CYP2J2

Functionⁱ

This enzyme metabolizes arachidonic acid predominantly via a NADPH-dependent olefin epoxidation to all four regioisomeric cis-epoxyeicosatrienoic acids. One of the predominant enzymes responsible for the epoxidation of endogenous cardiac arachidonic acid pools.

Catalytic activityⁱ

RH + [reduced NADPH--hemoprotein reductase] + O₂ = ROH + [oxidized NADPH--hemoprotein reductase] + H₂O.

Cofactorⁱ

hemeBy similarity

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Metal bindingⁱ	448	Iron (heme axial ligand)By similarity		1

GO - Molecular functionⁱ

arachidonic acid 11,12-epoxygenase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11901223
arachidonic acid 14,15-epoxygenase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11901223
arachidonic acid epoxygenase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11901223
aromatase activity Source: UniProtKB-EC
heme binding Source: InterPro
iron ion binding Source: InterPro
linoleic acid epoxygenase activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 11901223
monooxygenase activity Source: Reactome

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

epoxygenase P450 pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 11901223
icosanoid metabolic process
Source: ProtInc
Traceable author statementⁱ
- 8631948
linoleic acid metabolic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 11901223
regulation of heart contraction
Source: ProtInc
Traceable author statementⁱ
- 8631948
xenobiotic metabolic process
Source: BHF-UCL
Traceable author statementⁱ
- 11901223

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Monooxygenase, Oxidoreductase
Ligand	Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS05902-MONOMER
BRENDAⁱ	1.14.13.159 2681
Reactomeⁱ	R-HSA-211935 Fatty acids R-HSA-211981 Xenobiotics R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Chemistry databases

SwissLipidsⁱ	SLP:000001594

SwissLipidsⁱ

SLP:000001594

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cytochrome P450 2J2 (EC:1.14.14.1) Alternative name(s): Arachidonic acid epoxygenase CYPIIJ2
Gene namesⁱ	Name:CYP2J2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000134716.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2634 CYP2J2
MIMⁱ	601258 gene
neXtProtⁱ	NX_P51589

Keywords - Cellular componentⁱ

Endoplasmic reticulum, Membrane, Microsome

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	1573
Open Targets More...OpenTargetsⁱ	ENSG00000134716
PharmGKBⁱ	PA27112

Chemistry databases

ChEMBLⁱ	CHEMBL3491
Drug and drug target database More...DrugBankⁱ	DB06605 Apixaban DB00637 Astemizole DB00169 Cholecalciferol DB09148 Florbetaben (18F) DB08918 Levomilnacipran DB04725 Licofelone DB00179 Masoprocol DB08931 Riociguat DB06228 Rivaroxaban DB00342 Terfenadine
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1332

Polymorphism and mutation databases

BioMutaⁱ	CYP2J2
DMDMⁱ	21264413

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000051769	1 – 502	Cytochrome P450 2J2Add BLAST		502

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51589
PaxDbⁱ	P51589
PeptideAtlas More...PeptideAtlasⁱ	P51589
PRIDEⁱ	P51589
ProteomicsDBⁱ	56341

PTM databases

iPTMnetⁱ	P51589
PhosphoSitePlusⁱ	P51589

Expressionⁱ

Tissue specificityⁱ

Highly expressed in heart, present at lower levels in liver, ileum, jejunum, colon, and kidney.

Gene expression databases

Bgeeⁱ	ENSG00000134716
CleanExⁱ	HS_CYP2J2
Genevisibleⁱ	P51589 HS

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	107946, 27 interactors
IntActⁱ	P51589, 2 interactors
STRINGⁱ	9606.ENSP00000360247

Chemistry databases

BindingDBⁱ

P51589

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P51589
SMRⁱ	P51589
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the cytochrome P450 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140799
HOGENOMⁱ	HOG000036991
HOVERGENⁱ	HBG015789
InParanoidⁱ	P51589
KEGG Orthology (KO) More...KOⁱ	K07418
OMAⁱ	RTIFSCN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BT8
PhylomeDBⁱ	P51589
TreeFamⁱ	TF352043

