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Protein

Thiopurine S-methyltransferase

Gene

TPMT

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S-adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified.Curated2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by S-adenosyl-L-homocysteine (SAH).

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=18.5 µM for S-adenosyl-L-methionine (at pH 6.5 and 37 degrees Celsius)1 Publication
  2. KM=0.68 mM for 6-mercaptopurine (at pH 6.5 and 37 degrees Celsius)1 Publication
  3. KM=1.7 µM for S-adenosyl-L-methionine (at pH 7.5 and 37 degrees Celsius)1 Publication
  4. KM=0.32 mM for 6-mercaptopurine (at pH 7.5 and 37 degrees Celsius)1 Publication
  5. KM=0.20 mM for 6-thioguanine (at pH 7.5 and 37 degrees Celsius)1 Publication
  1. Vmax=1.23 nmol/sec/mg enzyme toward 6-mercaptopurine (at pH 6.5 and 37 degrees Celsius)1 Publication

pH dependencei

Optimum pH is 7.5.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei40SubstrateBy similarity1
Binding sitei69S-adenosyl-L-methionine; via carbonyl oxygen1
Binding sitei90S-adenosyl-L-methionine1
Binding sitei152S-adenosyl-L-methionine1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • drug metabolic process Source: UniProtKB
  • methylation Source: Reactome
  • nucleobase-containing compound metabolic process Source: ProtInc

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:HS06327-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.1.1.67 2681

Reactome - a knowledgebase of biological pathways and processes

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Reactomei
R-HSA-156581 Methylation
R-HSA-5578995 Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thiopurine S-methyltransferase1 Publication (EC:2.1.1.672 Publications)
Alternative name(s):
Thiopurine methyltransferase1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TPMT
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000137364.4

Human Gene Nomenclature Database

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HGNCi
HGNC:12014 TPMT

Online Mendelian Inheritance in Man (OMIM)

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MIMi
187680 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P51580

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi152R → E: Decreases affinity for 6-mercaptopurine. Slightly decreases catalytic activity. 1 Publication1

Organism-specific databases

DisGeNET

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DisGeNETi
7172

MalaCards human disease database

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MalaCardsi
TPMT
MIMi610460 phenotype

Open Targets

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OpenTargetsi
ENSG00000137364

Orphanet; a database dedicated to information on rare diseases and orphan drugs

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Orphaneti
413687 Azathioprine or 6-mercatopurine toxicity or dose selection
240863 Cisplatin toxicity

The Pharmacogenetics and Pharmacogenomics Knowledge Base

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PharmGKBi
PA356

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

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ChEMBLi
CHEMBL2500

Drug and drug target database

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DrugBanki
DB00993 Azathioprine
DB00436 Bendroflumethiazide
DB01327 Cefazolin
DB01033 Mercaptopurine
DB01250 Olsalazine
DB01021 Trichlormethiazide

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

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BioMutai
TPMT

Domain mapping of disease mutations (DMDM)

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DMDMi
1730006

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002201021 – 245Thiopurine S-methyltransferaseAdd BLAST245

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei14PhosphoserineCombined sources1
Modified residuei58N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P51580

MaxQB - The MaxQuant DataBase

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MaxQBi
P51580

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P51580

PeptideAtlas

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PeptideAtlasi
P51580

PRoteomics IDEntifications database

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PRIDEi
P51580

ProteomicsDB human proteome resource

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ProteomicsDBi
56338

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P51580

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P51580

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000137364 Expressed in 222 organ(s), highest expression level in buccal mucosa cell

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P51580 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P51580 HS

Organism-specific databases

Human Protein Atlas

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HPAi
HPA019851

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
113025, 1 interactor

STRING: functional protein association networks

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STRINGi
9606.ENSP00000312304

Chemistry databases

BindingDB database of measured binding affinities

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BindingDBi
P51580

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1245
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P51580

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P51580

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

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EvolutionaryTracei
P51580

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni29 – 40S-adenosyl-L-methionine bindingAdd BLAST12
Regioni134 – 135S-adenosyl-L-methionine binding2

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IGTR Eukaryota
ENOG4111GNF LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00390000016823

