IDH3G

Functionⁱ

Regulatory subunit which plays a role in the allosteric regulation of the enzyme catalyzing the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers.1 Publication

Cofactorⁱ

Mg²⁺2 Publications, Mn²⁺1 PublicationNote: Divalent metal cations; Mn²⁺ or Mg²⁺. Activity higher in presence of Mn²⁺ than of Mg²⁺. Binds 1 Mg²⁺ or Mn²⁺ ion per subunit.1 Publication

Activity regulationⁱ

The heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits can be allosterically activated by citrate (CIT) or/and ADP, and the two activators can act independently or synergistically. The heterodimer composed of IDH3A and IDH3B subunits cannot be allosterically regulated and the allosteric regulation of the heterotetramer is through the IDH3G subunit and not the IDH3B subunit. The IDH3G subunit contains the allosteric site which consists of a CIT-binding site and an ADP-binding site, and the binding of CIT and ADP causes conformational changes at the allosteric site which are transmitted to the active site in the catalytic subunit (IDH3A) through a cascade of conformational changes at the heterodimer interface, leading to stabilization of the isocitrate-binding at the active site and thus activation of the enzyme. ATP can activate the heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits at low concentrations but inhibits their activities at high concentrations, whereas ATP exhibits only inhibitory effect on the heterodimer composed of IDH3A and IDH3B subunits.2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	120	Allosteric activator citrate1 Publication	1
Binding siteⁱ	133	Allosteric activator citrate1 Publication	1
Binding siteⁱ	136	Substrate1 Publication	1
Binding siteⁱ	167	Substrate1 Publication	1
Metal bindingⁱ	254	Magnesium or manganese; shared with catalytic subunit1 Publication	1
Binding siteⁱ	254	Substrate1 Publication	1
Binding siteⁱ	312	Allosteric activator ADP1 Publication	1
Binding siteⁱ	313	Allosteric activator ADP1 Publication	1
Binding siteⁱ	324	Allosteric activator ADP1 Publication	1

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
isocitrate dehydrogenase (NAD+) activity Source: UniProtKB
magnesium ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 28098230
NAD binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

carbohydrate metabolic process
Source: ProtInc
Non-traceable author statementⁱ
- 9286695
isocitrate metabolic process Source: UniProtKB
tricarboxylic acid cycle Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Tricarboxylic acid cycle
Ligand	ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000067829-MONOMER
Reactomeⁱ	R-HSA-1268020 Mitochondrial protein import R-HSA-71403 Citric acid cycle (TCA cycle)
SABIO-RKⁱ	P51553

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial Alternative name(s): Isocitric dehydrogenase subunit gamma NAD(+)-specific ICDH subunit gamma
Gene namesⁱ	Name:IDH3G
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome X

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000067829.18
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5386 IDH3G
MIMⁱ	300089 gene
neXtProtⁱ	NX_P51553

