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UniProtKB - P51557 (STAR_MOUSE)
Protein
Steroidogenic acute regulatory protein, mitochondrial
Gene
Star
Organism
Mus musculus (Mouse)
Status
Functioni
Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Transporter that binds to and transport cholesterol through the intermembrane space of the mitochondrion.
By similarityCatalytic activityi
: cholesterol metabolism Pathwayi
This protein is involved in the pathway cholesterol metabolism, which is part of Steroid metabolism.By similarityView all proteins of this organism that are known to be involved in the pathway cholesterol metabolism and in Steroid metabolism.
GO - Molecular functioni
- cholesterol binding Source: MGI
- cholesterol transfer activity Source: InterPro
GO - Biological processi
- bile acid biosynthetic process Source: MGI
- biphenyl metabolic process Source: Ensembl
- brain development Source: Ensembl
- cellular lipid metabolic process Source: MGI
- cellular response to alkaloid Source: Ensembl
- cellular response to antibiotic Source: Ensembl
- cellular response to cadmium ion Source: Ensembl
- cellular response to cAMP Source: Ensembl
- cellular response to dexamethasone stimulus Source: Ensembl
- cellular response to epinephrine stimulus Source: Ensembl
- cellular response to fibroblast growth factor stimulus Source: Ensembl
- cellular response to follicle-stimulating hormone stimulus Source: Ensembl
- cellular response to glucose stimulus Source: Ensembl
- cellular response to growth hormone stimulus Source: Ensembl
- cellular response to insulin stimulus Source: Ensembl
- cellular response to interferon-alpha Source: MGI
- cellular response to interferon-gamma Source: Ensembl
- cellular response to lipopolysaccharide Source: Ensembl
- cellular response to luteinizing hormone stimulus Source: Ensembl
- cellular response to transforming growth factor beta stimulus Source: Ensembl
- cholesterol metabolic process Source: UniProtKB-UniPathway
- circadian sleep/wake cycle, REM sleep Source: Ensembl
- dibenzo-p-dioxin metabolic process Source: Ensembl
- diterpenoid metabolic process Source: Ensembl
- estrogen biosynthetic process Source: MGI
- glucocorticoid metabolic process Source: MGI
- insecticide metabolic process Source: Ensembl
- intracellular cholesterol transport Source: GO_Central
- male gonad development Source: Ensembl
- negative regulation of neuron apoptotic process Source: MGI
- phenol-containing compound metabolic process Source: Ensembl
- phthalate metabolic process Source: Ensembl
- positive regulation of bile acid biosynthetic process Source: MGI
- positive regulation of gene expression Source: MGI
- positive regulation of neurogenesis Source: MGI
- regulation of neuronal synaptic plasticity Source: MGI
- regulation of steroid biosynthetic process Source: MGI
- response to activity Source: Ensembl
- response to corticosterone Source: Ensembl
- response to estrogen Source: Ensembl
- response to ethanol Source: Ensembl
- response to fungicide Source: Ensembl
- response to herbicide Source: Ensembl
- response to hydrogen peroxide Source: Ensembl
- response to ionizing radiation Source: Ensembl
- response to lead ion Source: Ensembl
- response to leptin Source: Ensembl
- response to nicotine Source: Ensembl
- response to nutrient Source: Ensembl
- steroid biosynthetic process Source: GO_Central
- testosterone biosynthetic process Source: Ensembl
Keywordsi
Biological process | Lipid transport, Steroidogenesis, Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
Reactomei | R-MMU-196108, Pregnenolone biosynthesis |
UniPathwayi | UPA00296 |
Names & Taxonomyi
Protein namesi | Recommended name: Steroidogenic acute regulatory protein, mitochondrialShort name: StAR Alternative name(s): Luteinizing hormone-induced protein START domain-containing protein 1 Short name: StARD1 |
Gene namesi | Name:Star |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102760, Star |
VEuPathDBi | HostDB:ENSMUSG00000031574 |
Subcellular locationi
Mitochondrion
- Mitochondrion 2 Publications
Cytosol
- cytosol Source: MGI
Mitochondrion
- mitochondrial crista Source: MGI
- mitochondrial intermembrane space Source: MGI
- mitochondrion Source: MGI
Other locations
- neuron projection Source: MGI
- neuronal cell body Source: MGI
Keywords - Cellular componenti
MitochondrionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 62 | Mitochondrion1 PublicationAdd BLAST | 62 | |
ChainiPRO_0000033318 | 63 – 284 | Steroidogenic acute regulatory protein, mitochondrialAdd BLAST | 222 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 56 | Phosphoserine; by PKABy similarity | 1 | |
Modified residuei | 194 | Phosphoserine; by PKABy similarity | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
MaxQBi | P51557 |
PaxDbi | P51557 |
PRIDEi | P51557 |
ProteomicsDBi | 257368 |
PTM databases
iPTMneti | P51557 |
PhosphoSitePlusi | P51557 |
Expressioni
Tissue specificityi
Expressed within glia and neurons in discrete regions of the brain.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000031574, Expressed in adrenal gland and 156 other tissues |
ExpressionAtlasi | P51557, baseline and differential |
Genevisiblei | P51557, MM |
Interactioni
Subunit structurei
May interact with TSPO.
