UniProtKB - P51572 (BAP31_HUMAN)
B-cell receptor-associated protein 31
BCAP31
Functioni
GO - Molecular functioni
- MHC class I protein binding Source: Ensembl
- protein-containing complex binding Source: Ensembl
GO - Biological processi
- antigen processing and presentation of peptide antigen via MHC class I Source: Reactome
- apoptotic process Source: UniProtKB-KW
- calcium-mediated signaling using intracellular calcium source Source: UniProtKB
- endoplasmic reticulum to Golgi vesicle-mediated transport Source: GO_Central
- intracellular protein transport Source: InterPro
- negative regulation of endoplasmic reticulum calcium ion concentration Source: UniProtKB
- positive regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
- positive regulation of cytosolic calcium ion concentration Source: UniProtKB
- positive regulation of ER-associated ubiquitin-dependent protein catabolic process Source: ParkinsonsUK-UCL
- positive regulation of intrinsic apoptotic signaling pathway Source: UniProtKB
- positive regulation of mitochondrial calcium ion concentration Source: UniProtKB
- positive regulation of retrograde protein transport, ER to cytosol Source: ParkinsonsUK-UCL
- protein localization to endoplasmic reticulum exit site Source: GO_Central
- spermatogenesis Source: Ensembl
- viral process Source: UniProtKB-KW
Keywordsi
Biological process | Apoptosis, ER-Golgi transport, Host-virus interaction, Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-HSA-111465 Apoptotic cleavage of cellular proteins R-HSA-75153 Apoptotic execution phase R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Protein family/group databases
TCDBi | 3.A.5.9.1 the general secretory pathway (sec) family |
Names & Taxonomyi
Protein namesi | Recommended name: B-cell receptor-associated protein 31Short name: BCR-associated protein 31 Short name: Bap31 Alternative name(s): 6C6-AG tumor-associated antigen Protein CDM p28 |
Gene namesi | Name:BCAP31 Synonyms:BAP311 Publication, DXS1357E |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:16695 BCAP31 |
MIMi | 300398 gene |
neXtProti | NX_P51572 |
Subcellular locationi
Endoplasmic reticulum
- Endoplasmic reticulum membrane 2 Publications; Multi-pass membrane protein Sequence analysis
Other locations
- Endoplasmic reticulum-Golgi intermediate compartment membrane 2 Publications; Multi-pass membrane protein Sequence analysis
Note: May shuttle between the ER and the intermediate compartment/cis-Golgi complex.1 Publication
Cytosol
- cytosol Source: Reactome
Endoplasmic reticulum
- endoplasmic reticulum Source: UniProtKB
- endoplasmic reticulum membrane Source: GO_Central
- integral component of lumenal side of endoplasmic reticulum membrane Source: Reactome
- perinuclear endoplasmic reticulum Source: AgBase
Golgi apparatus
- Golgi cisterna membrane Source: Ensembl
Mitochondrion
- mitochondrion Source: GOC
Plasma Membrane
- integral component of plasma membrane Source: UniProtKB
Other locations
- cell Source: GOC
- clathrin-coated vesicle Source: Ensembl
- endoplasmic reticulum-Golgi intermediate compartment membrane Source: UniProtKB-SubCell
- lipid droplet Source: UniProtKB
- membrane Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 2 – 6 | LumenalSequence analysis | 5 | |
Transmembranei | 7 – 27 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 28 – 43 | CytoplasmicSequence analysisAdd BLAST | 16 | |
Transmembranei | 44 – 64 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 65 – 102 | LumenalSequence analysisAdd BLAST | 38 | |
