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UniProtKB - P51578 (P2RX5_RAT)
Protein
P2X purinoceptor 5
Gene
P2rx5
Organism
Rattus norvegicus (Rat)
Status
Functioni
Receptor for ATP that acts as a ligand-gated ion channel.
GO - Molecular functioni
- ATP binding Source: RGD
- extracellularly ATP-gated cation channel activity Source: RGD
- identical protein binding Source: RGD
- purinergic nucleotide receptor activity Source: InterPro
- voltage-gated ion channel activity Source: RGD
GO - Biological processi
- cation transmembrane transport Source: RGD
- cation transport Source: RGD
- positive regulation of calcium ion import across plasma membrane Source: RGD
- regulation of skeletal muscle tissue regeneration Source: RGD
- response to ATP Source: RGD
- response to calcium ion Source: RGD
- response to pH Source: RGD
- response to zinc ion Source: RGD
- skeletal muscle tissue growth Source: RGD
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel, Receptor |
Biological process | Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-RNO-139853, Elevation of cytosolic Ca2+ levels R-RNO-418346, Platelet homeostasis |
Names & Taxonomyi
Protein namesi | Recommended name: P2X purinoceptor 5Short name: P2X5 Alternative name(s): ATP receptor Purinergic receptor |
Gene namesi | Name:P2rx5 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 620256, P2rx5 |
Subcellular locationi
Other locations
Nucleus
- integral component of nuclear inner membrane Source: GO_Central
Plasma Membrane
- integral component of plasma membrane Source: InterPro
- plasma membrane Source: RGD
Other locations
- postsynapse Source: GOC
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 30 | CytoplasmicSequence analysisAdd BLAST | 30 | |
Transmembranei | 31 – 51 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 52 – 341 | ExtracellularSequence analysisAdd BLAST | 290 | |
Transmembranei | 342 – 362 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 363 – 455 | CytoplasmicSequence analysisAdd BLAST | 93 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Chemistry databases
ChEMBLi | CHEMBL2495 |
DrugCentrali | P51578 |
GuidetoPHARMACOLOGYi | 482 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000161556 | 1 – 455 | P2X purinoceptor 5Add BLAST | 455 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 77 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 118 ↔ 169 | By similarity | ||
Disulfide bondi | 129 ↔ 152 | By similarity | ||
Disulfide bondi | 135 ↔ 163 | By similarity | ||
Glycosylationi | 157 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 202 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 220 ↔ 229 | By similarity | ||
Disulfide bondi | 263 ↔ 272 | By similarity |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P51578 |
PTM databases
GlyGeni | P51578, 3 sites |
Expressioni
Tissue specificityi
Predominantly expressed in heart but are also present in brain, spinal cord and adrenal gland.
Interactioni
Subunit structurei
Functional P2XRs are organized as homomeric and heteromeric trimers.
