE AQPVHDLPVS ILASPTTEQP TATVTIADSG
1010 1020 1030 1040 1050
QGDVQPGTVT LVCSNPPCET HETGTTNTAT TTVVANLGGH PQPTQVQFVC
1060 1070 1080 1090 1100
DRQEAAASLV TSAVGQQNGN VVRVCSNPPC ETHETGTTNT ATTATSNMAG
1110 1120 1130 1140 1150
QHGCSNPPCE THETGTTSTA TTAMSSMGTG QQRDTRHTSS NPTVVRITVA
1160 1170 1180 1190 1200
PGALERTQGT VKPQCQTQQA NMTNTTMTVQ ATRSPCPAGP LLRPSVALEA
1210 1220 1230 1240 1250
GNHSPAFVQL ALPSVRVGLS GPSNKDMPTG HQLETYHTYT TNTPTTALSI
1260 1270 1280 1290 1300
MGAGELGTAR LIPTSTYESL QASSPSSTMT MTALEALLCP SATVTQVCSN
1310 1320 1330 1340 1350
PPCETHETGT TNTATTSNAG SAQRVCSNPP CETHETGTTH TATTATSNGG
1360 1370 1380 1390 1400
AGQPEGGQQP AGGRPCETHQ TTSTGTTMSV SVGALLPDAT PSHGTLESGL
1410 1420 1430 1440 1450
EVVAVSTVTS QAGATLLASF PTQRVCSNPP CETHETGTTH TATTVTSNMS
1460 1470 1480 1490 1500
SNQDPPPAAS DQGEVVSTQG DSANITSSSG ITTTVSSTLP RAVTTVTQST
1510 1520 1530 1540 1550
PVPGPSVPNI SSLTETPGAL TSEVPIPATI TVTIANTETS DMPFSAVDIL
1560 1570 1580 1590 1600
QPPEELQVSP GPRQQLPPRQ LLQSASTPLM GESSEVLSAS QTPELQAAVD
1610 1620 1630 1640 1650
LSSTGDPSSG QEPTSSAVVA TVVVQPPPPT QSEVDQLSLP QELMAEAQAG
1660 1670 1680 1690 1700
TTTLMVTGLT PEELAVTAAA EAAAQAAATE EAQALAIQAV LQAAQQAVMA
1710 1720 1730 1740 1750
GTGEPMDTSE AAAAVTQAEL GHLSAEGQEG QATTIPIVLT QQELAALVQQ
1760 1770 1780 1790 1800
QQQLQEVQAQ AQQQHHLPTE ALAPADSLND PSIESNCLNE LASAVPSTVA
1810 1820 1830 1840 1850
LLPSTATESL APSNTFVAPQ PVVVASPAKM QAAATLTEVD NGIESLGVKP
1860 1870 1880 1890 1900
DLPPPPSKAP VKKENQWFDV GVIKGTSVMV THYFLPPDDA VQSDDDSGTI
1910 1920 1930 1940 1950
PDYNQLKKQE LQPGTAYKFR VAGINACGRG PFSEISAFKT CLPGFPGAPC
1960 1970 1980 1990 2000
AIKISKSPDG AHLTWEPPSV TSGKIIEYSV YLAIQSSQAG GEPKSSTPAQ
2010 2020 2030 2040 2050
LAFMRVYCGP SPSCLVQSSS LSNAHIDYTT KPAIIFRIAA RNEKGYGPAT
2060 2070 2080 2090
QVRWLQETSK DSSGTKPASK RPMSSPEMKS APKKSKADGQ
Length:2,090
Mass (Da):214,942
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE495E8B1F2385E17
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
D45419 mRNA Translation: BAA08258.1

NCBI Reference Sequences

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RefSeqi
NP_001268286.1, NM_001281357.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
101830931

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D45419 mRNA Translation: BAA08258.1
RefSeqiNP_001268286.1, NM_001281357.1

3D structure databases

SMRiP51611
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10036.XP_005086983.1

Proteomic databases

PRIDEiP51611

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi101830931

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3054

Phylogenomic databases

OrthoDBi416932at2759

Family and domain databases

CDDicd00063 FN3, 2 hits
Gene3Di2.120.10.80, 2 hits
2.60.40.10, 2 hits
InterProiView protein in InterPro
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR037854 HCFC1
IPR013783 Ig-like_fold
IPR015915 Kelch-typ_b-propeller
IPR006652 Kelch_1
PANTHERiPTHR46003:SF3 PTHR46003:SF3, 3 hits
PfamiView protein in Pfam
PF01344 Kelch_1, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SUPFAMiSSF117281 SSF117281, 1 hit
SSF49265 SSF49265, 1 hit
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHCFC1_MESAU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51611
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: May 8, 2019
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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