Keywords - Cellular componentⁱ

Mitochondrion

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	117	N → A: No effect on the activation of the heterodimer composed of IDH3A and IDH3G subunits by citrate. 1 Publication	1
Mutagenesisⁱ	120	T → A: Significantly impairs the activation of the heterodimer composed of IDH3A and IDH3G subunits by citrate. 1 Publication	1
Mutagenesisⁱ	130	S → A: No significant effect on the activation of the heterodimer composed of IDH3A and IDH3G subunits by citrate. 1 Publication	1
Mutagenesisⁱ	133	N → A: Significantly impairs the activation of the heterodimer composed of IDH3A and IDH3G subunits by citrate. 1 Publication	1
Mutagenesisⁱ	136	R → A: Significantly impairs the activation of the heterodimer composed of IDH3A and IDH3G subunits by citrate. 1 Publication	1
Mutagenesisⁱ	167	R → A: Significantly impairs the activation of the heterodimer composed of IDH3A and IDH3G subunits by citrate. 1 Publication	1
Mutagenesisⁱ	173	E → A: No effect on the activation of the heterodimer composed of IDH3A and IDH3G subunits by citrate and ADP. 1 Publication	1
Mutagenesisⁱ	174	Y → F: Significantly impairs the activation of the heterodimer composed of IDH3A and IDH3G subunits by citrate. 1 Publication	1
Mutagenesisⁱ	190	K → A: Complete loss of the activation of the heterotetramer and the heterodimer composed of IDH3A and IDH3G subunits by citrate and ADP. 2 Publications	1
Mutagenesisⁱ	229	D → A: Significantly impairs the activation of the heterodimer composed of IDH3A and IDH3G subunits by citrate and ADP. 1 Publication	1
Mutagenesisⁱ	276	Y → F: Significantly impairs the activation of the heterodimer composed of IDH3A and IDH3G subunits by citrate and ADP. 1 Publication	1
Mutagenesisⁱ	311	R → A: Significantly impairs the activation of the heterodimer composed of IDH3A and IDH3G subunits by citrate. 1 Publication	1
Mutagenesisⁱ	312	N → A: Significantly impairs the activation of the heterodimer composed of IDH3A and IDH3G subunits by ADP. 1 Publication	1
Mutagenesisⁱ	313	T → A: Significantly impairs the activation of the heterodimer composed of IDH3A and IDH3G subunits by ADP. 1 Publication	1
Mutagenesisⁱ	315	K → A: No significant effect on the activation of the heterodimer composed of IDH3A and IDH3G subunits by ADP. 1 Publication	1
Mutagenesisⁱ	324	N → A: Complete loss of the activation of the heterodimer composed of IDH3A and IDH3G subunits by ADP. 1 Publication	1

Organism-specific databases

Open Targets More...OpenTargetsⁱ	ENSG00000067829
PharmGKBⁱ	PA29634

Chemistry databases

Drug and drug target database More...DrugBankⁱ	DB00157 NADH

DrugBankⁱ

DB00157 NADH

Polymorphism and mutation databases

BioMutaⁱ	IDH3G
DMDMⁱ	1708404

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Transit peptideⁱ	1 – 39	MitochondrionBy similarityAdd BLAST		39
ChainⁱPRO_0000014449	40 – 393	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrialAdd BLAST		354

Proteomic databases

EPDⁱ	P51553
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P51553
PaxDbⁱ	P51553
PeptideAtlas More...PeptideAtlasⁱ	P51553
PRIDEⁱ	P51553
ProteomicsDBⁱ	56332

PTM databases

iPTMnetⁱ	P51553
PhosphoSitePlusⁱ	P51553

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000067829 Expressed in 230 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_IDH3G
ExpressionAtlasⁱ	P51553 baseline and differential
Genevisibleⁱ	P51553 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA000425 HPA002017

HPAⁱ

HPA000425
HPA002017

Interactionⁱ

Subunit structureⁱ

Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.2 Publications

Protein-protein interaction databases

BioGridⁱ	109647, 28 interactors
ComplexPortalⁱ	CPX-553 Mitochondrial isocitrate dehydrogenase complex (NAD+)
IntActⁱ	P51553, 4 interactors
STRINGⁱ	9606.ENSP00000217901

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	55 – 60	Combined sources	6
Helixⁱ	66 – 79	Combined sources	14
Beta strandⁱ	84 – 88	Combined sources	5
Beta strandⁱ	95 – 97	Combined sources	3
Helixⁱ	98 – 110	Combined sources	13
Beta strandⁱ	111 – 115	Combined sources	5
Helixⁱ	131 – 138	Combined sources	8
Beta strandⁱ	143 – 149	Combined sources	7
Beta strandⁱ	152 – 154	Combined sources	3
Beta strandⁱ	162 – 168	Combined sources	7
Beta strandⁱ	170 – 172	Combined sources	3
Beta strandⁱ	178 – 182	Combined sources	5
Beta strandⁱ	185 – 193	Combined sources	9
Helixⁱ	194 – 210	Combined sources	17
Beta strandⁱ	215 – 220	Combined sources	6
Turnⁱ	222 – 224	Combined sources	3
Helixⁱ	228 – 240	Combined sources	13
Beta strandⁱ	246 – 252	Combined sources	7
Helixⁱ	253 – 260	Combined sources	8
Helixⁱ	264 – 266	Combined sources	3
Beta strandⁱ	268 – 272	Combined sources	5
Helixⁱ	274 – 287	Combined sources	14
Turnⁱ	291 – 293	Combined sources	3
Beta strandⁱ	295 – 299	Combined sources	5
Beta strandⁱ	304 – 308	Combined sources	5
Turnⁱ	315 – 321	Combined sources	7
Helixⁱ	326 – 338	Combined sources	13
Helixⁱ	342 – 356	Combined sources	15
Helixⁱ	359 – 361	Combined sources	3
Helixⁱ	364 – 366	Combined sources	3
Helixⁱ	372 – 386	Combined sources	15

Show more details

3D structure databases

ProteinModelPortalⁱ	P51553
SMRⁱ	P51553
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the isocitrate and isopropylmalate dehydrogenases family.Curated

Keywords - Domainⁱ

Transit peptide

Phylogenomic databases

eggNOGⁱ	KOG0784 Eukaryota COG0473 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00590000083091
HOGENOMⁱ	HOG000021113
HOVERGENⁱ	HBG052080
InParanoidⁱ	P51553
KEGG Orthology (KO) More...KOⁱ	K00030
OMAⁱ	GTSMFEP
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G094X
PhylomeDBⁱ	P51553
TreeFamⁱ	TF315033

Family and domain databases

InterProⁱ	View protein in InterPro IPR019818 IsoCit/isopropylmalate_DH_CS IPR004434 Isocitrate_DH_NAD IPR024084 IsoPropMal-DH-like_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00180 Iso_dh, 1 hit
SMARTⁱ	View protein in SMART SM01329 Iso_dh, 1 hit
TIGRFAMsⁱ	TIGR00175 mito_nad_idh, 1 hit
PROSITEⁱ	View protein in PROSITE PS00470 IDH_IMDH, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P51553-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALKVATVAG SAAKAVLGPA LLCRPWEVLG AHEVPSRNIF SEQTIPPSAK 
        60         70         80         90        100
YGGRHTVTMI PGDGIGPELM LHVKSVFRHA CVPVDFEEVH VSSNADEEDI 
       110        120        130        140        150
RNAIMAIRRN RVALKGNIET NHNLPPSHKS RNNILRTSLD LYANVIHCKS 
       160        170        180        190        200
LPGVVTRHKD IDILIVRENT EGEYSSLEHE SVAGVVESLK IITKAKSLRI 
       210        220        230        240        250
AEYAFKLAQE SGRKKVTAVH KANIMKLGDG LFLQCCREVA ARYPQITFEN 
       260        270        280        290        300
MIVDNTTMQL VSRPQQFDVM VMPNLYGNIV NNVCAGLVGG PGLVAGANYG 
       310        320        330        340        350
HVYAVFETAT RNTGKSIANK NIANPTATLL ASCMMLDHLK LHSYATSIRK 
       360        370        380        390 
AVLASMDNEN MHTPDIGGQG TTSEAIQDVI RHIRVINGRA VEA

Length:393

Mass (Da):42,794

Last modified:October 1, 1996 - v1

Checksum:ⁱA0870F2B7D228A37

GO

Isoform 2 (identifier: P51553-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
361-393: MHTPDIGGQGTTSEAIQDVIRHIRVINGRAVEA → VRFPSHPTLLPRPVSPCSLL

