P2rx6

Functionⁱ

Receptor for ATP that acts as a ligand-gated ion channel.

GO - Molecular functionⁱ

ATP binding Source: InterPro
extracellularly ATP-gated cation channel activity
Source: RGD
Inferred from direct assayⁱ
- 8786426
purinergic nucleotide receptor activity Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

protein heterooligomerization
Source: RGD
Inferred from direct assayⁱ
- 17449665
response to ATP Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Ligand-gated ion channel, Receptor
Biological process	Ion transport, Transport

Enzyme and pathway databases

Reactomeⁱ	R-RNO-139853 Elevation of cytosolic Ca2+ levels R-RNO-418346 Platelet homeostasis

Reactomeⁱ

R-RNO-139853 Elevation of cytosolic Ca2+ levels
R-RNO-418346 Platelet homeostasis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: P2X purinoceptor 6 Short name: P2X6 Alternative name(s): ATP receptor P2XM Purinergic receptor Purinergic receptor P2X-like 1
Gene namesⁱ	Name:P2rx6 Synonyms:P2rxl1
Organismⁱ	Rattus norvegicus (Rat)
Taxonomic identifierⁱ	10116 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus
Proteomesⁱ	UP000002494 Componentⁱ: Chromosome 11

Organism-specific databases

Rat genome database More...RGDⁱ	3243 P2rx6

RGDⁱ

3243 P2rx6

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 41	CytoplasmicSequence analysisAdd BLAST	41
Transmembraneⁱ	42 – 62	Helical; Name=1Sequence analysisAdd BLAST	21
Topological domainⁱ	63 – 335	ExtracellularSequence analysisAdd BLAST	273
Transmembraneⁱ	336 – 356	Helical; Name=2Sequence analysisAdd BLAST	21
Topological domainⁱ	357 – 389	CytoplasmicSequence analysisAdd BLAST	33

Keywords - Cellular componentⁱ

Membrane

Pathology & Biotechⁱ

Chemistry databases

ChEMBLⁱ	CHEMBL2122
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	483

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000161559	1 – 389	P2X purinoceptor 6Add BLAST		389

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	66	PhosphotyrosineBy similarity	1
Disulfide bondⁱ	129 ↔ 179	By similarity
Disulfide bondⁱ	140 ↔ 163	By similarity
Disulfide bondⁱ	146 ↔ 173	By similarity
Glycosylationⁱ	167	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	197	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	212	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	230 ↔ 240	By similarity
Disulfide bondⁱ	274 ↔ 283	By similarity

Post-translational modificationⁱ

N-glycosylated.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P51579
PRIDEⁱ	P51579

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSRNOG00000001873

Bgeeⁱ

ENSRNOG00000001873

Interactionⁱ

Subunit structureⁱ

Unlike most P2XRs, P2RX6 does not seem to form homotrimers or heterotrimers.By similarity

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
P2rx2	P49653	4	EBI-9511515,EBI-9511543

With

Entry

#Exp.

IntAct

Notes

P2rx2

P49653

4

EBI-9511515,EBI-9511543

Protein-protein interaction databases

IntActⁱ	P51579, 2 interactors
Molecular INTeraction database More...MINTⁱ	P51579
STRINGⁱ	10116.ENSRNOP00000002558

Chemistry databases

BindingDBⁱ

P51579

Structureⁱ

3D structure databases

SMRⁱ	P51579
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the P2X receptor family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFJF Eukaryota ENOG410XR0C LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016028
HOGENOMⁱ	HOG000232042
HOVERGENⁱ	HBG053086
InParanoidⁱ	P51579
KEGG Orthology (KO) More...KOⁱ	K05221
OMAⁱ	HYSFQLQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A2U
PhylomeDBⁱ	P51579
TreeFamⁱ	TF328633

Family and domain databases

Gene3Dⁱ	2.60.490.10, 1 hit
InterProⁱ	View protein in InterPro IPR003049 P2X6_purnocptor IPR027309 P2X_extracellular_dom_sf IPR001429 P2X_purnocptor
PANTHERⁱ	PTHR10125 PTHR10125, 1 hit PTHR10125:SF21 PTHR10125:SF21, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00864 P2X_receptor, 1 hit
PIRSFⁱ	PIRSF005713 P2X_purinoceptor, 1 hit
PRINTSⁱ	PR01313 P2X6RECEPTOR PR01307 P2XRECEPTOR
TIGRFAMsⁱ	TIGR00863 P2X, 1 hit
PROSITEⁱ	View protein in PROSITE PS01212 P2X_RECEPTOR, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P51579-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQLQPAGTGS MASAVAAALV SWGFLDYKTE KYVMTRNCWV GISQRLLQLG 
        60         70         80         90        100
VVVYVIGWAL LAKKGYQEWD MDPQISVITK LKGVSVTQVK ELEKRLWDVA 
       110        120        130        140        150
DFVRPSQGEN VFFLVTNFLV TPAQVQGRCP EHPSVPLANC WADEDCPEGE 
       160        170        180        190        200
MGTYSHGIKT GQCVAFNGTH RTCEIWSWCP VESSAVPRKP LLAQAKNFTL 
       210        220        230        240        250
FIKNTVTFNK FNFSRTNALD TWDNTYFKYC LYDSLSSPYC PVFRIGDLVA 
       260        270        280        290        300
MTGGDFEDLA LLGGAVGINI HWDCNLDTKG SDCSPQYSFQ LQERGYNFRT 
       310        320        330        340        350
ANYWWAASGV ESRSLLKLYG IRFDILVTGQ AGKFALIPTA ITVGTGAAWL 
       360        370        380 
GMVTFLCDLL LLYVDREAGF YWRTKYEEAR APKATTNSA