Transmembranei | 103 – 123 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 124 – 246 | CytoplasmicSequence analysisAdd BLAST | 123 |
Keywords - Cellular componenti
Endoplasmic reticulum, MembranePathology & Biotechi
Involvement in diseasei
Deafness, dystonia, and cerebral hypomyelination (DDCH)1 Publication
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 164 | D → A: Abolishes cleavage by caspases, inhibits apoptotic membrane blebbing and release of cytochrome c from mitochondria; when associated with A-238. 1 Publication | 1 | |
Mutagenesisi | 238 | D → A: Abolishes cleavage by caspases, inhibits apoptotic membrane blebbing and release of cytochrome c from mitochondria; when associated with A-164. 1 Publication | 1 |
Keywords - Diseasei
Deafness, Dystonia, Mental retardationOrganism-specific databases
DisGeNETi | 10134 |
MalaCardsi | BCAP31 |
MIMi | 300475 phenotype |
OpenTargetsi | ENSG00000185825 |
Orphaneti | 369942 CADDS 369939 Severe motor and intellectual disabilities-sensorineural deafness-dystonia syndrome |
PharmGKBi | PA128394569 |
Miscellaneous databases
Pharosi | P51572 |
Polymorphism and mutation databases
BioMutai | BCAP31 |
DMDMi | 1705725 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | Removed1 Publication | |||
ChainiPRO_0000142891 | 2 – 246 | B-cell receptor-associated protein 31Add BLAST | 245 |
Post-translational modificationi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 164 – 165 | Cleavage; by caspase-8Sequence analysis | 2 | |
Sitei | 238 – 239 | Cleavage; by caspase-8Sequence analysis | 2 |
Proteomic databases
EPDi | P51572 |
jPOSTi | P51572 |
MassIVEi | P51572 |
MaxQBi | P51572 |
PaxDbi | P51572 |
PeptideAtlasi | P51572 |
PRIDEi | P51572 |
ProteomicsDBi | 56335 [P51572-1] 56336 [P51572-2] |
TopDownProteomicsi | P51572-1 [P51572-1] P51572-2 [P51572-2] |
PTM databases
iPTMneti | P51572 |
PhosphoSitePlusi | P51572 |
SwissPalmi | P51572 |
Miscellaneous databases
PMAP-CutDBi | P51572 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000185825 Expressed in 230 organ(s), highest expression level in subcutaneous adipose tissue |
ExpressionAtlasi | P51572 baseline and differential |
Genevisiblei | P51572 HS |
Organism-specific databases
HPAi | CAB015350 CAB015424 HPA003906 |
Interactioni
Subunit structurei
Homodimer and heterodimer with BCAP29. Binds CASP8 (isoform 9) as a complex containing BCAP31, BCAP29, BCL2 and/or BCL2L1.
Interacts with VAMP3, VAMP1 and membrane IgD immunoglobulins. May interact with ACTG1 and non-muscle myosin II.
Interacts with HACD2 (PubMed:15024066).
4 Publications(Microbial infection) Interacts (via C-terminus) with HRSV membrane protein SH; this interaction is direct.
1 PublicationBinary interactionsi
GO - Molecular functioni
- MHC class I protein binding Source: Ensembl
Protein-protein interaction databases
BioGridi | 115437, 90 interactors |
IntActi | P51572, 66 interactors |
MINTi | P51572 |
STRINGi | 9606.ENSP00000392330 |
Structurei
Secondary structure
3D structure databases
SMRi | P51572 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 165 – 237 | 1 PublicationAdd BLAST | 73 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 243 – 246 | Di-lysine motif | 4 |
Sequence similaritiesi
Keywords - Domaini
Coiled coil, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG1962 Eukaryota COG5374 LUCA |
GeneTreei | ENSGT00390000011863 |
HOGENOMi | HOG000204790 |
InParanoidi | P51572 |
KOi | K14009 |
OMAi | YFFLIMG |
OrthoDBi | 1514108at2759 |
PhylomeDBi | P51572 |
TreeFami | TF315310 |
Family and domain databases
InterProi | View protein in InterPro IPR008417 BAP29/BAP31 IPR040463 BAP29/BAP31_N IPR041672 Bap31/Bap29_C |
