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Protein

P2X purinoceptor 5

Gene

P2rx5

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.

GO - Molecular functioni

GO - Biological processi

  • cation transport Source: GO_Central
  • ion transmembrane transport Source: GO_Central
  • neuronal action potential Source: RGD
  • protein homooligomerization Source: RGD
  • regulation of skeletal muscle tissue regeneration Source: RGD
  • response to ATP Source: InterPro
  • skeletal muscle tissue growth Source: RGD

Keywordsi

Molecular functionIon channel, Ligand-gated ion channel, Receptor
Biological processIon transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptor 5
Short name:
P2X5
Alternative name(s):
ATP receptor
Purinergic receptor
Gene namesi
Name:P2rx5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi620256 P2rx5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 30CytoplasmicSequence analysisAdd BLAST30
Transmembranei31 – 51Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini52 – 341ExtracellularSequence analysisAdd BLAST290
Transmembranei342 – 362Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini363 – 455CytoplasmicSequence analysisAdd BLAST93

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2495
GuidetoPHARMACOLOGYi482

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001615561 – 455P2X purinoceptor 5Add BLAST455

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi77N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi118 ↔ 169By similarity
Disulfide bondi129 ↔ 152By similarity
Disulfide bondi135 ↔ 163By similarity
Glycosylationi157N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi202N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi220 ↔ 229By similarity
Disulfide bondi263 ↔ 272By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP51578
PRIDEiP51578

Expressioni

Tissue specificityi

Predominantly expressed in heart but are also present in brain, spinal cord and adrenal gland.

Interactioni

Subunit structurei

Functional P2XRs are organized as homomeric and heteromeric trimers.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026156

Chemistry databases

BindingDBiP51578

Structurei

3D structure databases

SMRiP51578
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the P2X receptor family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
HOGENOMiHOG000232042
HOVERGENiHBG053086
InParanoidiP51578
KOiK05219
PhylomeDBiP51578

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003048 P2X5_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 1 hit
PTHR10125:SF12 PTHR10125:SF12, 1 hit
PfamiView protein in Pfam
PF00864 P2X_receptor, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01312 P2X5RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P51578-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQAAWKGFV LSLFDYKTAK FVVAKSKKVG LLYRVLQLII LLYLLIWVFL
60 70 80 90 100
IKKSYQDIDT SLQSAVVTKV KGVAYTNTTM LGERLWDVAD FVIPSQGENV
110 120 130 140 150
FFVVTNLIVT PNQRQGICAE REGIPDGECS EDDDCHAGES VVAGHGLKTG
160 170 180 190 200
RCLRVGNSTR GTCEIFAWCP VETKSMPTDP LLKDAESFTI SIKNFIRFPK
210 220 230 240 250
FNFSKANVLE TDNKHFLKTC HFSSTNLYCP IFRLGSIVRW AGADFQDIAL
260 270 280 290 300
KGGVIGIYIE WDCDLDKAAS KCNPHYYFNR LDNKHTHSIS SGYNFRFARY
310 320 330 340 350
YRDPNGVEFR DLMKAYGIRF DVIVNGKAGK FSIIPTVINI GSGLALMGAG
360 370 380 390 400
AFFCDLVLIY LIRKSEFYRD KKFEKVRGQK EDANVEVEAN EMEQERPEDE
410 420 430 440 450
PLERVRQDEQ SQELAQSGRK QNSNCQVLLE PARFGLRENA IVNVKQSQIL

HPVKT
Length:455
Mass (Da):51,479
Last modified:October 1, 1996 - v1
Checksum:iD4405BE440490F70
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V8I0G3V8I0_RAT
P2X purinoceptor
P2rx5 rCG_35401
455Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti191S → F in CAA65993 (PubMed:8690069).Curated1
Sequence conflicti396R → Q in CAA65993 (PubMed:8690069).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92069 mRNA Translation: CAA63052.1
X97328 mRNA Translation: CAA65993.1
PIRiS71344
RefSeqiNP_542958.2, NM_080780.2
UniGeneiRn.10257

Genome annotation databases

GeneIDi113995
KEGGirno:113995

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X92069 mRNA Translation: CAA63052.1
X97328 mRNA Translation: CAA65993.1
PIRiS71344
RefSeqiNP_542958.2, NM_080780.2
UniGeneiRn.10257

3D structure databases

SMRiP51578
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000026156

Chemistry databases

BindingDBiP51578
ChEMBLiCHEMBL2495
GuidetoPHARMACOLOGYi482

Proteomic databases

PaxDbiP51578
PRIDEiP51578

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi113995
KEGGirno:113995

Organism-specific databases

CTDi5026
RGDi620256 P2rx5

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
HOGENOMiHOG000232042
HOVERGENiHBG053086
InParanoidiP51578
KOiK05219
PhylomeDBiP51578

Miscellaneous databases

PROiPR:P51578

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003048 P2X5_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 1 hit
PTHR10125:SF12 PTHR10125:SF12, 1 hit
PfamiView protein in Pfam
PF00864 P2X_receptor, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01312 P2X5RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiP2RX5_RAT
AccessioniPrimary (citable) accession number: P51578
Secondary accession number(s): Q64613
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: November 7, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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