Length:389

Mass (Da):43,422

Last modified:January 31, 2018 - v2

Checksum:ⁱ1AE683A0191B6A0B

GO

Sequence cautionⁱ

The sequence CAA63053 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

The sequence CAA66044 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X97376 mRNA Translation: CAA66044.1 Different initiation. AABR07034750 Genomic DNA No translation available. CH473999 Genomic DNA Translation: EDL77896.1 X92070 mRNA Translation: CAA63053.1 Different initiation.
PIRⁱ	JC4843
NCBI Reference Sequences More...RefSeqⁱ	NP_036853.2, NM_012721.2
UniGeneⁱ	Rn.10258

Genome annotation databases

Ensemblⁱ	ENSRNOT00000002558; ENSRNOP00000002558; ENSRNOG00000001873
GeneIDⁱ	25041
KEGGⁱ	rno:25041

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P51579	P2X purinoceptor 6		MOUSE		389
UPI000A308CB6		MUSPA		389
UPI000A3178B2		MUSCR		389
UPI00038C17A7		MICOH		379
p2X purinoceptor		CRIGR		379
+1

Protein	Similar proteins		Species	Score	Length
P51579	P2X purinoceptor 6		MOUSE		389
UPI000A308CB6		MUSPA		389
UPI000A3178B2		MUSCR		389
UPI00042AE6DF		PERMB		379
p2X purinoceptor		CRIGR		379
+65

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X97376 mRNA Translation: CAA66044.1 Different initiation. AABR07034750 Genomic DNA No translation available. CH473999 Genomic DNA Translation: EDL77896.1 X92070 mRNA Translation: CAA63053.1 Different initiation.
PIRⁱ	JC4843
NCBI Reference Sequences More...RefSeqⁱ	NP_036853.2, NM_012721.2
UniGeneⁱ	Rn.10258

3D structure databases

SMRⁱ	P51579
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

IntActⁱ	P51579, 2 interactors
Molecular INTeraction database More...MINTⁱ	P51579
STRINGⁱ	10116.ENSRNOP00000002558

Chemistry databases

BindingDBⁱ	P51579
ChEMBLⁱ	CHEMBL2122
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	483

Proteomic databases

PaxDbⁱ	P51579
PRIDEⁱ	P51579

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSRNOT00000002558; ENSRNOP00000002558; ENSRNOG00000001873
GeneIDⁱ	25041
KEGGⁱ	rno:25041

Organism-specific databases

CTDⁱ	9127
Rat genome database More...RGDⁱ	3243 P2rx6

Phylogenomic databases

eggNOGⁱ	ENOG410IFJF Eukaryota ENOG410XR0C LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016028
HOGENOMⁱ	HOG000232042
HOVERGENⁱ	HBG053086
InParanoidⁱ	P51579
KEGG Orthology (KO) More...KOⁱ	K05221
OMAⁱ	HYSFQLQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A2U
PhylomeDBⁱ	P51579
TreeFamⁱ	TF328633

Enzyme and pathway databases

Reactomeⁱ	R-RNO-139853 Elevation of cytosolic Ca2+ levels R-RNO-418346 Platelet homeostasis

Reactomeⁱ

R-RNO-139853 Elevation of cytosolic Ca2+ levels
R-RNO-418346 Platelet homeostasis

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P51579

PROⁱ

PR:P51579

Gene expression databases

Bgeeⁱ	ENSRNOG00000001873

Bgeeⁱ

ENSRNOG00000001873

Family and domain databases

Gene3Dⁱ	2.60.490.10, 1 hit
InterProⁱ	View protein in InterPro IPR003049 P2X6_purnocptor IPR027309 P2X_extracellular_dom_sf IPR001429 P2X_purnocptor
PANTHERⁱ	PTHR10125 PTHR10125, 1 hit PTHR10125:SF21 PTHR10125:SF21, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00864 P2X_receptor, 1 hit
PIRSFⁱ	PIRSF005713 P2X_purinoceptor, 1 hit
PRINTSⁱ	PR01313 P2X6RECEPTOR PR01307 P2XRECEPTOR
TIGRFAMsⁱ	TIGR00863 P2X, 1 hit
PROSITEⁱ	View protein in PROSITE PS01212 P2X_RECEPTOR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	P2RX6_RAT
Accessionⁱ	P51579Primary (citable) accession number: P51579 Secondary accession number(s): R9PXR5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	January 31, 2018
	Last modified:	May 23, 2018
	This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

UniProtKB

UniParc

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Proteomes

Annotation systems

Supporting data

UniProtKB - P51579 (P2RX6_RAT)

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P2X purinoceptor 6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Nucleus

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