PANTHERi | PTHR12701 PTHR12701, 1 hit |
Pfami | View protein in Pfam PF05529 Bap31, 1 hit PF18035 Bap31_Bap29_C, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MSLQWTAVAT FLYAEVFVVL LLCIPFISPK RWQKIFKSRL VELLVSYGNT
60 70 80 90 100
FFVVLIVILV LLVIDAVREI RKYDDVTEKV NLQNNPGAME HFHMKLFRAQ
110 120 130 140 150
RNLYIAGFSL LLSFLLRRLV TLISQQATLL ASNEAFKKQA ESASEAAKKY
160 170 180 190 200
MEENDQLKKG AAVDGGKLDV GNAEVKLEEE NRSLKADLQK LKDELASTKQ
210 220 230 240
KLEKAENQVL AMRKQSEGLT KEYDRLLEEH AKLQAAVDGP MDKKEE
Computationally mapped potential isoform sequencesi
There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketC9JQ75 | C9JQ75_HUMAN | B-cell receptor-associated protein ... | BCAP31 | 187 | Annotation score: | ||
C9J0M4 | C9J0M4_HUMAN | B-cell receptor-associated protein ... | BCAP31 | 188 | Annotation score: | ||
C9JMD7 | C9JMD7_HUMAN | B-cell receptor-associated protein ... | BCAP31 | 178 | Annotation score: | ||
C9JSP1 | C9JSP1_HUMAN | B-cell receptor-associated protein ... | BCAP31 | 182 | Annotation score: | ||
A0A2R8Y5M6 | A0A2R8Y5M6_HUMAN | B-cell receptor-associated protein ... | BCAP31 | 211 | Annotation score: | ||
C9JM14 | C9JM14_HUMAN | B-cell receptor-associated protein ... | BCAP31 | 138 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 2 | S → T in CAA57415 (PubMed:8612576).Curated | 1 | |
Sequence conflicti | 72 | K → E in AAH14323 (PubMed:15489334).Curated | 1 | |
Sequence conflicti | 208 | Q → E in CAA57415 (PubMed:8612576).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_043116 | 1 | M → MGAEASSSWCPGTALPEERL SVKRASEISGFLGQGSSGEA ALDVLTHVLEGAGNKLTSSC GKPSSNRM in isoform 2. 1 Publication | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z31696 mRNA Translation: CAA83501.1 X81109 mRNA Translation: CAA57015.1 X81817 mRNA Translation: CAA57415.1 AK057613 mRNA Translation: BAG51941.1 AK125631 mRNA Translation: BAG54226.1 U52111 Genomic DNA No translation available. CH471172 Genomic DNA Translation: EAW72818.1 CH471172 Genomic DNA Translation: EAW72819.1 CH471172 Genomic DNA Translation: EAW72820.1 CH471172 Genomic DNA Translation: EAW72821.1 CH471172 Genomic DNA Translation: EAW72823.1 CH471172 Genomic DNA Translation: EAW72824.1 CH471172 Genomic DNA Translation: EAW72825.1 BC014323 mRNA Translation: AAH14323.1 BC065292 mRNA Translation: AAH65292.1 U36341 Genomic DNA Translation: AAA79508.1 |
CCDSi | CCDS14727.1 [P51572-1] CCDS48191.1 [P51572-2] |
PIRi | S44279 |
RefSeqi | NP_001132913.1, NM_001139441.1 [P51572-1] NP_001132929.1, NM_001139457.2 [P51572-2] NP_001243376.1, NM_001256447.1 [P51572-1] NP_005736.3, NM_005745.7 [P51572-1] |
Genome annotation databases
Ensembli | ENST00000345046; ENSP00000343458; ENSG00000185825 [P51572-1] ENST00000458587; ENSP00000392330; ENSG00000185825 [P51572-2] ENST00000647529; ENSP00000494052; ENSG00000185825 [P51572-1] |
GeneIDi | 10134 |
KEGGi | hsa:10134 |
UCSCi | uc004fid.4 human [P51572-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | Z31696 mRNA Translation: CAA83501.1 X81109 mRNA Translation: CAA57015.1 X81817 mRNA Translation: CAA57415.1 AK057613 mRNA Translation: BAG51941.1 AK125631 mRNA Translation: BAG54226.1 U52111 Genomic DNA No translation available. CH471172 Genomic DNA Translation: EAW72818.1 CH471172 Genomic DNA Translation: EAW72819.1 CH471172 Genomic DNA Translation: EAW72820.1 CH471172 Genomic DNA Translation: EAW72821.1 CH471172 Genomic DNA Translation: EAW72823.1 CH471172 Genomic DNA Translation: EAW72824.1 CH471172 Genomic DNA Translation: EAW72825.1 BC014323 mRNA Translation: AAH14323.1 BC065292 mRNA Translation: AAH65292.1 U36341 Genomic DNA Translation: AAA79508.1 |