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG003037

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P51580

KEGG Orthology (KO)

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KOi
K00569

Identification of Orthologs from Complete Genome Data

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OMAi
GFHQEQG

Database of Orthologous Groups

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OrthoDBi
EOG091G0VS2

Database for complete collections of gene phylogenies

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PhylomeDBi
P51580

TreeFam database of animal gene trees

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TreeFami
TF328951

Family and domain databases

HAMAP database of protein families

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HAMAPi
MF_00812 Thiopur_methtran, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR029063 SAM-dependent_MTases
IPR025835 Thiopurine_S-MeTrfase
IPR008854 TPMT

The PANTHER Classification System

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PANTHERi
PTHR10259 PTHR10259, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05724 TPMT, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF023956 Thiopurine_S-methyltransferase, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53335 SSF53335, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51585 SAM_MT_TPMT, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P51580-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDGTRTSLDI EEYSDTEVQK NQVLTLEEWQ DKWVNGKTAF HQEQGHQLLK
60 70 80 90 100
KHLDTFLKGK SGLRVFFPLC GKAVEMKWFA DRGHSVVGVE ISELGIQEFF
110 120 130 140 150
TEQNLSYSEE PITEIPGTKV FKSSSGNISL YCCSIFDLPR TNIGKFDMIW
160 170 180 190 200
DRGALVAINP GDRKCYADTM FSLLGKKFQY LLCVLSYDPT KHPGPPFYVP
210 220 230 240
HAEIERLFGK ICNIRCLEKV DAFEERHKSW GIDCLFEKLY LLTEK
Length:245
Mass (Da):28,180
Last modified:October 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i190E781155B97BB9
GO

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB71631 differs from that shown. Reason: Erroneous initiation.Curated
The sequence AAB71632 differs from that shown. Reason: Erroneous initiation.Curated

