UniProtKB - P51589 (CP2J2_HUMAN)
Protein
Cytochrome P450 2J2
Gene
CYP2J2
Organism
Homo sapiens (Human)
Status
Functioni
A cytochrome P450 monooxygenase involved in the metabolism of polyunsaturated fatty acids (PUFA) in the cardiovascular system (PubMed:8631948, PubMed:19965576). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase) (PubMed:8631948, PubMed:19965576). Catalyzes the epoxidation of double bonds of PUFA (PubMed:8631948, PubMed:19965576). Converts arachidonic acid to four regioisomeric epoxyeicosatrienoic acids (EpETrE), likely playing a major role in the epoxidation of endogenous cardiac arachidonic acid pools (PubMed:8631948). In endothelial cells, participates in eicosanoids metabolism by converting hydroperoxide species into hydroxy epoxy metabolites. In combination with 15-lipoxygenase metabolizes arachidonic acid and converts hydroperoxyicosatetraenoates (HpETEs) into hydroxy epoxy eicosatrienoates (HEETs), which are precursors of vasodilatory trihydroxyicosatrienoic acids (THETAs). This hydroperoxide isomerase activity is NADPH- and O2-independent (PubMed:19737933). Catalyzes the monooxygenation of a various xenobiotics, such as danazol, amiodarone, terfenadine, astemizole, thioridazine, tamoxifen, cyclosporin A and nabumetone (PubMed:19923256). Catalyzes hydroxylation of the anthelmintics albendazole and fenbendazole (PubMed:23959307). Catalyzes the sulfoxidation of fenbedazole (PubMed:19923256).5 Publications
Catalytic activityi
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = 5,6-epoxy-(8Z,11Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (8R,9S)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (8S,9R)-epoxy-(5Z,11Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (11R,12S)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (11S,12R)-epoxy-(5Z,8Z,14Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (14R,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z)-eicosatetraenoate + O2 + reduced [NADPH—hemoprotein reductase] = (14S,15R)-epoxy-(5Z,8Z,11Z)-eicosatrienoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]2 PublicationsThis reaction proceeds in the forward1 Publication direction.
- (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13S)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate = (13R)-hydroxy-(14S,15S)-epoxy-(5Z,8Z,11Z)-eicosatrienoate1 PublicationEC:5.4.4.71 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (17R,18S)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (5Z,8Z,11Z,14Z,17Z)-eicosapentaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (17S,18R)-epoxy-(5Z,8Z,11Z,14Z)-eicosatetraenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (19R,20S)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- (4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 + reduced [NADPH—hemoprotein reductase] = (19S,20R)-epoxy-(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
- albendazole + O2 + reduced [NADPH—hemoprotein reductase] = H+ + H2O + hydroxyalbendazole + oxidized [NADPH—hemoprotein reductase]1 PublicationEC:1.14.14.741 PublicationThis reaction proceeds in the forward1 Publication direction.
- albendazole + O2 + reduced [NADPH—hemoprotein reductase] = albendazole S-oxide + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationEC:1.14.14.731 PublicationThis reaction proceeds in the forward1 Publication direction.
- fenbendazole + O2 + reduced [NADPH—hemoprotein reductase] = fenbendazole S-oxide + H+ + H2O + oxidized [NADPH—hemoprotein reductase]1 PublicationThis reaction proceeds in the forward1 Publication direction.
