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Protein

Translocon-associated protein subunit delta

Gene

SSR4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins.

Enzyme and pathway databases

ReactomeiR-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane

Names & Taxonomyi

Protein namesi
Recommended name:
Translocon-associated protein subunit delta
Short name:
TRAP-delta
Alternative name(s):
Signal sequence receptor subunit delta
Short name:
SSR-delta
Gene namesi
Name:SSR4
Synonyms:TRAPD
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000180879.13
HGNCiHGNC:11326 SSR4
MIMi300090 gene
neXtProtiNX_P51571

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini24 – 144LumenalSequence analysisAdd BLAST121
Transmembranei145 – 165HelicalSequence analysisAdd BLAST21
Topological domaini166 – 173CytoplasmicSequence analysis8

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

Pathology & Biotechi

Involvement in diseasei

Congenital disorder of glycosylation 1Y (CDG1Y)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA form of congenital disorder of glycosylation, a multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.
See also OMIM:300934

Keywords - Diseasei

Congenital disorder of glycosylation

Organism-specific databases

DisGeNETi6748
MalaCardsiSSR4
MIMi300934 phenotype
OpenTargetsiENSG00000180879
Orphaneti370927 SSR4-CDG
PharmGKBiPA36150

Polymorphism and mutation databases

BioMutaiSSR4
DMDMi1711550

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000003329224 – 173Translocon-associated protein subunit deltaAdd BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi26 ↔ 57By similarity
Cross-linki73Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)

Keywords - PTMi

Disulfide bond, Isopeptide bond, Ubl conjugation

Proteomic databases

EPDiP51571
MaxQBiP51571
PaxDbiP51571
PeptideAtlasiP51571
PRIDEiP51571
ProteomicsDBi56334
TopDownProteomicsiP51571

PTM databases

iPTMnetiP51571
PhosphoSitePlusiP51571
SwissPalmiP51571

Expressioni

Gene expression databases

BgeeiENSG00000180879
CleanExiHS_SSR4
ExpressionAtlasiP51571 baseline and differential
GenevisibleiP51571 HS

Organism-specific databases

HPAiHPA045209

Interactioni

Subunit structurei

Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.

Protein-protein interaction databases

BioGridi112626, 76 interactors
CORUMiP51571
IntActiP51571, 39 interactors
MINTiP51571
STRINGi9606.ENSP00000317331

Structurei

3D structure databases

ProteinModelPortaliP51571
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAP-delta family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4088 Eukaryota
ENOG4111GCB LUCA
GeneTreeiENSGT00390000008992
HOGENOMiHOG000293353
HOVERGENiHBG002293
InParanoidiP51571
KOiK04571
OMAiGPWVNSE
OrthoDBiEOG091G0UKL
PhylomeDBiP51571
TreeFamiTF313158

Family and domain databases

InterProiView protein in InterPro
IPR008855 TRAP-delta
PANTHERiPTHR12731 PTHR12731, 1 hit
PfamiView protein in Pfam
PF05404 TRAP-delta, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51571-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAMASLGAL ALLLLSSLSR CSAEACLEPQ ITPSYYTTSD AVISTETVFI
60 70 80 90 100
VEISLTCKNR VQNMALYADV GGKQFPVTRG QDVGRYQVSW SLDHKSAHAG
110 120 130 140 150
TYEVRFFDEE SYSLLRKAQR NNEDISIIPP LFTVSVDHRG TWNGPWVSTE
160 170
VLAAAIGLVI YYLAFSAKSH IQA
Length:173
Mass (Da):18,999
Last modified:October 1, 1996 - v1
Checksum:i063CD2C8F6CE368B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti109E → K (PubMed:9286695).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_064161144G → R1 PublicationCorresponds to variant dbSNP:rs782018895Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90583 mRNA Translation: CAA62211.1
Z68129 Genomic DNA Translation: CAA92215.1
Z69043 mRNA Translation: CAA93157.1
BT007192 mRNA Translation: AAP35856.1
AK290493 mRNA Translation: BAF83182.1
U52111 Genomic DNA No translation available.
CH471172 Genomic DNA Translation: EAW72811.1
BC003371 mRNA Translation: AAH03371.1
BC032351 mRNA No translation available.
CCDSiCCDS14731.1
PIRiS59865
RefSeqiNP_001191455.1, NM_001204526.1
NP_006271.1, NM_006280.2
XP_011529488.1, XM_011531186.1
XP_011529489.1, XM_011531187.1
UniGeneiHs.409223

Genome annotation databases

EnsembliENST00000320857; ENSP00000317331; ENSG00000180879
ENST00000370086; ENSP00000359103; ENSG00000180879
ENST00000370087; ENSP00000359104; ENSG00000180879
GeneIDi6748
KEGGihsa:6748
UCSCiuc004fiw.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSSRD_HUMAN
AccessioniPrimary (citable) accession number: P51571
Secondary accession number(s): A8K378, Q53XY1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: June 20, 2018
This is version 161 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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