« Hide

        10         20         30         40         50
MALKVATVAG SAAKAVLGPA LLCRPWEVLG AHEVPSRNIF SEQTIPPSAK 
        60         70         80         90        100
YGGRHTVTMI PGDGIGPELM LHVKSVFRHA CVPVDFEEVH VSSNADEEDI 
       110        120        130        140        150
RNAIMAIRRN RVALKGNIET NHNLPPSHKS RNNILRTSLD LYANVIHCKS 
       160        170        180        190        200
LPGVVTRHKD IDILIVRENT EGEYSSLEHE SVAGVVESLK IITKAKSLRI 
       210        220        230        240        250
AEYAFKLAQE SGRKKVTAVH KANIMKLGDG LFLQCCREVA ARYPQITFEN 
       260        270        280        290        300
MIVDNTTMQL VSRPQQFDVM VMPNLYGNIV NNVCAGLVGG PGLVAGANYG 
       310        320        330        340        350
HVYAVFETAT RNTGKSIANK NIANPTATLL ASCMMLDHLK LHSYATSIRK 
       360        370        380
AVLASMDNEN VRFPSHPTLL PRPVSPCSLL

Note: Gene prediction based on EST data.

Show »

Length:380

Mass (Da):41,468

Checksum:ⁱ2D5987CC70725245

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	267	F → L in AAH01902 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_046771	361 – 393	MHTPD…RAVEA → VRFPSHPTLLPRPVSPCSLL in isoform 2. CuratedAdd BLAST		33

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z68907 mRNA Translation: CAA93143.1 Z68129 Genomic DNA Translation: CAA92214.1 U52111 Genomic DNA No translation available. U40272 mRNA Translation: AAD09357.1 BC000933 mRNA Translation: AAH00933.1 BC001902 mRNA Translation: AAH01902.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS14730.1 [P51553-1] CCDS44019.1 [P51553-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_004126.1, NM_004135.3 [P51553-1] NP_777358.1, NM_174869.2 [P51553-2]
UniGeneⁱ	Hs.410197

Genome annotation databases

Ensemblⁱ	ENST00000217901; ENSP00000217901; ENSG00000067829 [P51553-1] ENST00000370092; ENSP00000359110; ENSG00000067829 [P51553-2]
GeneIDⁱ	3421
KEGGⁱ	hsa:3421
UCSC genome browser More...UCSCⁱ	uc004fip.4 human [P51553-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P51553	Isocitrate dehydrogenase [NAD] subunit, mitochondrial		HUMAN		335	UniRef100_P51553
Isocitrate dehydrogenase [NAD] subunit, mitochondrial		HUMAN		340
UPI0009801536		HUMAN		354

Protein	Similar proteins		Species	Score	Length	Source
P51553	Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial		RAT		393	UniRef90_P51553
Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial		MOUSE		393
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial		BOVIN		392
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment)		MACFA		355
Isocitrate dehydrogenase [NAD] subunit, mitochondrial		HUMAN		335
+169
P51553-2	Isocitrate dehydrogenase [NAD] subunit, mitochondrial		DELLE		452	UniRef90_P51553-2
Isocitrate dehydrogenase [NAD] subunit, mitochondrial		HETGA		422
Isocitrate dehydrogenase [NAD] subunit, mitochondrial		AOTNA		399
Isocitrate dehydrogenase [NAD] subunit, mitochondrial		CANLF		392
Isocitrate dehydrogenase [NAD] subunit, mitochondrial		NEOSC		315
+40

Protein	Similar proteins		Species	Score	Length	Source
P51553	Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial		MOUSE		393	UniRef50_P51553
Isocitrate dehydrogenase [NAD] subunit gamma 1, mitochondrial		RAT		393
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial		BOVIN		392
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial (Fragment)		MACFA		355
Isocitrate dehydrogenase [NAD] subunit, mitochondrial		HUMAN		335
+253

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z68907 mRNA Translation: CAA93143.1 Z68129 Genomic DNA Translation: CAA92214.1 U52111 Genomic DNA No translation available. U40272 mRNA Translation: AAD09357.1 BC000933 mRNA Translation: AAH00933.1 BC001902 mRNA Translation: AAH01902.1
CCDSⁱ	CCDS14730.1 [P51553-1] CCDS44019.1 [P51553-2]
RefSeqⁱ	NP_004126.1, NM_004135.3 [P51553-1] NP_777358.1, NM_174869.2 [P51553-2]
UniGeneⁱ	Hs.410197