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008071 Cyt_P450_E_grp-I_CYP2J-like IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR01688 EP450ICYP2J PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P51589-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLAAMGSLAA ALWAVVHPRT LLLGTVAFLL AADFLKRRRP KNYPPGPWRL 
        60         70         80         90        100
PFLGNFFLVD FEQSHLEVQL FVKKYGNLFS LELGDISAVL ITGLPLIKEA 
       110        120        130        140        150
LIHMDQNFGN RPVTPMREHI FKKNGLIMSS GQAWKEQRRF TLTALRNFGL 
       160        170        180        190        200
GKKSLEERIQ EEAQHLTEAI KEENGQPFDP HFKINNAVSN IICSITFGER 
       210        220        230        240        250
FEYQDSWFQQ LLKLLDEVTY LEASKTCQLY NVFPWIMKFL PGPHQTLFSN 
       260        270        280        290        300
WKKLKLFVSH MIDKHRKDWN PAETRDFIDA YLKEMSKHTG NPTSSFHEEN 
       310        320        330        340        350
LICSTLDLFF AGTETTSTTL RWALLYMALY PEIQEKVQAE IDRVIGQGQQ 
       360        370        380        390        400
PSTAARESMP YTNAVIHEVQ RMGNIIPLNV PREVTVDTTL AGYHLPKGTM 
       410        420        430        440        450
ILTNLTALHR DPTEWATPDT FNPDHFLENG QFKKREAFMP FSIGKRACLG 
       460        470        480        490        500
EQLARTELFI FFTSLMQKFT FRPPNNEKLS LKFRMGITIS PVSHRLCAVP 

QV

Length:502

Mass (Da):57,611

Last modified:May 27, 2002 - v2

Checksum:ⁱB5F006581E249EC0

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	264	K → E in BAG37780 (PubMed:14702039).Curated	1
Sequence conflictⁱ	318	T → A in BAG37780 (PubMed:14702039).Curated	1
Sequence conflictⁱ	339	A → V in BAB85489 (PubMed:12386130).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_029159	49	R → S1 PublicationCorresponds to variant dbSNP:rs11572190Ensembl.	1
Natural variantⁱVAR_029160	113	V → M. Corresponds to variant dbSNP:rs11572242Ensembl.	1
Natural variantⁱVAR_022084	124	N → S. Corresponds to variant dbSNP:rs2228113Ensembl.	1
Natural variantⁱVAR_014317	143	T → A in allele CYP2J2*2; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs55753213Ensembl.	1
Natural variantⁱVAR_014318	158	R → C in allele CYP2J2*3; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs56307989Ensembl.	1
Natural variantⁱVAR_014319	192	I → N in allele CYP2J2*4; significantly reduced metabolism of arachidonic acid only. 1 PublicationCorresponds to variant dbSNP:rs66515830Ensembl.	1
Natural variantⁱVAR_014320	342	D → N in allele CYP2J2*5; no change in activity. 1 PublicationCorresponds to variant dbSNP:rs56053398Ensembl.	1
Natural variantⁱVAR_014321	404	N → Y in allele CYP2J2*6; significantly reduced metabolism of both arachidonic acid and linoleic acid. 1 PublicationCorresponds to variant dbSNP:rs72547598Ensembl.	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U37143 mRNA Translation: AAC50370.2 AB080265 mRNA Translation: BAB85489.1 AF272142 Genomic DNA Translation: AAM44456.1 AY426985 Genomic DNA Translation: AAQ93356.1 AK315387 mRNA Translation: BAG37780.1 BC032594 mRNA Translation: AAH32594.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS613.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000766.2, NM_000775.3
UniGeneⁱ	Hs.152096

Genome annotation databases

Ensemblⁱ	ENST00000371204; ENSP00000360247; ENSG00000134716
GeneIDⁱ	1573
KEGGⁱ	hsa:1573
UCSC genome browser More...UCSCⁱ	uc001czq.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P51589	CYP2J2 isoform 1		PANTR		502
CYP2J2 isoform 1		PONAB		502
Cytochrome P450 family 2 subfamily J member 2		MACMU		502
Cytochrome P450 2J2		MACFA		502
Cytochrome P450 family 2 subfamily J member 2		COLAP		502
+31

Protein	Similar proteins		Species	Score	Length
P51589	Cytochrome P450 family 2 subfamily J member 2		CHLSB		502
Cytochrome P450 family 2 subfamily J member 2		RHIBE		502
Cytochrome P450 family 2 subfamily J member 2		NOMLE		502
CYP2J2 isoform 1		PONAB		502
CYP2J2 isoform 1		PANTR		502
+463