Cofactori
hemeBy similarity
: arachidonate metabolism Pathwayi
This protein is involved in the pathway arachidonate metabolism, which is part of Lipid metabolism.3 PublicationsView all proteins of this organism that are known to be involved in the pathway arachidonate metabolism and in Lipid metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 448 | Iron (heme axial ligand)By similarity | 1 |
GO - Molecular functioni
- arachidonic acid 11,12-epoxygenase activity Source: BHF-UCL
- arachidonic acid 14,15-epoxygenase activity Source: BHF-UCL
- arachidonic acid epoxygenase activity Source: UniProtKB
- heme binding Source: GO_Central
- hydroperoxy icosatetraenoate isomerase activity Source: UniProtKB-EC
- iron ion binding Source: InterPro
- isomerase activity Source: UniProtKB
- linoleic acid epoxygenase activity Source: BHF-UCL
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen Source: GO_Central
- steroid hydroxylase activity Source: GO_Central
GO - Biological processi
- epoxygenase P450 pathway Source: UniProtKB
- exogenous drug catabolic process Source: GO_Central
- icosanoid metabolic process Source: UniProtKB
- linoleic acid metabolic process Source: BHF-UCL
- organic acid metabolic process Source: GO_Central
- oxidation-reduction process Source: GO_Central
- regulation of heart contraction Source: ProtInc
- xenobiotic metabolic process Source: GO_Central
Keywordsi
Molecular function | Isomerase, Monooxygenase, Oxidoreductase |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | Heme, Iron, Metal-binding |
Enzyme and pathway databases
BioCyci | MetaCyc:HS05902-MONOMER |
BRENDAi | 1.14.13.159, 2681 |
PathwayCommonsi | P51589 |
Reactomei | R-HSA-211935, Fatty acids R-HSA-211981, Xenobiotics R-HSA-2142670, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) |
UniPathwayi | UPA00383 |
Chemistry databases
SwissLipidsi | SLP:000001594 |
Names & Taxonomyi
Protein namesi | Recommended name: Cytochrome P450 2J2 (EC:1.14.14.-1 Publication)Alternative name(s): Albendazole monooxygenase (hydroxylating)Curated (EC:1.14.14.741 Publication) Albendazole monooxygenase (sulfoxide-forming)Curated (EC:1.14.14.731 Publication) Arachidonic acid epoxygenase1 Publication CYPIIJ2 Hydroperoxy icosatetraenoate isomerase1 Publication (EC:5.4.4.71 Publication) |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000134716.9 |
HGNCi | HGNC:2634, CYP2J2 |
MIMi | 601258, gene |
neXtProti | NX_P51589 |
Subcellular locationi
Endoplasmic reticulum
Endoplasmic reticulum
- endoplasmic reticulum membrane Source: Reactome
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
Other locations
- cytoplasm Source: GO_Central
- intracellular membrane-bounded organelle Source: GO_Central
Keywords - Cellular componenti
Endoplasmic reticulum, Membrane, MicrosomePathology & Biotechi
Organism-specific databases
DisGeNETi | 1573 |
OpenTargetsi | ENSG00000134716 |
PharmGKBi | PA27112 |
Miscellaneous databases
Pharosi | P51589, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3491 |
DrugBanki | DB01118, Amiodarone DB06605, Apixaban DB00637, Astemizole DB00169, Cholecalciferol DB04855, Dronedarone DB09148, Florbetaben (18F) DB08918, Levomilnacipran DB04725, Licofelone DB08931, Riociguat DB06228, Rivaroxaban DB00342, Terfenadine DB09030, Vorapaxar |
DrugCentrali | P51589 |
GuidetoPHARMACOLOGYi | 1332 |
Polymorphism and mutation databases
BioMutai | CYP2J2 |
DMDMi | 21264413 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000051769 | 1 – 502 | Cytochrome P450 2J2Add BLAST | 502 |
Proteomic databases
EPDi | P51589 |
jPOSTi | P51589 |
MassIVEi | P51589 |
MaxQBi | P51589 |
PaxDbi | P51589 |
PeptideAtlasi | P51589 |
PRIDEi | P51589 |
ProteomicsDBi | 56341 |
PTM databases
iPTMneti | P51589 |
PhosphoSitePlusi | P51589 |
Expressioni
Tissue specificityi
Highly expressed in heart, present at lower levels in liver, kidney and skeletal muscle (at protein level).1 Publication
