UniProtKB - P51579 (P2RX6_RAT)
Protein
P2X purinoceptor 6
Gene
P2rx6
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor for ATP that acts as a ligand-gated ion channel.
GO - Molecular functioni
- ATP binding Source: InterPro
- extracellularly ATP-gated cation channel activity Source: RGD
- protein-containing complex binding Source: RGD
- purinergic nucleotide receptor activity Source: InterPro
GO - Biological processi
- response to ATP Source: InterPro
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-139853, Elevation of cytosolic Ca2+ levels R-RNO-418346, Platelet homeostasis |
Names & Taxonomyi
Protein namesi | Recommended name: P2X purinoceptor 6Short name: P2X6 Alternative name(s): ATP receptor P2XM Purinergic receptor Purinergic receptor P2X-like 1 |
Gene namesi | Name:P2rx6 Synonyms:P2rxl1 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 3243, P2rx6 |
Subcellular locationi
Other locations
Nucleus
- integral component of nuclear inner membrane Source: GO_Central
Plasma Membrane
- integral component of plasma membrane Source: InterPro
Other locations
- cell junction Source: RGD
- cytoplasm Source: RGD
- dendritic spine Source: RGD
- membrane Source: RGD
- neuronal cell body Source: RGD
- postsynaptic density Source: RGD
- receptor complex Source: RGD
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 41 | CytoplasmicSequence analysisAdd BLAST | 41 | |
Transmembranei | 42 – 62 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 63 – 335 | ExtracellularSequence analysisAdd BLAST | 273 | |
Transmembranei | 336 – 356 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 357 – 389 | CytoplasmicSequence analysisAdd BLAST | 33 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL2122 |
DrugCentrali | P51579 |
GuidetoPHARMACOLOGYi | 483 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000161559 | 1 – 389 | P2X purinoceptor 6Add BLAST | 389 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 66 | PhosphotyrosineBy similarity | 1 | |
Disulfide bondi | 129 ↔ 179 | By similarity | ||
Disulfide bondi | 140 ↔ 163 | By similarity | ||
Disulfide bondi | 146 ↔ 173 | By similarity | ||
Glycosylationi | 167 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 197 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 212 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 230 ↔ 240 | By similarity | ||
Disulfide bondi | 274 ↔ 283 | By similarity |
Post-translational modificationi
N-glycosylated.By similarity
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
PaxDbi | P51579 |
PTM databases
GlyGeni | P51579, 3 sites |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000001873, Expressed in quadriceps femoris and 19 other tissues |
Interactioni
Subunit structurei
Unlike most P2XRs, P2RX6 does not seem to form homotrimers or heterotrimers.
By similarityBinary interactionsi
P51579
With | #Exp. | IntAct |
---|---|---|
P2rx2 [P49653] | 4 | EBI-9511515,EBI-9511543 |
Protein-protein interaction databases
IntActi | P51579, 2 interactors |
MINTi | P51579 |
STRINGi | 10116.ENSRNOP00000002558 |
Family & Domainsi
Sequence similaritiesi
Belongs to the P2X receptor family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502R480, Eukaryota |
GeneTreei | ENSGT01010000222414 |
InParanoidi | P51579 |
OMAi | ATHSTCE |
OrthoDBi | 1128763at2759 |
PhylomeDBi | P51579 |
TreeFami | TF328633 |
Family and domain databases
Gene3Di | 2.60.490.10, 1 hit |
InterProi | View protein in InterPro IPR003049, P2X6_purnocptor IPR027309, P2X_extracellular_dom_sf IPR001429, P2X_purnocptor |
PANTHERi | PTHR10125:SF21, PTHR10125:SF21, 1 hit |
PIRSFi | PIRSF005713, P2X_purinoceptor, 1 hit |
PRINTSi | PR01313, P2X6RECEPTOR PR01307, P2XRECEPTOR |
TIGRFAMsi | TIGR00863, P2X, 1 hit |
PROSITEi | View protein in PROSITE PS01212, P2X_RECEPTOR, 1 hit |
i Sequence
Sequence statusi: Complete.
