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Protein

N-acylglucosamine 2-epimerase

Gene

RENBP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of N-acetylglucosamine to N-acetylmannosamine. Binds to renin forming a protein complex called high molecular weight (HMW) renin and inhibits renin activity. Involved in the N-glycolylneuraminic acid (Neu5Gc) degradation pathway: although human is not able to catalyze formation of Neu5Gc due to the inactive CMAHP enzyme, Neu5Gc is present in food and must be degraded.1 Publication

Caution

It is uncertain whether Met-1 or Met-11 is the initiator.Curated

Catalytic activityi

N-acyl-D-glucosamine = N-acyl-D-mannosamine.

Pathwayi: N-acetylneuraminate degradation

This protein is involved in the pathway N-acetylneuraminate degradation, which is part of Amino-sugar metabolism.1 Publication
View all proteins of this organism that are known to be involved in the pathway N-acetylneuraminate degradation and in Amino-sugar metabolism.

GO - Molecular functioni

  • ATP binding Source: Ensembl
  • endopeptidase inhibitor activity Source: ProtInc
  • N-acylglucosamine 2-epimerase activity Source: UniProtKB
  • peptidase inhibitor activity Source: GO_Central
  • protein homodimerization activity Source: Ensembl

GO - Biological processi

Keywordsi

Molecular functionIsomerase

Enzyme and pathway databases

ReactomeiR-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine
SABIO-RKiP51606
UniPathwayi
UPA00629

Names & Taxonomyi

Protein namesi
Recommended name:
N-acylglucosamine 2-epimerase (EC:5.1.3.8)
Short name:
AGE
Alternative name(s):
GlcNAc 2-epimerase
N-acetyl-D-glucosamine 2-epimerase
Renin-binding protein
Short name:
RnBP
Gene namesi
Name:RENBP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102032.12
HGNCiHGNC:9959 RENBP
MIMi312420 gene
neXtProtiNX_P51606

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi5973
OpenTargetsiENSG00000102032
PharmGKBiPA34325

Chemistry databases

DrugBankiDB00141 N-Acetyl-D-glucosamine

Polymorphism and mutation databases

BioMutaiRENBP
DMDMi294862458

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002089491 – 427N-acylglucosamine 2-epimeraseAdd BLAST427

Proteomic databases

EPDiP51606
MaxQBiP51606
PaxDbiP51606
PeptideAtlasiP51606
PRIDEiP51606
ProteomicsDBi56342
56343 [P51606-2]

PTM databases

iPTMnetiP51606
PhosphoSitePlusiP51606

Expressioni

Gene expression databases

BgeeiENSG00000102032 Expressed in 106 organ(s), highest expression level in spleen
CleanExiHS_RENBP
ExpressionAtlasiP51606 baseline and differential
GenevisibleiP51606 HS

Organism-specific databases

HPAiHPA000428
HPA000522

Interactioni

Subunit structurei

Homodimer.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111905, 2 interactors
IntActiP51606, 3 interactors
STRINGi9606.ENSP00000377303

Structurei

3D structure databases

ProteinModelPortaliP51606
SMRiP51606
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni195 – 216Leucine-zipperAdd BLAST22

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410IE08 Eukaryota
COG2942 LUCA
GeneTreeiENSGT00390000013740
HOGENOMiHOG000252296
HOVERGENiHBG054048
InParanoidiP51606
KOiK01787
OMAiHDMKFWW
OrthoDBiEOG091G0EO8
PhylomeDBiP51606
TreeFamiTF329027

Family and domain databases

CDDicd00249 AGE, 1 hit
Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR034116 AGE_dom
SUPFAMiSSF48208 SSF48208, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P51606-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSKGLPARQD MEKERETLQA WKERVGQELD RVVAFWMEHS HDQEHGGFFT
60 70 80 90 100
CLGREGRVYD DLKYVWLQGR QVWMYCRLYR TFERFRHAQL LDAAKAGGEF
110 120 130 140 150
LLRYARVAPP GKKCAFVLTR DGRPVKVQRT IFSECFYTMA MNELWRATGE
160 170 180 190 200
VRYQTEAVEM MDQIVHWVQE DASGLGRPQL QGAPAAEPMA VPMMLLNLVE
210 220 230 240 250
QLGEADEELA GKYAELGDWC ARRILQHVQR DGQAVLENVS EGGKELPGCL
260 270 280 290 300
GRQQNPGHTL EAGWFLLRHC IRKGDPELRA HVIDKFLLLP FHSGWDPDHG
310 320 330 340 350
GLFYFQDADN FCPTQLEWAM KLWWPHSEAM IAFLMGYSDS GDPVLLRLFY
360 370 380 390 400
QVAEYTFRQF RDPEYGEWFG YLSREGKVAL SIKGGPFKGC FHVPRCLAMC
410 420
EEMLGALLSR PAPAPSPAPT PACRGAE
Length:427
Mass (Da):48,831
Last modified:April 20, 2010 - v2
Checksum:i40D5C485C30BE009
GO
Isoform 2 (identifier: P51606-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     230-254: RDGQAVLENVSEGGKELPGCLGRQQ → ATRWKPAGFCSVIAFGKATPNFEPT
     255-427: Missing.

