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Protein

Cytochrome P450 2J3

Gene

Cyp2j3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation mainly to 14,15-, 11,12-, and 8,9-epoxyeicosatrienoic acids (EET). It also acts as an omega-1-hydroxylase by metabolizing arachidonic acid to 19-hydroxyeicosatetraenoic acid (19-OH-AA).

Catalytic activityi

RH + [reduced NADPH--hemoprotein reductase] + O2 = ROH + [oxidized NADPH--hemoprotein reductase] + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi448Iron (heme axial ligand)By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionMonooxygenase, Oxidoreductase
LigandHeme, Iron, Metal-binding

Enzyme and pathway databases

BRENDAi1.14.13.159 5301

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 2J3 (EC:1.14.14.1)
Alternative name(s):
CYPIIJ3
Gene namesi
Name:Cyp2j3
Synonyms:Cyp2j9
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi631442 Cyp2j3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000517701 – 502Cytochrome P450 2J3Add BLAST502

Proteomic databases

PRIDEiP51590

PTM databases

PhosphoSitePlusiP51590

Expressioni

Tissue specificityi

Abundantly expressed in heart and liver.

Structurei

3D structure databases

ProteinModelPortaliP51590
SMRiP51590
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

HOGENOMiHOG000036991
HOVERGENiHBG015789
InParanoidiP51590
KOiK07418
PhylomeDBiP51590

Family and domain databases

Gene3Di1.10.630.10, 1 hit
InterProiView protein in InterPro
IPR001128 Cyt_P450
IPR017972 Cyt_P450_CS
IPR002401 Cyt_P450_E_grp-I
IPR008071 Cyt_P450_E_grp-I_CYP2J-like
IPR036396 Cyt_P450_sf
PfamiView protein in Pfam
PF00067 p450, 1 hit
PRINTSiPR00463 EP450I
PR01688 EP450ICYP2J
PR00385 P450
SUPFAMiSSF48264 SSF48264, 1 hit
PROSITEiView protein in PROSITE
PS00086 CYTOCHROME_P450, 1 hit

Sequencei

Sequence statusi: Complete.

P51590-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVTAGSLLG AIWTVLHLRI LLLAAVTFLF LADFLKHRRP KNYPPGPWRL
60 70 80 90 100
PLVGCLFHLD PKQPHLSLQQ FVKKYGNVLS LDFANIPSVV VTGMPLIKEI
110 120 130 140 150
FTQMEHNFLN RPVTLLRKHL FNKNGLIFSS GQTWKEQRRF ALMTLRNFGL
160 170 180 190 200
GKKSLEQRIQ EEAYHLVEAI KDEGGLPFDP HFNINKAVSN IICSVTFGER
210 220 230 240 250
FEYHDSQFQE MLRLLDEAMC LESSMMCQLY NIFPRILQYL PGSHQTLFSN
260 270 280 290 300
WRKLKLFISD IIKNHRRDWD PDEPRDFIDA FLKEMAKYPD KTTTSFNEEN
310 320 330 340 350
LICSTLDLFF AGTETTSTTL RWALLCMALY PEVQEKMQAE IDRVIGQGRQ
360 370 380 390 400
PNLADRDSMP YTNAVIHEVQ RIGNIIPFNV PREVAVDTYL AGFNLPKGTM
410 420 430 440 450
ILTNLTALHR DPKEWATPDT FNPEHFLENG QFKKRESFLP FSMGKRACLG
460 470 480 490 500
EQLARSELFI FITSLIQKFT FKPPVNEKLS LQFRMSVTIS PVSHRLCAIP

RL
Length:502
Mass (Da):57,969
Last modified:October 1, 1996 - v1
Checksum:iCCC0AE67977FFF31
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U39943 mRNA Translation: AAB48545.1
BC089766 mRNA Translation: AAH89766.1
RefSeqiNP_786942.1, NM_175766.3
UniGeneiRn.28757

Genome annotation databases

GeneIDi313375
KEGGirno:313375
UCSCiRGD:631442 rat

Similar proteinsi

Entry informationi

Entry nameiCP2J3_RAT
AccessioniPrimary (citable) accession number: P51590
Secondary accession number(s): Q5EBD7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: February 28, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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