Gene expression databases
Bgeei | ENSG00000134716, Expressed in heart and 198 other tissues |
ExpressionAtlasi | P51589, baseline and differential |
Genevisiblei | P51589, HS |
Organism-specific databases
HPAi | ENSG00000134716, Tissue enhanced (heart muscle, intestine, liver) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 107946, 28 interactors |
IntActi | P51589, 3 interactors |
STRINGi | 9606.ENSP00000360247 |
Chemistry databases
BindingDBi | P51589 |
Miscellaneous databases
RNActi | P51589, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the cytochrome P450 family.Curated
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00940000155417 |
HOGENOMi | CLU_001570_22_0_1 |
InParanoidi | P51589 |
OMAi | TCQLYNV |
OrthoDBi | 702827at2759 |
PhylomeDBi | P51589 |
TreeFami | TF352043 |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008071, Cyt_P450_E_grp-I_CYP2J-like IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01688, EP450ICYP2J PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
P51589-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLAAMGSLAA ALWAVVHPRT LLLGTVAFLL AADFLKRRRP KNYPPGPWRL
60 70 80 90 100
PFLGNFFLVD FEQSHLEVQL FVKKYGNLFS LELGDISAVL ITGLPLIKEA
110 120 130 140 150
LIHMDQNFGN RPVTPMREHI FKKNGLIMSS GQAWKEQRRF TLTALRNFGL
160 170 180 190 200
GKKSLEERIQ EEAQHLTEAI KEENGQPFDP HFKINNAVSN IICSITFGER
210 220 230 240 250
FEYQDSWFQQ LLKLLDEVTY LEASKTCQLY NVFPWIMKFL PGPHQTLFSN
260 270 280 290 300
WKKLKLFVSH MIDKHRKDWN PAETRDFIDA YLKEMSKHTG NPTSSFHEEN
310 320 330 340 350
LICSTLDLFF AGTETTSTTL RWALLYMALY PEIQEKVQAE IDRVIGQGQQ
360 370 380 390 400
PSTAARESMP YTNAVIHEVQ RMGNIIPLNV PREVTVDTTL AGYHLPKGTM
410 420 430 440 450
ILTNLTALHR DPTEWATPDT FNPDHFLENG QFKKREAFMP FSIGKRACLG
460 470 480 490 500
EQLARTELFI FFTSLMQKFT FRPPNNEKLS LKFRMGITIS PVSHRLCAVP
QV
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3IT99 | A0A3B3IT99_HUMAN | Cytochrome P450 2J2 | CYP2J2 hCG_22170 | 402 | Annotation score: | ||
A0A3B3IU95 | A0A3B3IU95_HUMAN | Cytochrome P450 2J2 | CYP2J2 | 355 | Annotation score: | ||
A0A3B3ITF2 | A0A3B3ITF2_HUMAN | Cytochrome P450 2J2 | CYP2J2 | 84 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 264 | K → E in BAG37780 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 318 | T → A in BAG37780 (PubMed:14702039).Curated | 1 | |
Sequence conflicti | 339 | A → V in BAB85489 (PubMed:12386130).Curated | 1 |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_029159 | 49 | R → S1 PublicationCorresponds to variant dbSNP:rs11572190Ensembl. | 1 | |
Natural variantiVAR_029160 | 113 | V → M. Corresponds to variant dbSNP:rs11572242Ensembl. | 1 | |
Natural variantiVAR_022084 | 124 | N → S. Corresponds to variant dbSNP:rs2228113Ensembl. | 1 | |
Natural variantiVAR_014317 | 143 | T → A in allele CYP2J2*2; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs55753213Ensembl. | 1 | |
Natural variantiVAR_014318 | 158 | R → C in allele CYP2J2*3; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs56307989Ensembl. | 1 | |
Natural variantiVAR_014319 | 192 | I → N in allele CYP2J2*4; significantly reduced metabolism of arachidonic acid only. 1 PublicationCorresponds to variant dbSNP:rs66515830Ensembl. | 1 | |
Natural variantiVAR_014320 | 342 | D → N in allele CYP2J2*5; no change in activity. 1 PublicationCorresponds to variant dbSNP:rs56053398Ensembl. | 1 | |
Natural variantiVAR_014321 | 404 | N → Y in allele CYP2J2*6; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs72547598Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U37143 mRNA Translation: AAC50370.2 AB080265 mRNA Translation: BAB85489.1 AF272142 Genomic DNA Translation: AAM44456.1 AY426985 Genomic DNA Translation: AAQ93356.1 AK315387 mRNA Translation: BAG37780.1 BC032594 mRNA Translation: AAH32594.1 |
CCDSi | CCDS613.1 |
RefSeqi | NP_000766.2, NM_000775.3 |
Genome annotation databases