By similarityProtein-protein interaction databases
IntActi | P51557, 1 interactor |
STRINGi | 10090.ENSMUSP00000033979 |
Miscellaneous databases
RNActi | P51557, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 66 – 279 | STARTPROSITE-ProRule annotationAdd BLAST | 214 |
Keywords - Domaini
Transit peptidePhylogenomic databases
eggNOGi | KOG3845, Eukaryota |
GeneTreei | ENSGT00940000155477 |
HOGENOMi | CLU_093200_1_0_1 |
InParanoidi | P51557 |
OMAi | KMPEQKG |
OrthoDBi | 1437203at2759 |
PhylomeDBi | P51557 |
TreeFami | TF313869 |
Family and domain databases
CDDi | cd08905, START_STARD1-like, 1 hit |
Gene3Di | 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR029866, StAR IPR000799, StAR-like IPR023393, START-like_dom_sf IPR002913, START_lipid-bd_dom |
PANTHERi | PTHR46489, PTHR46489, 1 hit |
Pfami | View protein in Pfam PF01852, START, 1 hit |
PRINTSi | PR00978, STARPROTEIN |
SMARTi | View protein in SMART SM00234, START, 1 hit |
PROSITEi | View protein in PROSITE PS50848, START, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P51557-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MFLATFKLCA GSSYRHMRNM KGLRHQAVLA IGQELNWRAL GDSSPGWMGQ
60 70 80 90 100
VRRRSSLLGS QLEATLYSDQ ELSYIQQGEV AMQKALGILN NQEGWKKESQ
110 120 130 140 150
QENGDEVLSK MVPDVGKVFR LEVVVDQPMD RLYEELVDRM EAMGEWNPNV
160 170 180 190 200
KEIKVLQRIG KDTVITHELA AAAAGNLVGP RDFVSVRCTK RRGSTCVLAG
210 220 230 240 250
MATHFGEMPE QSGVIRAEHG PTCMVLHPLA GSPSKTKLTW LLSIDLKGWL
260 270 280
PKTIINQVLS QTQIEFANHL RKRLEASPAS EAQC
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1B0GSV6 | A0A1B0GSV6_MOUSE | Steroidogenic acute regulatory prot... | Star | 157 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 139 | R → H in BAB31842 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L36062 mRNA Translation: AAB94783.1 AY032730 Genomic DNA Translation: AAK50433.2 AK019725 mRNA Translation: BAB31842.1 AK054470 mRNA Translation: BAC35791.1 AK136327 mRNA Translation: BAE22934.1 BC082283 mRNA Translation: AAH82283.1 |
CCDSi | CCDS22203.1 |
PIRi | A55455 |
RefSeqi | NP_035615.2, NM_011485.5 |
Genome annotation databases
Ensembli | ENSMUST00000033979; ENSMUSP00000033979; ENSMUSG00000031574 |
GeneIDi | 20845 |
KEGGi | mmu:20845 |
UCSCi | uc009lhb.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L36062 mRNA Translation: AAB94783.1 AY032730 Genomic DNA Translation: AAK50433.2 AK019725 mRNA Translation: BAB31842.1 AK054470 mRNA Translation: BAC35791.1 AK136327 mRNA Translation: BAE22934.1 BC082283 mRNA Translation: AAH82283.1 |
CCDSi | CCDS22203.1 |
PIRi | A55455 |
RefSeqi | NP_035615.2, NM_011485.5 |
3D structure databases
AlphaFoldDBi | P51557 |
SMRi | P51557 |
ModBasei | Search... |
Protein-protein interaction databases
IntActi | P51557, 1 interactor |
STRINGi | 10090.ENSMUSP00000033979 |
Chemistry databases
ChEMBLi | CHEMBL2029195 |
PTM databases
iPTMneti | P51557 |
PhosphoSitePlusi | P51557 |
Proteomic databases
MaxQBi | P51557 |
PaxDbi | P51557 |
PRIDEi | P51557 |
ProteomicsDBi | 257368 |
Protocols and materials databases
Antibodypediai | 23510, 326 antibodies from 35 providers |
DNASUi | 20845 |
Genome annotation databases
Ensembli | ENSMUST00000033979; ENSMUSP00000033979; ENSMUSG00000031574 |
GeneIDi | 20845 |
KEGGi | mmu:20845 |
UCSCi | uc009lhb.1, mouse |
Organism-specific databases
CTDi | 6770 |
MGIi | MGI:102760, Star |
VEuPathDBi | HostDB:ENSMUSG00000031574 |
Phylogenomic databases
eggNOGi | KOG3845, Eukaryota |
GeneTreei | ENSGT00940000155477 |
HOGENOMi | CLU_093200_1_0_1 |
InParanoidi | P51557 |
OMAi | KMPEQKG |
OrthoDBi | 1437203at2759 |
PhylomeDBi | P51557 |
TreeFami | TF313869 |
Enzyme and pathway databases
UniPathwayi | UPA00296 |
Reactomei | R-MMU-196108, Pregnenolone biosynthesis |
Miscellaneous databases
BioGRID-ORCSi | 20845, 3 hits in 74 CRISPR screens |
PROi | PR:P51557 |
RNActi | P51557, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000031574, Expressed in adrenal gland and 156 other tissues |
ExpressionAtlasi | P51557, baseline and differential |
Genevisiblei | P51557, MM |
Family and domain databases
CDDi | cd08905, START_STARD1-like, 1 hit |
Gene3Di | 3.30.530.20, 1 hit |
InterProi | View protein in InterPro IPR029866, StAR IPR000799, StAR-like IPR023393, START-like_dom_sf IPR002913, START_lipid-bd_dom |
PANTHERi | PTHR46489, PTHR46489, 1 hit |
Pfami | View protein in Pfam PF01852, START, 1 hit |
PRINTSi | PR00978, STARPROTEIN |
SMARTi | View protein in SMART SM00234, START, 1 hit |
PROSITEi | View protein in PROSITE PS50848, START, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | STAR_MOUSE | |
Accessioni | P51557Primary (citable) accession number: P51557 Secondary accession number(s): Q543A5, Q924Y5, Q9D2G1 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 1, 1996 |
Last sequence update: | October 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways