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Protein

Alpha-galactosidase A

Gene

Gla

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactolipids.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei170NucleophileBy similarity1
Active sitei231Proton donorBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosidase, Hydrolase

Enzyme and pathway databases

SABIO-RKiP51569

Protein family/group databases

CAZyiGH27 Glycoside Hydrolase Family 27

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-galactosidase A (EC:3.2.1.22By similarity)
Alternative name(s):
Alpha-D-galactosidase A
Alpha-D-galactoside galactohydrolase
Melibiase
Gene namesi
Name:Gla
Synonyms:Ags
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1347344 Gla

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Lysosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31By similarityAdd BLAST31
ChainiPRO_000000100532 – 419Alpha-galactosidase AAdd BLAST388

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi52 ↔ 94By similarity
Disulfide bondi56 ↔ 63By similarity
Glycosylationi139N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi142 ↔ 172By similarity
Modified residuei186PhosphotyrosineCombined sources1
Glycosylationi192N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi202 ↔ 223By similarity
Glycosylationi215N-linked (GlcNAc...) asparagineBy similarity1
Disulfide bondi378 ↔ 382By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP51569
MaxQBiP51569
PaxDbiP51569
PeptideAtlasiP51569
PRIDEiP51569

PTM databases

iPTMnetiP51569
PhosphoSitePlusiP51569

Expressioni

Gene expression databases

CleanExiMM_GLA

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP51569, 1 interactor
MINTiP51569
STRINGi10090.ENSMUSP00000033621

Structurei

3D structure databases

ProteinModelPortaliP51569
SMRiP51569
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni203 – 207Substrate bindingBy similarity5

Sequence similaritiesi

Belongs to the glycosyl hydrolase 27 family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG2366 Eukaryota
ENOG410XPF1 LUCA
HOVERGENiHBG001989
InParanoidiP51569

Family and domain databases

CDDicd14792 GH27, 1 hit
Gene3Di2.60.40.1180, 1 hit
3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002241 Glyco_hydro_27
IPR000111 Glyco_hydro_27/36_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR035373 Melibiase/NAGA_C
PANTHERiPTHR11452 PTHR11452, 1 hit
PfamiView protein in Pfam
PF16499 Melibiase_2, 1 hit
PF17450 Melibiase_2_C, 1 hit
PRINTSiPR00740 GLHYDRLASE27
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00512 ALPHA_GALACTOSIDASE, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P51569-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKLLSRDTRL VCELALCPLA LVFWSILGVR ALDNGLARTP TMGWLHWERF
60 70 80 90 100
MCNLDCQEEP DACISEQLFM QMAELMVSDG WRDAGYDYLC IDDCWMAPER
110 120 130 140 150
DSKGRLQADP QRFPSGIKHL ANYVHSKGLK LGIYADVGNK TCAGFPGSFG
160 170 180 190 200
SYDIDAQTFA DWGVDLLKFD GCHCDSVVSL ENGYKYMALA LNRTGRSIVY
210 220 230 240 250
SCEWPLYLRP FHKPNYTDIQ YYCNHWRNFD DVYDSWESIK NILSWTVVYQ
260 270 280 290 300
KEIVEVAGPG SWNDPDMLVI GNFGLSWDQQ VTQMALWAIM AAPLLMSNDL
310 320 330 340 350
RQISSQAKAL LQNKDVIAIN QDPLGKQGYC FRKENHIEVW ERPLSNLAWA
360 370 380 390 400
VAVRNLQEIG GPCPYTIQIS SLGRGLACNP GCIITQLLPE KVHLGFYEWT
410
LTLKTRVNPS GTVLFRLER
Length:419
Mass (Da):47,643
Last modified:October 1, 1996 - v1
Checksum:iBD5E6A99AC113613
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q8BGZ6Q8BGZ6_MOUSE
Alpha-galactosidase
Gla
421Annotation score:
A2BDV6A2BDV6_MOUSE
Alpha-galactosidase
Gla
77Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34071 mRNA Translation: AAA96749.1
L46651 Genomic DNA Translation: AAA74453.1
U58105 Genomic DNA Translation: AAB47244.1
U50716 mRNA Translation: AAC52584.1
U50715 Genomic DNA Translation: AAC52583.1
BC009021 mRNA Translation: AAH09021.1
PIRiJC4522
UniGeneiMm.1114

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U34071 mRNA Translation: AAA96749.1
L46651 Genomic DNA Translation: AAA74453.1
U58105 Genomic DNA Translation: AAB47244.1
U50716 mRNA Translation: AAC52584.1
U50715 Genomic DNA Translation: AAC52583.1
BC009021 mRNA Translation: AAH09021.1
PIRiJC4522
UniGeneiMm.1114

3D structure databases

ProteinModelPortaliP51569
SMRiP51569
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP51569, 1 interactor
MINTiP51569
STRINGi10090.ENSMUSP00000033621

Protein family/group databases

CAZyiGH27 Glycoside Hydrolase Family 27

PTM databases

iPTMnetiP51569
PhosphoSitePlusiP51569

Proteomic databases

EPDiP51569
MaxQBiP51569
PaxDbiP51569
PeptideAtlasiP51569
PRIDEiP51569

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1347344 Gla

Phylogenomic databases

eggNOGiKOG2366 Eukaryota
ENOG410XPF1 LUCA
HOVERGENiHBG001989
InParanoidiP51569

Enzyme and pathway databases

SABIO-RKiP51569

Miscellaneous databases

PROiPR:P51569
SOURCEiSearch...

Gene expression databases

CleanExiMM_GLA

Family and domain databases

CDDicd14792 GH27, 1 hit
Gene3Di2.60.40.1180, 1 hit
3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR002241 Glyco_hydro_27
IPR000111 Glyco_hydro_27/36_CS
IPR013780 Glyco_hydro_b
IPR017853 Glycoside_hydrolase_SF
IPR035373 Melibiase/NAGA_C
PANTHERiPTHR11452 PTHR11452, 1 hit
PfamiView protein in Pfam
PF16499 Melibiase_2, 1 hit
PF17450 Melibiase_2_C, 1 hit
PRINTSiPR00740 GLHYDRLASE27
SUPFAMiSSF51445 SSF51445, 1 hit
PROSITEiView protein in PROSITE
PS00512 ALPHA_GALACTOSIDASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAGAL_MOUSE
AccessioniPrimary (citable) accession number: P51569
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: October 1, 1996
Last modified: October 10, 2018
This is version 132 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
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Main funding by: National Institutes of Health

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