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Protein

P2X purinoceptor 6

Gene

P2rx6

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.

GO - Molecular functioni

GO - Biological processi

  • protein heterooligomerization Source: RGD
  • response to ATP Source: InterPro

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-139853 Elevation of cytosolic Ca2+ levels
R-RNO-418346 Platelet homeostasis

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 6
Short name:
P2X6
Alternative name(s):
ATP receptor
P2XM
Purinergic receptor
Purinergic receptor P2X-like 1
Gene namesi
Name:P2rx6
Synonyms:P2rxl1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi3243 P2rx6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 41CytoplasmicSequence analysisAdd BLAST41
Transmembranei42 – 62Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini63 – 335ExtracellularSequence analysisAdd BLAST273
Transmembranei336 – 356Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini357 – 389CytoplasmicSequence analysisAdd BLAST33

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2122
GuidetoPHARMACOLOGYi483

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001615591 – 389P2X purinoceptor 6Add BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei66PhosphotyrosineBy similarity1
Disulfide bondi129 ↔ 179By similarity
Disulfide bondi140 ↔ 163By similarity
Disulfide bondi146 ↔ 173By similarity
Glycosylationi167N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi212N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi230 ↔ 240By similarity
Disulfide bondi274 ↔ 283By similarity

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP51579
PRIDEiP51579

Expressioni

Gene expression databases

BgeeiENSRNOG00000001873

Interactioni

Subunit structurei

Unlike most P2XRs, P2RX6 does not seem to form homotrimers or heterotrimers.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
P2rx2P496534EBI-9511515,EBI-9511543

Protein-protein interaction databases

IntActiP51579, 2 interactors
MINTiP51579
STRINGi10116.ENSRNOP00000002558

Chemistry databases

BindingDBiP51579

Structurei

3D structure databases

SMRiP51579
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
GeneTreeiENSGT00390000016028
HOGENOMiHOG000232042
HOVERGENiHBG053086
InParanoidiP51579
KOiK05221
OMAiHYSFQLQ
OrthoDBiEOG091G0A2U
PhylomeDBiP51579
TreeFamiTF328633

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003049 P2X6_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 1 hit
PTHR10125:SF21 PTHR10125:SF21, 1 hit
PfamiView protein in Pfam
PF00864 P2X_receptor, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01313 P2X6RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

Sequencei

Sequence statusi: Complete.

P51579-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQLQPAGTGS MASAVAAALV SWGFLDYKTE KYVMTRNCWV GISQRLLQLG
60 70 80 90 100
VVVYVIGWAL LAKKGYQEWD MDPQISVITK LKGVSVTQVK ELEKRLWDVA
110 120 130 140 150
DFVRPSQGEN VFFLVTNFLV TPAQVQGRCP EHPSVPLANC WADEDCPEGE
160 170 180 190 200
MGTYSHGIKT GQCVAFNGTH RTCEIWSWCP VESSAVPRKP LLAQAKNFTL
210 220 230 240 250
FIKNTVTFNK FNFSRTNALD TWDNTYFKYC LYDSLSSPYC PVFRIGDLVA
260 270 280 290 300
MTGGDFEDLA LLGGAVGINI HWDCNLDTKG SDCSPQYSFQ LQERGYNFRT
310 320 330 340 350
ANYWWAASGV ESRSLLKLYG IRFDILVTGQ AGKFALIPTA ITVGTGAAWL
360 370 380
GMVTFLCDLL LLYVDREAGF YWRTKYEEAR APKATTNSA
Length:389
Mass (Da):43,422
Last modified:January 31, 2018 - v2
Checksum:i1AE683A0191B6A0B
GO

Sequence cautioni

The sequence CAA63053 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA66044 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97376 mRNA Translation: CAA66044.1 Different initiation.
AABR07034750 Genomic DNA No translation available.
CH473999 Genomic DNA Translation: EDL77896.1
X92070 mRNA Translation: CAA63053.1 Different initiation.
PIRiJC4843
RefSeqiNP_036853.2, NM_012721.2
UniGeneiRn.10258

Genome annotation databases

EnsembliENSRNOT00000002558; ENSRNOP00000002558; ENSRNOG00000001873
GeneIDi25041
KEGGirno:25041

Similar proteinsi

Entry informationi

Entry nameiP2RX6_RAT
AccessioniPrimary (citable) accession number: P51579
Secondary accession number(s): R9PXR5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 31, 2018
Last modified: May 23, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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