<p>This subsection of the ‘Sequence’ section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement_in_disease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Polymorphic variations define TPMT activity levels that are variable among ethnic groups. 90% of Caucasians have high TPMT activity, 10% have intermediate activity, and 1 in 300 individuals has low activity (PubMed:10208641). These differences influence the clinical use and therapeutic efficacy of thiopurine drugs, generally used as immunosuppressants or cytotoxic drugs in conditions including leukemia, autoimmune disease and organ transplantation. Intermediate or low TPMT activity is associated with thiopurine intolerance and patients are at risk of toxicity after receiving standard doses of thiopurine drugs [MIMi:610460] (PubMed:10751626, PubMed:15819814, PubMed:16220112, PubMed:16476125, PubMed:16789994, PubMed:7862671, PubMed:8561894, PubMed:8644731, PubMed:9246020, PubMed:9336428, PubMed:9711875, PubMed:9931345, PubMed:9931346). The most prevalent TPMT alleles associated with TPMT deficiency are TPMT*2 and TPMT*3A. The proteins encoded by TPMT*2 and TPMT*3A mutant are degraded more rapidly by an ATP-dependent proteasome-mediated pathway (PubMed:9177237, PubMed:8644731).15 Publications
TPMT*3A is the most common allele in the Caucasians and American Caucasians; it is the only mutant allele found in the South West Asians; it is not found in the Chinese. TPMT*3C is common in African-Americans and is the only allele in Chinese, Japanese and Taiwanese individuals. This allele is found at a low frequency in the Caucasians. This suggests that TPMT*3C is the oldest mutation, with TPMT*3B being acquired later to form the TPMT*3A allele in the Caucasian and South West Asian populations. TPMT*2 appears to be a more recent allele, which has only been detected in Caucasians to date.3 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_00563649L → S Polymorphism; allele TPMT*5; has very low activity when expressed in a heterologous system. 2 PublicationsCorresponds to variant dbSNP:rs72552740Ensembl.1
Natural variantiVAR_00563780A → P Polymorphism; allele TPMT*2; TPMT*2 allele frequency is 0.5%; seems to be restricted to the Caucasian population; 100-fold reduction in activity; protein shows enhanced degradation. 8 PublicationsCorresponds to variant dbSNP:rs1800462EnsemblClinVar.1
Natural variantiVAR_005638154A → T Polymorphism; allele TPMT*3A and allele TPMT*3B; very low activity; protein shows enhanced degradation leading to strongly reduced protein levels. 13 PublicationsCorresponds to variant dbSNP:rs1800460EnsemblClinVar.1
Natural variantiVAR_052368179Q → H. Corresponds to variant dbSNP:rs6921269Ensembl.1
Natural variantiVAR_005639180Y → F Polymorphism; allele TPMT*6; reduced activity. 2 PublicationsCorresponds to variant dbSNP:rs75543815Ensembl.1
Natural variantiVAR_008715215R → H Polymorphism; allele TPMT*8; intermediate activity. 2 PublicationsCorresponds to variant dbSNP:rs56161402EnsemblClinVar.1
Natural variantiVAR_005640227H → Q Polymorphism; allele TPMT*7; reduced activity. 2 PublicationsCorresponds to variant dbSNP:rs72552736Ensembl.1
Natural variantiVAR_005641240Y → C Polymorphism; allele TPMT*3B and allele TPMT*3C; reduced activity; protein shows enhanced degradation. 12 PublicationsCorresponds to variant dbSNP:rs1142345EnsemblClinVar.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S62904 mRNA Translation: AAB27277.1
U12387 mRNA Translation: AAC50130.1
U30518
, U30512, U30513, U30514, U30515, U30516, U30517 Genomic DNA Translation: AAC50368.1
AF019369
, AF019364, AF019365, AF019366, AF019367, AF019368 Genomic DNA Translation: AAC51865.1
U81562 Genomic DNA Translation: AAB71625.1
U81563 Genomic DNA Translation: AAB71626.1
U81564 Genomic DNA Translation: AAB71627.1
U81565 Genomic DNA Translation: AAB71628.1
U81566 Genomic DNA Translation: AAB71629.1
U81567 Genomic DNA Translation: AAB71630.1
U81568 Genomic DNA Translation: AAB71631.1 Different initiation.
U81569 Genomic DNA Translation: AAB71632.1 Different initiation.
U81570 Genomic DNA Translation: AAB71633.1
U81571 Genomic DNA Translation: AAB71634.1
U81572 Genomic DNA Translation: AAB71635.1
U81573 Genomic DNA Translation: AAB71636.1
AB045146 Genomic DNA Translation: BAA97037.1
AL589723 Genomic DNA No translation available.
BC009596 mRNA Translation: AAH09596.1
AF035426 Genomic DNA Translation: AAC32289.1
AF021876 mRNA Translation: AAB80746.1
AF021877 mRNA Translation: AAB80747.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS4543.1

Protein sequence database of the Protein Information Resource

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PIRi
I57946

NCBI Reference Sequences

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RefSeqi
NP_000358.1, NM_000367.4
NP_001333746.1, NM_001346817.1
NP_001333747.1, NM_001346818.1

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Hs.444319

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000309983; ENSP00000312304; ENSG00000137364

Database of genes from NCBI RefSeq genomes

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GeneIDi
7172

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:7172

UCSC genome browser

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UCSCi
uc003ncm.4 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S62904 mRNA Translation: AAB27277.1
U12387 mRNA Translation: AAC50130.1
U30518
, U30512, U30513, U30514, U30515, U30516, U30517 Genomic DNA Translation: AAC50368.1
AF019369
, AF019364, AF019365, AF019366, AF019367, AF019368 Genomic DNA Translation: AAC51865.1
U81562 Genomic DNA Translation: AAB71625.1
U81563 Genomic DNA Translation: AAB71626.1
U81564 Genomic DNA Translation: AAB71627.1
U81565 Genomic DNA Translation: AAB71628.1
U81566 Genomic DNA Translation: AAB71629.1
U81567 Genomic DNA Translation: AAB71630.1
U81568 Genomic DNA Translation: AAB71631.1 Different initiation.
U81569 Genomic DNA Translation: AAB71632.1 Different initiation.
U81570 Genomic DNA Translation: AAB71633.1
U81571 Genomic DNA Translation: AAB71634.1
U81572 Genomic DNA Translation: AAB71635.1
U81573 Genomic DNA Translation: AAB71636.1
AB045146 Genomic DNA Translation: BAA97037.1
AL589723 Genomic DNA No translation available.
BC009596 mRNA Translation: AAH09596.1
AF035426 Genomic DNA Translation: AAC32289.1
AF021876 mRNA Translation: AAB80746.1
AF021877 mRNA Translation: AAB80747.1
CCDSiCCDS4543.1
PIRiI57946
RefSeqiNP_000358.1, NM_000367.4
NP_001333746.1, NM_001346817.1
NP_001333747.1, NM_001346818.1
UniGeneiHs.444319