Ensembli | ENST00000371204; ENSP00000360247; ENSG00000134716 |
GeneIDi | 1573 |
KEGGi | hsa:1573 |
UCSCi | uc001czq.4, human |
Keywords - Coding sequence diversityi
PolymorphismSimilar proteinsi
Cross-referencesi
Web resourcesi
Cytochrome P450 Allele Nomenclature Committee CYP2J2 alleles |
NIEHS-SNPs |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U37143 mRNA Translation: AAC50370.2 AB080265 mRNA Translation: BAB85489.1 AF272142 Genomic DNA Translation: AAM44456.1 AY426985 Genomic DNA Translation: AAQ93356.1 AK315387 mRNA Translation: BAG37780.1 BC032594 mRNA Translation: AAH32594.1 |
CCDSi | CCDS613.1 |
RefSeqi | NP_000766.2, NM_000775.3 |
3D structure databases
SMRi | P51589 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107946, 28 interactors |
IntActi | P51589, 3 interactors |
STRINGi | 9606.ENSP00000360247 |
Chemistry databases
BindingDBi | P51589 |
ChEMBLi | CHEMBL3491 |
DrugBanki | DB01118, Amiodarone DB06605, Apixaban DB00637, Astemizole DB00169, Cholecalciferol DB04855, Dronedarone DB09148, Florbetaben (18F) DB08918, Levomilnacipran DB04725, Licofelone DB08931, Riociguat DB06228, Rivaroxaban DB00342, Terfenadine DB09030, Vorapaxar |
DrugCentrali | P51589 |
GuidetoPHARMACOLOGYi | 1332 |
SwissLipidsi | SLP:000001594 |
PTM databases
iPTMneti | P51589 |
PhosphoSitePlusi | P51589 |
Polymorphism and mutation databases
BioMutai | CYP2J2 |
DMDMi | 21264413 |
Proteomic databases
EPDi | P51589 |
jPOSTi | P51589 |
MassIVEi | P51589 |
MaxQBi | P51589 |
PaxDbi | P51589 |
PeptideAtlasi | P51589 |
PRIDEi | P51589 |
ProteomicsDBi | 56341 |
Protocols and materials databases
Antibodypediai | 33278, 349 antibodies |
DNASUi | 1573 |
Genome annotation databases
Ensembli | ENST00000371204; ENSP00000360247; ENSG00000134716 |
GeneIDi | 1573 |
KEGGi | hsa:1573 |
UCSCi | uc001czq.4, human |
Organism-specific databases
CTDi | 1573 |
DisGeNETi | 1573 |
EuPathDBi | HostDB:ENSG00000134716.9 |
GeneCardsi | CYP2J2 |
HGNCi | HGNC:2634, CYP2J2 |
HPAi | ENSG00000134716, Tissue enhanced (heart muscle, intestine, liver) |
MIMi | 601258, gene |
neXtProti | NX_P51589 |
OpenTargetsi | ENSG00000134716 |
PharmGKBi | PA27112 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG0156, Eukaryota |
GeneTreei | ENSGT00940000155417 |
HOGENOMi | CLU_001570_22_0_1 |
InParanoidi | P51589 |
OMAi | TCQLYNV |
OrthoDBi | 702827at2759 |
PhylomeDBi | P51589 |
TreeFami | TF352043 |
Enzyme and pathway databases
UniPathwayi | UPA00383 |
BioCyci | MetaCyc:HS05902-MONOMER |
BRENDAi | 1.14.13.159, 2681 |
PathwayCommonsi | P51589 |
Reactomei | R-HSA-211935, Fatty acids R-HSA-211981, Xenobiotics R-HSA-2142670, Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) |
Miscellaneous databases
BioGRID-ORCSi | 1573, 4 hits in 844 CRISPR screens |
ChiTaRSi | CYP2J2, human |
GeneWikii | CYP2J2 |
GenomeRNAii | 1573 |
Pharosi | P51589, Tchem |
PROi | PR:P51589 |
RNActi | P51589, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000134716, Expressed in heart and 198 other tissues |
ExpressionAtlasi | P51589, baseline and differential |
Genevisiblei | P51589, HS |
Family and domain databases
Gene3Di | 1.10.630.10, 1 hit |
InterProi | View protein in InterPro IPR001128, Cyt_P450 IPR017972, Cyt_P450_CS IPR002401, Cyt_P450_E_grp-I IPR008071, Cyt_P450_E_grp-I_CYP2J-like IPR036396, Cyt_P450_sf |
Pfami | View protein in Pfam PF00067, p450, 1 hit |
PRINTSi | PR00463, EP450I PR01688, EP450ICYP2J PR00385, P450 |
SUPFAMi | SSF48264, SSF48264, 1 hit |
PROSITEi | View protein in PROSITE PS00086, CYTOCHROME_P450, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CP2J2_HUMAN | |
Accessioni | P51589Primary (citable) accession number: P51589 Secondary accession number(s): B2RD33, Q8TF13 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | May 27, 2002 | |
Last modified: | December 2, 2020 | |
This is version 191 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations