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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotation
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei138SubstrateBy similarity1
Active sitei151Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 33NADBy similarityAdd BLAST24

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenase (EC:1.1.1.1)
Gene namesi
Name:Adh
ORF Names:GH13025
OrganismiDrosophila grimshawi (Hawaiian fruit fly) (Idiomyia grimshawi)
Taxonomic identifieri7222 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaHawaiian Drosophila
Proteomesi
  • UP000001070 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0012316 Dgri\Adh

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000544622 – 254Alcohol dehydrogenaseAdd BLAST253

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

STRINGi7222.FBpp0146931

Structurei

3D structure databases

ProteinModelPortaliP51551
SMRiP51551
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4169 Eukaryota
COG1028 LUCA
InParanoidiP51551
KOiK00001
OMAiWSKHWDS
OrthoDBiEOG091G0OC9
PhylomeDBiP51551

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P51551-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVIANSNIIF VAGLGGIGLD TSREIVKSGP KNLVVLDRVD NPAAIAELKA
60 70 80 90 100
LNPKVTITFY PYDVTVPLAE TKKLLKTIFD KLKTVDLLIN GAGILDDNQI
110 120 130 140 150
ERTIAVNFTG TVNTTTAILD FWDKRKGGPG GVVANICSVT GFNSIYQVPV
160 170 180 190 200
YSASKAAALS FTTSIAKLAH ITGVTAYSIN PGITKTVLVH KFNSWLGVEP
210 220 230 240 250
RVAELLLEHP TQTTLQCAQN FVKAIEANQN GAIWKLDLGR LDAIEWTKHW

DSGI
Length:254
Mass (Da):27,417
Last modified:January 23, 2007 - v2
Checksum:i2449DD6304777EC9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48714 Genomic DNA Translation: AAB40357.1
CH916372 Genomic DNA Translation: EDV99435.1
RefSeqiXP_001993510.1, XM_001993474.1

Genome annotation databases

EnsemblMetazoaiFBtr0148439; FBpp0146931; FBgn0012316
GeneIDi6567072
KEGGidgr:Dgri_GH13025

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U48714 Genomic DNA Translation: AAB40357.1
CH916372 Genomic DNA Translation: EDV99435.1
RefSeqiXP_001993510.1, XM_001993474.1

3D structure databases

ProteinModelPortaliP51551
SMRiP51551
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi7222.FBpp0146931

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0148439; FBpp0146931; FBgn0012316
GeneIDi6567072
KEGGidgr:Dgri_GH13025

Organism-specific databases

FlyBaseiFBgn0012316 Dgri\Adh

Phylogenomic databases

eggNOGiKOG4169 Eukaryota
COG1028 LUCA
InParanoidiP51551
KOiK00001
OMAiWSKHWDS
OrthoDBiEOG091G0OC9
PhylomeDBiP51551

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiADH_DROGR
AccessioniPrimary (citable) accession number: P51551
Secondary accession number(s): B4JRA5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1996
Last sequence update: January 23, 2007
Last modified: September 12, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
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Main funding by: National Institutes of Health

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