Cross-referencesⁱ

Web resourcesⁱ

Cytochrome P450 Allele Nomenclature Committee

CYP2J2 alleles

NIEHS-SNPs

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U37143 mRNA Translation: AAC50370.2 AB080265 mRNA Translation: BAB85489.1 AF272142 Genomic DNA Translation: AAM44456.1 AY426985 Genomic DNA Translation: AAQ93356.1 AK315387 mRNA Translation: BAG37780.1 BC032594 mRNA Translation: AAH32594.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS613.1
NCBI Reference Sequences More...RefSeqⁱ	NP_000766.2, NM_000775.3
UniGeneⁱ	Hs.152096

3D structure databases

ProteinModelPortalⁱ	P51589
SMRⁱ	P51589
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	107946, 27 interactors
IntActⁱ	P51589, 2 interactors
STRINGⁱ	9606.ENSP00000360247

Chemistry databases

BindingDBⁱ	P51589
ChEMBLⁱ	CHEMBL3491
Drug and drug target database More...DrugBankⁱ	DB06605 Apixaban DB00637 Astemizole DB00169 Cholecalciferol DB09148 Florbetaben (18F) DB08918 Levomilnacipran DB04725 Licofelone DB00179 Masoprocol DB08931 Riociguat DB06228 Rivaroxaban DB00342 Terfenadine
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	1332
SwissLipidsⁱ	SLP:000001594

PTM databases

iPTMnetⁱ	P51589
PhosphoSitePlusⁱ	P51589

Polymorphism and mutation databases

BioMutaⁱ	CYP2J2
DMDMⁱ	21264413

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51589
PaxDbⁱ	P51589
PeptideAtlas More...PeptideAtlasⁱ	P51589
PRIDEⁱ	P51589
ProteomicsDBⁱ	56341

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	1573
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371204; ENSP00000360247; ENSG00000134716
GeneIDⁱ	1573
KEGGⁱ	hsa:1573
UCSC genome browser More...UCSCⁱ	uc001czq.4 human

Organism-specific databases

CTDⁱ	1573
DisGeNET More...DisGeNETⁱ	1573
EuPathDBⁱ	HostDB:ENSG00000134716.9
GeneCardsⁱ	CYP2J2
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:2634 CYP2J2
MIMⁱ	601258 gene
neXtProtⁱ	NX_P51589
Open Targets More...OpenTargetsⁱ	ENSG00000134716
PharmGKBⁱ	PA27112
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0156 Eukaryota COG2124 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140799
HOGENOMⁱ	HOG000036991
HOVERGENⁱ	HBG015789
InParanoidⁱ	P51589
KEGG Orthology (KO) More...KOⁱ	K07418
OMAⁱ	RTIFSCN
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0BT8
PhylomeDBⁱ	P51589
TreeFamⁱ	TF352043

Enzyme and pathway databases

BioCycⁱ	MetaCyc:HS05902-MONOMER
BRENDAⁱ	1.14.13.159 2681
Reactomeⁱ	R-HSA-211935 Fatty acids R-HSA-211981 Xenobiotics R-HSA-2142670 Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)

Miscellaneous databases

ChiTaRSⁱ	CYP2J2 human
GeneWikiⁱ	CYP2J2
GenomeRNAiⁱ	1573
Protein Ontology More...PROⁱ	PR:P51589
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000134716
CleanExⁱ	HS_CYP2J2
Genevisibleⁱ	P51589 HS

Family and domain databases

Gene3Dⁱ	1.10.630.10, 1 hit
InterProⁱ	View protein in InterPro IPR001128 Cyt_P450 IPR017972 Cyt_P450_CS IPR002401 Cyt_P450_E_grp-I IPR008071 Cyt_P450_E_grp-I_CYP2J-like IPR036396 Cyt_P450_sf
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00067 p450, 1 hit
PRINTSⁱ	PR00463 EP450I PR01688 EP450ICYP2J PR00385 P450
SUPFAMⁱ	SSF48264 SSF48264, 1 hit
PROSITEⁱ	View protein in PROSITE PS00086 CYTOCHROME_P450, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CP2J2_HUMAN
Accessionⁱ	P51589Primary (citable) accession number: P51589 Secondary accession number(s): B2RD33, Q8TF13
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	May 27, 2002
	Last modified:	June 20, 2018
	This is version 174 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P51589 (CP2J2_HUMAN)

Your basket is currently empty. i <p>When browsing through different UniProt proteins, you can use the ‘basket’ to save them, so that you can back to find or analyse them later.<p><a href='/help/basket' target='_top'>More...</a></p>

Cytochrome P450 2J2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Endoplasmic reticulum

Endoplasmic reticulum

Extracellular region or secreted

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

UniProt is an ELIXIR core data resource

Your basket is currently empty. ⁱ

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