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	5GRE	X-ray	2.65	B	40-393	[»]
	5GRF	X-ray	2.50	B	40-393	[»]
	5GRH	X-ray	2.80	B	40-393	[»]
	5GRI	X-ray	2.31	B	40-393	[»]
	5GRL	X-ray	2.79	B	40-393	[»]
	5YVT	X-ray	2.40	B	40-393	[»]
ProteinModelPortalⁱ	P51553
SMRⁱ	P51553
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109647, 28 interactors
ComplexPortalⁱ	CPX-553 Mitochondrial isocitrate dehydrogenase complex (NAD+)
IntActⁱ	P51553, 4 interactors
STRINGⁱ	9606.ENSP00000217901

Chemistry databases

DrugBankⁱ	DB00157 NADH

DrugBankⁱ

DB00157 NADH

PTM databases

iPTMnetⁱ	P51553
PhosphoSitePlusⁱ	P51553

Polymorphism and mutation databases

BioMutaⁱ	IDH3G
DMDMⁱ	1708404

Proteomic databases

EPDⁱ	P51553
MaxQBⁱ	P51553
PaxDbⁱ	P51553
PeptideAtlasⁱ	P51553
PRIDEⁱ	P51553
ProteomicsDBⁱ	56332

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3421
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000217901; ENSP00000217901; ENSG00000067829 [P51553-1] ENST00000370092; ENSP00000359110; ENSG00000067829 [P51553-2]
GeneIDⁱ	3421
KEGGⁱ	hsa:3421
UCSCⁱ	uc004fip.4 human [P51553-1]

Organism-specific databases

CTDⁱ	3421
EuPathDBⁱ	HostDB:ENSG00000067829.18
GeneCardsⁱ	IDH3G
HGNCⁱ	HGNC:5386 IDH3G
HPAⁱ	HPA000425 HPA002017
MIMⁱ	300089 gene
neXtProtⁱ	NX_P51553
OpenTargetsⁱ	ENSG00000067829
PharmGKBⁱ	PA29634
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0784 Eukaryota COG0473 LUCA
GeneTreeⁱ	ENSGT00590000083091
HOGENOMⁱ	HOG000021113
HOVERGENⁱ	HBG052080
InParanoidⁱ	P51553
KOⁱ	K00030
OMAⁱ	GTSMFEP
OrthoDBⁱ	EOG091G094X
PhylomeDBⁱ	P51553
TreeFamⁱ	TF315033

Enzyme and pathway databases

BioCycⁱ	MetaCyc:ENSG00000067829-MONOMER
Reactomeⁱ	R-HSA-1268020 Mitochondrial protein import R-HSA-71403 Citric acid cycle (TCA cycle)
SABIO-RKⁱ	P51553

Miscellaneous databases

ChiTaRSⁱ	IDH3G human
GeneWikiⁱ	IDH3G
GenomeRNAiⁱ	3421
Protein Ontology More...PROⁱ	PR:P51553
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000067829 Expressed in 230 organ(s), highest expression level in right hemisphere of cerebellum
CleanExⁱ	HS_IDH3G
ExpressionAtlasⁱ	P51553 baseline and differential
Genevisibleⁱ	P51553 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR019818 IsoCit/isopropylmalate_DH_CS IPR004434 Isocitrate_DH_NAD IPR024084 IsoPropMal-DH-like_dom
Pfamⁱ	View protein in Pfam PF00180 Iso_dh, 1 hit
SMARTⁱ	View protein in SMART SM01329 Iso_dh, 1 hit
TIGRFAMsⁱ	TIGR00175 mito_nad_idh, 1 hit
PROSITEⁱ	View protein in PROSITE PS00470 IDH_IMDH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IDH3G_HUMAN
Accessionⁱ	P51553Primary (citable) accession number: P51553 Secondary accession number(s): E9PDD5, Q9BUU5
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 1, 1996
	Last sequence update:	October 1, 1996
	Last modified:	September 12, 2018
	This is version 189 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome X
Human chromosome X: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P51553 (IDH3G_HUMAN)

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Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Mitochondrion

Mitochondrion

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