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Protein

N-acylglucosamine 2-epimerase

Gene

Renbp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway.

Caution

It is uncertain whether Met-1, Met-2 or Met-12 is the initiator.Curated

Catalytic activityi

N-acyl-D-glucosamine = N-acyl-D-mannosamine.

Pathwayi: N-acetylneuraminate degradation

This protein is involved in the pathway N-acetylneuraminate degradation, which is part of Amino-sugar metabolism.
View all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate degradation and in Amino-sugar metabolism.

GO - Molecular functioni

  • ATP binding Source: RGD
  • endopeptidase inhibitor activity Source: GO_Central
  • enzyme inhibitor activity Source: RGD
  • N-acylglucosamine 2-epimerase activity Source: RGD
  • protein homodimerization activity Source: RGD
  • purine nucleotide binding Source: RGD

GO - Biological processi

  • N-acetylglucosamine metabolic process Source: RGD
  • N-acetylmannosamine metabolic process Source: RGD
  • N-acetylneuraminate catabolic process Source: UniProtKB-UniPathway
  • negative regulation of catalytic activity Source: RGD
  • negative regulation of endopeptidase activity Source: RGD

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

ReactomeiR-RNO-446210 Synthesis of UDP-N-acetyl-glucosamine
UniPathwayiUPA00629

Names & Taxonomyi

Protein namesi
Recommended name:
N-acylglucosamine 2-epimerase (EC:5.1.3.8)
Short name:
AGE
Alternative name(s):
GlcNAc 2-epimerase
N-acetyl-D-glucosamine 2-epimerase
Renin-binding protein
Short name:
RnBP
Gene namesi
Name:Renbp
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome X

Organism-specific databases

RGDi621688 Renbp

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002089521 – 430N-acylglucosamine 2-epimeraseAdd BLAST430

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei429PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP51607
PRIDEiP51607

Expressioni

Tissue specificityi

Kidney, adrenal gland, brain, lung, spleen, ovary, testis and heart.1 Publication

Gene expression databases

BgeeiENSRNOG00000054765
GenevisibleiP51607 RN

Interactioni

Subunit structurei

Homodimer.

GO - Molecular functioni

  • protein homodimerization activity Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000053175

Structurei

3D structure databases

ProteinModelPortaliP51607
SMRiP51607
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni196 – 217Leucine-zipperAdd BLAST22

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IE08 Eukaryota
COG2942 LUCA
GeneTreeiENSGT00390000013740
HOGENOMiHOG000252296
HOVERGENiHBG054048
InParanoidiP51607
KOiK01787
OMAiPMMLLNL
OrthoDBiEOG091G0EO8
PhylomeDBiP51607

Family and domain databases

CDDicd00249 AGE, 1 hit
Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR034116 AGE_dom
SUPFAMiSSF48208 SSF48208, 1 hit

Sequencei

Sequence statusi: Complete.

P51607-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMDPGLLVLQ DMEKERETLQ VWKQRVGQEL DSVIAFWMEH SHDQEHGGFF
60 70 80 90 100
TCLGRDGQVY DHLKYVWLQG RQVWMYCRLY RTFERFRRVE LLDAAKAGGE
110 120 130 140 150
FLLSYARVAP PGKKCAFVLT QDGRPVKVQR TIFSECFYTM AMNELWKVTG
160 170 180 190 200
EMHYQREAVE MMDQIIHWVR EDPAGLGRPQ LSGTLATEPM AVPMMLLNLV
210 220 230 240 250
EQLGEEDEEM TDKYAELGDW CAHRILQHVQ RDGQVVLENV SEDGKELPGC
260 270 280 290 300
LGRHQNPGHT LEAGWFLLQY ALRKGDPKLQ RHIIDKFLLL PFHSGWDPEH
310 320 330 340 350
GGLFYFQDAD DLCPTQLEWN MKLWWPHTEA MIAFLMGYRD SGDPALLNLF
360 370 380 390 400
YQVAEYTFHQ FRDPEYGEWF GYLNQEGKVA LTIKGGPFKG CFHVPRCLAM
410 420 430
CEQILGALLQ RLGPAPLGSL PAVPTREGSK
Length:430
Mass (Da):49,605
Last modified:April 20, 2010 - v2
Checksum:i6DECB8A7A727EE6F
GO

Sequence cautioni

The sequence BAA01083 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CB691242 mRNA No translation available.
D10233 mRNA Translation: BAA01083.1 Different initiation.
PIRiJX0187
RefSeqiNP_112357.1, NM_031095.1
XP_006229677.1, XM_006229615.3
UniGeneiRn.11116

Genome annotation databases

EnsembliENSRNOT00000083442; ENSRNOP00000069721; ENSRNOG00000054765
GeneIDi81759
KEGGirno:81759

Similar proteinsi

Entry informationi

Entry nameiRENBP_RAT
AccessioniPrimary (citable) accession number: P51607
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 20, 2010
Last modified: May 23, 2018
This is version 119 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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