P51579-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQLQPAGTGS MASAVAAALV SWGFLDYKTE KYVMTRNCWV GISQRLLQLG
60 70 80 90 100
VVVYVIGWAL LAKKGYQEWD MDPQISVITK LKGVSVTQVK ELEKRLWDVA
110 120 130 140 150
DFVRPSQGEN VFFLVTNFLV TPAQVQGRCP EHPSVPLANC WADEDCPEGE
160 170 180 190 200
MGTYSHGIKT GQCVAFNGTH RTCEIWSWCP VESSAVPRKP LLAQAKNFTL
210 220 230 240 250
FIKNTVTFNK FNFSRTNALD TWDNTYFKYC LYDSLSSPYC PVFRIGDLVA
260 270 280 290 300
MTGGDFEDLA LLGGAVGINI HWDCNLDTKG SDCSPQYSFQ LQERGYNFRT
310 320 330 340 350
ANYWWAASGV ESRSLLKLYG IRFDILVTGQ AGKFALIPTA ITVGTGAAWL
360 370 380
GMVTFLCDLL LLYVDREAGF YWRTKYEEAR APKATTNSA
Sequence cautioni
The sequence CAA63053 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAA66044 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97376 mRNA Translation: CAA66044.1 Different initiation. AABR07034750 Genomic DNA No translation available. CH473999 Genomic DNA Translation: EDL77896.1 X92070 mRNA Translation: CAA63053.1 Different initiation. |
PIRi | JC4843 |
RefSeqi | NP_036853.2, NM_012721.2 |
Genome annotation databases
Ensembli | ENSRNOT00000002558; ENSRNOP00000002558; ENSRNOG00000001873 |
GeneIDi | 25041 |
KEGGi | rno:25041 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X97376 mRNA Translation: CAA66044.1 Different initiation. AABR07034750 Genomic DNA No translation available. CH473999 Genomic DNA Translation: EDL77896.1 X92070 mRNA Translation: CAA63053.1 Different initiation. |
PIRi | JC4843 |
RefSeqi | NP_036853.2, NM_012721.2 |
3D structure databases
SMRi | P51579 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P51579, 2 interactors |
MINTi | P51579 |
STRINGi | 10116.ENSRNOP00000002558 |
Chemistry databases
ChEMBLi | CHEMBL2122 |
DrugCentrali | P51579 |
GuidetoPHARMACOLOGYi | 483 |
PTM databases
GlyGeni | P51579, 3 sites |
Proteomic databases
PaxDbi | P51579 |
Genome annotation databases
Ensembli | ENSRNOT00000002558; ENSRNOP00000002558; ENSRNOG00000001873 |
GeneIDi | 25041 |
KEGGi | rno:25041 |
Organism-specific databases
CTDi | 9127 |
RGDi | 3243, P2rx6 |
Phylogenomic databases
eggNOGi | ENOG502R480, Eukaryota |
GeneTreei | ENSGT01010000222414 |
InParanoidi | P51579 |
OMAi | ATHSTCE |
OrthoDBi | 1128763at2759 |
PhylomeDBi | P51579 |
TreeFami | TF328633 |
Enzyme and pathway databases
Reactomei | R-RNO-139853, Elevation of cytosolic Ca2+ levels R-RNO-418346, Platelet homeostasis |
Miscellaneous databases
PROi | PR:P51579 |
Gene expression databases
Bgeei | ENSRNOG00000001873, Expressed in quadriceps femoris and 19 other tissues |
Family and domain databases
Gene3Di | 2.60.490.10, 1 hit |
InterProi | View protein in InterPro IPR003049, P2X6_purnocptor IPR027309, P2X_extracellular_dom_sf IPR001429, P2X_purnocptor |
PANTHERi | PTHR10125:SF21, PTHR10125:SF21, 1 hit |
PIRSFi | PIRSF005713, P2X_purinoceptor, 1 hit |
PRINTSi | PR01313, P2X6RECEPTOR PR01307, P2XRECEPTOR |
TIGRFAMsi | TIGR00863, P2X, 1 hit |
PROSITEi | View protein in PROSITE PS01212, P2X_RECEPTOR, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | P2RX6_RAT | |
Accessioni | P51579Primary (citable) accession number: P51579 Secondary accession number(s): R9PXR5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | January 31, 2018 | |
Last modified: | December 2, 2020 | |
This is version 147 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families