Show »
Length:254
Mass (Da):29,270
Checksum:i9CB7FE6EED3368F7
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A6NKZ2A6NKZ2_HUMAN
N-acylglucosamine 2-epimerase
RENBP
413Annotation score:
H7C2G7H7C2G7_HUMAN
N-acylglucosamine 2-epimerase
RENBP
116Annotation score:
H7C1A7H7C1A7_HUMAN
N-acylglucosamine 2-epimerase
RENBP
159Annotation score:
H7C317H7C317_HUMAN
N-acylglucosamine 2-epimerase
RENBP
125Annotation score:
F8WE83F8WE83_HUMAN
N-acylglucosamine 2-epimerase
RENBP
60Annotation score:

Sequence cautioni

The sequence AAH15558 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAA01082 differs from that shown. Contaminating sequence.Curated
The sequence BAA01082 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti236L → P in AAH15558 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_029339169Q → R. Corresponds to variant dbSNP:rs2229241Ensembl.1
Natural variantiVAR_049182284D → G. Corresponds to variant dbSNP:rs2269371Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039022230 – 254RDGQA…LGRQQ → ATRWKPAGFCSVIAFGKATP NFEPT in isoform 2. 1 PublicationAdd BLAST25
Alternative sequenceiVSP_039023255 – 427Missing in isoform 2. 1 PublicationAdd BLAST173

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298125 mRNA Translation: BAG60405.1
U52112 Genomic DNA No translation available.
BC015558 mRNA Translation: AAH15558.1 Different initiation.
D10232 mRNA Translation: BAA01082.1 Sequence problems.
CCDSiCCDS14738.2 [P51606-1]
PIRiJX0188
RefSeqiNP_002901.2, NM_002910.5 [P51606-1]
XP_016885187.1, XM_017029698.1
UniGeneiHs.158331

Genome annotation databases

EnsembliENST00000393700; ENSP00000377303; ENSG00000102032 [P51606-1]
GeneIDi5973
KEGGihsa:5973
UCSCiuc004fjo.3 human [P51606-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK298125 mRNA Translation: BAG60405.1
U52112 Genomic DNA No translation available.
BC015558 mRNA Translation: AAH15558.1 Different initiation.
D10232 mRNA Translation: BAA01082.1 Sequence problems.
CCDSiCCDS14738.2 [P51606-1]
PIRiJX0188
RefSeqiNP_002901.2, NM_002910.5 [P51606-1]
XP_016885187.1, XM_017029698.1
UniGeneiHs.158331

3D structure databases

ProteinModelPortaliP51606
SMRiP51606
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111905, 2 interactors
IntActiP51606, 3 interactors
STRINGi9606.ENSP00000377303

Chemistry databases

DrugBankiDB00141 N-Acetyl-D-glucosamine

PTM databases

iPTMnetiP51606
PhosphoSitePlusiP51606

Polymorphism and mutation databases

BioMutaiRENBP
DMDMi294862458

Proteomic databases

EPDiP51606
MaxQBiP51606
PaxDbiP51606
PeptideAtlasiP51606
PRIDEiP51606
ProteomicsDBi56342
56343 [P51606-2]

Protocols and materials databases

DNASUi5973
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393700; ENSP00000377303; ENSG00000102032 [P51606-1]
GeneIDi5973
KEGGihsa:5973
UCSCiuc004fjo.3 human [P51606-1]

Organism-specific databases

CTDi5973
DisGeNETi5973
EuPathDBiHostDB:ENSG00000102032.12
GeneCardsiRENBP
H-InvDBiHIX0203300
HGNCiHGNC:9959 RENBP
HPAiHPA000428
HPA000522
MIMi312420 gene
neXtProtiNX_P51606
OpenTargetsiENSG00000102032
PharmGKBiPA34325
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE08 Eukaryota
COG2942 LUCA
GeneTreeiENSGT00390000013740
HOGENOMiHOG000252296
HOVERGENiHBG054048
InParanoidiP51606
KOiK01787
OMAiHDMKFWW
OrthoDBiEOG091G0EO8
PhylomeDBiP51606
TreeFamiTF329027

Enzyme and pathway databases

UniPathwayi
UPA00629

ReactomeiR-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine
SABIO-RKiP51606

Miscellaneous databases

ChiTaRSiRENBP human
GeneWikiiRENBP
GenomeRNAii5973
PROiPR:P51606
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102032 Expressed in 106 organ(s), highest expression level in spleen
CleanExiHS_RENBP
ExpressionAtlasiP51606 baseline and differential
GenevisibleiP51606 HS

Family and domain databases

CDDicd00249 AGE, 1 hit
Gene3Di1.50.10.10, 1 hit
InterProiView protein in InterPro
IPR008928 6-hairpin_glycosidase_sf
IPR012341 6hp_glycosidase-like_sf
IPR034116 AGE_dom
SUPFAMiSSF48208 SSF48208, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRENBP_HUMAN
AccessioniPrimary (citable) accession number: P51606
Secondary accession number(s): B4DNZ3, Q96BI6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: April 20, 2010
Last modified: November 7, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
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Main funding by: National Institutes of Health

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