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2BZGX-ray1.58A16-245[»]
2H11X-ray1.89A/B17-245[»]
ProteinModelPortaliP51580
SMRiP51580
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113025, 1 interactor
STRINGi9606.ENSP00000312304

Chemistry databases

BindingDBiP51580
ChEMBLiCHEMBL2500
DrugBankiDB00993 Azathioprine
DB00436 Bendroflumethiazide
DB01327 Cefazolin
DB01033 Mercaptopurine
DB01250 Olsalazine
DB01021 Trichlormethiazide

PTM databases

iPTMnetiP51580
PhosphoSitePlusiP51580

Polymorphism and mutation databases

BioMutaiTPMT
DMDMi1730006

Proteomic databases

EPDiP51580
MaxQBiP51580
PaxDbiP51580
PeptideAtlasiP51580
PRIDEiP51580
ProteomicsDBi56338

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
7172
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309983; ENSP00000312304; ENSG00000137364
GeneIDi7172
KEGGihsa:7172
UCSCiuc003ncm.4 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
7172
DisGeNETi7172
EuPathDBiHostDB:ENSG00000137364.4

GeneCards: human genes, protein and diseases

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GeneCardsi
TPMT
HGNCiHGNC:12014 TPMT
HPAiHPA019851
MalaCardsiTPMT
MIMi187680 gene
610460 phenotype
neXtProtiNX_P51580
OpenTargetsiENSG00000137364
Orphaneti413687 Azathioprine or 6-mercatopurine toxicity or dose selection
240863 Cisplatin toxicity
PharmGKBiPA356

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiENOG410IGTR Eukaryota
ENOG4111GNF LUCA
GeneTreeiENSGT00390000016823
HOVERGENiHBG003037
InParanoidiP51580
KOiK00569
OMAiGFHQEQG
OrthoDBiEOG091G0VS2
PhylomeDBiP51580
TreeFamiTF328951

Enzyme and pathway databases

BioCyciMetaCyc:HS06327-MONOMER
BRENDAi2.1.1.67 2681
ReactomeiR-HSA-156581 Methylation
R-HSA-5578995 Defective TPMT causes Thiopurine S-methyltransferase deficiency (TPMT deficiency)

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
TPMT human
EvolutionaryTraceiP51580

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Thiopurine_methyltransferase

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
7172

Protein Ontology

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PROi
PR:P51580

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000137364 Expressed in 222 organ(s), highest expression level in buccal mucosa cell
ExpressionAtlasiP51580 baseline and differential
GenevisibleiP51580 HS

Family and domain databases

HAMAPiMF_00812 Thiopur_methtran, 1 hit
InterProiView protein in InterPro
IPR029063 SAM-dependent_MTases
IPR025835 Thiopurine_S-MeTrfase
IPR008854 TPMT
PANTHERiPTHR10259 PTHR10259, 1 hit
PfamiView protein in Pfam
PF05724 TPMT, 1 hit
PIRSFiPIRSF023956 Thiopurine_S-methyltransferase, 1 hit
SUPFAMiSSF53335 SSF53335, 1 hit
PROSITEiView protein in PROSITE
PS51585 SAM_MT_TPMT, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTPMT_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P51580
Secondary accession number(s): O14806
, O15423, O15424, O15425, O15426, O15515, O15548, O43213, Q5VUK6, Q9UBE6, Q9UBT8, Q9UE62
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: December 5, 2018
This is version 184 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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