CCDSi | CCDS14727.1 [P51572-1] CCDS48191.1 [P51572-2] |
PIRi | S44279 |
RefSeqi | NP_001132913.1, NM_001139441.1 [P51572-1] NP_001132929.1, NM_001139457.2 [P51572-2] NP_001243376.1, NM_001256447.1 [P51572-1] NP_005736.3, NM_005745.7 [P51572-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4JZL | X-ray | 2.20 | A/B/C/D | 168-233 | [»] | |
4JZP | X-ray | 2.10 | A/B | 168-233 | [»] | |
SMRi | P51572 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGridi | 115437, 90 interactors |
IntActi | P51572, 66 interactors |
MINTi | P51572 |
STRINGi | 9606.ENSP00000392330 |
Protein family/group databases
TCDBi | 3.A.5.9.1 the general secretory pathway (sec) family |
PTM databases
iPTMneti | P51572 |
PhosphoSitePlusi | P51572 |
SwissPalmi | P51572 |
Polymorphism and mutation databases
BioMutai | BCAP31 |
DMDMi | 1705725 |
Proteomic databases
EPDi | P51572 |
jPOSTi | P51572 |
MassIVEi | P51572 |
MaxQBi | P51572 |
PaxDbi | P51572 |
PeptideAtlasi | P51572 |
PRIDEi | P51572 |
ProteomicsDBi | 56335 [P51572-1] 56336 [P51572-2] |
TopDownProteomicsi | P51572-1 [P51572-1] P51572-2 [P51572-2] |
Protocols and materials databases
DNASUi | 10134 |
Genome annotation databases
Ensembli | ENST00000345046; ENSP00000343458; ENSG00000185825 [P51572-1] ENST00000458587; ENSP00000392330; ENSG00000185825 [P51572-2] ENST00000647529; ENSP00000494052; ENSG00000185825 [P51572-1] |
GeneIDi | 10134 |
KEGGi | hsa:10134 |
UCSCi | uc004fid.4 human [P51572-1] |
Organism-specific databases
CTDi | 10134 |
DisGeNETi | 10134 |
GeneCardsi | BCAP31 |
HGNCi | HGNC:16695 BCAP31 |
HPAi | CAB015350 CAB015424 HPA003906 |
MalaCardsi | BCAP31 |
MIMi | 300398 gene 300475 phenotype |
neXtProti | NX_P51572 |
OpenTargetsi | ENSG00000185825 |
Orphaneti | 369942 CADDS 369939 Severe motor and intellectual disabilities-sensorineural deafness-dystonia syndrome |
PharmGKBi | PA128394569 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1962 Eukaryota COG5374 LUCA |
GeneTreei | ENSGT00390000011863 |
HOGENOMi | HOG000204790 |
InParanoidi | P51572 |
KOi | K14009 |
OMAi | YFFLIMG |
OrthoDBi | 1514108at2759 |
PhylomeDBi | P51572 |
TreeFami | TF315310 |
Enzyme and pathway databases
Reactomei | R-HSA-111465 Apoptotic cleavage of cellular proteins R-HSA-75153 Apoptotic execution phase R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC |
Miscellaneous databases
ChiTaRSi | BCAP31 human |
GeneWikii | BCAP31 |
GenomeRNAii | 10134 |
Pharosi | P51572 |
PMAP-CutDBi | P51572 |
PROi | PR:P51572 |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000185825 Expressed in 230 organ(s), highest expression level in subcutaneous adipose tissue |
ExpressionAtlasi | P51572 baseline and differential |
Genevisiblei | P51572 HS |
Family and domain databases
InterProi | View protein in InterPro IPR008417 BAP29/BAP31 IPR040463 BAP29/BAP31_N IPR041672 Bap31/Bap29_C |
PANTHERi | PTHR12701 PTHR12701, 1 hit |
Pfami | View protein in Pfam PF05529 Bap31, 1 hit PF18035 Bap31_Bap29_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | BAP31_HUMAN | |
Accessioni | P51572Primary (citable) accession number: P51572 Secondary accession number(s): B3KQ79 Q96CF0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | January 23, 2007 | |
Last modified: | November 13, 2019 | |
This is version 188 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Complete proteome, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM - SIMILARITY comments
Index of protein domains and families - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references