By similarityGO - Molecular functioni
- identical protein binding Source: RGD
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000026156 |
Chemistry databases
BindingDBi | P51578 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 384 – 422 | DisorderedSequence analysisAdd BLAST | 39 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 384 – 410 | Basic and acidic residuesSequence analysisAdd BLAST | 27 |
Sequence similaritiesi
Belongs to the P2X receptor family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QSUI, Eukaryota |
InParanoidi | P51578 |
OrthoDBi | 1128763at2759 |
PhylomeDBi | P51578 |
Family and domain databases
Gene3Di | 2.60.490.10, 1 hit |
InterProi | View protein in InterPro IPR003048, P2X5_purnocptor IPR027309, P2X_extracellular_dom_sf IPR001429, P2X_purnocptor |
PANTHERi | PTHR10125:SF12, PTHR10125:SF12, 1 hit |
PIRSFi | PIRSF005713, P2X_purinoceptor, 1 hit |
PRINTSi | PR01312, P2X5RECEPTOR PR01307, P2XRECEPTOR |
TIGRFAMsi | TIGR00863, P2X, 1 hit |
PROSITEi | View protein in PROSITE PS01212, P2X_RECEPTOR, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P51578-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGQAAWKGFV LSLFDYKTAK FVVAKSKKVG LLYRVLQLII LLYLLIWVFL
60 70 80 90 100
IKKSYQDIDT SLQSAVVTKV KGVAYTNTTM LGERLWDVAD FVIPSQGENV
110 120 130 140 150
FFVVTNLIVT PNQRQGICAE REGIPDGECS EDDDCHAGES VVAGHGLKTG
160 170 180 190 200
RCLRVGNSTR GTCEIFAWCP VETKSMPTDP LLKDAESFTI SIKNFIRFPK
210 220 230 240 250
FNFSKANVLE TDNKHFLKTC HFSSTNLYCP IFRLGSIVRW AGADFQDIAL
260 270 280 290 300
KGGVIGIYIE WDCDLDKAAS KCNPHYYFNR LDNKHTHSIS SGYNFRFARY
310 320 330 340 350
YRDPNGVEFR DLMKAYGIRF DVIVNGKAGK FSIIPTVINI GSGLALMGAG
360 370 380 390 400
AFFCDLVLIY LIRKSEFYRD KKFEKVRGQK EDANVEVEAN EMEQERPEDE
410 420 430 440 450
PLERVRQDEQ SQELAQSGRK QNSNCQVLLE PARFGLRENA IVNVKQSQIL
HPVKT
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketG3V8I0 | G3V8I0_RAT | P2X purinoceptor | P2rx5 rCG_35401 | 455 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 191 | S → F in CAA65993 (PubMed:8690069).Curated | 1 | |
Sequence conflicti | 396 | R → Q in CAA65993 (PubMed:8690069).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X92069 mRNA Translation: CAA63052.1 X97328 mRNA Translation: CAA65993.1 |
PIRi | S71344 |
RefSeqi | NP_542958.2, NM_080780.2 |
Genome annotation databases
GeneIDi | 113995 |
KEGGi | rno:113995 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X92069 mRNA Translation: CAA63052.1 X97328 mRNA Translation: CAA65993.1 |
PIRi | S71344 |
RefSeqi | NP_542958.2, NM_080780.2 |
3D structure databases
SMRi | P51578 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000026156 |
Chemistry databases
BindingDBi | P51578 |
ChEMBLi | CHEMBL2495 |
DrugCentrali | P51578 |
GuidetoPHARMACOLOGYi | 482 |
PTM databases
GlyGeni | P51578, 3 sites |
Proteomic databases
PaxDbi | P51578 |
Genome annotation databases
GeneIDi | 113995 |
KEGGi | rno:113995 |
Organism-specific databases
CTDi | 5026 |
RGDi | 620256, P2rx5 |
Phylogenomic databases
eggNOGi | ENOG502QSUI, Eukaryota |
InParanoidi | P51578 |
OrthoDBi | 1128763at2759 |
PhylomeDBi | P51578 |
Enzyme and pathway databases
Reactomei | R-RNO-139853, Elevation of cytosolic Ca2+ levels R-RNO-418346, Platelet homeostasis |
Miscellaneous databases
PROi | PR:P51578 |
Family and domain databases
Gene3Di | 2.60.490.10, 1 hit |
InterProi | View protein in InterPro IPR003048, P2X5_purnocptor IPR027309, P2X_extracellular_dom_sf IPR001429, P2X_purnocptor |
PANTHERi | PTHR10125:SF12, PTHR10125:SF12, 1 hit |
PIRSFi | PIRSF005713, P2X_purinoceptor, 1 hit |
PRINTSi | PR01312, P2X5RECEPTOR PR01307, P2XRECEPTOR |
TIGRFAMsi | TIGR00863, P2X, 1 hit |
PROSITEi | View protein in PROSITE PS01212, P2X_RECEPTOR, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | P2RX5_RAT | |
Accessioni | P51578Primary (citable) accession number: P51578 Secondary accession number(s): Q64613 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 133 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families